1,446
Views
30
CrossRef citations to date
0
Altmetric
Review Article

Current and evolving approaches for improving the oral permeability of BCS Class III or analogous molecules

, , , &
Pages 177-189 | Received 04 Oct 2016, Accepted 30 Nov 2016, Published online: 20 Dec 2016

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (1)

Rudra Pangeni, Saurav Kumar Jha, Ruby Maharjan, Jeong Uk Choi, Kwan-Young Chang, Young Kweon Choi, Youngro Byun & Jin Woo Park. (2019) Intestinal transport mechanism and in vivo anticancer efficacy of a solid oral formulation incorporating an ion-pairing complex of pemetrexed with deoxycholic acid derivative. International Journal of Nanomedicine 14, pages 6339-6356.
Read now

Articles from other publishers (29)

Sapir Ifrah, Arik Dahan & Nir Debotton. (2023) Towards Effective Antiviral Oral Therapy: Development of a Novel Self-Double Emulsifying Drug Delivery System for Improved Zanamivir Intestinal Permeability. Pharmaceutics 15:10, pages 2518.
Crossref
Catriona C. James, Bas de Bruin & Joost N. H. Reek. (2023) Transition Metal Catalysis in Living Cells: Progress, Challenges, and Novel Supramolecular Solutions. Angewandte Chemie International Edition 62:41.
Crossref
Catriona C. James, Bas de Bruin & Joost N. H. Reek. (2023) Transition Metal Catalysis in Living Cells: Progress, Challenges, and Novel Supramolecular Solutions. Angewandte Chemie 135:41.
Crossref
Wenzhan Yang, Maya Lipert & Rebecca Nofsinger. (2023) Current screening, design, and delivery approaches to address low permeability of chemically synthesized modalities in drug discovery and early clinical development. Drug Discovery Today 28:9, pages 103685.
Crossref
Mengchen Liu, Jiaqiang Xu, Qianna Jin & Yunqiao Li. (2023) Interaction of Intestinal Microbiota with Medications. Current Drug Metabolism 24:8, pages 554-567.
Crossref
Hany A. Al-Hussaniy, Yasir Q. Аlmajidi, Amjad I. Oraibi & Abdulwahhab Нameed Alkarawi. (2023) Nanoemulsions as medicinal components in insoluble medicines. Pharmacia 70:3, pages 537-547.
Crossref
Muhammad Asad, Akhtar Rasul, Ghulam Abbas, Muhammad Ajmal Shah & Imran Nazir. (2023) Self-emulsifying drug delivery systems: A versatile approach to enhance the oral delivery of BCS class III drug via hydrophobic ion pairing. PLOS ONE 18:6, pages e0286668.
Crossref
Sri Rekha M., Sangeetha S. & Seetha Devi A.. (2023) Solid Lipid Nanoparticles: A Potential Option for Enhancing Oral Bioavailability of Highly Soluble and Poorly Permeable (BCS Class III) Drugs. Current Drug Delivery 20:3, pages 223-236.
Crossref
Orlando G. Elso, Augusto E. Bivona, Rocío Cenizo, Emilio L. Malchiodi & Guadalupe García Liñares. (2023) Enzymatic synthesis of amlodipine amides and evaluation of their anti- Trypanosoma cruzi activity . Organic & Biomolecular Chemistry 21:7, pages 1411-1421.
Crossref
Omar Y. Mady, Mohamed A. Osman, Naglaa I. Sarhan, Ali A. Shatla & Yusuf A. Haggag. (2023) Bioavailability enhancement of acyclovir by honey: Analytical and histological evidence. Journal of Drug Delivery Science and Technology 80, pages 104155.
Crossref
Tejas Girish Agnihotri, Amit Alexander, Mukta Agrawal, Sunil Kumar Dubey & Aakanchha Jain. (2023) In vitro-in vivo correlation in nanocarriers: From protein corona to therapeutic implications. Journal of Controlled Release 354, pages 794-809.
Crossref
Menna M. Abdellatif, Sara Mohamed Ahmed, Mohamed A. El-Nabarawi & Mahmoud Teaima. (2022) Oral Bioavailability Enhancement of Vancomycin Hydrochloride with Cationic Nanocarrier (Leciplex): Optimization, In Vitro, Ex Vivo, and In Vivo Studies. Scientia Pharmaceutica 91:1, pages 1.
Crossref
Catriona C. James, Dinghao Wu, Eduard O. Bobylev, Alexander Kros, Bas de Bruin & Joost N. H. Reek. (2022) Protection of a Gold Catalyst by a Supramolecular Cage Improves Bioorthogonality. ChemCatChem 14:23.
Crossref
Noopur Pandey & Animesh Ghosh. (2022) An outlook on permeability escalation through cocrystallization for developing pharmaceuticals with improved biopharmaceutical properties. Journal of Drug Delivery Science and Technology 76, pages 103757.
