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Cancer Investigation Volume 28, 2010 - Issue 4
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ORIGINAL ARTICLECellular and Molecular Biology

ACB-PCR Quantification of K-RAS Codon 12 GAT and GTT Mutant Fraction in Colon Tumor and Non-Tumor Tissue

Barbara L. ParsonsUS FDA, National Center for Toxicological Research, Division of Genetic and Reproductive Toxicology, Jefferson, Arkansas, USA
,
Kathryn E. Marchant-MirosMedical Research Service, Central Arkansas Veterans Healthcare System, Little Rock, Arkansas, USA,
,
Robert R. DelongchampDepartment of Epidemiology, College of Public Health, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA,
,
Tracie L. VerklerUS FDA, National Center for Toxicological Research, Division of Genetic and Reproductive Toxicology, Jefferson, Arkansas, USA
,
Tucker A. PattersonUS FDA, National Center for Toxicological Research, Division of Neurotoxicology, Jefferson, Arkansas, USA,
,
Page B. McKinzieUS FDA, National Center for Toxicological Research, Division of Genetic and Reproductive Toxicology, Jefferson, Arkansas, USA
&
Lawrence T. KimDepartment of Surgery, Central Arkansas Veterans Healthcare System, Surgical Service 112, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
 show all
Pages 364-375 | Published online: 22 Apr 2010

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Chad M. Thompson, Marilyn J. Aardema, Melissa M. Heintz, James T. MacGregor & Robert R. Young. (2021) A review of mammalian in vivo genotoxicity of hexavalent chromium: implications for oral carcinogenicity risk assessment. Critical Reviews in Toxicology 51:10, pages 820-849.
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Habib Zarredar, Khalil Ansarin, Behzad Baradaran, Shiva Ahdi Khosroshahi & Safar Farajnia. (2018) Potential Molecular Targets in the Treatment of Lung Cancer Using siRNA Technology. Cancer Investigation 36:1, pages 37-58.
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Meagan B Myers, Yiying Wang, Karen L McKim & Barbara L Parsons. (2012) Hotspot oncomutations: implications for personalized cancer treatment. Expert Review of Molecular Diagnostics 12:6, pages 603-620.
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Articles from other publishers (32)

Kelly L Harris, Karen L McKim, Meagan B Myers, Binsheng Gong, Joshua Xu & Barbara L Parsons. (2021) Assessment of Clonal Expansion Using CarcSeq Measurement of Lung Cancer Driver Mutations and Correlation With Mouse Strain- and Sex-Related Incidence of Spontaneous Lung Neoplasia. Toxicological Sciences 184:1, pages 1-14.
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Karen L McKim, Meagan B Myers, Kelly L Harris, Binsheng Gong, Joshua Xu & Barbara L Parsons. (2021) CarcSeq Measurement of Rat Mammary Cancer Driver Mutations and Relation to Spontaneous Mammary Neoplasia. Toxicological Sciences.
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Kelly L. Harris, Vijay Walia, Binsheng Gong, Karen L. McKim, Meagan B. Myers, Joshua Xu & Barbara L. Parsons. (2020) Quantification of cancer driver mutations in human breast and lung DNA using targeted, error‐corrected CarcSeq . Environmental and Molecular Mutagenesis 61:9, pages 872-889.
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Malathi Banda, Karen L. McKim, Meagan B. Myers, Masahiro Inoue & Barbara L. Parsons. (2020) Outgrowth of erlotinib-resistant subpopulations recapitulated in patient-derived lung tumor spheroids and organoids. PLOS ONE 15:9, pages e0238862.
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Meagan B. Myers, Karen L. McKim, Yiying Wang, Malathi Banda & Barbara L. Parsons. 2020. Molecular Toxicology Protocols. Molecular Toxicology Protocols 395 417 .
Kelly L. Harris, Meagan B. Myers, Karen L. McKim, Rosalie K. Elespuru & Barbara L. Parsons. (2019) Rationale and Roadmap for Developing Panels of Hotspot Cancer Driver Gene Mutations as Biomarkers of Cancer Risk. Environmental and Molecular Mutagenesis 61:1, pages 152-175.
