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Original Research

The Effects of Long-Chain Omega-3 Fish Oils and Multivitamins on Cognitive and Cardiovascular Function: A Randomized, Controlled Clinical Trial

, PhD, , DPsyc.c, , BSc, , PhD, , PhD, , PhD & , PhD show all

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Klára Daďová, Miroslav Petr, James J Tufano, Lenka Sontáková, Eva Krauzová, Marek Štěpán, Michaela Šiklová & Michal Šteffl. (2022) Calanus Oil Supplementation Does Not Further Improve Short-Term Memory or Brain-Derived Neurotrophic Factor in Older Women Who Underwent Exercise Training. Clinical Interventions in Aging 17, pages 1227-1236.
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Ling Huang, Jing Zhao, Yongjie Chen, Fei Ma, Guowei Huang & Wen Li. (2022) Baseline folic acid status affects the effectiveness of folic acid supplements in cognitively relevant outcomes in older adults: a systematic review. Aging & Mental Health 26:3, pages 457-463.
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Alexandra T. Wade, Courtney R. Davis, Kathryn A. Dyer, Jonathan M. Hodgson, Richard J. Woodman, Hannah A. D. Keage & Karen J. Murphy. (2020) A Mediterranean diet supplemented with dairy foods improves mood and processing speed in an Australian sample: results from the MedDairy randomized controlled trial. Nutritional Neuroscience 23:8, pages 646-658.
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Brendan Tan, Franklin Rosenfeldt, Ruchong Ou & Con Stough. (2019) Evidence and mechanisms for statin-induced cognitive decline. Expert Review of Clinical Pharmacology 12:5, pages 397-406.
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Jingyuan Ya & Ulvi Bayraktutan. (2023) Vascular Ageing: Mechanisms, Risk Factors, and Treatment Strategies. International Journal of Molecular Sciences 24:14, pages 11538.
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Gabriele Brosolo, Andrea Da Porto, Stefano Marcante, Alessandro Picci, Filippo Capilupi, Patrizio Capilupi, Nicole Bertin, Cinzia Vivarelli, Luca Bulfone, Antonio Vacca, Cristiana Catena & Leonardo A. Sechi. (2023) Omega-3 Fatty Acids in Arterial Hypertension: Is There Any Good News?. International Journal of Molecular Sciences 24:11, pages 9520.
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B. Andriambelo, M. Stiffel, K. Roke & M. Plourde. (2023) New perspectives on randomized controlled trials with omega-3 fatty acid supplements and cognition: A scoping review. Ageing Research Reviews 85, pages 101835.
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Lauren M. Young, Sarah Gauci, Lizanne Arnoldy, Laura Martin, Naomi Perry, David J. White, Denny Meyer, Annie-Claude Lassemillante, Edward Ogden, Beata Silber, Andrew Scholey & Andrew Pipingas. (2022) Investigating the Effects of a Multinutrient Supplement on Cognition, Mood and Biochemical Markers in Middle-Aged Adults with ‘Optimal’ and ‘Sub-Optimal’ Diets: A Randomized Double Blind Placebo Controlled Trial. Nutrients 14:23, pages 5079.
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Xin Zhang, Jennifer A. Ritonja, Na Zhou, Bingshu E. Chen & Xinzhi Li. (2022) Omega‐3 Polyunsaturated Fatty Acids Intake and Blood Pressure: A Dose‐Response Meta‐Analysis of Randomized Controlled Trials. Journal of the American Heart Association 11:11.
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Paul Fairbairn, Simon C. Dyall & Fotini Tsofliou. (2022) The effects of multi-nutrient formulas containing a combination of n -3 PUFA and B vitamins on cognition in the older adult: a systematic review and meta-analysis . British Journal of Nutrition, pages 1-14.
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Wolfgang Marx, Elena S. George, Hannah L. Mayr, Colleen J. Thomas, Katerina Sarapis, George Moschonis, Greg Kennedy, Andrew Pipingas, Jane C. Willcox, Luke A. Prendergast & Catherine Itsiopoulos. (2019) Effect of high polyphenol extra virgin olive oil on markers of cardiovascular disease risk in healthy Australian adults (OLIVAUS): A protocol for a double‐blind randomised, controlled, cross‐over study. Nutrition & Dietetics 77:5, pages 523-528.
