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Journal of Biomolecular Structure and Dynamics Volume 40, 2022 - Issue 12
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Research Articles

Withanolides from Withania somnifera as an immunity booster and their therapeutic options against COVID-19

Pukar Khanala Department of Pharmacology and Toxicology, KLE College of Pharmacy Belagavi, KLE Academy of Higher Education and Research (KAHER), Belagavi, IndiaORCID Iconhttps://orcid.org/0000-0002-8187-2120
ORCID Icon,
Rupesh Chikhaleb School of Pharmacy, University of East Anglia, Norwich, UKORCID Iconhttps://orcid.org/0000-0001-5622-3981
ORCID Icon,
Yadu Nandan Deyc School of Pharmaceutical Technology, Adamas University, Kolkata, West Bengal, India
,
Ismail Pashad Department of Pharmacology, Orotta College of Medicine and Health Sciences, Asmara University, Asmara, Eritrea
,
Sharad Chande Department of Pharmacy Practice, NGSM Institute of Pharmaceutical Sciences, NITTE (Deemed to be University), Deralakatte, Karnataka, India
,
Nilambari Guravf PES’s Rajaram and Tarabai Bandekar College of Pharmacy, Ponda, Goa University, Goa, IndiaORCID Iconhttps://orcid.org/0000-0001-6369-9961
ORCID Icon,
Muniappan Ayyanarg Department of Botany, A. Veeriya Vandayar Memorial Sri Pushpam College (Autonomous), Affiliated to Bharathidasan University, Thanjavur, India
,
B. M. Patila Department of Pharmacology and Toxicology, KLE College of Pharmacy Belagavi, KLE Academy of Higher Education and Research (KAHER), Belagavi, IndiaCorrespondence[email protected] [email protected]
&
Shailendra Guravh Goa College of Pharmacy, Department of Pharmacognosy, Panaji, Goa University, Goa, IndiaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0001-5564-2121
ORCID Icon show all
Pages 5295-5308 | Received 12 Aug 2020, Accepted 22 Dec 2020, Published online: 18 Jan 2021

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Pabllo Abreu Alves, Késya Amanda Dantas Rocha, Lucas Lima Bezerra, Alejandro Pedro Ayala, Norberto de Kássio Vieira Monteiro & Otília Deusdênia Loiola Pessoa. (2023) Withanolides of Athenaea velutina with potential inhibitory properties against SARS coronavirus main protease (mpro): molecular modeling studies. Journal of Biomolecular Structure and Dynamics 41:21, pages 12267-12275.
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Dharmendra Kashyap, Rajarshi Roy, Parimal Kar & Hem Chandra Jha. (2023) Plant-derived active compounds as a potential nucleocapsid protein inhibitor of SARS-CoV-2: an in-silico study. Journal of Biomolecular Structure and Dynamics 41:10, pages 4770-4785.
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Simna Siddique & R. Pradeep Kumar. (2023) 3β-Acetoxy-21α-H-hop-22(29)ene, a novel multitargeted phytocompound against SARS-CoV-2: in silico screening. Journal of Biomolecular Structure and Dynamics 41:9, pages 3884-3891.
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Luana L. Dutra, Rafael J. Borges, Vinícius G. Maltarollo, Tiago A. O. Mendes, Gustavo C. Bressan & João Paulo V. Leite. (2023) In silico evaluation of pharmacokinetics properties of withanolides and simulation of their biological activities against Alzheimer’s disease. Journal of Biomolecular Structure and Dynamics 0:0, pages 1-16.
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Aditya Rathi, Vipul Kumar & Durai Sundar. (2023) Insights into the potential of withanolides as Phosphodiesterase-4 (PDE4D) inhibitors. Journal of Biomolecular Structure and Dynamics 41:6, pages 2108-2117.
