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Original Article

Nobiletin derivative, 5-acetoxy-6,7,8,3’,4’-pentamethoxyflavone, inhibits neuroinflammation through the inhibition of TLR4/MyD88/MAPK signaling pathways and STAT3 in microglia

Jimmy Ming-Jung Chuanga Department of Neurosurgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University, College of Medicine, Kaohsiung, TaiwanView further author information
,
Hsien-Lin Chenb Division of General Surgery, Department of Surgery, Chi Mei Medical Center, Liouying, Tainan, TaiwanView further author information
,
Chi-I Changc Department of Biological Science and Technology, National Pingtung University of Science and Technology, Research Centre for Active Natural Products Development, National Pingtung University of Science and Technology, Pingtung, TaiwanView further author information
,
Jia-Syuan Lind Department of Pharmacology, School of Post-Baccalaureate Medicine; Division of Pharmacology and Traditional Chinese Medicine, Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, TaiwanView further author information
,
Hui-Min Changd Department of Pharmacology, School of Post-Baccalaureate Medicine; Division of Pharmacology and Traditional Chinese Medicine, Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, TaiwanView further author information
,
Wan-Ju Wud Department of Pharmacology, School of Post-Baccalaureate Medicine; Division of Pharmacology and Traditional Chinese Medicine, Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, TaiwanView further author information
,
Mei-Ying Line Community Health Promotion Center, Kaohsiung Municipal Ci-Jin Hospital, Kaohsiung, TaiwanView further author information
,
Wu-Fu Chena Department of Neurosurgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University, College of Medicine, Kaohsiung, Taiwan;f Department of Marine Biotechnology and Resources, National Sun Yat-Sen University, Kaohsiung, TaiwanCorrespondence[email protected]
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&
Chien-Hsing Leec Department of Biological Science and Technology, National Pingtung University of Science and Technology, Research Centre for Active Natural Products Development, National Pingtung University of Science and Technology, Pingtung, Taiwan;d Department of Pharmacology, School of Post-Baccalaureate Medicine; Division of Pharmacology and Traditional Chinese Medicine, Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan;g Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan;h Drug Development and Value Creation Research Center, Kaohsiung Medical University, Kaohsiung, TaiwanCorrespondence[email protected] [email protected]
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Received 12 Jul 2023, Accepted 18 May 2024, Published online: 04 Jun 2024

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