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Lauren M. Young, Sarah Gauci, Andrew Scholey, David J. White, Annie-Claude Lassemillante, Denny Meyer & Andrew Pipingas. (2020) Self-Reported Diet Quality Differentiates Nutrient Intake, Blood Nutrient Status, Mood, and Cognition: Implications for Identifying Nutritional Neurocognitive Risk Factors in Middle Age. Nutrients 12:10, pages 2964.
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Jessica E. Singh. (2020) Dietary Sources of Omega-3 Fatty Acids Versus Omega-3 Fatty Acid Supplementation Effects on Cognition and Inflammation. Current Nutrition Reports 9:3, pages 264-277.
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Anu Alex, Kylie A Abbott, Mark McEvoy, Peter W Schofield & Manohar L Garg. (2020) Long-chain omega-3 polyunsaturated fatty acids and cognitive decline in non-demented adults: a systematic review and meta-analysis. Nutrition Reviews 78:7, pages 563-578.
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Sepideh Goudarzi & Mohammad Abdollahi. 2020. Nutrients and Nutraceuticals for Active & Healthy Ageing. Nutrients and Nutraceuticals for Active & Healthy Ageing 167 194 .
Yat-Fung Shea & Steven T. DeKosky. 2019. Cognitive Changes and the Aging Brain. Cognitive Changes and the Aging Brain 291 306 .
Victoria A. Serhiyenko, Boris N. Mankovsky, Ludmila М. Serhiyenko & Aleksandr A. Serhiyenko. (2019) The effect of OMEGA-3 polyunsaturated fatty acids on ambulatory blood pressure monitoring parameters in patients with type 2 diabetes mellitus and cardiovascular autonomic neuropathy. Diabetes mellitus 22:1, pages 62-69.
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Masoumeh Tangestani Fard & Con Stough. (2019) A Review and Hypothesized Model of the Mechanisms That Underpin the Relationship Between Inflammation and Cognition in the Elderly. Frontiers in Aging Neuroscience 11.
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Grace E. Giles, Caroline R. Mahoney & Robin B. Kanarek. 2019. Omega Fatty Acids in Brain and Neurological Health. Omega Fatty Acids in Brain and Neurological Health 313 355 .
Anne WS Rutjes, David A Denton, Marcello Di Nisio, Lee-Yee Chong, Rajesh P Abraham, Aalya S Al-Assaf, John L Anderson, Muzaffar A Malik, Robin WM Vernooij, Gabriel Martínez, Naji Tabet & Jenny McCleery. (2018) Vitamin and mineral supplementation for maintaining cognitive function in cognitively healthy people in mid and late life. Cochrane Database of Systematic Reviews 2019:1.
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Victoria Serhiyenko, Ludmila Serhiyenko & Alexandr Serhiyenko. (2018) Omega-3 Polyunsaturated Fatty Acids Improved Arterial Stiffness Parameters in Type 2 Diabetic Patients with Cardiac Autonomic Neuropathy. Romanian Journal of Diabetes Nutrition and Metabolic Diseases 25:4, pages 363-368.
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Jenny McCleery, Rajesh P Abraham, David A Denton, Anne WS Rutjes, Lee-Yee Chong, Aalya S Al-Assaf, Daniel J Griffith, Shireen Rafeeq, Hakan Yaman, Muzaffar A Malik, Marcello Di Nisio, Gabriel Martínez, Robin WM Vernooij & Naji Tabet. (2018) Vitamin and mineral supplementation for preventing dementia or delaying cognitive decline in people with mild cognitive impairment. Cochrane Database of Systematic Reviews 2019:2.
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Ana StupinLidija RasicAnita MaticMarko StupinZlata KralikGordana KralikManuela GrcevicInes Drenjancevic. (2018) Omega-3 polyunsaturated fatty acids-enriched hen eggs consumption enhances microvascular reactivity in young healthy individuals. Applied Physiology, Nutrition, and Metabolism 43:10, pages 988-995.
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Vincenzo Solfrizzi, Pasquale Agosti, Madia Lozupone, Carlo Custodero, Andrea Schilardi, Vincenzo Valiani, Rodolfo Sardone, Vittorio Dibello, Luca Di Lena, Angela Lamanna, Roberta Stallone, Antonello Bellomo, Antonio Greco, Antonio Daniele, Davide Seripa, Carlo Sabbà, Giancarlo Logroscino & Francesco Panza. (2018) Nutritional Intervention as a Preventive Approach for Cognitive-Related Outcomes in Cognitively Healthy Older Adults: A Systematic Review. Journal of Alzheimer's Disease 64:s1, pages S229-S254.
