Advanced search
Publication Cover
International Reviews of Immunology Volume 23, 2004 - Issue 3-4
Submit an article Journal homepage
339
Views
55
CrossRef citations to date
0
Altmetric
Research Article

MITOCHONDRIAL DYSFUNCTION IN T CELLS OF PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS

ANDRAS PERL Department of Medicine and Department of Microbiology and Immunology, State University of New York, Upstate Medical University, College of Medicine, Syracuse, New York, USACorrespondence[email protected]
,
PETER GERGELY JR. Department of Medicine, State University of New York, Upstate Medical University, College of Medicine, Syracuse, New York, USA
&
KATALIN BANKI Department of Pathology, State University of New York, Upstate Medical University, College of Medicine, Syracuse, New York, USA
Pages 293-313 | Published online: 03 Aug 2009

Citations (55)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (3)

Hoim Jeong, Beomgu Lee, Seung Jin Han & Dong Hyun Sohn. (2023) Glucose metabolic reprogramming in autoimmune diseases. Animal Cells and Systems 27:1, pages 149-158.
Read now
Marcela Muñoz-Urbano, Diana C. Quintero-González & Gloria Vasquez. (2022) T cell metabolism and possible therapeutic targets in systemic lupus erythematosus: a narrative review. Immunopharmacology and Immunotoxicology 44:4, pages 457-470.
Read now
Tongyu C Wikramanayake, Jérémy Chéret, Alec Sevilla, Mark Birch-Machin & Ralf Paus. (2022) Targeting mitochondria in dermatological therapy: beyond oxidative damage and skin aging. Expert Opinion on Therapeutic Targets 26:3, pages 233-259.
Read now

Articles from other publishers (52)

Tinkara Pirc Marolt, Barbara Kramar, Andrej Vovk, Helena Podgornik, Dušan Šuput & Irina Milisav. (2023) Therapeutic Dosage of Antipsychotic Drug Aripiprazole Induces Persistent Mitochondrial Hyperpolarisation, Moderate Oxidative Stress in Liver Cells, and Haemolysis. Antioxidants 12:11, pages 1930.
Crossref
Matthew Hunt, Monica Torres, Etty Bachar-Wikström & Jakob D. Wikström. (2023) Multifaceted roles of mitochondria in wound healing and chronic wound pathogenesis. Frontiers in Cell and Developmental Biology 11.
Crossref
Yi Lin, Yuecen Ding, Yue Wu, Yiwen Yang, Ziqi Liu, Leihong Xiang & Chengfeng Zhang. (2023) The underestimated role of mitochondria in vitiligo: From oxidative stress to inflammation and cell death. Experimental Dermatology.
Crossref
Ghislaine Boungou-Tsona, Maël Gainche, Caroline Decombat, Isabelle Ripoche, Kevin Bikindou, Laetitia Delort, Florence Caldefie-Chézet, Aubin Loumouamou & Pierre Chalard. (2023) Chemical Profile, Antioxidant and Anti-Inflammatory Potency of Extracts of Vitex madiensis Oliv. and Crossopteryx febrifuga (Afzel ex G. Don). Plants 12:2, pages 386.
Crossref
Ying Teng, Zi-Ye Yan, Lin-Lin Wang, Yu-Hua Wang, Ting-Yu Zhang, Zhen Li, Shuang Liu, Jing Cai, Yang-Fan Chen, Mu Li, Sheng-Xiu Liu, Zhou-Zhou Xu, Hai-Liang Huang, Fang Wang, Fa-Ming Pan, Hai-Feng Pan, Hong Su & Yan-Feng Zou. (2022) Mitochondrial DNA genetic variants are associated with systemic lupus erythematosus susceptibility, glucocorticoids efficacy and prognosis. Rheumatology 61:6, pages 2652-2662.
Crossref
Qian Chen, Jie Wang, Mengmeng Xiang, Yilun Wang, Zhixiong Zhang, Jun Liang & Jinhua Xu. (2022) The Potential Role of Ferroptosis in Systemic Lupus Erythematosus. Frontiers in Immunology 13.
Crossref
Xiangyu TengJosephine BrownLaurence Morel. (2022) Redox Homeostasis Involvement in the Pharmacological Effects of Metformin in Systemic Lupus Erythematosus. Antioxidants & Redox Signaling 36:7-9, pages 462-479.
Crossref
Christopher S. Wilson, Blair T. Stocks, Emilee M. Hoopes, Jillian P. Rhoads, Kelsey L. McNew, Amy S. Major & Daniel J. Moore. (2021) Metabolic preconditioning in CD4+ T cells restores inducible immune tolerance in lupus-prone mice. JCI Insight 6:19.
