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Original Research

Decreasing, Null and Increasing Effects of Eight Popular Types of Ginseng on Acute Postprandial Glycemic Indices in Healthy Humans: The Role of Ginsenosides

, PhD, , PhD, , MD & , PhD
Pages 248-258 | Received 20 Jun 2003, Accepted 11 Nov 2003, Published online: 19 Jun 2013

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John L. Sievenpiper, Mi-Kyung Sung, Marco Di Buono, Kwang Seung-Lee, Ki Yeul Nam, John T. Arnason, Lawrence A. Leiter & Vladimir Vuksan. (2006) Korean Red Ginseng Rootlets Decrease Acute Postprandial Glycemia: Results from Sequential Preparation- and Dose-Finding Studies. Journal of the American College of Nutrition 25:2, pages 100-107.
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Lars P. Christensen. 2008. 1 99 .
. 2008. Essentials of Sports Nutrition Study Guide. Essentials of Sports Nutrition Study Guide 335 393 .
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Crossref
Timothy S. Tracy. 2007. Herbal Products. Herbal Products 177 194 .
Ronald Tamler & Jeffrey I Mechanick. (2006) Dietary supplements and nutraceuticals in the management of endocrine disorders. Current Opinion in Endocrinology and Diabetes 13:5, pages 425-430.
Crossref
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Shefali Dham, Viral Shah, Sondra Hirsch & Mary Ann Banerji. (2006) The role of complementary and alternative medicine in diabetes. Current Diabetes Reports 6:3, pages 251-258.
Crossref
Catherine Buettner, Gloria Y Yeh, Russell S Phillips, Murray A Mittleman & Ted J Kaptchuk. (2016) Systematic Review of the Effects of Ginseng on Cardiovascular Risk Factors. Annals of Pharmacotherapy 40:1, pages 83-95.
Crossref
P. Mark StavroMinna WooTibor F. HeimLawrence A. LeiterVladimir Vuksan. (2005) North American Ginseng Exerts a Neutral Effect on Blood Pressure in Individuals With Hypertension. Hypertension 46:2, pages 406-411.
Crossref
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Crossref

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