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Original Article

Adipose tissue is prominent in salivary glands of Sjögren’s syndrome patients and appears to influence the microenvironment in these organs

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Pages 338-346 | Received 22 Dec 2015, Accepted 10 Apr 2016, Published online: 20 May 2016

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (5)

Lara A. Aqrawi, Janicke Liaaen Jensen, Siren Fromreide, Hilde Kanli Galtung & Kathrine Skarstein. (2020) Expression of NGAL-specific cells and mRNA levels correlate with inflammation in the salivary gland, and its overexpression in the saliva, of patients with primary Sjögren’s syndrome. Autoimmunity 53:6, pages 333-343.
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Kathrine Skarstein, Janicke Liaaen Jensen, Hilde Galtung, Roland Jonsson, Karl Brokstad & Lara A. Aqrawi. (2019) Autoantigen-specific B cells and plasma cells are prominent in areas of fatty infiltration in salivary glands of patients with primary Sjögren’s syndrome. Autoimmunity 52:7-8, pages 242-250.
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Lara A. Aqrawi, Janicke Liaaen Jensen, Gunnvor Øijordsbakken, Ann-Kristin Ruus, Ståle Nygård, Marit Holden, Roland Jonsson, Hilde Kanli Galtung & Kathrine Skarstein. (2018) Signalling pathways identified in salivary glands from primary Sjögren’s syndrome patients reveal enhanced adipose tissue development. Autoimmunity 51:3, pages 135-146.
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Kerry M. Leehan, Nathan P. Pezant, Astrid Rasmussen, Kiely Grundahl, Jacen S. Moore, Lida Radfar, David M. Lewis, Donald U. Stone, Christopher J. Lessard, Nelson L. Rhodus, Barbara M. Segal, C. Erick Kaufman, R. Hal Scofield, Kathy L. Sivils, Courtney Montgomery & A. Darise Farris. (2017) Fatty infiltration of the minor salivary glands is a selective feature of aging but not Sjögren’s syndrome. Autoimmunity 50:8, pages 451-457.
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Articles from other publishers (21)

