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Original Paper

The Effect of Lactulose on the Composition of the Intestinal Microbiota and Short-chain Fatty Acid Production in Human Volunteers and a Computer-controlled Model of the Proximal Large Intestine

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Pages 94-105 | Received 15 Apr 2003, Accepted 29 Sep 2003, Published online: 11 Jul 2009

REFERENCES

  • Havenaar R, Van Dokkum W Lactulose. A review on effects, clinical results, and safety aspects in relation to its influence on the colonic environment. In: Sungsoo Cho S, Dreher ML, eds. Handbook of Dietary Fibre. New York: Marcel Dekker, 2001: 179–93.
  • Van den Heuvel EG, Muijs T, Van Dokkum W, Schaafsma G. Lactulose stimulates calcium absorption in postmenopausal women. J Bone Miner Res 1999; 14: 1211–6.
  • Holtug K, Clausen MR, Hove H, Christiansen J, Mortensen PB. The colon in carbohydrate malabsorption: short-chain fatty acids, pH, and osmotic diarrhoea. Scand J Gastroenterol 1992; 27: 545–52.
  • Florent C, Flourie B, Leblond A, Rautureau M, Bernier J-J, Rambaud JC. Influence of chronic lactulose ingestion on the colonic metabolism of lactulose in man (an in vivo study). J Clin Invest 1985; 75: 608–13.
  • Nagendra R, Venkat Rao S. Effects of incorporation of lactulose in infant formulas on the intestinal bifidobacteria flora in rats. Int J Food Sci Nutr 1992; 43: 169–73.
  • Nagendra R, Venkat Rao S. Effect of feeding infant formula-tions containing bifidus factors on in vivo proliferation of bifidobacteria and stimulation of intraperitoneal macrophage activity in rats. J Nutr Immunol 1994; 2: 61–8.
  • Smart JB, Pillidge CJ, Garman JH. Growth of lactic acid bacteria and bifidobacteria on lactose and lactose-related mono-, di- and trisaccharides and correlation with distribution of beta-galactosidase and phospho-beta-galactosidase. J Dairy Res 1993; 60: 557–68.
  • Hove H, Rye-Clausen M, Brobech-Mortensen P. Lactate and pH in faeces from patients with colonic adenomas or cancer. Gut 1993; 34: 625–9.
  • Uribe M, Campollo O, Cote C. Effect of lactulose on the metabolism of short-chain fatty acids. Hepatology 1990; 12: 1251–2.
  • Terada A, Hara H, Kataoka M, Mitsuoka T. Effects of lactulose on the composition and metabolic activity of human fecal microflora. Microb Ecol Health Dis 1992; 5: 43–50.
  • Terada A, Hara H, Shou-Tou-Li, Ikegame K, Sasaki M, Mitsuoka T. Lecithinase-positive clostridia isolated from hu-man feces on consumption of lactulose and lactosucrose. Jpn J Food Microbiol 1994; 11: 119–23.
  • Riggio O, Varriale M, Testore GP, Di Rosa R, Di Rosa E, Merli M, Romiti A, Candiani C, Capocaccia L. Effect of lactitol and lactulose administration on the fecal flora in cirrhotic patients. J Clin Gastroenterol 1990; 12: 433–6.
  • Mortensen PB, Clausen MR. Short-chain fatty acids in the human colon: relation to gastrointestinal health and disease. Scand J Gastroenterol 1996; 216: 132–48.
  • Gibson GR, Cummings JH, Macfarlane GT. Use of a three-stage continuous culture system to study the effect of mucin on dissimilatory sulphate reduction and methanogenesis by mixed populations of human gut bacteria. Appl Environ Microbiol 1988; 54: 2750–5.
  • De Boever P, Wouters R, Vermeirssen V, Boon N, Verstraete W Development of a six-stage culture system for simulating the gastrointestinal microbiota of weaned infants. Microb Ecol Health Dis 2001; 13: 111–23.
  • Minekus M, Marteau P, Havenaar R, Huis-in-`t-Veld JHH. A multicompartmental dynamic computer-controlled model si-mulating the stomach and small intestine. ATLA 1995; 23: 197–209.
  • Minekus M, Smeets-Peeters M, Bernalier A, Marol-Bonnin S, Havenaar R, Marteau P, Alric M, Fonty G, Huis in't Veld JH. A computer-controlled system to simulate conditions of the large intestine with peristaltic mixing, water absorption and absorption of fermentation products. Appl Microbiol Biotech-nol 1999; 53: 108–14.
