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International Reviews of Immunology Volume 41, 2022 - Issue 2
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Tuberculosis vaccine BCG: the magical effect of the old vaccine in the fight against the COVID-19 pandemic

Ashok Aspatwara Faculty of Medicine and Health Technology, Tampere University, Tampere, FinlandCorrespondence[email protected] [email protected]
ORCID Iconhttps://orcid.org/0000-0002-6938-7835
ORCID Icon,
Wenping Gongb Army Tuberculosis Prevention and Control Key Laboratory, Beijing Key Laboratory of New Techniques of Tuberculosis Diagnosis and Treatment, Institute for Tuberculosis Research, the 8th Medical Center of Chinese PLA General Hospital, Beijing, ChinaORCID Iconhttps://orcid.org/0000-0002-0333-890X
ORCID Icon,
Shuyong Wangb Army Tuberculosis Prevention and Control Key Laboratory, Beijing Key Laboratory of New Techniques of Tuberculosis Diagnosis and Treatment, Institute for Tuberculosis Research, the 8th Medical Center of Chinese PLA General Hospital, Beijing, ChinaORCID Iconhttps://orcid.org/0000-0002-0779-3395
ORCID Icon,
Xueqiong Wub Army Tuberculosis Prevention and Control Key Laboratory, Beijing Key Laboratory of New Techniques of Tuberculosis Diagnosis and Treatment, Institute for Tuberculosis Research, the 8th Medical Center of Chinese PLA General Hospital, Beijing, ChinaCorrespondence[email protected] [email protected]
ORCID Iconhttps://orcid.org/0000-0001-8894-1929
ORCID Icon &
Seppo Parkkilaa Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland;c Fimlab Laboratories Ltd, Tampere University Hospital, Tampere, FinlandORCID Iconhttps://orcid.org/0000-0001-7323-8536
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Pages 283-296 | Received 13 Jan 2021, Accepted 21 Apr 2021, Published online: 07 May 2021

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Wenping Gong, Seppo Parkkila, Xueqiong Wu & Ashok Aspatwar. (2023) SARS-CoV-2 variants and COVID-19 vaccines: Current challenges and future strategies. International Reviews of Immunology 42:6, pages 393-414.
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Giuseppe Murdaca, Francesca Paladin, Gloria Mangini, Debora Tiso & Sebastiano Gangemi. (2023) TBC and COVID: an interplay between two infections. Expert Opinion on Drug Safety 22:4, pages 303-311.
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Ruda Wei, Pengchuan Li, Yong Xue, Yinping Liu, Wenping Gong & Weiguo Zhao. (2022) Impact of Diabetes Mellitus on the Immunity of Tuberculosis Patients: A Retrospective, Cross-Sectional Study. Risk Management and Healthcare Policy 15, pages 611-627.
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Wenping Gong, Ashok Aspatwar, Shuyong Wang, Seppo Parkkila & Xueqiong Wu. (2021) COVID-19 pandemic: SARS-CoV-2 specific vaccines and challenges, protection via BCG trained immunity, and clinical trials. Expert Review of Vaccines 20:7, pages 857-880.
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Articles from other publishers (16)

