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Nucleosides and Nucleotides Volume 16, 1997 - Issue 7-9
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I. PROGRESS IN SECOND GENERATION OLIGOMER THERAPEUTICS

Mixed-Backbone Oligonucleotides Containing Phosphorothioate and Methylphosphonate Linkages as Second Generation Antisense Oligonucleotide

Sudhir Agrawal Hybridon, Inc., One Innovation Drive, Worcester, MA, 01605
,
Zhiwei Jiang Hybridon, Inc., One Innovation Drive, Worcester, MA, 01605
,
Qiuyan Zhao Hybridon, Inc., One Innovation Drive, Worcester, MA, 01605
,
Denise Shaw Lurleen B. Wallace Tumor Institute, University of Alabama at Birmingham, 1824 6th Ave., South, Birmingham, AL, 35233
,
Daisy Sun Hybridon, Inc., One Innovation Drive, Worcester, MA, 01605
&
Carl Saxinger National Cancer Institute-Division of Basic Sciences, Building 37, Room 6B04, Bethesda, MD, 20892
Pages 927-936 | Published online: 16 Aug 2006

Citations (8)

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Peter Schell, WolfgangH. G. Laux & JoachimW. Engels. (1999) Triarylmethyl Substituted 4,5-Dicyanoimidazoles as Activators for Rp-Diastereoselective Synthesis of TpN Dinucleoside Methylphosphonates. Nucleosides and Nucleotides 18:6-7, pages 1169-1174.
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Articles from other publishers (7)

Sara Flür & Ronald Micura. (2016) Chemical synthesis of RNA with site-specific methylphosphonate modifications. Methods 107, pages 79-88.
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Sudhir Agrawal & Ekambar R Kandimalla. (2000) Antisense therapeutics: is it as simple as complementary base recognition?. Molecular Medicine Today 6:2, pages 72-81.
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Sudhir Agrawal. (1999) Importance of nucleotide sequence and chemical modifications of antisense oligonucleotides. Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 1489:1, pages 53-67.
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Dev P. Arya & Thomas C. Bruice. (1998) Positively Charged Deoxynucleic Methylthioureas:  Synthesis and Binding Properties of Pentameric Thymidyl Methylthiourea. Journal of the American Chemical Society 120:48, pages 12419-12427.
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Peter Schell & Joachim W. Engels. (1998) Rp-Diastereoselective synthesis of dinucleoside methylphosphonates by the phosphoramidite approach. Tetrahedron Letters 39:47, pages 8629-8632.
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Dev P. Arya & Thomas C. Bruice. (1998) Replacement of the Negative Phosphodiester Linkages of DNA by Positive S -Methylthiourea Linkers:  A Novel Approach to Putative Antisense Agents . Journal of the American Chemical Society 120:26, pages 6619-6620.
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P. Dan Cook. 1998. 313 325 .

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