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Microbial Ecology in Health and Disease Volume 15, 2003 - Issue 2-3
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Original Paper

The Effect of Lactulose on the Composition of the Intestinal Microbiota and Short-chain Fatty Acid Production in Human Volunteers and a Computer-controlled Model of the Proximal Large Intestine

Koen Venema Department of Nutritional Physiology, TNO Nutrition and Food Research, PO Box 360, 3700 AJ ZeistCorrespondenceE-mail: [email protected]
,
Marleen H.M.C. van Nuenen Department of Nutritional Physiology, TNO Nutrition and Food Research, PO Box 360, 3700 AJ Zeist
,
Ellen G. van den Heuvel Department of Nutritional Physiology, TNO Nutrition and Food Research, PO Box 360, 3700 AJ ZeistCorrespondenceE-mail: [email protected]
,
Wietske Pool Department of Nutritional Physiology, TNO Nutrition and Food Research, PO Box 360, 3700 AJ Zeist
&
Jos M.B.M. van der Vossen Department of Nutritional Physiology, TNO Nutrition and Food Research, PO Box 360, 3700 AJ Zeist
Pages 94-105 | Received 15 Apr 2003, Accepted 29 Sep 2003, Published online: 11 Jul 2009

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D. Dupont, M. Alric, S. Blanquet-Diot, G. Bornhorst, C. Cueva, A. Deglaire, S. Denis, M. Ferrua, R. Havenaar, J. Lelieveld, A. R. Mackie, M. Marzorati, O. Menard, M. Minekus, B. Miralles, I. Recio & P. Van den Abbeele. (2019) Can dynamic in vitro digestion systems mimic the physiological reality?. Critical Reviews in Food Science and Nutrition 59:10, pages 1546-1562.
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Dayang Marshitah Bajury, Siti Maisarah Nashri, Patricia King Jie Hung & Shahrul Razid Sarbini. (2018) Evaluation of potential prebiotics: a review. Food Reviews International 34:7, pages 639-664.
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Koen Venema, Susanne H.F. Vermunt & Elizabeth J. Brink. (2005) D-Tagatose increases butyrate production by the colonic microbiota in healthy men and women. Microbial Ecology in Health and Disease 17:1, pages 47-57.
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Articles from other publishers (42)

R. Venkataraman, R. Shenoy, J. J. Ahire, J. Neelamraju & R. S. Madempudi. (2021) Effect of Bacillus coagulans Unique IS2 with Lactulose on Functional Constipation in Adults: a Double-Blind Placebo Controlled Study. Probiotics and Antimicrobial Proteins 15:2, pages 379-386.
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Azis Boing Sitanggang. 2023. Enzymes Beyond Traditional Applications in Dairy Science and Technology. Enzymes Beyond Traditional Applications in Dairy Science and Technology 403 423 .
Natural Chu, James Ling, He Jie, Kathy Leung & Emily Poon. (2022) The potential role of lactulose pharmacotherapy in the treatment and prevention of diabetes. Frontiers in Endocrinology 13.
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R.A. RastallM. Diez-MunicioS.D. ForsstenB. HamakerA. MeynierF. Javier MorenoF. RespondekB. StahK. VenemaM. Wiese. (2022) Structure and function of non-digestible carbohydrates in the gut microbiome. Beneficial Microbes 13:2, pages 95-168.
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Ingrid S. Surono, Abraham Simatupang, Pratiwi D. Kusumo, Priyo Waspodo, Sanne Verbruggen, Jessica Verhoeven & Koen Venema. (2022) Effect of Different Functional Food Supplements on the Gut Microbiota of Prediabetic Indonesian Individuals during Weight Loss. Nutrients 14:4, pages 781.
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Miriam J. Oost, Francisca C. Velkers, Aletta D. Kraneveld & Koen Venema. (2021) Development of the in vitro Cecal Chicken ALIMEntary tRact mOdel-2 to Study Microbiota Composition and Function. Frontiers in Microbiology 12.
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Tarkan Karakan, Kieran Michael Tuohy & Gwendolyn Janssen-van Solingen. (2021) Low-Dose Lactulose as a Prebiotic for Improved Gut Health and Enhanced Mineral Absorption. Frontiers in Nutrition 8.
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K. VenemaJ. VerhoevenS. VerbruggenD. Keller. (2020) Xylo-oligosaccharides from sugarcane show prebiotic potential in a dynamic computer-controlled in vitro model of the adult human large intestine . Beneficial Microbes 11:2, pages 191-200.