Susan Martins Pereira, Florisneide Rodrigues Barreto, Ramon Andrade de Souza, Carlos Antonio de Souza Teles Santos, Marcos Pereira, Enny Santos da Paixão, Carla Cristina Oliveira de Jesus Lima, Marcio Santos da Natividade, Ana Angélica Bulcão Portela Lindoso, Eder Gatti Fernandes, Evonio Barros Campelo Junior, Julia Moreira Pescarini, Kaio Vinicius Freitas de Andrade, Fernanda Mattos de Souza, Elisangela Alves de Britto, Ceuci Nunes, Maria Yuri Ichihara, Margareth Dalcolmo, Anete Trajman, Manoel Barral-Netto, Ibrahim Abubakar, Mauricio Lima Barreto, Ricardo Arraes de Alencar Ximenes & Laura Cunha Rodrigues. (2023) Previous BCG vaccination is associated with less severe clinical progression of COVID-19. BMC Medicine 21:1.
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Jingli Du, Yue Su, Ruilan Wang, Enjun Dong, Yan Cao, Wenjuan Zhao & Wenping Gong. (2023) Research progress on specific and non-specific immune effects of BCG and the possibility of BCG protection against COVID-19. Frontiers in Immunology 14.
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Peng Cheng, Yong Xue, Jie Wang, Zaixing Jia, Liang Wang & Wenping Gong. (2022) Evaluation of the consistence between the results of immunoinformatics predictions and real-world animal experiments of a new tuberculosis vaccine MP3RT. Frontiers in Cellular and Infection Microbiology 12.
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Nadia Rahali & Chokri Bahloul. (2022) Induction of Cross-Reacting Antibodies Against the COVID-19 by BCG Vaccination in the Mouse Model. Current Microbiology 79:9.
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Wenping Gong, Huiru An, Jie Wang, Peng Cheng & Yong Qi. (2022) The Natural Effect of BCG Vaccination on COVID-19: The Debate Continues. Frontiers in Immunology 13.
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Wenping Gong, Yingqing Mao, Yuexi Li & Yong Qi. (2022) BCG Vaccination: A potential tool against COVID-19 and COVID-19-like Black Swan incidents. International Immunopharmacology 108, pages 108870.
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Jacek M. Witkowski, Tamas Fulop & Ewa Bryl. (2022) Immunosenescence and COVID-19. Mechanisms of Ageing and Development 204, pages 111672.
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E. V. Savintseva, P. V. Isaeva & G. F. Nizamova. (2022) Tuberculosis and COVID-19: Medical and Social Aspects. Tuberculosis and Lung Diseases 100:3, pages 13-17.
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Wenping Gong, Chao Pan, Peng Cheng, Jie Wang, Guangyu Zhao & Xueqiong Wu. (2022) Peptide-Based Vaccines for Tuberculosis. Frontiers in Immunology 13.
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Shinobu Kitayama, Nicholas P. Camp & Cristina E. Salvador. (2022) Culture and the COVID‐19 Pandemic: Multiple Mechanisms and Policy Implications. Social Issues and Policy Review 16:1, pages 164-211.
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İdris YAZGAN. (2021) mRNA SARS-CoV2 Specific and Childhood Vaccines against Covid-19 PandemicCovid-19’a karşı mRNA SARS-CoV2 spesifik ve Çocukluk Dönemi Aşıları. Türk Doğa ve Fen Dergisi 10:2, pages 338-350.
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Wenping Gong & Xueqiong Wu. (2021) Differential Diagnosis of Latent Tuberculosis Infection and Active Tuberculosis: A Key to a Successful Tuberculosis Control Strategy. Frontiers in Microbiology 12.
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Kent J. Koster, Hilary L. Webb & Jeffrey D. Cirillo. (2021) COVID-19 and Beyond: Exploring Public Health Benefits from Non-Specific Effects of BCG Vaccination. Microorganisms 9:10, pages 2120.
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Alexandra L. Morrison, Sally Sharpe, Andrew D. White & Mark Bodman-Smith. (2021) Cheap and Commonplace: Making the Case for BCG and γδ T Cells in COVID-19. Frontiers in Immunology 12.
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Nathella Pavan Kumar, Chandrasekaran Padmapriyadarsini, Anuradha Rajamanickam, Perumal Kannabiran Bhavani, Arul Nancy, Bharathi Jeyadeepa, Nandhini Selvaraj, Dinesh Ashokan, Rachel Mariam Renji, Vijayalakshmi Venkataramani, Srikanth Tripathy & Subash Babu. (2021) BCG vaccination induces enhanced frequencies of dendritic cells and altered plasma levels of type I and type III interferons in elderly individuals. International Journal of Infectious Diseases 110, pages 98-104.
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Jianqin Liang, Guizeng Liu, Shuzhuang Yu, Yang Yang, Yanchun Li, Hongli Tian, Zhe Chen & Wenping Gong. (2021) Dynamic Changes in Chest CT Images Over 167 Days in 11 Patients with COVID-19: A Case Series and Literature Review. Zoonoses 1:1.
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