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Journal of Biomolecular Structure and Dynamics Volume 29, 2012 - Issue 4
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Original Articles

Peculiarities of Copper Binding to α-Synuclein

Atta Ahmad Department of Chemistry and Biochemistry, University of California, Santa Cruz, California, 95064, USA; Life Sciences Institute, University of Michigan, Ann Arbor, Michigan, 48109, USA; Contributed equally
,
Colin S. Burns Department of Chemistry and Biochemistry, University of California, Santa Cruz, California, 95064, USA; Department of Chemistry, East Carolina University, Greenville, North Carolina, 27858, USA; Contributed equally
,
Anthony L. Fink Department of Chemistry and Biochemistry, University of California, Santa Cruz, California, 95064, USA; Dedicated to the memory of Prof. A. L. Fink.
&
Vladimir N. Uversky Department of Molecular Medicine, College of Medicine, University of South Florida, Tampa, Florida, 33612, USA; Institute for Biological Instrumentation, Russian Academy of Sciences, 142290, Pushchino, Moscow Region, Russia
Pages 825-842 | Received 20 Jul 2011, Published online: 11 Jul 2012

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Anna Villar-Piqué, Giulia Rossetti, Salvador Ventura, Paolo Carloni, Claudio O. Fernández & Tiago Fleming Outeiro. (2017) Copper(II) and the pathological H50Q α-synuclein mutant: Environment meets genetics. Communicative & Integrative Biology 10:1.
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Articles from other publishers (27)

