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Drug Development and Industrial Pharmacy Volume 44, 2018 - Issue 9
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Research Article

Pharmacokinetics, tissue distribution, bioavailability, and excretion of nuciferine, an alkaloid from lotus, in rats by LC/MS/MS

Fugang WangSchool of Pharmacy, Taishan Medical University, Taian, People’s Republic of China; Correspondence[email protected]
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,
Juan CaoSchool of Pharmacy, Taishan Medical University, Taian, People’s Republic of China; Correspondence[email protected]
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,
Xueqin HouSchool of Pharmacy, Taishan Medical University, Taian, People’s Republic of China; View further author information
,
Zhiyong LiDepartment of Pharmacology, China Minority Traditional Medical Center of Min Zu University of China, Beijing, People’s Republic of ChinaView further author information
&
Xiaolan QuSchool of Pharmacy, Taishan Medical University, Taian, People’s Republic of China; View further author information
Pages 1557-1562 | Received 11 Apr 2018, Accepted 24 May 2018, Published online: 21 Jun 2018

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Zhenyu Wang, Yong Li, Dandan Ma, Maomao Zeng, Zhaojun Wang, Fang Qin, Jie Chen, Mark Christian & Zhiyong He. (2023) Alkaloids from lotus (Nelumbo nucifera): recent advances in biosynthesis, pharmacokinetics, bioactivity, safety, and industrial applications. Critical Reviews in Food Science and Nutrition 63:21, pages 4867-4900.
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Dalia M. N. Abouhussein, Dina Bahaa El Din Mahmoud & Ebtehal Mohammad F.. (2019) Design of a liquid nano-sized drug delivery system with enhanced solubility of rivaroxaban for venous thromboembolism management in paediatric patients and emergency cases. Journal of Liposome Research 29:4, pages 399-412.
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Jing Sun, Xingtian Zhan, Weimin Wang, Xiaojie Yang, Yichen Liu, Huanzhi Yang, Jianjun Deng & Haixia Yang. (2023) Natural aporphine alkaloids: A comprehensive review of phytochemistry, pharmacokinetics, anticancer activities, and clinical application. Journal of Advanced Research.
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Jingjing Tai, Chaoyin Ye, Xiaoji Cao, Huang Hu, Wanzhen Li & Hong Zhang. (2023) Study on the anti-gout activity of the lotus seed pod by UPLC-QTOF-MS and virtual molecular docking. Fitoterapia 167, pages 105500.
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Zixiong Zhou, Jing Qi, Yajiao Wu, Chutao Li, Wenqiang Bao, Xiaohuang Lin & An Zhu. (2023) Nuciferine Effectively Protects Mice against Acetaminophen-Induced Liver Injury. Antioxidants 12:4, pages 949.
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Jia-wei Guan, Yu Xu, Wei Yu, Li-hua Wei, Rui Xue, Hang Yu, Jing-min Fan, Hong-zheng Wang, Abudumijiti Abulizi, Wen Chen & Bo Han. (2023) Biosensor-based active ingredient recognition system for screening TNF-α inhibitors from lotus leaves. Analytical and Bioanalytical Chemistry 415:9, pages 1641-1655.
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Zili Guo, Bianbian Gao, Miaoliang Fan, Lisha Chen, Changjun Zhang, Xianrui Liang, Weike Su & Yuanyuan Xie. (2023) Study on Absorption, Distribution and Excretion of a New Candidate Compound XYY-CP1106 against Alzheimer’s Disease in Rats by LC-MS/MS. Molecules 28:5, pages 2377.
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Chang Chen, Feipeng Duan, Yongyan Xie, Quan Wan, Haiyun Liu, Jinpeng Gong, Liping Huang & Zonghua Song. (2022) Nuciferine attenuates acute ischemic stroke in a rat model: a metabolomic approach for the mechanistic study. Molecular Omics 18:8, pages 765-778.
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Joanne E. Haughan, Jaclyn R. Missanelli, Youwen You, Darko Stefanovski, Lawrence R. Soma & Mary A. Robinson. (2022) Pharmacokinetics of glaucine after intravenous and oral administrations and detection of systemic aporphine alkaloids after ingestion of tulip poplar shavings in horses. Journal of Veterinary Pharmacology and Therapeutics 45:3, pages 273-282.
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Xiaobo Huang, Nan Hao, Genqiang Chen, Shengming Liu & Zhiping Che. (2022) Chemistry and biology of nuciferine. Industrial Crops and Products 179, pages 114694.
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Lian-Yong Liu, Lin Zhou, Xing-Zhen Liu & Da-Jin Zou. (2022) Effect of Hedan Tablets on Body Weight and Insulin Resistance in Patients with Metabolic Syndrome. Obesity Facts 15:2, pages 180-185.
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Yan Wan, Jia Xia, Jin-feng Xu, Lu Chen, Yu Yang, Jiao-Jiao Wu, Fei Tang, Hui Ao & Cheng Peng. (2022) Nuciferine, an active ingredient derived from lotus leaf, lights up the way for the potential treatment of obesity and obesity-related diseases. Pharmacological Research 175, pages 106002.
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Qun Yu & Liuping Fan. (2021) Improving the bioactive ingredients and functions of asparagus from efficient to emerging processing technologies: A review. Food Chemistry 358, pages 129903.
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Zhenyu Wang, Yong Cheng, Maomao Zeng, Zhaojun Wang, Fang Qin, Yongzhi Wang, Jie Chen & Zhiyong He. (2021) Lotus (Nelumbo nucifera Gaertn.) leaf: A narrative review of its Phytoconstituents, health benefits and food industry applications. Trends in Food Science & Technology 112, pages 631-650.
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Danyu Li, Bing Liu, Yumei Fan, Ming Liu, Bihui Han, Yanxiu Meng, Xiao Xu, Zhiyuan Song, Xiaopeng Liu, Qiang Hao, Xianglin Duan, Akira Nakai, Yanzhong Chang, Pengxiu Cao & Ke Tan. (2021) Nuciferine protects against folic acid‐induced acute kidney injury by inhibiting ferroptosis. British Journal of Pharmacology 178:5, pages 1182-1199.
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Hassan Rasouli, Reza Yarani, Flemming Pociot & Jelena Popović-Djordjević. (2020) Anti-diabetic potential of plant alkaloids: Revisiting current findings and future perspectives. Pharmacological Research 155, pages 104723.
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