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Jakub Ruszkowski & Jacek M. Witkowski. (2019) Lactulose: Patient- and dose-dependent prebiotic properties in humans. Anaerobe 59, pages 100-106.
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Marisa da Fonseca Ferreira, Silke Salavati Schmitz, Jeffrey Joseph Schoenebeck, Dylan Neil Clements, Susan Mary Campbell, Donna Elaine Gaylor, Richard J. Mellanby, Adam George Gow & Mazdak Salavati. (2019) Lactulose drives a reversible reduction and qualitative modulation of the faecal microbiota diversity in healthy dogs. Scientific Reports 9:1.
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Travis WallerIan M. MarcusChen ChenSharon L. Walker. (2018) Influence of Food and Industrial Grade Titanium Dioxide Nanoparticles on Microbial Diversity and Phenotypic Response in Model Septic System. Environmental Engineering Science 35:10, pages 1049-1061.
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Javier Fernández, F. J. Moreno, Agustín Olano, Alfonso Clemente, Claudio J. Villar & Felipe Lombó. (2018) A Galacto-Oligosaccharides Preparation Derived From Lactulose Protects Against Colorectal Cancer Development in an Animal Model. Frontiers in Microbiology 9.
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Ezgi Özcan, Rachel Levantovsky & David A. Sela. 2018. Functional Foods and Beverages. Functional Foods and Beverages 87 136 .
Maria Wiese, Bekzod Khakimov, Sebastian Nielsen, Helena Sørensen, Frans van den Berg & Dennis Sandris Nielsen. (2018) CoMiniGut—a small volume in vitro colon model for the screening of gut microbial fermentation processes . PeerJ 6, pages e4268.
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Travis WallerChen ChenSharon L. Walker. (2017) Food and Industrial Grade Titanium Dioxide Impacts Gut Microbiota. Environmental Engineering Science 34:8, pages 537-550.
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Melanie Bothe, Annet Maathuis, Susann Bellmann, Jos van der Vossen, Dirk Berressem, Annalena Koehler, Susann Schwejda-Guettes, Barbara Gaigg, Angelika Kuchinka-Koch & John Stover. (2017) Dose-Dependent Prebiotic Effect of Lactulose in a Computer-Controlled In Vitro Model of the Human Large Intestine. Nutrients 9:7, pages 767.
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Pittaya Chaikham & Paweena Rattanasena. (2017) Combined effects of low-fat ice cream supplemented with probiotics on colon microfloral communities and their metabolites during fermentation in a human gut reactor. Food Bioscience 17, pages 35-41.
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M. AguirreK. Venema. (2017) Challenges in simulating the human gut for understanding the role of the microbiota in obesity. Beneficial Microbes 8:1, pages 31-53.
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Bingyong Mao, Dongyao Li, Chunqing Ai, Jianxin Zhao, Hao Zhang & Wei Chen. (2016) Lactulose Differently Modulates the Composition of Luminal and Mucosal Microbiota in C57BL/6J Mice. Journal of Agricultural and Food Chemistry 64:31, pages 6240-6247.
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S. H. Thilakarathna, M. Rogers, Y. Lan, S. Huynh, A. G. Marangoni, L. E. Robinson & A. J. Wright. (2016) Investigations of in vitro bioaccessibility from interesterified stearic and oleic acid-rich blends. Food & Function 7:4, pages 1932-1940.
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Alicia A. TaylorIan M. MarcusRisa L. GuysiSharon L. Walker. (2015) Metal Oxide Nanoparticles Induce Minimal Phenotypic Changes in a Model Colon Gut Microbiota. Environmental Engineering Science 32:7, pages 602-612.
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Koen Venema. 2015. Beneficial Microorganisms in Medical and Health Applications. Beneficial Microorganisms in Medical and Health Applications 1 18 .
Koen Venema. 2015. The Impact of Food Bioactives on Health. The Impact of Food Bioactives on Health 293 304 .
Marisol Aguirre, Javier Ramiro-Garcia, Marjorie E. Koenen & Koen Venema. (2014) To pool or not to pool? Impact of the use of individual and pooled fecal samples for in vitro fermentation studies. Journal of Microbiological Methods 107, pages 1-7.
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Uttara S. Ramasamy, Koen Venema, Harry Gruppen & Henk A. Schols. (2014) The fate of chicory root pulp polysaccharides during fermentation in the TNO in vitro model of the colon (TIM-2). Bioactive Carbohydrates and Dietary Fibre 4:1, pages 48-57.
