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Original Research

Supplementation of Soy Isoflavones Improved Sex Hormones, Blood Pressure, and Postmenopausal Symptoms

, PhD, , PhD, , PhD & , MSc
Pages 42-48 | Received 18 Nov 2012, Accepted 21 Oct 2013, Published online: 03 Feb 2015

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Mark Messina, Sonia Blanco Mejia, Aedin Cassidy, Alison Duncan, Mindy Kurzer, Chisato Nagato, Martin Ronis, Ian Rowland, John Sievenpiper & Stephen Barnes. (2022) Neither soyfoods nor isoflavones warrant classification as endocrine disruptors: a technical review of the observational and clinical data. Critical Reviews in Food Science and Nutrition 62:21, pages 5824-5885.
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Silvia Maffei, Michela Franchini, Loredana Fortunato & Letizia Guiducci. (2022) Long-term effects of a combination of isoflavones, agnus castus and magnolia extracts on climacteric symptoms and cardiometabolic risk profile in postmenopausal women. Gynecological Endocrinology 38:4, pages 339-344.
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Zhao-min Liu, Guoyi Li, Di Zhang, Suzanne C. Ho, Yu-ming Chen, Jing Ma, Qi Huang, Shuyi Li & Wen-hua Ling. (2020) Effect of whole soy and purified daidzein on androgenic hormones in chinese equol-producing post-menopausal women: a six-month randomised, double-blinded and Placebo-Controlled trial. International Journal of Food Sciences and Nutrition 71:5, pages 644-652.
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Sheenam Garg, Vaibhao Kisanrao Lule, Ravinder Kumar Malik & Sudhir Kumar Tomar. (2016) Soy Bioactive Components in Functional Perspective: A Review. International Journal of Food Properties 19:11, pages 2550-2574.
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Evayne de Barros, Paola Cristine de Bortoli dos Santos, Maiara Frigo, Jucieli Weber, Carla Zanelatto & Eloá Angélica Koehnlein. (2023) Effects of a Combination of Phytoestrogens on Risk Factors for Cardiovascular Diseases in Climacteric Women: A Randomized, Placebocontrolled Trial. Current Bioactive Compounds 19:2.
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Shahnaz Rimaz, Seyedeh Tayebeh Rahideh, Jamileh Abolghasemi, Shima Jazayeri, Sanaz Jamshidi, Manijeh Motevalian, Masoud Solaymani-Dodaran, Mohsen Taghizadeh, Afsaneh Gholamrezayi & Naheed Aryaeian. (2023) The effect of Cornus mas fruit extract on vasomotor symptoms and sex hormones in postmenopausal women: a randomized, double-blind, clinical trial. Menopause 30:2, pages 201-207.
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Xinyu Bian, Xiaoyu Zhuang, Junpeng Xing, Shu Liu, Zhiqiang Liu & Fengrui Song. (2022) Native Mass Spectrometry Coupled to Spectroscopic Methods to Investigate the Effect of Soybean Isoflavones on Structural Stability and Aggregation of Zinc Deficient and Metal-Free Superoxide Dismutase. Molecules 27:21, pages 7303.
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Mark Messina, Alison Duncan, Virginia Messina, Heidi Lynch, Jessica Kiel & John W. ErdmanJr.Jr.. (2022) The health effects of soy: A reference guide for health professionals. Frontiers in Nutrition 9.
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Deepika Kathuria, Anju K. Dhiman & Attri Surekha. (2021) Effect of different extraction techniques and drying conditions for the assay of isoflavone from Harit soya seeds . Journal of Food Processing and Preservation 46:1.
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Junjie Zhu, Qi Zhao, Yun Qiu, Yue Zhang, Shuheng Cui, Yuting Yu, Bo Chen, Meiying Zhu, Na Wang, Xing Liu, Yonggen Jiang, Wanghong Xu & Genming Zhao. (2021) Soy Isoflavones Intake and Obesity in Chinese Adults: A Cross-Sectional Study in Shanghai, China. Nutrients 13:8, pages 2715.
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Marta Trius-Soler, María Marhuenda-Muñoz, Emily P. Laveriano-Santos, Miriam Martínez-Huélamo, Gemma Sasot, Carolina E. Storniolo, Ramon Estruch, Rosa M. Lamuela-Raventós & Anna Tresserra-Rimbau. (2021) Moderate Consumption of Beer (with and without Ethanol) and Menopausal Symptoms: Results from a Parallel Clinical Trial in Postmenopausal Women. Nutrients 13:7, pages 2278.
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Eun Yeong Lim, So-Young Lee, Hee Soon Shin, Jaekwang Lee, Young-Do Nam, Dong Ock Lee, Ji Young Lee, Sung Hum Yeon, Rak Ho Son, Chae Lee Park, Yun Haeng Heo & Yun Tai Kim. (2020) The Effect of Lactobacillus acidophilus YT1 (MENOLACTO) on Improving Menopausal Symptoms: A Randomized, Double-Blinded, Placebo-Controlled Clinical Trial. Journal of Clinical Medicine 9:7, pages 2173.
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Maud J. M. Geerkens, Nieck S. A. Pouwels & Harry P. Beerlage. (2019) The effectiveness of lifestyle interventions to reduce side effects of androgen deprivation therapy for men with prostate cancer: a systematic review. Quality of Life Research 29:4, pages 843-865.
