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ORIGINAL ARTICLEClinical Translational Therapeutics

Phase I Clinical Study of Three Times a Day Oral Administration of TAS-102 in Patients with Solid Tumors

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Pages 794-799 | Published online: 11 Jun 2009

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Xicheng Wang, Jianfeng Zhou, Yan Li, Yuping Ge, Yanping Zhou, Chunmei Bai & Lin Shen. (2020) Pharmacokinetics, Safety, and Preliminary Efficacy of Oral Trifluridine/Tipiracil in Chinese Patients with Solid Tumors: A Phase 1b, Open-Label Study. Clinical Pharmacology: Advances and Applications 12, pages 21-33.
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Akihito Kawazoe & Kohei Shitara. (2020) Trifluridine/tipiracil for the treatment of metastatic gastric cancer. Expert Review of Gastroenterology & Hepatology 14:2, pages 65-70.
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Julia Martinez-Perez, M. Carmen Riesco-Martinez & Rocio Garcia-Carbonero. (2018) The safety of trifluridine and tipiracil for the treatment of metastatic colorectal cancer. Expert Opinion on Drug Safety 17:6, pages 643-650.
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Yu Sunakawa, Naoki Izawa, Takuro Mizukami, Yoshiki Horie, Mami Hirakawa, Hiroyuki Arai, Takashi Ogura, Takashi Tsuda & Takako Eguchi Nakajima. (2017) Profile of trifluridine/tipiracil hydrochloride in the treatment of metastatic colorectal cancer: efficacy, safety, and place in therapy. OncoTargets and Therapy 10, pages 4599-4605.
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Jeevan M Puthiamadathil & Benjamin A Weinberg. (2017) Emerging combination therapies for metastatic colorectal cancer – impact of trifluridine/tipiracil. Cancer Management and Research 9, pages 461-469.
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Diana L. Hanna & Heinz-Josef Lenz. (2016) Novel therapeutics in metastatic colorectal cancer: molecular insights and pharmacogenomic implications. Expert Review of Clinical Pharmacology 9:8, pages 1091-1108.
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Yuji Miyamoto, Heinz-Josef Lenz & Hideo Baba. (2016) A novel antimetabolite: TAS-102 for metastatic colorectal cancer. Expert Review of Clinical Pharmacology 9:3, pages 355-365.
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Lisa Salvatore, Daniele Rossini, Roberto Moretto, Chiara Cremolini, Marta Schirripa, Carlotta Antoniotti, Federica Marmorino, Fotios Loupakis, Alfredo Falcone & Gianluca Masi. (2015) TAS-102 for the treatment of metastatic colorectal cancer. Expert Review of Anticancer Therapy 15:11, pages 1283-1292.
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Hiroshi Yasui, Giichiro Tsurita & Kohzoh Imai. (2014) DNA synthesis inhibitors for the treatment of gastrointestinal cancer. Expert Opinion on Pharmacotherapy 15:16, pages 2361-2372.
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Norihiko Suzuki & Masakazu Fukushima. (2010) Simple and Rapid Enzymatic Method for the Synthesis of Single-Strand Oligonucleotides Containing Trifluorothymidine. Nucleosides, Nucleotides & Nucleic Acids 29:11-12, pages 896-904.
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Articles from other publishers (47)

Becka M. Warfield & Philip Reigan. (2022) Multifunctional role of thymidine phosphorylase in cancer. Trends in Cancer 8:6, pages 482-493.
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Sakti Chakrabarti, Grant Wintheiser, Sri Harsha Tella, Carolyn Oxencis & Amit Mahipal. (2021) TAS-102: A resurrected novel Fluoropyrimidine with expanding role in the treatment of gastrointestinal malignancies. Pharmacology & Therapeutics 224, pages 107823.
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M. Yu. Fedyanin. (2020) Trifluridine / tipiracil (FTd / TPI, TAS-102) in the treatment of patients with metastatic colon cancer: from preclinical experiments to routine clinical practice. Pelvic Surgery and Oncology 10:3-4, pages 11-26.
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Giandomenico Roviello, Sara Fancelli, Marta Rita Gatta Michelet, Giuseppe Aprile, Stefania Nobili, Franco Roviello, Fabio Cianchi, Enrico Mini & Daniele Lavacchi. (2020) TAS-102 in gastric cancer: Development and perspectives of a new biochemically modulated fluroropyrimidine drug combination. Critical Reviews in Oncology/Hematology 152, pages 102987.
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T. Yoshino, J.M. Cleary, E. Van Cutsem, R.J. Mayer, A. Ohtsu, E. Shinozaki, A. Falcone, K. Yamazaki, T. Nishina, R. Garcia-Carbonero, Y. Komatsu, H. Baba, G. Argilés, A. Tsuji, A. Sobrero, K. Yamaguchi, M. Peeters, K. Muro, A. Zaniboni, N. Sugimoto, Y. Shimada, Y. Tsuji, H.S. Hochster, T. Moriwaki, B. Tran, T. Esaki, C. Hamada, T. Tanase, F. Benedetti, L. Makris, F. Yamashita & H.-J. Lenz. (2020) Neutropenia and survival outcomes in metastatic colorectal cancer patients treated with trifluridine/tipiracil in the RECOURSE and J003 trials. Annals of Oncology 31:1, pages 88-95.
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Aneta L. Zygulska. 2019. Multidisciplinary Approach for Colorectal Cancer. Multidisciplinary Approach for Colorectal Cancer.
Yoichiro Yoshida, Takeshi Yamada, Hiroshi Matsuoka, Hiromichi Sonoda, Atsuko Fukazawa, Hiroshi Yoshida, Hideyuki Ishida, Keiji Hirata, Suguru Hasegawa, Kazuhiro Sakamoto, Toshiaki Otsuka & Keiji Koda. (2019) A Trial Protocol of Biweekly TAS-102 and Bevacizumab as Third-Line Chemotherapy for Advanced/Recurrent Colorectal Cancer: A Phase II Multicenter Clinical Trial (The TAS-CC4 Study). Journal of the Anus, Rectum and Colon 3:3, pages 136-141.
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Muhammad Wasif Saif, Lee Rosen, Michelle A. Rudek, Weijing Sun, Dale R. Shepard, Carlos Becerra, Fumiaki Yamashita, Paul Bebeau & Robert Winkler. (2019) Open‐label study to evaluate trifluridine/tipiracil safety, tolerability and pharmacokinetics in patients with advanced solid tumours and hepatic impairment. British Journal of Clinical Pharmacology 85:6, pages 1239-1246.
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Betty M Chan, Howard S Hochster & Heinz-Josef Lenz. (2019) The safety and efficacy of trifluridine–tipiracil for metastatic colorectal cancer: A pharmacy perspective. American Journal of Health-System Pharmacy 76:6, pages 339-348.
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Robert J. Mayer, Howard S. Hochster, Steven J. Cohen, Robert Winkler, Lukas Makris & Axel Grothey. (2018) Safety of trifluridine/tipiracil in an open-label expanded-access program in elderly and younger patients with metastatic colorectal cancer. Cancer Chemotherapy and Pharmacology 82:6, pages 961-969.
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Norihiko Suzuki, Masanobu Ito & Teiji Takechi. 2018. Successful Drug Discovery. Successful Drug Discovery 417 441 .
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