Crossref
Rohit Y. Sathe & Prasad V. Bharatam. (2022) Drug-dendrimer complexes and conjugates: Detailed furtherance through theory and experiments. Advances in Colloid and Interface Science 303, pages 102639.
Crossref
Kleyton S. Veras, Flávia Nathiely S. Fachel, Helder F. Teixeira & Letícia S. Koester. (2022) Technological strategies applied for rosmarinic acid delivery through different routes – A review. Journal of Drug Delivery Science and Technology 68, pages 103054.
Crossref
Lingling Huang, Jianmiao Yang, Tiantian Wang, Jianqing Gao & Donghang Xu. (2022) Engineering of small-molecule lipidic prodrugs as novel nanomedicines for enhanced drug delivery. Journal of Nanobiotechnology 20:1.
Crossref
Rayhanus Salam, Surid Mohammad Chowdhury, Sarah R. Marshall, Hassan Gneid & Nathalie Busschaert. (2021) Increasing membrane permeability of carboxylic acid-containing drugs using synthetic transmembrane anion transporters. Chemical Communications 57:97, pages 13122-13125.
Crossref
Ritu Gupta, Yuan Chen & Huan Xie. (2021) In vitro dissolution considerations associated with nano drug delivery systems. WIREs Nanomedicine and Nanobiotechnology 13:6.
Crossref
Nikhil Suthar, Jagruti Desai & Hetal Paresh Thakkar. (2021) Investigation on Potential of Chitosan Nanoparticles for Oral Bioavailability Enhancement of Risedronate Sodium. AAPS PharmSciTech 22:7.
Crossref
Xintong Zhang, Ying Han, Wei Huang, Mingji Jin & Zhonggao Gao. (2021) The influence of the gut microbiota on the bioavailability of oral drugs. Acta Pharmaceutica Sinica B 11:7, pages 1789-1812.
Crossref
Dianxiong Zou, Meenakshi Arora, Raghu Ganugula, Mokshada Kumar, Erin M. Scott, Dhaval Shah & M.N.V. Ravi Kumar. (2021) Nanoparticles that do not compete with endogenous ligands – Molecular characterization in vitro, acute safety in canine, and interspecies pharmacokinetics modeling to humans. Journal of Controlled Release 332, pages 64-73.
Crossref
Feiyang Deng & You Han Bae. (2020) Bile acid transporter-mediated oral drug delivery. Journal of Controlled Release 327, pages 100-116.
Crossref
Alexander Gamboa, Nina Schüßler, Eduardo Soto-Bustamante, Patricio Romero-Hasler, Lorenz Meinel & Javier O. Morales. (2020) Delivery of ionizable hydrophilic drugs based on pharmaceutical formulation of ion pairs and ionic liquids. European Journal of Pharmaceutics and Biopharmaceutics 156, pages 203-218.
Crossref
Meichen Guo, Shichao Yu, Yuying Huang, Hang Song, Mo Li, Dan Liu, Qiang Fu & Zhonggui He. (2020) A novel cascade strategy using a nanonized targeted prodrug for enhanced oral delivery efficiency. International Journal of Pharmaceutics 587, pages 119638.
Crossref
Irina E. Antonescu, Karina F. Rasmussen, Sibylle Neuhoff, Xavier Fretté, Maria Karlgren, Christel A. S. Bergström, Carsten Uhd Nielsen & Bente Steffansen. (2019) The Permeation of Acamprosate Is Predominantly Caused by Paracellular Diffusion across Caco-2 Cell Monolayers: A Paracellular Modeling Approach. Molecular Pharmaceutics 16:11, pages 4636-4650.
Crossref
Yeimy L. Cueto, Wilfrido L. Ortega & Reinaldo G. Sotomayor. (2019) Sistemas de entrega de fármacos autoemulsificables: una plataforma de desarrollo alternativa para la industria farmacéutica colombiana. Revista Colombiana de Ciencias Químico-Farmacéuticas 48:2, pages 260-313.
Crossref
Shimaa M. Ashmawy, Mohamed A. Osman, Sanaa A. El-Gizawy & Gamal M. El Maghraby. (2019) d-glucose elicits significant increase in the oral bioavailability of model BCS class III drugs in the rabbit. Journal of Drug Delivery Science and Technology 49, pages 521-526.
Crossref
Hyuck Jung, Myoung Ho, Sungwan Ahn, Young Han & Myung Kang. (2018) Synthesis and Physicochemical Evaluation of Entecavir-Fatty Acid Conjugates in Reducing Food Effect on Intestinal Absorption. Molecules 23:4, pages 731.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.