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Greg Kennedy, Denny Meyer, Roy J. Hardman, Helen Macpherson, Andrew B. Scholey & Andrew Pipingas. (2018) Physical Fitness and Aortic Stiffness Explain the Reduced Cognitive Performance Associated with Increasing Age in Older People. Journal of Alzheimer's Disease 63:4, pages 1307-1316.
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Jeffery M. Reddan, David J. White, Helen Macpherson, Andrew Scholey & Andrew Pipingas. (2018) Glycerophospholipid Supplementation as a Potential Intervention for Supporting Cerebral Structure in Older Adults. Frontiers in Aging Neuroscience 10.
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Oscar D Rangel-Huerta & Angel Gil. (2018) Effect of omega-3 fatty acids on cognition: an updated systematic review of randomized clinical trials. Nutrition Reviews 76:1, pages 1-20.
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Alexandra T. Wade, Courtney R. Davis, Kathryn A. Dyer, Jonathan M. Hodgson, Richard J. Woodman, Hannah A. D. Keage & Karen J. Murphy. (2017) Including pork in the Mediterranean diet for an Australian population: Protocol for a randomised controlled trial assessing cardiovascular risk and cognitive function. Nutrition Journal 16:1.
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Julia Kuszewski, Rachel Wong & Peter Howe. (2017) Effects of Long-Chain Omega-3 Polyunsaturated Fatty Acids on Endothelial Vasodilator Function and Cognition—Are They Interrelated?. Nutrients 9:5, pages 487.
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Alexandra Wade, Courtney Davis, Kathryn Dyer, Jonathan Hodgson, Richard Woodman, Hannah Keage & Karen Murphy. (2017) A Mediterranean Diet to Improve Cardiovascular and Cognitive Health: Protocol for a Randomised Controlled Intervention Study. Nutrients 9:2, pages 145.
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Joseph Mathew Antony, Ian Weaver, Matthew Rueffer, Najla Guthrie & Malkanthi Evans. (2017) The essentials of a global index for cognitive function. Translational Neuroscience 8:1.
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Jessica R. Santos-Parker, Talia R. Strahler, Candace J. Bassett, Nina Z. Bispham, Michel B. Chonchol & Douglas R. Seals. (2017) Curcumin supplementation improves vascular endothelial function in healthy middle-aged and older adults by increasing nitric oxide bioavailability and reducing oxidative stress. Aging 9:1, pages 187-208.
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Kurt S. Tande, Trung D. Vo & Barry S. Lynch. (2016) Clinical safety evaluation of marine oil derived from Calanus finmarchicus. Regulatory Toxicology and Pharmacology 80, pages 25-31.
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J.E. Radcliffe, J. Thomas, A.L. Bramley, A. Kouris-Blazos, B.E. Radford, A.B. Scholey, A. Pipingas, C.J. Thomas & C. Itsiopoulos. (2016) Controversies in omega-3 efficacy and novel concepts for application. Journal of Nutrition & Intermediary Metabolism 5, pages 11-22.
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Oscar H. Del Brutto, Robertino M. Mera, Jennifer Gillman, Mauricio Zambrano & Jung-eun Ha. (2015) Oily Fish Intake and Cognitive Performance in Community-Dwelling Older Adults: The Atahualpa Project. Journal of Community Health 41:1, pages 82-86.
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Andrew Pipingas, Andrew Sinclair, Kevin D. Croft, Andrzej S. Januszewski, Alicia J. Jenkins, Trevor A. Mori, Robyn Cockerell, Natalie A. Grima, Con Stough, Andrew Scholey, Stephen P. Myers, Avni Sali & Matthew P. Pase. (2015) Fish oil and multivitamin supplementation reduces oxidative stress but not inflammation in healthy older adults: A randomised controlled trial. Journal of Functional Foods 19, pages 949-957.
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Andrew Pipingas, Robyn Cockerell, Natalie Grima, Andrew Sinclair, Con Stough, Andrew Scholey, Stephen Myers, Kevin Croft, Avni Sali & Matthew Pase. (2014) Randomized Controlled Trial Examining the Effects of Fish Oil and Multivitamin Supplementation on the Incorporation of n-3 and n-6 Fatty Acids into Red Blood Cells. Nutrients 6:5, pages 1956-1970.
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