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Research Article

The Role of Complement in Pregnancy and Fetal Loss

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Pages 19-26 | Published online: 07 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Luciano Marcondes Machado Nardozza, Liliam Cristine Rolo, Edward Araujo Júnior, Paulo Martin Nowak, João Bortoletti Filho & Antonio Fernandes Moron. (2010) Comparison of gestational sac volume by 3D-sonography using planimetric, virtual organ computer-aided analysis and extended imaging virtual organ computer-aided analysis methods between 7 and 11 weeks of pregnancy. Acta Obstetricia et Gynecologica Scandinavica 89:3, pages 328-334.
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Edi Vaisbuch, Roberto Romero, Offer Erez, Shali Mazaki-Tovi, Kusanovic Juan Pedro, Eleazar Soto, Francesca Gotsch, Zhong Dong, Tinnakorn Chaiworapongsa, Sun Kwon Kim, Pooja Mittal, Percy Pacora, Lami Yeo & Sonia S. Hassan. (2009) Fragment Bb in amniotic fluid: evidence for complement activation by the alternative pathway in women with intra-amniotic infection/inflammation. The Journal of Maternal-Fetal & Neonatal Medicine 22:10, pages 905-916.
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Karina Richani, Eleazar Soto, Roberto Romero, Jimmy Espinoza, Tinnakorn Chaiworapongsa, Jyh Kae Nien, Samuel Edwin, Yeon Mee Kim, Joon-Seok Hong & Moshe Mazor. (2005) Normal pregnancy is characterized by systemic activation of the complement system. The Journal of Maternal-Fetal & Neonatal Medicine 17:4, pages 239-245.
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Articles from other publishers (37)

JOERN-HENDRIK WEITKAMP, DAVID B. LEWIS & OFER LEVY. 2024. Avery's Diseases of the Newborn. Avery's Diseases of the Newborn 409 438.e8 .
Deepa R.J. Arachchillage & Charis Pericleous. (2023) Evolution of Antiphospholipid Syndrome. Seminars in Thrombosis and Hemostasis 49:03, pages 295-304.
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Leying Zhang, Lidong Cao, Pengfei Feng, Xu Han & Ling Yang. (2021) Complement regulation in ovine lymph nodes during early pregnancy. Experimental and Therapeutic Medicine 23:2.
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Min Liu, Xiaolei Luo, Qin Xu, Hongbiao Yu, Linbo Gao, Rong Zhou & Tao Wang. (2021) Adipsin of the Alternative Complement Pathway Is a Potential Predictor for Preeclampsia in Early Pregnancy. Frontiers in Immunology 12.
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S So, E Fischer, M Gangadharan Komala & B Bose. (2020) Postpartum atypical hemolytic uremic syndrome: Evaluating thrombotic microangiopathy in the pregnant woman. Obstetric Medicine 14:2, pages 105-108.
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Sivan Livson, Hanna Jarva, Ilkka Kalliala, A. Inkeri Lokki, Jenni Heikkinen-Eloranta, Pekka Nieminen & Seppo Meri. (2021) Activation of the Complement System in the Lower Genital Tract During Pregnancy and Delivery. Frontiers in Immunology 11.
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Hiwa Abdulrahman Ahmad, Mehri Mirhaj Muhammd salih & Kamal Ahmed Khidir. (2018) Complement protein and Immunoglobulins Serum levels in Normal Pregnant and Spontaneous Aborted Women. Kurdistan Journal of Applied Research, pages 129-133.
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Masoud Lotfan, Syed Azmal Ali, Munna Lal Yadav, Suman Choudhary, Manoj Kumar Jena, Sudarshan Kumar & Ashok Kumar Mohanty. (2018) Genome-wide gene expression analysis of 45 days pregnant fetal cotyledons vis-a-vis non-pregnant caruncles in buffalo ( Bubalus bubalis ). Gene 654, pages 127-137.
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. 2017. High-Risk Pregnancy. High-Risk Pregnancy.
Joern-Hendrik Weitkamp, David B. Lewis & Ofer Levy. 2018. Avery's Diseases of the Newborn. Avery's Diseases of the Newborn 453 481.e7 .
