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Autoimmunity Volume 51, 2018 - Issue 7
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Original Article

TREX1 D18N mice fail to process erythroblast DNA resulting in inflammation and dysfunctional erythropoiesis

Stephen L. RegoDepartment of Biochemistry, Center for Structural Biology, Wake Forest School of Medicine, Winston-Salem, NC, USA; View further author information
,
Scott HarveyDepartment of Biochemistry, Center for Structural Biology, Wake Forest School of Medicine, Winston-Salem, NC, USA; View further author information
,
Sean R. SimpsonDepartment of Biochemistry, Center for Structural Biology, Wake Forest School of Medicine, Winston-Salem, NC, USA; View further author information
,
Wayne O. HemphillDepartment of Biochemistry, Center for Structural Biology, Wake Forest School of Medicine, Winston-Salem, NC, USA; View further author information
,
Zachariah A. McIverDepartment of Microbiology and Immunology, Wake Forest School of Medicine, Winston-Salem, NC, USAView further author information
,
Jason M. GraysonDepartment of Microbiology and Immunology, Wake Forest School of Medicine, Winston-Salem, NC, USAView further author information
&
Fred W. PerrinoDepartment of Biochemistry, Center for Structural Biology, Wake Forest School of Medicine, Winston-Salem, NC, USA; Correspondence[email protected]
View further author information
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Pages 333-344 | Received 14 May 2018, Accepted 07 Sep 2018, Published online: 13 Nov 2018

Citations (13)

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Feng Lin, Yan-Dong Tang & Chunfu Zheng. (2022) The crosstalk between DNA damage response components and DNA-sensing innate immune signaling pathways. International Reviews of Immunology 41:2, pages 231-239.
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Articles from other publishers (12)

Naomi I Maria, Julien Papoin, Chirag Raparia, Zeguo Sun, Rachel Josselsohn, Ailing Lu, Hani Katerji, Mahrukh M Syeda, David Polsky, Robert Paulson, Theodosia Kalfa, Betsy J Barnes, Weijia Zhang, Lionel Blanc & Anne Davidson. (2023) Human TLR8 induces inflammatory bone marrow erythromyeloblastic islands and anemia in SLE-prone mice. Life Science Alliance 6:10, pages e202302241.
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Roy Anindya. (2022) Cytoplasmic DNA in cancer cells: Several pathways that potentially limit DNase2 and TREX1 activities. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1869:8, pages 119278.
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Giulia Amico, Wayne O. Hemphill, Mariasavina Severino, Claudio Moratti, Rosario Pascarella, Marta Bertamino, Flavia Napoli, Stefano Volpi, Francesca Rosamilia, Sara Signa, Fred Perrino, Marialuisa Zedde & Isabella Ceccherini. (2022) Genotype-Phenotype Correlation and Functional Insights for Two Monoallelic TREX1 Missense Variants Affecting the Catalytic Core. Genes 13:7, pages 1179.
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Qing Wang, Juan Du, Shucheng Hua & Ke Zhao. (2022) TREX1 plays multiple roles in human diseases. Cellular Immunology 375, pages 104527.
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Matthias Kettwig, Katharina Ternka, Kristin Wendland, Dennis Manfred Krüger, Silvia Zampar, Charlotte Schob, Jonas Franz, Abhishek Aich, Anne Winkler, M. Sadman Sakib, Lalit Kaurani, Robert Epple, Hauke B. Werner, Samy Hakroush, Julia Kitz, Marco Prinz, Eva Bartok, Gunther Hartmann, Simone Schröder, Peter Rehling, Marco Henneke, Susann Boretius, A. Alia, Oliver Wirths, Andre Fischer, Christine Stadelmann, Stefan Nessler & Jutta Gärtner. (2021) Interferon-driven brain phenotype in a mouse model of RNaseT2 deficient leukoencephalopathy. Nature Communications 12:1.
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Xuan Song, Jacqueline T. M. Aw, Fulin Ma, Ming Fung Cheung, Danny Leung & Karl Herrup. (2021) DNA Repair Inhibition Leads to Active Export of Repetitive Sequences to the Cytoplasm Triggering an Inflammatory Response. The Journal of Neuroscience 41:45, pages 9286-9307.
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Wayne O. Hemphill, Sean R. Simpson, Mingyong Liu, Freddie R. SalsburyJrJr, Thomas Hollis, Jason M. Grayson & Fred W. Perrino. (2021) TREX1 as a Novel Immunotherapeutic Target. Frontiers in Immunology 12.
Crossref
Ruihua Ma, Tatiana P. Ortiz Serrano, Jennifer Davis, Andrew D. Prigge & Karen M. Ridge. (2020) The cGAS‐STING pathway: The role of self‐DNA sensing in inflammatory lung disease. The FASEB Journal 34:10, pages 13156-13170.
Crossref
Sean R. Simpson, Wayne O. Hemphill, Teesha Hudson & Fred W. Perrino. (2020) TREX1 – Apex predator of cytosolic DNA metabolism. DNA Repair 94, pages 102894.
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Sean R. Simpson, Stephen L. Rego, Scott E. Harvey, Mingyong Liu, Wayne O. Hemphill, Rajkumar Venkatadri, Rahul Sharma, Jason M. Grayson & Fred W. Perrino. (2020) T Cells Produce IFN-α in the TREX1 D18N Model of Lupus-like Autoimmunity. The Journal of Immunology 204:2, pages 348-359.
Crossref
Sha-Sha Tao, Guo-Cui Wu, Qin Zhang, Tian-Ping Zhang, Rui-Xue Leng, Hai-Feng Pan & Dong-Qing Ye. (2019) TREX1 As a Potential Therapeutic Target for Autoimmune and Inflammatory Diseases. Current Pharmaceutical Design 25:30, pages 3239-3247.
Crossref
Wayne O. Hemphill & Fred W. Perrino. 2019. DNA Sensors and Inflammasomes. DNA Sensors and Inflammasomes 109 133 .

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