Crossref
Prashant Rai, Kyathanahalli S. Janardhan, Julie Meacham, Jennifer H. Madenspacher, Wan-Chi Lin, Peer W. F. Karmaus, Jennifer Martinez, Quan-Zhen Li, Mei Yan, Jialiu Zeng, Mark W. Grinstaff, Orian S. Shirihai, Gregory A. Taylor & Michael B. Fessler. (2021) IRGM1 links mitochondrial quality control to autoimmunity. Nature Immunology 22:3, pages 312-321.
Crossref
Y. Ana, J.D. Rojas Marquez, L. Fozzatti, R.E. Baigorrí, C. Marin, B.A. Maletto, F.M. Cerbán, R. Radi, L. Piacenza & C.C. Stempin. (2021) An exacerbated metabolism and mitochondrial reactive oxygen species contribute to mitochondrial alterations and apoptosis in CD4 T cells during the acute phase of Trypanosoma cruzi infection. Free Radical Biology and Medicine 163, pages 268-280.
Crossref
Sheetal Ramani, Ayush Pathak, Vikram Dalal, Anamika Paul & Sagarika Biswas. (2020) Oxidative Stress in Autoimmune Diseases: An Under Dealt Malice. Current Protein & Peptide Science 21:6, pages 611-621.
Crossref
Mohammad javad Tavassolifar, Mohammad Vodjgani, Zahra Salehi & Maryam Izad. (2020) The Influence of Reactive Oxygen Species in the Immune System and Pathogenesis of Multiple Sclerosis. Autoimmune Diseases 2020, pages 1-14.
Crossref
Annapoorna Sreedhar, Leopoldo Aguilera-Aguirre & Keshav K. Singh. (2020) Mitochondria in skin health, aging, and disease. Cell Death & Disease 11:6.
Crossref
Shi-Kun Yang, Hao-Ran Zhang, Shu-Peng Shi, Ying-Qiu Zhu, Na Song, Qing Dai, Wei Zhang, Ming Gui & Hao Zhang. (2020) The Role of Mitochondria in Systemic Lupus Erythematosus: A Glimpse of Various Pathogenetic Mechanisms. Current Medicinal Chemistry 27:20, pages 3346-3361.
Crossref
Milena Vukelic, Michihito Kono & George C. Tsokos. (2020) T cell Metabolism in Lupus. Immunometabolism 2:2.
Crossref
Alessandra Colamatteo, Teresa Micillo, Sara Bruzzaniti, Clorinda Fusco, Silvia Garavelli, Veronica De Rosa, Mario Galgani, Maria Immacolata Spagnuolo, Francesca Di Rella, Annibale A. Puca, Paola de Candia & Giuseppe Matarese. (2019) Metabolism and Autoimmune Responses: The microRNA Connection. Frontiers in Immunology 10.
Crossref
Chang-Youh Tsai, Chieh-Yu Shen, Hsien-Tzung Liao, Ko-Jen Li, Hui-Ting Lee, Cheng-Shiun Lu, Cheng-Han Wu, Yu-Min Kuo, Song-Chou Hsieh & Chia-Li Yu. (2019) Molecular and Cellular Bases of Immunosenescence, Inflammation, and Cardiovascular Complications Mimicking “Inflammaging” in Patients with Systemic Lupus Erythematosus. International Journal of Molecular Sciences 20:16, pages 3878.
Crossref
Timo Gaber, Yuling Chen, Pierre-Louis Krauß & Frank Buttgereit. 2019. Biology of T Cells - Part B. Biology of T Cells - Part B 95 148 .
Laurence Morel. 2019. Dubois' Lupus Erythematosus and Related Syndromes. Dubois' Lupus Erythematosus and Related Syndromes 153 163 .
Brandon J. Berry, Adam J. Trewin, Andrea M. Amitrano, Minsoo Kim & Andrew P. Wojtovich. (2018) Use the Protonmotive Force: Mitochondrial Uncoupling and Reactive Oxygen Species. Journal of Molecular Biology 430:21, pages 3873-3891.
Crossref
Chhanda Biswas. 2018. Immunity and Inflammation in Health and Disease. Immunity and Inflammation in Health and Disease 223 237 .
Gohar Tsakanova, Elina Arakelova, Violetta Ayvazyan, Anna Ayvazyan, Stepan Tatikyan, Rouben Aroutiounian, Yeva Dalyan, Samvel Haroutiunian, Vasili Tsakanov & Arsen Arakelyan. (2017) Two-photon microscopy imaging of oxidative stress in human living erythrocytes. Biomedical Optics Express 8:12, pages 5834.