Xiaofang Shen, Xin Liu, Peng Zhu, Yuhua Zhang, Jiahui Wang, Yanwei Wang, Wenting Wang, Juan Liu, Ning Li & Fujun Liu. (2017) Proteomic analysis of human follicular fluid associated with successful in vitro fertilization. Reproductive Biology and Endocrinology 15:1.
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Elisabeth CodsiVesna D. Garovic, Maria L. Gonzalez-Suarez, Natasa Milic, Kristi S. BorowskiCarl H. RoseNorman P. DaviesKianoush B. Kashani, John C. Lieske & Wendy M. White. (2017) Longitudinal characterization of renal proximal tubular markers in normotensive and preeclamptic pregnancies. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 312:5, pages R773-R778.
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Angela P. Cadavid. (2017) Aspirin: The Mechanism of Action Revisited in the Context of Pregnancy Complications. Frontiers in Immunology 8.
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Chloë R. McDonald, Lindsay S. Cahill, Keith T. Ho, Jimmy Yang, Hani Kim, Karlee L. Silver, Peter A. Ward, Howard T. Mount, W. Conrad Liles, John G. Sled & Kevin C. Kain. (2015) Experimental Malaria in Pregnancy Induces Neurocognitive Injury in Uninfected Offspring via a C5a-C5a Receptor Dependent Pathway. PLOS Pathogens 11:9, pages e1005140.
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M. Teresa de la Morena. 2014. Stiehm's Immune Deficiencies. Stiehm's Immune Deficiencies 815 822 .
Chloe R. McDonald, Robyn E. Elphinstone & Kevin C. Kain. (2013) The impact of placental malaria on neurodevelopment of exposed infants: a role for the complement system?. Trends in Parasitology 29:5, pages 213-219.
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Dara S. Berger, Zaher Merhi, W. Allen Hogge & Robert E. Ferrell. (2013) Mannose binding lectin genotypes are not associated with increased risk of unexplained recurrent pregnancy loss. Journal of Assisted Reproduction and Genetics 30:5, pages 723-727.
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Wendy Heywood, Darrell Wang, Tracey E. Madgett, Neil D. Avent, Simon Eaton, Lyn S. Chitty & Kevin Mills. (2012) The development of a peptide SRM-based tandem mass spectrometry assay for prenatal screening of Down syndrome. Journal of Proteomics 75:11, pages 3248-3257.
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Wendy Heywood, Kevin Mills, Darrell Wang, Julie Hogg, Tracey E. Madgett, Neil D. Avent & Lyn S.Chitty. (2012) Identification of new biomarkers for Down's syndrome in maternal plasma. Journal of Proteomics 75:9, pages 2621-2628.
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Calvin B. Williams, Eli M. Eisenstein & F. Sessions Cole. 2012. Avery's Diseases of the Newborn. Avery's Diseases of the Newborn 445 467 .
Guillermina Girardi, Zoltán Prohászka, Roberta Bulla, Francesco Tedesco & Sicco Scherjon. (2011) Complement activation in animal and human pregnancies as a model for immunological recognition. Molecular Immunology 48:14, pages 1621-1630.
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Jeff M. Denney, Troy Flint Porter & D. Ware Branch. 2011. High Risk Pregnancy. High Risk Pregnancy 763 794.e8 .
Fadi Fakhouri, Lubka Roumenina, François Provot, Marion Sallée, Sophie Caillard, Lionel Couzi, Marie Essig, David Ribes, Marie-Agnès Dragon-Durey, Frank Bridoux, Eric Rondeau & Veronique Frémeaux-Bacchi. (2010) Pregnancy-Associated Hemolytic Uremic Syndrome Revisited in the Era of Complement Gene Mutations. Journal of the American Society of Nephrology 21:5, pages 859-867.
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Edi Vaisbuch, Roberto Romero, Offer Erez, Shali Mazaki‐Tovi, Juan Pedro Kusanovic, Eleazar Soto, Zhong Dong, Tinnakorn Chaiworapongsa, Sun Kwon Kim, Giovanna Ogge, Percy Pacora, Lami Yeo & Sonia S. Hassan. (2010) ORIGINAL ARTICLE: Activation of the Alternative Pathway of Complement is a Feature of Pre‐Term Parturition but not of Spontaneous Labor at Term. American Journal of Reproductive Immunology 63:4, pages 318-330.
