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VI. CHEMICAL DEVELOPMENT AND ANALYTICAL CHEMISTRY

Evaluation of Sulfur-Transfer Reagents for Large Scale Synthesis of Oligonucleotide Phosphorothioate Analogues

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Pages 1585-1588 | Published online: 16 Aug 2006

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Read on this site (5)

Joshua A. Mukhlall, Bruce C. Noll & William H. Hersh. (2011) Synthesis of chiral disulfides: potential reagents for enantioselective sulfurization. Journal of Sulfur Chemistry 32:3, pages 199-212.
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Achim H. Krotz, Alice Hang, Dennis Gorman & Anthony N. Scozzari. (2005) Polysulfide Reagent in Solid-Phase Synthesis of Phosphorothioate Oligonucleotides: Greater than 99.8% Sulfurization Efficiency. Nucleosides, Nucleotides & Nucleic Acids 24:9, pages 1293-1299.
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Eli Zysman-colman, Patrick G. Farrell & David N. Harpp. (2004) Desulfurization of aromatic polysulfides with triphenylphosphine. Journal of Sulfur Chemistry 25:2-3, pages 101-109.
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Zacharia S. Cheruvallath, R. Krishna Kumar, Claus Rentel, Douglas L. Cole & Vasulinga T. Ravikumar. (2003) Solid Phase Synthesis of Phosphorothioate Oligonucleotides Utilizing Diethyldithiocarbonate Disulfide (DDD) as an Efficient Sulfur Transfer Reagent. Nucleosides, Nucleotides & Nucleic Acids 22:4, pages 461-468.
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ZachariaS. Cheruvallath, PatrickD. Wheeler, DouglasL. Cole & VasulingaT. Ravikumar. (1999) Use of Phenylacetyl Disulfide (PADS) in the Synthesis of Oligodeoxyribonucleotide Phosphorothioates. Nucleosides and Nucleotides 18:3, pages 485-492.
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Articles from other publishers (6)

Serge L. Beaucage. 2001. Encyclopedia of Reagents for Organic Synthesis. Encyclopedia of Reagents for Organic Synthesis.
Oleksandr Ponomarov, Andrew P. Laws & Jiří Hanusek. (2012) 1,2,4-Dithiazole-5-ones and 5-thiones as efficient sulfurizing agents of phosphorus(iii) compounds – a kinetic comparative study. Organic & Biomolecular Chemistry 10:44, pages 8868.
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Oleksandr Ponomarov, Zdeňka Padělková & Jiří Hanusek. (2011) Synthesis and structure of substituted 5-phenoxy-1,2,4-dithiazole-3-ones. Journal of Heterocyclic Chemistry 48:6, pages 1225-1228.
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Daniel C. Capaldi, Hans J. Gaus, Recaldo L. Carty, Max N. Moore, Brett J. Turney, Stella D. Decottignies, James V. McArdle, Anthony N. Scozzari, Vasulinga T. Ravikumar & Achim H. Krotz. (2004) Formation of 4,4′-dimethoxytrityl-C-phosphonate oligonucleotides. Bioorganic & Medicinal Chemistry Letters 14:18, pages 4683-4690.
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Serge L. Beaucage. 2001. Encyclopedia of Reagents for Organic Synthesis. Encyclopedia of Reagents for Organic Synthesis.
Zacharia S. CheruvallathRecaldo L. CartyMax N. MooreDaniel C. CapaldiAchim H. KrotzPatrick D. WheelerBrett J. TurneyStephen R. CraigHans J. GausAnthony N. ScozzariDouglas L. ColeVasulinga T. Ravikumar. (1999) Synthesis of Antisense Oligonucleotides:  Replacement of 3H-1,2-Benzodithiol-3-one 1,1-Dioxide (Beaucage Reagent) with Phenylacetyl Disulfide (PADS) As Efficient Sulfurization Reagent:  From Bench to Bulk Manufacture of Active Pharmaceutical Ingredient. Organic Process Research & Development 4:3, pages 199-204.
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