Loizos Savva & James A. Platts. (2023) How Cu(II) binding affects structure and dynamics of α-synuclein revealed by molecular dynamics simulations. Journal of Inorganic Biochemistry 239, pages 112068.
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Munishwar Nath Gupta & Vladimir N. Uversky. 2023. Structure and Intrinsic Disorder in Enzymology. Structure and Intrinsic Disorder in Enzymology 241 277 .
Madhuparna Roy, Arnab Kumar Nath, Ishita Pal & Somdatta Ghosh Dey. (2022) Second Sphere Interactions in Amyloidogenic Diseases. Chemical Reviews 122:14, pages 12132-12206.
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Tapan Behl, Piyush Madaan, Aayush Sehgal, Sukhbir Singh, Md Khalid Anwer, Hafiz A. Makeen, Mohammed Albratty, Syam Mohan & Simona Bungau. (2022) Mechanistic Insights Expatiating the Redox-Active-Metal-Mediated Neuronal Degeneration in Parkinson’s Disease. International Journal of Molecular Sciences 23:2, pages 678.
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Xiangyu Teng, Alena Sheveleva, Floriana Tuna, Keith R. Willison & Liming Ying. (2021) Acetylation Rather than H50Q Mutation Impacts the Kinetics of Cu(II) Binding to α‐Synuclein. ChemPhysChem 22:23, pages 2413-2419.
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Aswir Abd Rashed, Ahmad Zuhairi Abd Rahman & Devi Nair Gunasegavan Rathi. (2021) Essential Oils as a Potential Neuroprotective Remedy for Age-Related Neurodegenerative Diseases: A Review. Molecules 26:4, pages 1107.
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Nazareno González, Trinidad Arcos‐López, Annekatrin König, Liliana Quintanar, Mauricio Menacho Márquez, Tiago F. Outeiro & Claudio O. Fernández. (2019) Effects of alpha‐synuclein post‐translational modifications on metal binding. Journal of Neurochemistry 150:5, pages 507-521.
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Piriya Wongkongkathep, Jong Yoon Han, Tae Su Choi, Sheng Yin, Hugh I. Kim & Joseph A. Loo. (2018) Native Top-Down Mass Spectrometry and Ion Mobility MS for Characterizing the Cobalt and Manganese Metal Binding of α-Synuclein Protein. Journal of the American Society for Mass Spectrometry 29:9, pages 1870-1880.
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Juan Zhao, Lihui Xu, Qingnan Liang, Qing Sun, Congheng Chen, Yuan Zhang, Yu Ding & Ping Zhou. (2017) Metal chelator EGCG attenuates Fe(III)-induced conformational transition of α-synuclein and protects AS-PC12 cells against Fe(III)-induced death. Journal of Neurochemistry 143:1, pages 136-146.
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Vladimir N. Uversky. (2017) Looking at the recent advances in understanding α-synuclein and its aggregation through the proteoform prism. F1000Research 6, pages 525.
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Roger Deloncle, Bernard Fauconneau, Olivier Guillard, José Delaval, Gérard Lesage & Alain Pineau. (2017) Copper brain protein protection against free radical-induced neuronal death: Survival ratio in SH-SY5Y neuroblastoma cell cultures. Journal of Trace Elements in Medicine and Biology 39, pages 50-53.
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Atta Ahmad, Caleb M. Stratton, Jean-Luc Scemama & Mahvish Muzaffar. (2016) Effect of Ca2+ on Aß40 fibrillation is characteristically different. International Journal of Biological Macromolecules 89, pages 297-304.
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A. P. Lan, J. Chen, Z. F. Chai & Y. Hu. (2016) The neurotoxicity of iron, copper and cobalt in Parkinson’s disease through ROS-mediated mechanisms. BioMetals 29:4, pages 665-678.
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Simon C. Drew. (2016) Probing the quaternary structure of metal-bridged peptide oligomers. Journal of Inorganic Biochemistry 158, pages 30-34.
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Dina Morshedi & Mahour Nasouti. (2016) Essential Oils May Lead α -Synuclein towards Toxic Fibrils Formation . Parkinson's Disease 2016, pages 1-10.
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Simon C. Drew. (2015) The N Terminus of α-Synuclein Forms Cu II -Bridged Oligomers . Chemistry - A European Journal 21:19, pages 7111-7118.
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Julia Bornhorst, Sudipta Chakraborty, Sören Meyer, Hanna Lohren, Sigrid Große Brinkhaus, Adam L. Knight, Kim A. Caldwell, Guy A. Caldwell, Uwe Karst, Tanja Schwerdtle, Aaron Bowman & Michael Aschner. (2014) The effects of pdr1, djr1.1 and pink1 loss in manganese-induced toxicity and the role of α-synuclein in C. elegans. Metallomics 6:3, pages 476-490.
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. 2013. Metal-based Neurodegeneration. Metal-based Neurodegeneration 131 168 .
Peizhong Mao. (2013) Oxidative Stress and Its Clinical Applications in Dementia. Journal of Neurodegenerative Diseases 2013, pages 1-15.
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Zanxia Cao, Lei Liu, Liling Zhao, Haiyan Li & Jihua Wang. (2012) Comparison of the structural characteristics of Cu2+-bound and unbound α-syn12 peptide obtained in simulations using different force fields. Journal of Molecular Modeling 19:3, pages 1237-1250.
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Francesca Camponeschi, Daniela Valensin, Isabella Tessari, Luigi Bubacco, Simone Dell’Acqua, Luigi Casella, Enrico Monzani, Elena Gaggelli & Gianni Valensin. (2013) Copper(I)-α-Synuclein Interaction: Structural Description of Two Independent and Competing Metal Binding Sites. Inorganic Chemistry 52:3, pages 1358-1367.
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Bin Xue, Victoria Jeffers, William J. Sullivan & Vladimir N. Uversky. (2013) Protein intrinsic disorder in the acetylome of intracellular and extracellular Toxoplasma gondii. Molecular BioSystems 9:4, pages 645.
Crossref
Kurt A. Jellinger. 2013. Metal Related Neurodegenerative Disease. Metal Related Neurodegenerative Disease 1 47 .
Andrés Binolfi, Liliana Quintanar, Carlos W. Bertoncini, Christian Griesinger & Claudio O. Fernández. (2012) Bioinorganic chemistry of copper coordination to alpha-synuclein: Relevance to Parkinson's disease. Coordination Chemistry Reviews 256:19-20, pages 2188-2201.
Crossref
Sónia S. Leal, Hugo M. Botelho & Cláudio M. Gomes. (2012) Metal ions as modulators of protein conformation and misfolding in neurodegeneration. Coordination Chemistry Reviews 256:19-20, pages 2253-2270.
Crossref
Peizhong Mao. (2012) Recent progress and concerns in dementia: Distinguishing Alzheimer's disease and dementia with Lewy bodies via biochemical markers in the cerebrospinal fluid. Advances in Biological Chemistry 02:02, pages 176-190.
Crossref
Jeffrey R. Liddell, Ashley I. Bush & Anthony R. White. 2012. Encyclopedia of Inorganic and Bioinorganic Chemistry. Encyclopedia of Inorganic and Bioinorganic Chemistry 1 21 .

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