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Inhalation Toxicology
International Forum for Respiratory Research
Volume 16, 2004 - Issue 6-7
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Research Article

Effects of Instilled Combustion-Derived Particles in Spontaneously Hypertensive Rats. Part I: Cardiovascular Responses

L. B. Wichers Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina, Chapel Hill, North Carolina, USA
,
J. P. Nolan Pulmonary Toxicology Branch, Experimental Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, USA
,
D. W. Winsett Pulmonary Toxicology Branch, Experimental Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, USA
,
A. D. Ledbetter Pulmonary Toxicology Branch, Experimental Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, USA
,
U. P. Kodavanti Pulmonary Toxicology Branch, Experimental Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, USA
,
M. C. J. Schladweiler Pulmonary Toxicology Branch, Experimental Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, USA
,
D. L. Costa Pulmonary Toxicology Branch, Experimental Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, USA
&
W. P. Watkinson Pulmonary Toxicology Branch, Experimental Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, USA
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Pages 391-405 | Published online: 01 Oct 2008

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Christopher J. Gordon, Mette C. Schladweiler, Todd Krantz, Charly King & Urmila P. Kodavanti. (2012) Cardiovascular and thermoregulatory responses of unrestrained rats exposed to filtered or unfiltered diesel exhaust. Inhalation Toxicology 24:5, pages 296-309.
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Jonathan H. Shannahan, Urmila P. Kodavanti & Jared M. Brown. (2012) Manufactured and airborne nanoparticle cardiopulmonary interactions: a review of mechanisms and the possible contribution of mast cells. Inhalation Toxicology 24:5, pages 320-339.
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Heather A. Palko, Jennifer Y. Fung & Angelique Y. Louie. (2010) Positron emission tomography: A novel technique for investigating the biodistribution and transport of nanoparticles. Inhalation Toxicology 22:8, pages 657-688.
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Annette C. Rohr, James G. Wagner, Masako Morishita, Ali Kamal, Gerald J. Keeler & Jack R. Harkema. (2010) Cardiopulmonary responses in spontaneously hypertensive and Wistar-Kyoto rats exposed to concentrated ambient particles from Detroit, Michigan. Inhalation Toxicology 22:6, pages 522-533.
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Alex P. Carll, Najwa Haykal-Coates, Darrell W. Winsett, William H. Rowan$suffix/text()$suffix/text(), Mehdi S. Hazari, Allen D. Ledbetter, Abraham Nyska, Wayne E. Cascio, William P. Watkinson, Daniel L. Costa & Aimen K. Farraj. (2010) Particulate matter inhalation exacerbates cardiopulmonary injury in a rat model of isoproterenol-induced cardiomyopathy. Inhalation Toxicology 22:5, pages 355-368.
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J. Grace Wallenborn, MetteC. Schladweiler, Abraham Nyska, Jo Anne Johnson, Ronald Thomas, RichardH. Jaskot, JudyH. Richards, AllenD. Ledbetter & UrmilaP. Kodavanti. (2007) Cardiopulmonary Responses of Wistar Kyoto, Spontaneously Hypertensive, and Stroke-prone Spontaneously Hypertensive Rats to Particulate Matter (PM) Exposure. Journal of Toxicology and Environmental Health, Part A 70:22, pages 1912-1922.
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Chuen-Chau Chang, Jing-Shiang Hwang, Chang-Chuan Chan, Peng-Yau Wang & Tsun-Jen Cheng. (2007) Effects of Concentrated Ambient Particles on Heart Rate, Blood Pressure, and Cardiac Contractility in Spontaneously Hypertensive Rats During a Dust Storm Event. Inhalation Toxicology 19:11, pages 973-978.
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Lisa Kobos & Jonathan Shannahan. (2021) Particulate matter inhalation and the exacerbation of cardiopulmonary toxicity due to metabolic disease. Experimental Biology and Medicine 246:7, pages 822-834.
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Jing-Wen Yang, Yang Ye, Xue-Rui Wang, Fang Li, Ling-Yong Xiao, Guang-Xia Shi & Cun-Zhi Liu. (2017) Acupuncture Attenuates Renal Sympathetic Activity and Blood Pressure via Beta-Adrenergic Receptors in Spontaneously Hypertensive Rats. Neural Plasticity 2017, pages 1-9.
