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Original Article

Monozygotic twins discordant for epilepsy differ in the levels of potentially pathogenic autoantibodies and cytokines

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Pages 139-150 | Received 24 Aug 2004, Accepted 14 Feb 2005, Published online: 07 Jul 2009

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Read on this site (2)

Mia Levite & Yonatan Ganor. (2008) Autoantibodies to glutamate receptors can damage the brain in epilepsy, systemic lupus erythematosus and encephalitis. Expert Review of Neurotherapeutics 8:7, pages 1141-1160.
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Articles from other publishers (11)

Mia Levite & Hadassa Goldberg. (2022) Autoimmune Epilepsy - Novel Multidisciplinary Analysis, Discoveries and Insights. Frontiers in Immunology 12.
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Tao-Ran Li, Yu-Di Zhang, Qun Wang, Xiao-Qiu Shao, Zhi-Mei Li & Rui-Juan Lv. (2020) Intravenous methylprednisolone or immunoglobulin for anti-glutamic acid decarboxylase 65 antibody autoimmune encephalitis: which is better?. BMC Neuroscience 21:1.
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Chiara Spinello, Giovanni Laviola & Simone Macrì. (2016) Pediatric Autoimmune Disorders Associated with Streptococcal Infections and Tourette's Syndrome in Preclinical Studies. Frontiers in Neuroscience 10.
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Mia Levite. (2014) GLUTAMATE RECEPTOR ANTIBODIES IN NEUROLOGICAL DISEASES: Anti-AMPA-GluR3 antibodies, Anti-NMDA-NR1 antibodies, Anti-NMDA-NR2A/B antibodies, Anti-mGluR1 antibodies or Anti-mGluR5 antibodies are present in subpopulations of patients with either: Epilepsy, Encephalitis, Cerebellar Ataxia, Systemic Lupus Erythematosus (SLE) and Neuropsychiatric SLE, Sjogren’s syndrome, Schizophrenia, Mania or Stroke. These autoimmune anti-glutamate receptor antibodies can bind neurons in few brain regions, activate glutamate receptors, decrease glutamate receptor’s expression, impair glutamate-induced signaling and function, activate Blood Brain Barrier endothelial cells, kill neurons, damage the brain, induce behavioral/psychiatric/cognitive abnormalities and Ataxia in animal models, and can be removed or silenced in some patients by immunotherapy. Journal of Neural Transmission 121:8, pages 1029-1075.
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Hadassa Goldberg-Stern, Yonatan Ganor, Ran Cohen, Lea Pollak, Vivian Teichberg & Mia Levite. (2014) Glutamate receptor antibodies directed against AMPA receptors subunit 3 peptide B (GluR3B) associate with some cognitive/psychiatric/behavioral abnormalities in epilepsy patients. Psychoneuroendocrinology 40, pages 221-231.
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Amene Saghazadeh, Maryam Gharedaghi, Alipasha Meysamie, Sebastian Bauer & Nima Rezaei. (2014) Proinflammatory and anti-inflammatory cytokines in febrile seizures and epilepsy: systematic review and meta-analysis. Reviews in the Neurosciences 25:2.
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Yubin Zhang, Valerie J. Bolivar & David A. Lawrence. (2013) Maternal Exposure to Mercury Chloride During Pregnancy and Lactation Affects the Immunity and Social Behavior of Offspring. Toxicological Sciences 133:1, pages 101-111.
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Yukitoshi Takahashi, Jyun Mine, Yuko Kubota, Etsuko Yamazaki & Tateki Fujiwara. (2009) A substantial number of Rasmussen syndrome patients have increased IgG, CD4 + T cells, TNFα, and Granzyme B in CSF . Epilepsia 50:6, pages 1419-1431.
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Yonatan Ganor, Vivian I. Teichberg & Mia Levite. (2007) TCR Activation Eliminates Glutamate Receptor GluR3 from the Cell Surface of Normal Human T Cells, via an Autocrine/Paracrine Granzyme B-Mediated Proteolytic Cleavage. The Journal of Immunology 178:2, pages 683-692.
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Yonatan Ganor, Miroslav Gottlieb, Raya Eilam, Hanoch Otmy, Vivian I. Teichberg & Mia Levite. (2005) Immunization with the glutamate receptor-derived peptide GluR3B induces neuronal death and reactive gliosis, but confers partial protection from pentylenetetrazole-induced seizures. Experimental Neurology 195:1, pages 92-102.
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Yonatan Ganor, Hadassa Goldberg-Stern, Tally Lerman-Sagie, Vivian I. Teichberg & Mia Levite. (2005) Autoimmune epilepsy: Distinct subpopulations of epilepsy patients harbor serum autoantibodies to either glutamate/AMPA receptor GluR3, glutamate/NMDA receptor subunit NR2A or double-stranded DNA. Epilepsy Research 65:1-2, pages 11-22.
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