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Meagan Myers, Karen McKim, Malathi Banda, Nysia George & Barbara Parsons. (2019) Low-Frequency Mutational Heterogeneity of Invasive Ductal Carcinoma Subtypes: Information to Direct Precision Oncology. International Journal of Molecular Sciences 20:5, pages 1011.
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Francesco Damin, Silvia Galbiati, Nadia Soriani, Valentina Burgio, Monica Ronzoni, Maurizio Ferrari & Marcella Chiari. (2018) Analysis of KRAS, NRAS and BRAF mutational profile by combination of in-tube hybridization and universal tag-microarray in tumor tissue and plasma of colorectal cancer patients. PLOS ONE 13:12, pages e0207876.
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Barbara L. Parsons. (2018) Modern conception of carcinogenesis creates opportunities to advance cancer risk assessment. Current Opinion in Toxicology 11-12, pages 1-9.
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Anna M. Nicholson, Cora Olpe, Alice Hoyle, Ann-Sofie Thorsen, Teja Rus, Mathilde Colombé, Roxanne Brunton-Sim, Richard Kemp, Kate Marks, Phil Quirke, Shalini Malhotra, Rogier ten Hoopen, Ashraf Ibrahim, Cecilia Lindskog, Meagan B. Myers, Barbara Parsons, Simon Tavaré, Mark Wilkinson, Edward Morrissey & Douglas J. Winton. (2018) Fixation and Spread of Somatic Mutations in Adult Human Colonic Epithelium. Cell Stem Cell 22:6, pages 909-918.e8.
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Yu. A. Shelygin, O. A. Maynovskaya, E. G. Rybakov, V. P. Shubin, S. V. Chernyshov, S. A. Frolov, V. N. Kashnikov & N. I. Pospekhova. (2016) Mutations in RAS/BRAF genes in rectal tumors: From adenomas to early carcinomas. Russian Journal of Genetics 53:10, pages 1146-1151.
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Barbara L. Parsons, Karen L. McKim & Meagan B. Myers. (2017) Variation in organ-specific PIK3CA and KRAS mutant levels in normal human tissues correlates with mutation prevalence in corresponding carcinomas . Environmental and Molecular Mutagenesis 58:7, pages 466-476.
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Ulrike Luderer, Meagan B. Myers, Malathi Banda, Karen L. McKim, Laura Ortiz & Barbara L. Parsons. (2017) Ovarian effects of prenatal exposure to benzo[a]pyrene: Roles of embryonic and maternal glutathione status. Reproductive Toxicology 69, pages 187-195.
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Meagan B. Myers, Malathi Banda, Karen L. McKim, Yiying Wang, Michael J. Powell & Barbara L. Parsons. (2016) Breast Cancer Heterogeneity Examined by High-Sensitivity Quantification of PIK3CA, KRAS, HRAS, and BRAF Mutations in Normal Breast and Ductal Carcinomas. Neoplasia 18:4, pages 253-263.
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Christopher D. Zahm, Joseph M. Szulczewski, Alyssa A. Leystra, Terrah J. Paul Olson, Linda Clipson, Dawn M. Albrecht, Malisa Middlebrooks, Andrew T. Thliveris, Kristina A. Matkowskyj, Mary Kay Washington, Michael A. Newton, Kevin W. Eliceiri & Richard B. Halberg. (2016) Advanced Intestinal Cancers often Maintain a Multi-Ancestral Architecture. PLOS ONE 11:2, pages e0150170.
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Jamie N. Hadac, Alyssa A. Leystra, Terrah J. Paul Olson, Molly E. Maher, Susan N. Payne, Alexander E. Yueh, Alexander R. Schwartz, Dawn M. Albrecht, Linda Clipson, Cheri A. Pasch, Kristina A. Matkowskyj, Richard B. Halberg & Dustin A. Deming. (2015) Colon Tumors with the Simultaneous Induction of Driver Mutations in APC , KRAS , and PIK3CA Still Progress through the Adenoma-to-carcinoma Sequence . Cancer Prevention Research 8:10, pages 952-961.
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Malathi Banda. (2015) Detection of Mutant RAS Subpopulations in Colorectal Cancer Patients. EBioMedicine 2:4, pages 280-281.
