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CONTROVERSIES IN PATIENT MANAGEMENT

Should Continuous Infusion 5-Fluorouracil Become the Standard of Care in the USA as It Is in Europe?

, M.D. & , M.D.
Pages 50-55 | Published online: 11 Jun 2009

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Wei Sun, Yinghui Chen & Weien Yuan. (2013) Hemostatic absorbable gelatin sponge loaded with 5-fluorouracil for treatment of tumors. International Journal of Nanomedicine 8, pages 1499-1506.
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Xiaoqing Cai, Qingyun Zhao, Yuxia Luan, Yue Jiang, Jiaojiao Shi & Wei Shao. (2012) Polymer Fibrous Materials Composed of Sodium Carboxymethylcellulose and Poly(vinyl alcohol) for a Hydrophilic Anticancer Drug Release. Journal of Dispersion Science and Technology 33:6, pages 835-839.
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Bruno Vincenzi, Gaia Schiavon, Marianna Silletta, Daniele Santini & Giuseppe Tonini. (2006) The new era in the treatment of advanced colorectal cancer patients: the role of monoclonal antibodies. Expert Opinion on Emerging Drugs 11:4, pages 665-683.
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Articles from other publishers (17)

Hung-Chang Wu, Wen-Li Lin, Chien-Liang Lin, Cheng-Yao Lin, Shang-Wen Chen, Yan-Xun Chen, Chao-Hsun Chen, Sung-Wei Lee, Shang-Hung Chen, Chao-Jung Tsao, Wen-Tsung Huang & How-Ran Guo. (2021) Age as a modifier of the effects of chemoradiotherapy with infusional 5-fluorouracil after D2 dissection in gastric cancer. Aging 13:13, pages 17337-17348.
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Jing Zhang, Jiashen Li, Chengshu Xu, Zhihua Xi, Yan Ren, Qingwen Song & Shaofeng Lu. (2020) Novel pH-sensitive drug-loaded electrospun nanofibers based on regenerated keratin for local tumor chemotherapy. Textile Research Journal 90:19-20, pages 2336-2349.
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Rafael C. Coelho, Pedro D.P. Abreu, Mariana R. Monteiro, Ana Paula Stramosk, Alvaro Henrique I. Garces, Andreia Cristina Melo, Marcia S. Graudenz & Carlos Jose C. Andrade. (2019) Cisplatin, Fluorouracil in Bolus Injection, and Leucovorin in First-Line Therapy for Advanced Gastric Cancer as an Alternative to Protocols With Infusional Fluorouracil. Journal of Global Oncology:5, pages 1-8.
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Hodjatollah Shahbazian, Sasan Razmjoo, Shoale Arvandi, Seyed Mohammad Hosseini, Mehran Hoseinzadeh, Ahmad Ahmadzadeh Deilamani & Fatemeh Mohammadian. (2016) Comparison of the Eight-Hour With the 22-Hour Infusion of 5-Fluorouracil, in the FOLFOX Chemotherapy of Colon Cancer: A Retrospective Study. Jundishapur Journal of Natural Pharmaceutical Products 11:2.
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Chantal Al Sabbagh, Nicolas Tsapis, Anthony Novell, Patricia Calleja-Gonzalez, Jean-Michel Escoffre, Ayache Bouakaz, Hélène Chacun, Stéphanie Denis, Juliette Vergnaud, Claire Gueutin & Elias Fattal. (2014) Formulation and Pharmacokinetics of Thermosensitive Stealth® Liposomes Encapsulating 5-Fluorouracil. Pharmaceutical Research 32:5, pages 1585-1603.
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QING LIN, YUNPENG CAI, MINGLU YUAN, LIN MA, MINGFENG QIU & JING SU. (2014) Development of a 5-fluorouracil-loaded PLGA microsphere delivery system by a solid-in-oil-in-hydrophilic oil (S/O/hO) novel method for the treatment of tumors. Oncology Reports 32:6, pages 2405-2410.
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Lucía Cortejoso & Luis A López-Fernández. (2012) Pharmacogenetic markers of toxicity for chemotherapy in colorectal cancer patients. Pharmacogenomics 13:10, pages 1173-1191.