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Koen Venema. 2014. Food Oligosaccharides. Food Oligosaccharides 217 237 .
Raylene Reimer, Annet Maathuis, Koen Venema, Michael Lyon, Roland Gahler & Simon Wood. (2014) Effect of the Novel Polysaccharide PolyGlycopleX® on Short-Chain Fatty Acid Production in a Computer-Controlled in Vitro Model of the Human Large Intestine. Nutrients 6:3, pages 1115-1127.
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Koen Venema & Pieter van den Abbeele. (2013) Experimental models of the gut microbiome. Best Practice & Research Clinical Gastroenterology 27:1, pages 115-126.
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Koen Venema. (2012) Intestinal fermentation of lactose and prebiotic lactose derivatives, including human milk oligosaccharides. International Dairy Journal 22:2, pages 123-140.
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Karin Förster-Fromme, Regina Schuster-Wolff-Bühring, Annette Hartwig, Aline Holder, Andreas Schwiertz, Stephan C. Bischoff & Jörg Hinrichs. (2011) A new enzymatically produced 1-lactulose: A pilot study to test the bifidogenic effects. International Dairy Journal 21:12, pages 940-948.
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Armagan Hayirli, Huzur Derya Umucalilar, Nurettin Gulsen & Ozcan Baris Citil. (2010) Role of Lactulose as a Modifier in Rumen Fermentation. Journal of Animal and Veterinary Advances 9:19, pages 2537-2545.
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Koen Venema. 2010. Nondigestible Carbohydrates and Digestive Health. Nondigestible Carbohydrates and Digestive Health 125 164 .
Trevor A. Faber & George C. FaheyJr.Jr.. 2010. Nondigestible Carbohydrates and Digestive Health. Nondigestible Carbohydrates and Digestive Health 97 123 .
T. Binsl, A. De Graaf, K. Venema, J. Heringa, A. Maathuis, P. De Waard & J.H. Van Beek. (2010) Measuring non-steady-state metabolic fluxes in starch-converting faecal microbiota in vitro . Beneficial Microbes 1:4, pages 391-405.
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R. Schuster-Wolff-Bühring, L. Fischer & J. Hinrichs. (2010) Production and physiological action of the disaccharide lactulose. International Dairy Journal 20:11, pages 731-741.
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Marcel Roberfroid, Glenn R. Gibson, Lesley Hoyles, Anne L. McCartney, Robert Rastall, Ian Rowland, Danielle Wolvers, Bernhard Watzl, Hania Szajewska, Bernd Stahl, Francisco Guarner, Frederique Respondek, Kevin Whelan, Veronique Coxam, Marie-Jeanne Davicco, Laurent Léotoing, Yohann Wittrant, Nathalie M. Delzenne, Patrice D. Cani, Audrey M. Neyrinck & Agnes Meheust. (2010) Prebiotic effects: metabolic and health benefits. British Journal of Nutrition 104:S2, pages S1-S63.
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Koen Venema. (2010) Role of gut microbiota in the control of energy and carbohydrate metabolism. Current Opinion in Clinical Nutrition and Metabolic Care 13:4, pages 432-438.
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K. Venema, R. Havenaar & M. Minekus. 2009. Designing Functional Foods. Designing Functional Foods 314 339 .
Srini Tenjarla, Vallente Romasanta, Evelijn Zeijdner, Roberto Villa & Luigi Moro. (2007) Release of 5-aminosalicylate from an MMX mesalamine tablet during transit through a simulated gastrointestinal tract system. Advances in Therapy 24:4, pages 826-840.
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Markus Egert, Albert A. De Graaf, Annet Maathuis, Pieter De Waard, Caroline M. Plugge, Hauke Smidt, Nicolaas E. P. Deutz, Cor Dijkema, Willem M. De Vos & Koen Venema. (2007) Identification of glucose-fermenting bacteria present in an in vitro model of the human intestine by RNA-stable isotope probing. FEMS Microbiology Ecology 60:1, pages 126-135.
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Albert A. de Graaf & Koen Venema. 2007. 73 314 .
Caroline Fässler, Eva Arrigoni, Koen Venema, Fred Brouns & Renato Amadò. (2006) In vitro fermentability of differently digested resistant starch preparations. Molecular Nutrition & Food Research 50:12, pages 1220-1228.
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