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Drug Development and Industrial Pharmacy Volume 42, 2016 - Issue 12
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Research Articles

Lubricant sensitivity in function of paddle movement in the forced feeder of a high-speed tablet press

Elisabeth PeetersLaboratory of Pharmaceutical Technology, Ghent University, Ghent, Belgium
,
Valérie VanhoorneLaboratory of Pharmaceutical Technology, Ghent University, Ghent, Belgium
,
Chris VervaetLaboratory of Pharmaceutical Technology, Ghent University, Ghent, BelgiumCorrespondence[email protected]
&
Jean-Paul RemonLaboratory of Pharmaceutical Technology, Ghent University, Ghent, Belgium
Pages 2078-2085 | Received 03 Jan 2016, Accepted 07 Jun 2016, Published online: 26 Jun 2016

Citations (25)

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Maren Zimmermann, Felix Michel, Jens Bartsch & Markus Thommes. (2022) A novel approach of external lubrication in a rotary tablet press using electrostatics. Drug Development and Industrial Pharmacy 48:12, pages 737-744.
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Articles from other publishers (24)

Valentinë Lura, Stefan Klinken & Jörg Breitkreutz. (2023) Challenges in the transfer and scale-up of mini-tableting: Case study with losartan potassium. European Journal of Pharmaceutics and Biopharmaceutics 192, pages 161-173.
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David Blanco, Hanna Pentikäinen, Osmo Antikainen & Anne Juppo. (2023) Behaviour of magnesium stearate at particle–particle interfaces: Microdynamic flowability to monitor distribution in powders. Powder Technology 419, pages 118337.
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Cedrine de Backere, Thomas De Beer, Chris Vervaet & Valérie Vanhoorne. (2023) Upscaling of external lubrication from a compaction simulator to a rotary tablet press. International Journal of Pharmaceutics 633, pages 122616.
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Cedrine de Backere, Margot Surmont, Thomas De Beer, Chris Vervaet & Valérie Vanhoorne. (2023) Screening of lubricants towards their applicability for external lubrication. International Journal of Pharmaceutics 632, pages 122553.
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Daniel Puckhaber, Ann Kathrin Schomberg, Arno Kwade & Jan Henrik Finke. (2022) A compactibility-based lubricant dispersion model describing the effect of formulation and paddle speed. International Journal of Pharmaceutics 628, pages 122300.
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Cedrine de Backere, Julian Quodbach, Thomas De Beer, Chris Vervaet & Valérie Vanhoorne. (2022) Impact of alternative lubricants on process and tablet quality for direct compression. International Journal of Pharmaceutics 624, pages 122012.
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Cedrine de Backere, Thomas De Beer, Chris Vervaet & Valérie Vanhoorne. (2022) Effect of feed frame on lubricant sensitivity during upscaling from a compaction simulator to a rotary tablet press. International Journal of Pharmaceutics 616, pages 121562.
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Martin Dominik, Barbora Vraníková, Petra Svačinová, Jan Elbl, Sylvie Pavloková, Barbora Blahová Prudilová, Zdeňka Šklubalová & Aleš Franc. (2021) Comparison of Flow and Compression Properties of Four Lactose-Based Co-Processed Excipients: Cellactose® 80, CombiLac®, MicroceLac® 100, and StarLac®. Pharmaceutics 13:9, pages 1486.
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Nobel O. Sierra-Vega, Krizia M. Karry, Rodolfo J. Romañach & Rafael Méndez. (2021) Monitoring of high-load dose formulations based on co-processed and non co-processed excipients. International Journal of Pharmaceutics 606, pages 120910.
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Ryoichi Furukawa, Ravendra Singh & Marianthi Ierapetritou. (2021) Experimental investigation and modelling of tensile strength of pharmaceutical tablets based on shear force applied by feed frame paddles. International Journal of Pharmaceutics 606, pages 120908.
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Ewa Nauka, Chi So, Edward Yost, Chen Mao & Ajit S. Narang. (2021) A Scale-Up, Phenomenological Model Incorporating the Effect of Both Feed Frame Lubrication and Tumble Blending-Driven Lubrication on Tablet Mechanical Strength. Journal of Pharmaceutical Sciences 110:7, pages 2669-2676.
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Cedrine de Backere, Thomas De Beer, Chris Vervaet & Valérie Vanhoorne. (2020) Evaluation of an external lubrication system implemented in a compaction simulator. International Journal of Pharmaceutics 587, pages 119675.
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Isabell Wünsch, Irene Friesen, Daniel Puckhaber, Thomas Schlegel & Jan Henrik Finke. (2020) Scaling Tableting Processes from Compaction Simulator to Rotary Presses—Mind the Sub-Processes. Pharmaceutics 12:4, pages 310.
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Cheol-Hee Cho, Ju-Young Kim & Eun-Seok Park. (2020) Systematic approach to elucidate compaction behavior of acyclovir using a compaction simulator. International Journal of Pharmaceutics 575, pages 118904.
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Claudia Hildebrandt, Srikanth R. Gopireddy, Regina Scherließ & Nora A. Urbanetz. (2020) A DEM approach to assess the influence of the paddle wheel shape on force feeding during pharmaceutical tableting. Advanced Powder Technology 31:2, pages 755-769.
Crossref
Nobel O. Sierra-Vega, Rodolfo J. Romañach & Rafael Méndez. (2019) Feed frame: The last processing step before the tablet compaction in pharmaceutical manufacturing. International Journal of Pharmaceutics 572, pages 118728.
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Alexander Kalies, Hüseyin Özcoban & Claudia S. Leopold. (2019) Application of Externally Applied Lower Punch Vibration and its Effects on Tablet Manufacturing. Pharmaceutical Research 36:12.
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Hui Ping Goh, Paul Wan Sia Heng & Celine Valeria Liew. (2019) The Effects of Feed Frame Parameters and Turret Speed on Mini-Tablet Compression. Journal of Pharmaceutical Sciences 108:3, pages 1161-1171.
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Claudia Hildebrandt, Srikanth R. Gopireddy, Regina Scherließ & Nora A. Urbanetz. (2019) Investigation of powder flow within a pharmaceutical tablet press force feeder – A DEM approach. Powder Technology 345, pages 616-632.
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Claudia Hildebrandt, Srikanth R. Gopireddy, Regina Scherließ & Nora A. Urbanetz. (2019) Assessment of material and process attributes' influence on tablet quality using a QbD and DEM combined approach. Powder Technology 345, pages 390-404.
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Hui Ping Goh, Paul Wan Sia Heng & Celine Valeria Liew. (2018) Investigation on the impact of powder arching in small die filling. International Journal of Pharmaceutics 551:1-2, pages 42-51.
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B. Van Snick, W. Grymonpré, J. Dhondt, K. Pandelaere, G. Di Pretoro, J.P. Remon, T. De Beer, C. Vervaet & V. Vanhoorne. (2018) Impact of blend properties on die filling during tableting. International Journal of Pharmaceutics 549:1-2, pages 476-488.
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W. Grymonpré, V. Vanhoorne, B. Van Snick, B. Blahova Prudilova, F. Detobel, J.P. Remon, T. De Beer & C. Vervaet. (2018) Optimizing feed frame design and tableting process parameters to increase die-filling uniformity on a high-speed rotary tablet press. International Journal of Pharmaceutics 548:1, pages 54-61.
Crossref
Hui Ping Goh, Paul Wan Sia Heng & Celine Valeria Liew. (2018) Understanding effects of process parameters and forced feeding on die filling. European Journal of Pharmaceutical Sciences 122, pages 105-115.
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