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Mukesh Kumar, Anik Roy, Ravindra Singh Rawat, Amit Alok, Kishore K. R. Tetala, Nihar Ranjan Biswas, Punit Kaur & Sanjit Kumar. (2022) Identification and structural studies of natural inhibitors against SARS-CoV-2 viral RNA methyltransferase (NSP16). Journal of Biomolecular Structure and Dynamics 40:24, pages 13965-13975.
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Suaidah Ramli, Yuan Seng Wu, Kalaivani Batumalaie, Rhanye Mac Guad, Ker Woon Choy, Ashok Kumar, Subash C. B. Gopinath, Md. Moklesur Rahman Sarker, Vetriselvan Subramaniyan, Mahendran Sekar, Neeraj Kumar Fuloria, Shivkanya Fuloria, Suresh V. Chinni & Gobinath Ramachawolran. (2023) Phytochemicals of Withania somnifera as a Future Promising Drug against SARS-CoV-2: Pharmacological Role, Molecular Mechanism, Molecular Docking Evaluation, and Efficient Delivery. Microorganisms 11:4, pages 1000.
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Paulina Mikulska, Marta Malinowska, Miłosz Ignacyk, Paweł Szustowski, Joanna Nowak, Karolina Pesta, Monika Szeląg, Damian Szklanny, Eliza Judasz, Gabriela Kaczmarek, Ovinuchi Prince Ejiohuo, Magdalena Paczkowska-Walendowska, Anna Gościniak & Judyta Cielecka-Piontek. (2023) Ashwagandha (Withania somnifera)—Current Research on the Health-Promoting Activities: A Narrative Review. Pharmaceutics 15:4, pages 1057.
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Zaigham Abbas Rizvi, Prabhakar Babele, Upasna Madan, Srikanth Sadhu, Manas Ranjan Tripathy, Sandeep Goswami, Shailendra Mani, Madhu Dikshit & Amit Awasthi. (2023) Pharmacological potential of Withania somnifera (L.) Dunal and Tinospora cordifolia (Willd.) Miers on the experimental models of COVID-19, T cell differentiation, and neutrophil functions. Frontiers in Immunology 14.
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Raj Kumar Chinnadurai, Saravanaraman Ponne, Loganathan Chitra, Rajender Kumar, Palvannan Thayumanavan & Balanehru Subramanian. (2022) Pharmacoinformatic approach to identify potential phytochemicals against SARS-CoV-2 spike receptor-binding domain in native and variants of concern. Molecular Diversity.
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Yue Yang, Fei Zhou, Min Wang, Mukhammadrizo Turanazarov, Xiao-Rong Wang, Changqiang Ke, Sheng Yao, Ligen Lin, Chunping Tang & Yang Ye. (2022) Chantriolides F–P, Highly Oxidized Withanolides with Hepatoprotective Activity from Tacca chantrieri. Molecules 27:23, pages 8197.
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Riya Dahiya, Mr. Puneet, Sunil Kumar Dhiman & Anjali Priyadarshani. (2022) A Comprehensive Review on Potential and Prospects of Traditional Medicinal Plants for Management of Coronavirus Disease (COVID-19). Vantage: Journal of Thematic Analysis, pages 88-103.
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Zaid Al-Nuaimi & Ali Jaafar Al-Baniwes. (2022) Evaluation the Protective Effect of Withania somnifera Extract on the Level of Sex Hormone in Morphine Addicted Female Rats. Open Access Macedonian Journal of Medical Sciences 10:A, pages 1330-1333.
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Yamini Shah & Kavish Shah. (2022) Anti-viral herbal phytoconstituents of tulsi (Ocimum sanctum) against Covid-19. IP International Journal of Comprehensive and Advanced Pharmacology 7:2, pages 77-80.
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Vivek K. Kashyap, Godwin Peasah-Darkwah, Anupam Dhasmana, Meena Jaggi, Murali M. Yallapu & Subhash C. Chauhan. (2022) Withania somnifera: Progress towards a Pharmaceutical Agent for Immunomodulation and Cancer Therapeutics. Pharmaceutics 14:3, pages 611.