Crossref
Jing Chen, Anna V. Chernatynskaya, Jian-Wei Li, Matthew R. Kimbrell, Richard J. Cassidy, Daniel J. Perry, Andrew B. Muir, Mark A. Atkinson, Todd M. Brusko & Clayton E. Mathews. (2017) T cells display mitochondria hyperpolarization in human type 1 diabetes. Scientific Reports 7:1.
Crossref
Laurence Morel. (2017) Immunometabolism in systemic lupus erythematosus. Nature Reviews Rheumatology 13:5, pages 280-290.
Crossref
Yuchuan Wang, Jennifer M Coughlin, Shuangchao Ma, Christopher J Endres, Michael Kassiou, Akira Sawa, Robert F Dannals, Michelle Petri & Martin G Pomper. (2016) Neuroimaging of translocator protein in patients with systemic lupus erythematosus: a pilot study using [ 11 C]DPA-713 positron emission tomography . Lupus 26:2, pages 170-178.
Crossref
Iwona A. BuskiewiczTheresa MontgomeryElizabeth C. YasewiczSally A. HuberMichael P. MurphyRichard C. HartleyRyan KellyMary K. CrowAndras PerlRalph C. BuddAndreas Koenig. (2016) Reactive oxygen species induce virus-independent MAVS oligomerization in systemic lupus erythematosus. Science Signaling 9:456.
Crossref
Richa Rai, Sudhir Kumar Chauhan, Vikas Vikram Singh, Madhukar Rai & Geeta Rai. (2016) RNA-seq Analysis Reveals Unique Transcriptome Signatures in Systemic Lupus Erythematosus Patients with Distinct Autoantibody Specificities. PLOS ONE 11:11, pages e0166312.
Crossref
Santhosh Kumar Venugopalan, Shanmugarajan T.S.Navaratnam V.Mansor S.M.Ramanathan S.. (2016) Dexamethasone provoked mitochondrial perturbations in thymus: Possible role of N-acetylglucosamine in restoration of mitochondrial function. Biomedicine & Pharmacotherapy 83, pages 1485-1492.
Crossref
Hui-Ting Lee, Tsai-Hung Wu, Chen-Sung Lin, Chyou-Shen Lee, Yau-Huei Wei, Chang-Youh Tsai & Deh-Ming Chang. (2016) The pathogenesis of systemic lupus erythematosus - From the viewpoint of oxidative stress and mitochondrial dysfunction. Mitochondrion 30, pages 1-7.
Crossref
Jelena Dinić, Miroslav Novaković, Ana Podolski-Renić, Vlatka Vajs, Vele Tešević, Aleksandra Isaković & Milica Pešić. (2016) Structural differences in diarylheptanoids analogues from Alnus viridis and Alnus glutinosa influence their activity and selectivity towards cancer cells. Chemico-Biological Interactions 249, pages 36-45.
Crossref
Ji Yang, Xue Yang, Hejian Zou & Ming Li. (2016) Oxidative Stress and Treg and Th17 Dysfunction in Systemic Lupus Erythematosus. Oxidative Medicine and Cellular Longevity 2016, pages 1-9.
Crossref
Youzhou Tang, Li Wang, Min Zhu, Ming Yang, Kuangbiao Zhong, Qing Du, Hao Zhang & Ming Gui. (2015) Association of mtDNA M/N haplogroups with systemic lupus erythematosus: a case-control study of Han Chinese women. Scientific Reports 5:1.
Crossref
Dilip Shah, Nidhi Mahajan, Sangita Sah, Swapan K Nath & Bishnuhari Paudyal. (2014) Oxidative stress and its biomarkers in systemic lupus erythematosus. Journal of Biomedical Science 21:1.
Crossref
L López-López, M Nieves-Plaza, M del R Castro, YM Font, CA Torres-Ramos, LM Vilá & S Ayala-Peña. (2014) Mitochondrial DNA damage is associated with damage accrual and disease duration in patients with Systemic Lupus Erythematosus. Lupus 23:11, pages 1133-1141.
Crossref
René G. Feichtinger, Wolfgang Sperl, Johann W. Bauer & Barbara Kofler. (2014) Mitochondrial dysfunction: a neglected component of skin diseases. Experimental Dermatology 23:9, pages 607-614.
Crossref
Dilip Shah, Sangita Sah & Swapan K. Nath. (2013) Interaction between glutathione and apoptosis in systemic lupus erythematosus. Autoimmunity Reviews 12:7, pages 741-751.
Crossref
Katie E. Crump, P. Kent Langston, Sujana Rajkarnikar & Jason M. Grayson. (2013) Antioxidant Treatment Regulates the Humoral Immune Response during Acute Viral Infection. Journal of Virology 87:5, pages 2577-2586.
