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Annals of Medicine Volume 50, 2018 - Issue 1
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Original Article

Enhancing the ‘real world’ prediction of cardiovascular events and major bleeding with the CHA2DS2-VASc and HAS-BLED scores using multiple biomarkers

Vanessa RoldánDepartment of Hematology and Clinical Oncology, Hospital General Universitario Morales Meseguer, University of Murcia, Instituto Murciano de Investigación Biosanitaria (IMIB-Arrixaca), Murcia, Spain; Correspondence[email protected]
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José Miguel Rivera-CaravacaDepartment of Hematology and Clinical Oncology, Hospital General Universitario Morales Meseguer, University of Murcia, Instituto Murciano de Investigación Biosanitaria (IMIB-Arrixaca), Murcia, Spain; ORCID Iconhttp://orcid.org/0000-0003-0492-6241View further author information
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Alena ShantsilaInstitute of Cardiovascular Sciences, University of Birmingham, Birmingham, UK; View further author information
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Amaya García-FernándezDepartment of Cardiology, Hospital General Universitario de Alicante, Alicante, Spain; View further author information
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María Asunción Esteve-PastorDepartment of Cardiology, Hospital Clínico Universitario Virgen de la Arrixaca, University of Murcia, CIBER-CV, IMIB-Arrixaca, Murcia, Spain; View further author information
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Juan Antonio VilchezDepartment of Clinical Analysis, Hospital General Universitario Santa Lucía, IMIB-Arrixaca, Murcia, Spain; View further author information
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Marta RomeraDepartment of Hematology and Clinical Oncology, Hospital General Universitario Morales Meseguer, University of Murcia, Instituto Murciano de Investigación Biosanitaria (IMIB-Arrixaca), Murcia, Spain; View further author information
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Mariano ValdésDepartment of Cardiology, Hospital Clínico Universitario Virgen de la Arrixaca, University of Murcia, CIBER-CV, IMIB-Arrixaca, Murcia, Spain; View further author information
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Vicente VicenteDepartment of Hematology and Clinical Oncology, Hospital General Universitario Morales Meseguer, University of Murcia, Instituto Murciano de Investigación Biosanitaria (IMIB-Arrixaca), Murcia, Spain; View further author information
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Francisco MarínDepartment of Cardiology, Hospital Clínico Universitario Virgen de la Arrixaca, University of Murcia, CIBER-CV, IMIB-Arrixaca, Murcia, Spain; View further author information
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Gregory Y. H. LipInstitute of Cardiovascular Sciences, University of Birmingham, Birmingham, UK; ;Aalborg Thrombosis Research Unit, Department of Clinical Medicine, Faculty of Health, Aalborg University, Aalborg, DenmarkView further author information
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Pages 26-34 | Received 05 Jun 2017, Accepted 05 Sep 2017, Published online: 18 Sep 2017

Citations (21)

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Eva Soler-Espejo, María Asunción Esteve-Pastor, José Miguel Rivera-Caravaca, Vanessa Roldan & Francisco Marín. (2023) Reducing bleeding risk in patients on oral anticoagulation therapy. Expert Review of Cardiovascular Therapy 0:0, pages 1-14.
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Sylvia E. Choi, Dimitrios Sagris, Andrew Hill, Gregory Y.H. Lip & Azmil H. Abdul-Rahim. (2023) Atrial fibrillation and stroke. Expert Review of Cardiovascular Therapy 21:1, pages 35-56.
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José Miguel Rivera-Caravaca, María Asunción Esteve-Pastor, Anny Camelo-Castillo, Inmaculada Ramírez-Macías, Gregory Y. H. Lip, Vanessa Roldán & Francisco Marín. (2020) Treatment strategies for patients with atrial fibrillation and anticoagulant-associated intracranial hemorrhage: an overview of the pharmacotherapy. Expert Opinion on Pharmacotherapy 21:15, pages 1867-1881.
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Nicola Tidbury, Joshua Preston, Wern Yew Ding, José Miguel Rivera-Caravaca, Francisco Marín & Gregory Y. H. Lip. (2020) Utilizing biomarkers associated with cardiovascular events in atrial fibrillation: informing a precision medicine response. Expert Review of Precision Medicine and Drug Development 5:5, pages 331-345.
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Articles from other publishers (17)