Yujun Rao, Nan Xu, Yongbin Zhang, Yuxuan Fang, Longlong Tian, Xingxing Min, Guiyu Chen, Tiantian Dai, Nianxing Liu, Xuanhan Wang, Xiuting Gu, Hanpeng Lai, Wei Wang & Guoqing Li. (2022) Value of magnetic resonance imaging and sialography of the parotid gland for diagnosis of primary Sjögren syndrome. International Journal of Rheumatic Diseases 26:3, pages 454-463.
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Qipeng Zhan, Jianan Zhang, Yubin Lin, Wenjing Chen, Xinzou Fan & Dunfang Zhang. (2023) Pathogenesis and treatment of Sjogren’s syndrome: Review and update. Frontiers in Immunology 14.
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Ari Lee, Yoon Joo Choi, Kug Jin Jeon, Sang-Sun Han & Chena Lee. (2023) Impact of physiological parameters on the parotid gland fat fraction in a normal population. Scientific Reports 13:1.
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Lihua Chang, Aibin Kong, Yun Guo, Jing Zhang, Yue Sun, Penglu Chen & Xiaofei Wang. (2022) Quercetin ameliorates salivary gland apoptosis and inflammation in primary Sjögren's syndrome through regulation of the leptin/OB‐R signaling. Drug Development Research 83:6, pages 1351-1361.
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Rosa Elda Barbosa-Cobos, Rubén Torres-González, Ana Victoria Meza-Sánchez, Lucio Ventura-Ríos, Luz Elena Concha-Del-Río, Julián Ramírez-Bello, Everardo Álvarez-Hernández, Claudia Irene Meléndez-Mercado, Favio Edmundo Enríquez-Sosa, Cinthia Jahoska Samuria-Flores, Gustavo Esteban Lugo-Zamudio & Cristina Hernández-Díaz. (2022) A Novel Technique for the Evaluation and Interpretation of Elastography in Salivary Gland Involvement in Primary Sjögren Syndrome. Frontiers in Medicine 9.
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Esther Mossel, Martha S van Ginkel, Erlin A Haacke, Suzanne Arends, Silvia C Liefers, Konstantina Delli, Jolien F van Nimwegen, Alja J Stel, Fred K L Spijkervet, Arjan Vissink, Bert van der Vegt, Frans G M Kroese & Hendrika Bootsma. (2022) Histopathology, salivary flow and ultrasonography of the parotid gland: three complementary measurements in primary Sjögren’s syndrome. Rheumatology 61:6, pages 2472-2482.
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Roland Jonsson. (2022) Disease mechanisms in Sjögren’s syndrome: What do we know?. Scandinavian Journal of Immunology 95:3.
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Janaina Barbieri dos Santos HELMS, Carlos Augusto BARBOSA, Aline Corrêa ABRAHÃO, Marcia Grillo CABRAL, Blanca Elena Rios Gomes BICA & Sandra Regina TORRES. (2022) Are salivary flow rates associated with histopathologic aspects in patients with rheumatoid arthritis?. Brazilian Oral Research 36.
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Tea Samuelsen, Lara A. Aqrawi, Kathrine Skarstein & Janicke L. Jensen. (2021) Evaluering av spyttkjertelbiopsier ved utredning av Sjögrens syndrom. Den norske tannlegeforenings Tidende 132:11.
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Fredrik Fineide, Xiangjun Chen, Thomas Bjellaas, Valeria Vitelli, Tor Paaske Utheim, Janicke Liaaen Jensen & Hilde Kanli Galtung. (2021) Characterization of Lipids in Saliva, Tears and Minor Salivary Glands of Sjögren’s Syndrome Patients Using an HPLC/MS-Based Approach. International Journal of Molecular Sciences 22:16, pages 8997.
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Ning Li, Lei Li, Mengyao Wu, Yusi Li, Jie Yang, Yicheng Wu, Haimin Xu, Danyang Luo, Yiming Gao, Xiaochun Fei & Liting Jiang. (2021) Integrated Bioinformatics and Validation Reveal Potential Biomarkers Associated With Progression of Primary Sjögren’s Syndrome. Frontiers in Immunology 12.
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Tamandeep K. Bharaj, Lara A. Aqrawi, Siren Fromreide, Roland Jonsson, Johan G. Brun, Silke Appel & Kathrine Skarstein. (2021) Inflammatory Stratification in Primary Sjögren’s Syndrome Reveals Novel Immune Cell Alterations in Patients’ Minor Salivary Glands. Frontiers in Immunology 12.
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Pilar Jimenez-Royo, Michele Bombardieri, Coziana Ciurtin, Michalis Kostapanos, Anwar R Tappuni, Natasha Jordan, Azeem Saleem, Teresa Fuller, Kathleen Port, Elena Pontarini, Davide Lucchesi, Robert Janiczek, Paul Galette, Graham Searle, Neel Patel, Lucy Kershaw, Calum Gray, Nirav Ratia, André van Maurik, Marius de Groot, Nicolas Wisniacki, Mats Bergstrom & Ruth Tarzi. (2021) Advanced imaging for quantification of abnormalities in the salivary glands of patients with primary Sjögren’s syndrome. Rheumatology 60:5, pages 2396-2408.
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Martha S. van Ginkel, Andor W.J.M. Glaudemans, Bert van der Vegt, Esther Mossel, Frans G.M. Kroese, Hendrika Bootsma & Arjan Vissink. (2020) Imaging in Primary Sjögren’s Syndrome. Journal of Clinical Medicine 9:8, pages 2492.
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Lara A. Aqrawi, Hilde Kanli Galtung, Eduarda M. Guerreiro, Reidun Øvstebø, Bernd Thiede, Tor Paaske Utheim, Xiangjun Chen, Øygunn Aass Utheim, Øyvind Palm, Kathrine Skarstein & Janicke Liaaen Jensen. (2019) Proteomic and histopathological characterisation of sicca subjects and primary Sjögren’s syndrome patients reveals promising tear, saliva and extracellular vesicle disease biomarkers. Arthritis Research & Therapy 21:1.
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Roland Jonsson, Karl A. Brokstad, Malin V. Jonsson, Nicolas Delaleu & Kathrine Skarstein. (2018) Current concepts on Sjögren's syndrome – classification criteria and biomarkers. European Journal of Oral Sciences 126:S1, pages 37-48.
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Nishat Tasnim, Laura De la Vega, Shweta Anil Kumar, Laila Abelseth, Matthew Alonzo, Meitham Amereh, Binata Joddar & Stephanie M. Willerth. (2018) 3D Bioprinting Stem Cell Derived Tissues. Cellular and Molecular Bioengineering 11:4, pages 219-240.
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Lara A. Aqrawi, Hilde Kanli Galtung, Beate Vestad, Reidun Øvstebø, Bernd Thiede, Shermin Rusthen, Alix Young, Eduarda M. Guerreiro, Tor Paaske Utheim, Xiangjun Chen, Øygunn Aass Utheim, Øyvind Palm & Janicke Liaaen Jensen. (2017) Identification of potential saliva and tear biomarkers in primary Sjögren’s syndrome, utilising the extraction of extracellular vesicles and proteomics analysis. Arthritis Research & Therapy 19:1.
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Sarah Wicheta, Troy Van der Groen, William C. Faquin & Meredith August. (2017) Minor Salivary Gland Biopsy—An Important Contributor to the Diagnosis of Sjögren Syndrome. Journal of Oral and Maxillofacial Surgery 75:12, pages 2573-2578.
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Carlo Selmi. (2017) Autoimmunity in 2016. Clinical Reviews in Allergy & Immunology 53:1, pages 126-139.
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Anne Isine Bolstad & Kathrine Skarstein. (2016) Epidemiology of Sjögren’s Syndrome—from an Oral Perspective. Current Oral Health Reports 3:4, pages 328-336.
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