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Xiaofan Zhang, Julia Li Zhong, Wei Liu, Zuhua Gao, Xia Xue, Pan Yue, Limei Wang, Cuirong Zhao, Wenfang Xu & Xianjun Qu. (2009) N3-o-toluyl-fluorouracil inhibits human hepatocellular carcinoma cell growth via sustained release of 5-FU. Cancer Chemotherapy and Pharmacology 66:1, pages 11-19.
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He Wei, Du Qing, Cao De-Ying, Xiang Bai & Fan Li-Fang. (2008) In-vitro and in-vivo studies of pectin/ethylcellulose-film-coated pellets of 5-fluorouracil for colonic targeting. Journal of Pharmacy and Pharmacology 60:1, pages 35-44.
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Raja Venkatasubramanian, Michael A. Henson & Neil S. Forbes. (2008) Integrating cell-cycle progression, drug penetration and energy metabolism to identify improved cancer therapeutic strategies. Journal of Theoretical Biology 253:1, pages 98-117.
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Patrick A. Singleton, Joe G.N. Garcia & Jonathan Moss. (2008) Synergistic effects of methylnaltrexone with 5-fluorouracil and bevacizumab on inhibition of vascular endothelial growth factor–induced angiogenesis. Molecular Cancer Therapeutics 7:6, pages 1669-1679.
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Tim A.D. Smith, Rituka I. Sharma, Weiguang G. Wang, Andy E. Welch, Lutz F. Schweiger & Elaina S.R. Collie-Duguid. (2007) Decreased [18F]fluoro-2-deoxy-d-glucose incorporation and increased glucose transport are associated with resistance to 5FU in MCF7 cells in vitro. Nuclear Medicine and Biology 34:8, pages 955-960.
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Jian Liu, Xun Li, Yan-na Cheng, Shu-xiang Cui, Ming-hui Chen, Wen-fang Xu, Zhi-gang Tian, Masatoshi Makuuchi, Wei Tang & Xian-jun Qu. (2007) Inhibition of human gastric carcinoma cell growth by treatment of N3-o-toluyl-fluorouracil as a precursor of 5-fluorouracil. European Journal of Pharmacology 574:1, pages 1-7.
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Paola Fogar, Filippo Navaglia, Daniela Basso, Eliana Greco, Carlo-Federico Zambon, Elisa Fadi, Alessandra Falda, Alessia Stranges, Francesca Vannozzi, Romano Danesi, Sergio Pedrazzoli & Mario Plebani. (2007) Suicide Gene Therapy With the Yeast Fusion Gene Cytosine Deaminase/Uracil Phosphoribosyltransferase Is Not Enough for Pancreatic Cancer. Pancreas 35:3, pages 224-231.
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Roberto L. Sastre, Rosa Olmo, César Teijón, Enriqueta Muñíz, José M. Teijón & M. Dolores Blanco. (2007) 5-Fluorouracil plasma levels and biodegradation of subcutaneously injected drug-loaded microspheres prepared by spray-drying poly(d,l-lactide) and poly(d,l-lactide-co-glycolide) polymers. International Journal of Pharmaceutics 338:1-2, pages 180-190.
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Robert R. McWilliams, Matthew P. Goetz, Bruce W. Morlan, Muhammad Salim, Kendrith M. Rowland, James E. Krook, Matthew M. Ames & Charles Erlichman. (2007) Phase II Trial of Oxaliplatin/Irinotecan/5-Fluorouracil/Leucovorin for Metastatic Colorectal Cancer. Clinical Colorectal Cancer 6:7, pages 516-521.
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Hao Gao, Yueqing Gu & Qineng Ping. (2007) The implantable 5-fluorouracil-loaded poly(l-lactic acid) fibers prepared by wet-spinning from suspension. Journal of Controlled Release 118:3, pages 325-332.
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