Jennifer Susan Lees, Nicole L De La Mata, Michael K Sullivan, Melanie L Wyld, Brenda M Rosales, Rachel Cutting, James Alan Hedley, Elaine Rutherford, Patrick Barry Mark & Angela C Webster. (2023) Sex differences in associations between creatinine and cystatin C-based kidney function measures with stroke and major bleeding. European Stroke Journal, pages 239698732311732.
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Sofie A.M. Dhaese & An S. De Vriese. (2023) Oral Anticoagulation in Patients With Advanced Chronic Kidney Disease and Atrial Fibrillation: Beyond Anticoagulation. Mayo Clinic Proceedings 98:5, pages 750-770.
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Hizir Ozdemir, Dimitrios Sagris, Gregory Y. H. Lip & Azmil H. Abdul-Rahim. (2023) Stroke in Atrial Fibrillation and Other Atrial Dysrhythmias. Current Cardiology Reports 25:5, pages 357-369.
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Vera H W van der Endt, Jet Milders, Bas B L Penning de Vries, Serge A Trines, Rolf H H Groenwold, Olaf M Dekkers, Marco Trevisan, Juan J Carrero, Merel van Diepen, Friedo W Dekker & Ype de Jong. (2022) Comprehensive comparison of stroke risk score performance: a systematic review and meta-analysis among 6 267 728 patients with atrial fibrillation. EP Europace 24:11, pages 1739-1753.
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Luxiang Shang, Ling Zhang, Yankai Guo, Huaxin Sun, Xiaoxue Zhang, Yakun Bo, Xianhui Zhou & Baopeng Tang. (2021) A Review of Biomarkers for Ischemic Stroke Evaluation in Patients With Non-valvular Atrial Fibrillation. Frontiers in Cardiovascular Medicine 8.
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Kalyani A. Boralkar, Francois Haddad & Benjamin D. Horne. (2020) Biomarkers and Risk Prediction Tools for Stroke and Dementia in Patients with Atrial Fibrillation. Current Cardiovascular Risk Reports 14:12.
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Yuan-Zheng Ye, Ya-Fei Chang, Bao-Zhu Wang, Yi-Tong Ma & Xiang Ma. (2020) Prognostic value of von Willebrand factor for patients with atrial fibrillation: a meta-analysis of prospective cohort studies. Postgraduate Medical Journal 96:1135, pages 267-276.
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Vasileios-Arsenios Lioutas, Nitin Goyal, Aristeidis H. Katsanos, Christos Krogias, Ramin Zand, Vijay K. Sharma, Panayiotis Varelas, Konark Malhotra, Maurizio Paciaroni, Theodore Karapanayiotides, Aboubakar Sharaf, Jason Chang, Odysseas Kargiotis, Abhi Pandhi, Lina Palaiodimou, Christoph Schroeder, Argyrios Tsantes, Efstathios Boviatsis, Chandan Mehta, Aspasia Serdari, Konstantinos Vadikolias, Panayiotis D. Mitsias, Magdy H. Selim, Andrei V. Alexandrov & Georgios Tsivgoulis. (2019) Optimization of risk stratification for anticoagulation-associated intracerebral hemorrhage: net risk estimation. Journal of Neurology 267:4, pages 1053-1062.
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Magdalena Domek, Jakub Gumprecht, Michał Mazurek, Tze-Fan Chao & Gregory Y. H. Lip. (2019) Should We Judge Stroke Risk by Static or Dynamic Risk Scores? A Focus on the Dynamic Nature of Stroke and Bleeding Risks in Patients With Atrial Fibrillation. Journal of Cardiovascular Pharmacology 74:6, pages 491-498.
Crossref