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Karla Jarkovska, Jirina Martinkova, Lucie Liskova, Petr Halada, Jiri Moos, Karel Rezabek, Suresh Jivan Gadher & Hana Kovarova. (2010) Proteome Mining of Human Follicular Fluid Reveals a Crucial Role of Complement Cascade and Key Biological Pathways in Women Undergoing in Vitro Fertilization . Journal of Proteome Research 9:3, pages 1289-1301.
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Jaume Alijotas-Reig & Miquel Vilardell-Tarres. (2010) Is Obstetric Antiphospholipid Syndrome a Primary Nonthrombotic, Proinflammatory, Complement-Mediated Disorder Related to Antiphospholipid Antibodies?. Obstetrical & Gynecological Survey 65:1, pages 39-45.
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Jaume Alijotas-Reig. (2010) Sistema del complemento como pieza clave en la patogenia del síndrome antifosfolipídico obstétrico. Medicina Clínica 134:1, pages 30-34.
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J. Alijotas-Reig. (2008) Hipocomplementemia en el síndrome antifosfolípido obstétrico. Revista Clínica Española 208:11, pages 592-593.
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Sandra M. Blois, Gabriela Barrientos, Mariana G. Garcia, Arif S. Orsal, Mareike Tometten, Rosalia I. Cordo-Russo, Burghard F. Klapp, Angela Santoni, Nelson Fernández, Peter Terness & Petra C. Arck. (2008) Interaction between dendritic cells and natural killer cells during pregnancy in mice. Journal of Molecular Medicine 86:7, pages 837-852.
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J. Carbone, E. Sarmiento, J. Rodríguez-Molina & E. Fernández-Cruz. (2008) Hipocomplementemia C3 y C4 en el síndrome antifosfolípido obstétrico. Revista Clínica Española 208:3, pages 170-171.
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D. Micheloud, E. Sarmiento, R. Teijeiro, J. Jensen, J.J. Rodríguez Molina, E. Fernández-Cruz & J. Carbone. (2007) Hypocomplementemia in the absence of autoantibodies in women with recurrent pregnancy loss. Allergologia et Immunopathologia 35:3, pages 90-94.
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M. Goldberg, N. Luknar-Gabor, R. Keidar & Y. Katz. (2007) Synthesis of complement proteins in the human chorion is differentially regulated by cytokines. Molecular Immunology 44:7, pages 1737-1742.
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V. Bachy & K. Khosrotehrani. (2007) Mécanismes de la tolérance immunitaire du fœtus. EMC - Obstétrique 2:1, pages 1-7.
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Calla Holmgren & D. Ware Branch. 2007. Obstetrics: Normal and Problem Pregnancies. Obstetrics: Normal and Problem Pregnancies 1080 1103 .
Xipeng Wang, Zhengwen Ma, Yan Hong, Aimin Zhao, Lihua Qiu, Peihua Lu & Qide Lin. (2005) The Skewed TCR-BV Repertoire Displayed at the Maternal-Fetal Interface of Women with Unexplained Pregnancy Loss. American Journal of Reproductive Immunology 54:2, pages 84-95.
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Jiae Lee, Bum-Chae Choi, Chunghee Cho, Joseph A. Hill, Kwang-Hyun Baek & Jeong-Wook Kim. (2005) Trophoblast apoptosis is increased in women with evidence of TH1 immunity. Fertility and Sterility 83:4, pages 1047-1049.
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Karina Richani, Roberto Romero, Eleazar Soto, Jimmy Espinoza, Jyh Kae Nien, Tinnakorn Chaiworapongsa, Jerrie Refuerzo, Sean Blackwell, Samuel S. Edwin, Joaquin Santolaya-Forgas & Moshe Mazor. (2005) Unexplained intrauterine fetal death is accompanied by activation of complement. Journal of Perinatal Medicine 33:4.
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