  • Venema K, Van Nuenen M, Smeets-Peeters M, Minekus M, Havenaar R. TNO's in vitro large intestinal model: an excellent screening tool for functional food and pharmaceutical research. Ernährung 2000; 24: 558–64.
  • Van Nuenen HMC, Meyer PD, Venema K. The effect of various inulins and Clostridium difficile on the metabolic activity of the human colonic microbiota in vitro. Microb Ecol Health Dis 2003; 15: 137–44.
  • Jouany JP. Volatile fatty acids and alcohols determination in digestive contents, silage juice, bacterial culture and anaerobic fermentor contents. Sci Aliments 1982; 2: 131–44.
  • Hartemink R, Rombouts FM. Comparison of media for the detection of bifidobacteria, lactobacilli and total anaerobes from faecal samples. J Microbiol Methods 1999; 36: 181–92.
  • Harmsen HJ, Wildeboer-Veloo AC, Raangs GC, Wagendorp AA, Klijn N, Bindels JG, Welling GW. Analysis of intestinal flora development in breast-fed and formula-fed infants by using molecular identification and detection methods. J Pediatr Gastroenterol Nutr 2000; 30: 61–7.
  • Langendijk PS, Schut F, Jansen GJ, Raangs GC, Kamphuis GR, Wilkinson MH, Welling GW. Quantitative fluorescence in situ hybridization of Bifidobacterium spp. with genus-specific 16S rRNA-targeted probes and its application in fecal samples. Appl Environ Microbiol 1995; 61: 3069–75.
  • Amann RI, Ludwig W, Schleifer KH. Phylogenetic identifica-tion and in situ detection of individual microbial cells without cultivation. Microbiol Rev 1995; 59: 143–69.
  • Franks AH, Harmsen HJ, Raangs GC, Jansen GJ, Schut F, Welling GW. Variations of bacterial populations in human feces measured by fluorescent in situ hybridization with group-specific 16S rRNA-targeted oligonucleotide probes. Appl En-viron Microbiol 1998; 64: 3336–45.
  • Harmsen HJ, Wildeboer-Veloo AC, Grijpstra J, Knol J, Degener JE, Welling GW. Development of 16S rRNA-based probes for the Coriobacterium group and the Atopobium cluster and their application for enumeration of Coriobacter-iaceae in human feces from volunteers of different age groups. Appl Environ Microbiol 2000; 66: 4523–7.
  • Harmsen HJ, Raangs GC, He T, Degener JE, Welling GW. Extensive set of 16S rRNA-based probes for detection of bacteria in human feces. Appl Environ Microbiol 2002; 68: 2982–90.
  • Jansen GJ, Wildeboer-Veloo AC, Tonk RH, Franks AH, Welling GW. Development and validation of an automated, microscopy-based method for enumeration of groups of intestinal bacteria. J Microbiol Methods 1999; 37: 215–21.
  • Poulsen LK, Licht TR, Rang C, Krogfelt KA, Molin S. Physiological state of Escherichia coli BJ4 growing in the large intestines of streptomycin-treated mice. J Bacteriol 2002; 177: 5840–5.
  • Stackebrandt E, Goebel BM. Taxonomic note: a place for DNA-DNA reassociation and 16S rRNA sequence analysis in the present species definition in bacteriology. Int J Syst Bacteriol 1994; 44: 846–9.
  • Cummings JH, Macfarlane GT. The control and consequences of bacterial fermentation in the human colon. J Appl Bacteriol 1991; 70: 443–59.
  • Cummings JH, Pomar EW, Branch WJ, Naylor CPE, MacFar-lane GT. Short chain fatty acids in human large intestine, portal, hepatic and venous blood. Gut 1987; 28: 1221–7.
  • Mangin I, Bouhnik Y, Suau A, Rochet V, Raskine L, Crenn P, Dyard F, Rambaud J-C, Doré J. Molecular analysis of intestinal microbiota composition to evaluate the effect of PEG and lactulose laxatives in humans. Microb Ecol Health Dis 2002; 14: 54–62.
  • Touhy KM, Ziemer CJ, Klinder A, Knöbel Y, Pool-Zobel BL, Gibson G. A human volunteer study to determine the prebiotic effects of lactulose powder on human colonic microbiota. Microb Ecol Health Dis 2002; 14: 165–73.
  • Krul C, Humblot C, Philippe C, Vermeulen M, van Nuenen M, Havenaar R, Rabot S. Metabolism of sinigrin (2-propenyl glucosinolate) by the human colonic microflora in a dynamic in vitro large-intestinal model. Carcinogenesis 2002; 23: 1009–16.