Monika KoziełTatjana S. PotparaGregory Y.H. Lip. (2019) Using Blood Biomarkers to Identify Atrial Fibrillation–Related Stroke. Stroke 50:8, pages 1956-1957.
Crossref
José Miguel Rivera-CaravacaFrancisco MarínJuan Antonio VilchezJosefa GálvezMaría Asunción Esteve-PastorVicente VicenteGregory Y.H. LipVanessa Roldán. (2019) Refining Stroke and Bleeding Prediction in Atrial Fibrillation by Adding Consecutive Biomarkers to Clinical Risk Scores. Stroke 50:6, pages 1372-1379.
Crossref
Ammar M Killu, Christopher B Granger & Bernard J Gersh. (2019) Risk stratification for stroke in atrial fibrillation: a critique. European Heart Journal 40:16, pages 1294-1302.
Crossref
Gregory Y H Lip, Jean-Phillippe Collet, Michael Haude, Robert Byrne, Eugene H Chung, Laurent Fauchier, Sigrun Halvorsen, Dennis Lau, Nestor Lopez-Cabanillas, Maddalena Lettino, Francisco Marin, Israel Obel, Andrea Rubboli, Robert F Storey, Marco Valgimigli, Kurt Huber, Tatjana Potpara, Carina Blomström Lundqvist, Harry Crijns, Jan Steffel, Hein Heidbüchel, Goran Stankovic, Juhani Airaksinen, Jurrien M Ten Berg, Davide Capodanno, Stefan James, Hector Bueno, Joao Morais, Dirk Sibbing, Bianca Rocca, Ming-Hsiung Hsieh, Nazem Akoum, Deborah J Lockwood, Jorge Rafael Gomez Flores & Ronald Jardine. (2019) 2018 Joint European consensus document on the management of antithrombotic therapy in atrial fibrillation patients presenting with acute coronary syndrome and/or undergoing percutaneous cardiovascular interventions: a joint consensus document of the European Heart Rhythm Association (EHRA), European Society of Cardiology Working Group on Thrombosis, European Association of Percutaneous Cardiovascular Interventions (EAPCI), and European Association of Acute Cardiac Care (ACCA) endorsed by the Heart Rhythm Society (HRS), Asia-Pacific Heart Rhythm Society (APHRS), Latin America Heart Rhythm Society (LAHRS), and Cardiac Arrhythmia Society of Southern Africa (CASSA). EP Europace 21:2, pages 192-193.
Crossref
Ahsan A Khan & Gregory Y H Lip. (2019) The prothrombotic state in atrial fibrillation: pathophysiological and management implications. Cardiovascular Research 115:1, pages 31-45.
Crossref
Abhinav SharmaZiad HijaziUlrika AnderssonSana M. Al-KhatibRenato D. LopesJohn H. AlexanderClaes HeldElaine M. HylekSergio LeonardiMichael HannaJustin A. EzekowitzAgneta SiegbahnChristopher B. GrangerLars Wallentin. (2018) Use of Biomarkers to Predict Specific Causes of Death in Patients With Atrial Fibrillation. Circulation 138:16, pages 1666-1676.
Crossref
Ana B. ArroyoAscensión M. de los Reyes-GarcíaJosé M. Rivera-CaravacaPatricia ValledorNuria García-BarberáVanessa RoldánVicente VicenteConstantino MartínezRocío González-Conejero. (2018) MiR-146a Regulates Neutrophil Extracellular Trap Formation That Predicts Adverse Cardiovascular Events in Patients With Atrial Fibrillation. Arteriosclerosis, Thrombosis, and Vascular Biology 38:4, pages 892-902.
Crossref
Seung Yong Shin & Gregory Y. H. Lip. (2018) Novel biomarker-based risk prediction for new onset atrial fibrillation in patients with ST elevation myocardial infarction: Balancing simplicity and practicality. International Journal of Clinical Practice 72:4, pages e13090.
Crossref

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