Crossref
Ryan D. Michalek, Katie E. Crump, Ashley E. Weant, Elizabeth M. Hiltbold, Daniel G. Juneau, Eun-Yi Moon, Dae-Yeul Yu, Leslie B. Poole & Jason M. Grayson. (2012) Peroxiredoxin II Regulates Effector and Secondary Memory CD8 + T Cell Responses . Journal of Virology 86:24, pages 13629-13641.
Crossref
Tiffany N. Caza, Gergely Talaber & Andras Perl. (2012) Metabolic regulation of organelle homeostasis in lupus T cells. Clinical Immunology 144:3, pages 200-213.
Crossref
Hui-Ting Lee, Chen-Sung Lin, Wei-Sheng Chen, Hsien-Tzung Liao, Chang-Youh Tsai & Yau-Huei Wei. (2012) Leukocyte Mitochondrial DNA Alteration in Systemic Lupus Erythematosus and Its Relevance to the Susceptibility to Lupus Nephritis. International Journal of Molecular Sciences 13:7, pages 8853-8868.
Crossref
Daniel J. Perry, Yiming Yin, Tiffany Telarico, Henry V. Baker, Igor Dozmorov, Andras Perl & Laurence Morel. (2012) Murine Lupus Susceptibility Locus Sle1c2 Mediates CD4+ T Cell Activation and Maps to Estrogen-Related Receptor γ . The Journal of Immunology 189:2, pages 793-803.
Crossref
Nursamaa Abdoel, Susana Brun, Carmen Bracho, Martín A. Rodríguez & Ana M. Blasini. (2012) Linker for activation of T cells is displaced from lipid rafts and decreases in lupus T cells after activation via the TCR/CD3 pathway. Clinical Immunology 142:3, pages 243-251.
Crossref
Taibur Rahman, Ismail Hosen, M. M. Towhidul Islam & Hossain Uddin Shekhar. (2012) Oxidative stress and human health. Advances in Bioscience and Biotechnology 03:07, pages 997-1019.
Crossref
Laurence Morel. 2012. Advances in Immunology Volume 115. Advances in Immunology Volume 115 113 139 .
DR Wahl, B. Petersen, R. Warner, BC Richardson, GD GlickAW Opipari. (2010) Characterization of the metabolic phenotype of chronically activated lymphocytes. Lupus 19:13, pages 1492-1501.
Crossref
Dilip Shah, Ravi Kiran, Ajay Wanchu & Archana Bhatnagar. (2010) Oxidative stress in systemic lupus erythematosus: Relationship to Th1 cytokine and disease activity. Immunology Letters 129:1, pages 7-12.
Crossref
Enn Seppet, Marju Gruno, Ants Peetsalu, Zemfira Gizatullina, Huu Phuc Nguyen, Stefan Vielhaber, Manfred Wussling, Sonata Trumbeckaite, Odeta Arandarcikaite, Doreen Jerzembeck, Maria Sonnabend, Katharina Jegorov, Stephan Zierz, Frank Striggow & Frank Gellerich. (2009) Mitochondria and Energetic Depression in Cell Pathophysiology. International Journal of Molecular Sciences 10:5, pages 2252-2303.
Crossref
Kensuke Tanaka, Takehiko Iijima, Tatsuya Mishima, Kei Suga, Kimio Akagawa & Yasuhide Iwao. (2008) Ca2+ Buffering Capacity of Mitochondria After Oxygen-Glucose Deprivation in Hippocampal Neurons. Neurochemical Research 34:2, pages 221-226.
Crossref
Ryan D. Michalek, Kimberly J. Nelson, Beth C. Holbrook, John S. Yi, Daya Stridiron, Larry W. Daniel, Jacquelyn S. Fetrow, S. Bruce King, Leslie B. Poole & Jason M. Grayson. (2007) The Requirement of Reversible Cysteine Sulfenic Acid Formation for T Cell Activation and Function. The Journal of Immunology 179:10, pages 6456-6467.
Crossref
Enn Seppet, Zemfira Gizatullina, Sonata Trumbeckaite, Stephan Zierz, Frank Striggow & Frank Norbert Gellerich. 2007. Molecular System Bioenergetics. Molecular System Bioenergetics 479 520 .
Philip L. Cohen. (2006) Apoptotic cell death and lupus. Springer Seminars in Immunopathology 28:2, pages 145-152.
Crossref
Chen Xue, Wang Lan-lan, Cai Bei, Chen Jie & Feng Wei-hua. (2006) Abnormal Fas/FasL and caspase-3-mediated apoptotic signaling pathways of T lymphocyte subset in patients with systemic lupus erythematosus. Cellular Immunology 239:2, pages 121-128.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.