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Ankit Kumar Dubey, Suman Kumar Chaudhry, Harikesh Bahadur Singh, Vijai Kumar Gupta & Ajeet Kaushik. (2022) Perspectives on nano-nutraceuticals to manage pre and post COVID-19 infections. Biotechnology Reports 33, pages e00712.
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V. Evanjalin Monica, Shubham Nimbkar, Arunkumar Elumalai, J. A. Moses & C. Anandharamakrishnan. 2022. Immunomodulators and Human Health. Immunomodulators and Human Health 39 70 .
Rajeshwari Singh, Sumeet Goel, Pascale Bourgeade, Lotfi Aleya & Devesh Tewari. (2021) Ayurveda Rasayana as antivirals and immunomodulators: potential applications in COVID-19. Environmental Science and Pollution Research 28:40, pages 55925-55951.
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Seyyed Sasan Mousavi, Akbar Karami, Tahereh Movahhed Haghighi, Sefren Geiner Tumilaar, Fatimawali, Rinaldi Idroes, Shafi Mahmud, Ismail Celik, Duygu Ağagündüz, Trina Ekawati Tallei, Talha Bin Emran & Raffaele Capasso. (2021) In Silico Evaluation of Iranian Medicinal Plant Phytoconstituents as Inhibitors against Main Protease and the Receptor-Binding Domain of SARS-CoV-2. Molecules 26:18, pages 5724.
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Rupesh V. Chikhale, Saurabh K. Sinha, Pukar Khanal, Nilambari S. Gurav, Muniappan Ayyanar, Satyendra K. Prasad, Manish M. Wanjari, Rajesh B. Patil & Shailendra S. Gurav. (2021) Computational and network pharmacology studies of Phyllanthus emblica to tackle SARS-CoV-2. Phytomedicine Plus 1:3, pages 100095.
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Prarambh SR Dwivedi, V. P. Rasal, Ekta Kotharkar, Shailaja Nare & Pukar Khanal. (2021) Gene set enrichment analysis of PPAR-γ regulators from Murraya odorata Blanco. Journal of Diabetes & Metabolic Disorders 20:1, pages 369-375.
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Jiaxin Liang, Linda Oyang, Shan Rao, Yaqian Han, Xia Luo, Pin Yi, Jinguan Lin, Longzheng Xia, Jiaqi Hu, Shiming Tan, Lu Tang, Qing Pan, Yanyan Tang, Yujuan Zhou & Qianjin Liao. (2021) Rac1, A Potential Target for Tumor Therapy. Frontiers in Oncology 11.
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Akash Saggam, Kirti Limgaokar, Swapnil Borse, Preeti Chavan-Gautam, Santosh Dixit, Girish Tillu & Bhushan Patwardhan. (2021) Withania somnifera (L.) Dunal: Opportunity for Clinical Repurposing in COVID-19 Management. Frontiers in Pharmacology 12.
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Prarambh S. R. Dwivedi, Pukar Khanal, Vishakha Parab Gaonkar, V. P. Rasal & B. M. Patil. (2021) Identification of PTP1B regulators from Cymbopogon citratus and its enrichment analysis for diabetes mellitus. In Silico Pharmacology 9:1.
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Pukar Khanal, Taaza Duyu, B. M. Patil, Yadu Nandan Dey, Ismail Pasha, Rohini S. Kavalapure, Sharad Chand & Shailendra Gurav. (2021) Screening of JAK-STAT modulators from the antiviral plants of Indian traditional system of medicine with the potential to inhibit 2019 novel coronavirus using network pharmacology. 3 Biotech 11:3.
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Pukar Khanal, Yadu Nandan Dey, Rajesh Patil, Rupesh Chikhale, Manish M. Wanjari, Shailendra S. Gurav, B. M. Patil, Bhavana Srivastava & Sudesh N. Gaidhani. (2021) Combination of system biology to probe the anti-viral activity of andrographolide and its derivative against COVID-19. RSC Advances 11:9, pages 5065-5079.
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