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Takayuki Yoshino, Kei Muro, Kensei Yamaguchi, Tomohiro Nishina, Tadamichi Denda, Toshihiro Kudo, Wataru Okamoto, Hiroya Taniguchi, Kiwamu Akagi, Takeshi Kajiwara, Shuichi Hironaka & Taroh Satoh. (2015) Clinical Validation of a Multiplex Kit for RAS Mutations in Colorectal Cancer: Results of the RASKET (RAS KEy Testing) Prospective, Multicenter Study. EBioMedicine 2:4, pages 317-323.
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Meagan B Myers, Karen L McKim, Fanxue Meng & Barbara L Parsons. (2015) Low-frequency KRAS mutations are prevalent in lung adenocarcinomas . Personalized Medicine 12:2, pages 83-98.
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Yuliang Liu, Haukur Gudnason, Yi-Ping Li, Dang Bang & Anders Wolff. (2014) An oligonucleotide-tagged microarray for routine diagnostics of colon cancer by genotyping KRAS mutations. International Journal of Oncology.
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Najie Song, Xueting Zhong & Qingge Li. (2014) Real-Time Bidirectional Pyrophosphorolysis-Activated Polymerization for Quantitative Detection of Somatic Mutations. PLoS ONE 9:4, pages e96420.
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Paolo Battaglia, Elisabetta Baritono, Andrea Remo, Roberto Vendraminelli & Antonio Conti. (2018) KRAS Mutations and M2PK Upregulation in Stool Samples from Individuals with Positive Fecal Occult Blood Tests Screened for Colorectal Cancer. Tumori Journal 100:2, pages 122-127.
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Meagan B. Myers, Karen L. McKim & Barbara L. Parsons. (2014) A subset of papillary thyroid carcinomas contain KRAS mutant subpopulations at levels above normal thyroid . Molecular Carcinogenesis 53:2, pages 159-167.
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Meagan B. Myers, Page B. McKinzie, Yiying Wang, Fanxue Meng & Barbara L. Parsons. 2014. Molecular Toxicology Protocols. Molecular Toxicology Protocols 345 363 .
Barbara L ParsonsMeagan B Myers. (2013) KRAS mutant tumor subpopulations can subvert durable responses to personalized cancer treatments . Personalized Medicine 10:2, pages 191-199.
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Vincent L. Wilson. 2013. Environmental Toxicology. Environmental Toxicology 203 238 .
Yiying Wang, Volker M. Arlt, Candice A. Roufosse, Karen L. McKim, Meagan B. Myers, David H. Phillips & Barbara L. Parsons. (2012) ACB‐PCR measurement of H‐ ras codon 61 CAA→CTA mutation provides an early indication of aristolochic acid I carcinogenic effect in tumor target tissues . Environmental and Molecular Mutagenesis 53:7, pages 495-504.
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Jean Philippe Arnault, Christine Mateus, Bernard Escudier, Gorana Tomasic, Janine Wechsler, Emilie Hollville, Jean-Charles Soria, David Malka, Alain Sarasin, Magalie Larcher, Jocelyne André, Nyam Kamsu-Kom, Lise Boussemart, Ludovic Lacroix, Alain Spatz, Alexander M. Eggermont, Sabine Druillennec, Stephan Vagner, Alain Eychène, Nicolas Dumaz & Caroline Robert. (2012) Skin Tumors Induced by Sorafenib; Paradoxic RAS–RAF Pathway Activation and Oncogenic Mutations of HRAS , TP53 , and TGFBR1 . Clinical Cancer Research 18:1, pages 263-272.
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Vincent L. Wilson. 2012. Encyclopedia of Sustainability Science and Technology. Encyclopedia of Sustainability Science and Technology 3595 3620 .
Barbara L. Parsons. (2011) Monoclonal tumor origin is an underlying misconception of the RESIC approach. Proceedings of the National Academy of Sciences 108:5.
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Lynn H. Pottenger & B. Bhaskar Gollapudi. (2010) Genotoxicity testing: Moving beyond qualitative “screen and bin” approach towards characterization of dose‐response and thresholds. Environmental and Molecular Mutagenesis 51:8-9, pages 792-799.
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Barbara L. Parsons, Meagan B. Myers, Fanxue Meng, Yiying Wang & Page B. McKinzie. (2010) Oncomutations as biomarkers of cancer risk. Environmental and Molecular Mutagenesis 51:8-9, pages 836-850.
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