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Pablo Evelson, Timoteo Marchini, Mariana Garces, Lourdes Cáceres, Natalia Magnani & Silvia Alvarez. 2016. Biochemistry of Oxidative Stress. Biochemistry of Oxidative Stress 275 285 .
In-Soo Kim, Ji-Yong Jang, Tae-Hoon Kim, Junbeom Park, Jaemin Shim, Jin-Bae Kim, Young Sup Byun, Jung-Hoon Sung, Young Won Yoon, Jong-Youn Kim, Yang-Je Cho, Changsoo Kim & Boyoung Joung. (2015) Guidelines for the prevention and management of cardiovascular disease associated with fine dust/Asian dust exposure. Journal of the Korean Medical Association 58:11, pages 1044.
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Alex Watkins, Marlon Danilewitz, Marjan Kusha, Stéphane Massé, Bruce Urch, Kenneth Quadros, Danna Spears, Talha Farid & Kumaraswamy Nanthakumar. (2013) Air Pollution and Arrhythmic Risk: The Smog Is Yet to Clear. Canadian Journal of Cardiology 29:6, pages 734-741.
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Abderrahim Nemmar, Shaheen Zia, Deepa Subramaniyan, Mohamed A. Fahim & Badreldin H. Ali. (2011) Exacerbation of thrombotic events by diesel exhaust particle in mouse model of hypertension. Toxicology 285:1-2, pages 39-45.
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Alex P. Carll, Monte S. Willis, Robert M. Lust, Daniel L. Costa & Aimen K. Farraj. (2011) Merits of Non-Invasive Rat Models of Left Ventricular Heart Failure. Cardiovascular Toxicology 11:2, pages 91-112.
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L. W. Stanek, J. S. Brown, J. Stanek, J. Gift & D. L. Costa. (2010) Air Pollution Toxicology--A Brief Review of the Role of the Science in Shaping the Current Understanding of Air Pollution Health Risks. Toxicological Sciences 120:Supplement 1, pages S8-S27.
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Robert D. Brook & Sanjay Rajagopalan. 2011. Cardiovascular Effects of Inhaled Ultrafine and Nanosized Particles. Cardiovascular Effects of Inhaled Ultrafine and Nanosized Particles 351 377 .
Laurel E. Plummer, Kent E. Pinkerton, Amy K. Madl & Dennis W. Wilson. 2011. Cardiovascular Effects of Inhaled Ultrafine and Nanosized Particles. Cardiovascular Effects of Inhaled Ultrafine and Nanosized Particles 317 350 .
Urmila P. Kodavanti, Lung-Chi Chen & Daniel L. Costa. 2011. Cardiovascular Effects of Inhaled Ultrafine and Nanosized Particles. Cardiovascular Effects of Inhaled Ultrafine and Nanosized Particles 185 215 .
Z. Ying & S. Rajagopalan. 2010. Environmental Cardiology. Environmental Cardiology 121 142 .
Robert D. Brook, Sanjay Rajagopalan, C. Arden PopeIIIIII, Jeffrey R. Brook, Aruni Bhatnagar, Ana V. Diez-Roux, Fernando Holguin, Yuling Hong, Russell V. Luepker, Murray A. Mittleman, Annette Peters, David Siscovick, Sidney C. SmithJrJr, Laurie Whitsel & Joel D. Kaufman. (2010) Particulate Matter Air Pollution and Cardiovascular Disease. Circulation 121:21, pages 2331-2378.
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T.L. Knuckles, M.J. Campen & L.W. Stanek. 2010. Comprehensive Toxicology. Comprehensive Toxicology 465 487 .
Antonella Zanobetti, Meredith Franklin, Petros Koutrakis & Joel Schwartz. (2009) Fine particulate air pollution and its components in association with cause-specific emergency admissions. Environmental Health 8:1.
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Robert D. Brook & Sanjay Rajagopalan. (2009) Particulate matter, air pollution, and blood pressure. Journal of the American Society of Hypertension 3:5, pages 332-350.
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Miriam E. Gerlofs-Nijland, Melina Rummelhard, A. John F. Boere, Daan L. A. C. Leseman, Rodger Duffin, Roel P. F. Schins, Paul J. A. Borm, Markus Sillanpää, Raimo O. Salonen & Flemming R. Cassee. (2009) Particle Induced Toxicity in Relation to Transition Metal and Polycyclic Aromatic Hydrocarbon Contents. Environmental Science & Technology 43:13, pages 4729-4736.