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Evangelia Mareti, Christina Ampatzi, Stavroula A. Paschou, Evangelia Voziki & Dimitrios G. Goulis. (2019) Non-Hormonal Replacement Therapy Regimens: Do they have an Effect on Cardiovascular Risk?. Current Vascular Pharmacology 17:6, pages 573-578.
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Kazuo Yamagata. (2019) Soy Isoflavones Inhibit Endothelial Cell Dysfunction and Prevent Cardiovascular Disease. Journal of Cardiovascular Pharmacology 74:3, pages 201-209.
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Maryam Abshirini, Fereydoun Siassi, Fariba Koohdani, Mostafa Qorbani, Shahla Khosravi, Mehdi Hedayati, Zahra Aslani, Mahshid Soleymani & Gity Sotoudeh. (2018) Dietary total antioxidant capacity is inversely related to menopausal symptoms: a cross-sectional study among Iranian postmenopausal women. Nutrition 55-56, pages 161-167.
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Makoto KinoshitaKoutaro Yokote, Hidenori Arai, Mami Iida, Yasushi Ishigaki, Shun Ishibashi, Seiji Umemoto, Genshi Egusa, Hirotoshi Ohmura, Tomonori Okamura, Shinji Kihara, Shinji Koba, Isao Saito, Tetsuo Shoji, Hiroyuki Daida, Kazuhisa Tsukamoto, Juno Deguchi, Seitaro DohiKazushige Dobashi, Hirotoshi Hamaguchi, Masumi Hara, Takafumi Hiro, Sadatoshi Biro, Yoshio Fujioka, Chizuko Maruyama, Yoshihiro Miyamoto, Yoshitaka Murakami, Masayuki Yokode, Hiroshi Yoshida, Hiromi Rakugi, Akihiko Wakatsuki & Shizuya Yamashita. (2018) Japan Atherosclerosis Society (JAS) Guidelines for Prevention of Atherosclerotic Cardiovascular Diseases 2017. Journal of Atherosclerosis and Thrombosis 25:9, pages 846-984.
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Xue-shan Zhong, Jing Ge, Shao-wei Chen, Yi-quan Xiong, Shu-juan Ma & Qing Chen. (2018) Association between Dietary Isoflavones in Soy and Legumes and Endometrial Cancer: A Systematic Review and Meta-Analysis. Journal of the Academy of Nutrition and Dietetics 118:4, pages 637-651.
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Gianluca Rizzo & Luciana Baroni. (2018) Soy, Soy Foods and Their Role in Vegetarian Diets. Nutrients 10:1, pages 43.
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Juliene G Costa, Jéssica S Giolo, Igor M Mariano, Jaqueline P Batista, Ana Luiza A Ribeiro, Tállita Cristina F Souza, Erick P de Oliveira, Ana Paula M Resende & Guilherme M Puga. (2017) Combined exercise training reduces climacteric symptoms without the additive effects of isoflavone supplementation: A clinical, controlled, randomised, double-blind study. Nutrition and Health 23:4, pages 271-279.
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Yu Ra Kim, Hee Soo Pyo, Bong Chul Chung, Myeong Hee Moon & Jeongae Lee. (2017) GC-MS Analysis of Various Phytoestrogens in Health Functional Foods. Bulletin of the Korean Chemical Society 38:4, pages 448-458.
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Joao Tomé-Carneiro & Francesco Visioli. (2016) Polyphenol-based nutraceuticals for the prevention and treatment of cardiovascular disease: Review of human evidence. Phytomedicine 23:11, pages 1145-1174.
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Mitsuyoshi Kano, Norihiro Kubota, Norie Masuoka, Tetsuji Hori, Kouji Miyazaki & Fumiyasu Ishikawa. (2016) Oral Administration of Fermented Soymilk Products Protects the Skin of Hairless Mice against Ultraviolet Damage. Nutrients 8:8, pages 514.
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Takayuki NAGINO, Mitsuyoshi KANO, Norie MASUOKA, Chiaki KAGA, Michitoshi ANBE, Kouji MIYAZAKI, Keiko KAMACHI, Mariko ISOZAKI, Chigusa SUZUKI, Chikako KASUGA & Akira TANAKA. (2016) Intake of a fermented soymilk beverage containing moderate levels of isoflavone aglycones enhances bioavailability of isoflavones in healthy premenopausal Japanese women: a double-blind, placebo-controlled, single-dose, crossover trial. Bioscience of Microbiota, Food and Health 35:1, pages 9-17.
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Yan Tang, Shuangyue Li, Ping Zhang, Jinbiao Zhu, Guoliang Meng, Liping Xie, Ying Yu, Yong Ji & Yi Han. (2016) Soy Isoflavone Protects Myocardial Ischemia/Reperfusion Injury through Increasing Endothelial Nitric Oxide Synthase and Decreasing Oxidative Stress in Ovariectomized Rats. Oxidative Medicine and Cellular Longevity 2016, pages 1-14.
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Akimitsu Takagi, Mitsuyoshi Kano & Chiaki Kaga. (2015) Possibility of Breast Cancer Prevention: Use of Soy Isoflavones and Fermented Soy Beverage Produced Using Probiotics. International Journal of Molecular Sciences 16:12, pages 10907-10920.
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