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L.F. Maatz, G.J.A. Wood, D.H.R.F. Rivero & P.H.N. Saldiva. (2009) Tracheal instillation of urban PM2.5 suspension promotes acute cardiac polarization changes in rats. Brazilian Journal of Medical and Biological Research 42:2, pages 207-213.
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Maria Helfenstein, Michele Miragoli, Stephan Rohr, Loretta Müller, Peter Wick, Martin Mohr, Peter Gehr & Barbara Rothen-Rutishauser. (2008) Effects of combustion-derived ultrafine particles and manufactured nanoparticles on heart cells in vitro. Toxicology 253:1-3, pages 70-78.
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J. Grace Wallenborn, Paul Evansky, Jonathan H. Shannahan, Beena Vallanat, Allen D. Ledbetter, Mette C. Schladweiler, Judy H. Richards, Reddy R. Gottipolu, Abraham Nyska & Urmila P. Kodavanti. (2008) Subchronic inhalation of zinc sulfate induces cardiac changes in healthy rats. Toxicology and Applied Pharmacology 232:1, pages 69-77.
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Abderrahim Nemmar & Ibrahim M. Inuwa. (2008) Diesel exhaust particles in blood trigger systemic and pulmonary morphological alterations. Toxicology Letters 176:1, pages 20-30.
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Robert D. Brook. (2007) Why Physicians Who Treat Hypertension Should Know More About Air Pollution. The Journal of Clinical Hypertension 9:8, pages 629-635.
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Chuen-Chau Chang, Jing-Shiang Hwang, Chang-Chuan Chan & Tsun-Jen Cheng. (2007) Interaction Effects of Ultrafine Carbon Black with Iron and Nickel on Heart Rate Variability in Spontaneously Hypertensive Rats. Environmental Health Perspectives 115:7, pages 1012-1017.
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Abderrahim Nemmar, Sultan Al-Maskari, Badreldin H. Ali & Issa S. Al-Amri. (2007) Cardiovascular and lung inflammatory effects induced by systemically administered diesel exhaust particles in rats. American Journal of Physiology-Lung Cellular and Molecular Physiology 292:3, pages L664-L670.
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William H. RowanIIIIII, Matthew J. Campen, Lindsay B. Wichers & William P. Watkinson. (2007) Heart rate variability in rodents: uses and caveats in toxicological studies. Cardiovascular Toxicology 7:1, pages 28-51.
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R.D. Brook. (2007) Is air pollution a cause of cardiovascular disease? Updated review and controversies. Reviews on Environmental Health 22:2.
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Lindsay B Wichers, Allen D Ledbetter, John K McGee, Robert B Kellogg, William H RowanIIIIII, Julianne P Nolan, Daniel L Costa & William P Watkinson. (2006) A method for exposing rodents to resuspended particles using whole-body plethysmography. Particle and Fibre Toxicology 3:1.
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Lindsay B. Wichers, William H. RowanIIIIII, Julianne P. Nolan, Allen D. Ledbetter, John K. McGee, Daniel L. Costa & William P. Watkinson. (2006) Particle Deposition in Spontaneously Hypertensive Rats Exposed via Whole-Body Inhalation: Measured and Estimated Dose. Toxicological Sciences 93:2, pages 400-410.
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Timothy R. Nurkiewicz, Dale W. Porter, Mark Barger, Lyndell Millecchia, K. Murali K. Rao, Paul J. Marvar, Ann F. Hubbs, Vincent Castranova & Matthew A. Boegehold. (2006) Systemic Microvascular Dysfunction and Inflammation after Pulmonary Particulate Matter Exposure. Environmental Health Perspectives 114:3, pages 412-419.
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Robert D. Brook. (2005) You are what you breathe: Evidence linking air pollution and blood pressure. Current Hypertension Reports 7:6, pages 427-434.
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Dolores Helena Rodriguez Ferreira Rivero, Carolina Sassaki, Geraldo Lorenzi-Filho & Paulo Hilário Nascimento Saldiva. (2005) PM2.5 induces acute electrocardiographic alterations in healthy rats. Environmental Research 99:2, pages 262-266.
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