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Inhalation Toxicology
International Forum for Respiratory Research
Volume 32, 2020 - Issue 2
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Review Article

Expert workshop on the hazards and risks of poorly soluble low toxicity particles

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Pages 53-62 | Received 05 Nov 2019, Accepted 22 Feb 2020, Published online: 09 Mar 2020

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Chiu-wing Lam, Vincent Castranova, Kevin Driscoll, David Warheit, Valerie Ryder, Ye Zhang, Patti Zeidler-Erdely, Robert Hunter, Robert Scully, William Wallace, John James, Brian Crucian, Mayra Nelman, Richard McCluskey, Donald Gardner, Roger Renne & Roger McClellan. (2023) A review of pulmonary neutrophilia and insights into the key role of neutrophils in particle-induced pathogenesis in the lung from animal studies of lunar dusts and other poorly soluble dust particles. Critical Reviews in Toxicology 53:8, pages 441-479.
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L. Perez, J. Ambroise, F. Huaux & D. Lison. (2023) P17-11: Poorly soluble low toxicity (PSLT) particles modulate genes related to inflammation and cancer development to a greater extent in rat than in mouse alveolar macrophages. Toxicology Letters 384, pages S207-S208.
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P. Borm. (2023) CEC05-02: Occupational exposure to (nano)particles: never a dull moment. Toxicology Letters 384, pages S12.
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Craig A. Poland, Rodger Duffin, Klaus Weber, Wolfgang Dekant & Paul J.A. Borm. (2023) Is pulmonary inflammation a valid predictor of particle induced lung pathology? The case of amorphous and crystalline silicas. Toxicology Letters.
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Robert J. McCunney, Len Levy, Ishrat Chaudhuri, Yufanyi Ngiewih, Mei Yong & Wesley Wampler. 2003. Patty's Toxicology. Patty's Toxicology 1 25 .
Soyeon Jeon, Wang Sik Lee, Kyung Seuk Song, Jiyoung Jeong, Sinuk Lee, Songyeon Kim, Gyuri Kim, Ji-Su Kim, Jinyoung Jeong & Wan-Seob Cho. (2023) Differential particle and ion kinetics of silver nanoparticles in the lungs and biotransformation to insoluble silver sulfide. Journal of Hazardous Materials 452, pages 131223.
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Nathaly Ortiz Peña, Kondareddy Cherukula, Benjamin Even, Ding‐Kun Ji, Sarah Razafindrakoto, Shiyuan Peng, Amanda K. A. Silva, Cécilia Ménard‐Moyon, Hervé Hillaireau, Alberto Bianco, Elias Fattal, Damien Alloyeau & Florence Gazeau. (2023) Resolution of MoS 2 Nanosheets‐Induced Pulmonary Inflammation Driven by Nanoscale Intracellular Transformation and Extracellular‐Vesicle Shuttles . Advanced Materials 35:13.
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Paul J.A. Borm. (2023) Talc Inhalation in Rats and Humans. Journal of Occupational & Environmental Medicine 65:2, pages 152-159.
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Wolfgang Dekant, Evangelia E. Antoniou, Axel Bosch, Gustav Gerd Bruer, Thomas Colnot, Otto Creutzenberg, Claus-Peter Drexel, Rodger Duffin, Nils Krueger, Jürgen Nolde, Craig Poland, Dirk Schaudien, Tobias B. Schuster, Michael Stintz, Klaus Weber, Benno Wessely & Maurice P. Zeegers. (2023) Issues in the inhalation toxicity testing and hazard assessment for low density particulate materials such as synthetic amorphous silica (SAS). Toxicology Letters.
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Nienke Ruijter, Lya G. Soeteman-Hernández, Marie Carrière, Matthew Boyles, Polly McLean, Julia Catalán, Alberto Katsumiti, Joan Cabellos, Camilla Delpivo, Araceli Sánchez Jiménez, Ana Candalija, Isabel Rodríguez-Llopis, Socorro Vázquez-Campos, Flemming R. Cassee & Hedwig Braakhuis. (2023) The State of the Art and Challenges of In Vitro Methods for Human Hazard Assessment of Nanomaterials in the Context of Safe-by-Design. Nanomaterials 13:3, pages 472.
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Dina Mourad Saleh, Shengyong Luo, Omnia Hosny Mohamed Ahmed, David B. Alexander, William T. Alexander, Sivagami Gunasekaran, Ahmed M. El-Gazzar, Mohamed Abdelgied, Takamasa Numano, Hiroshi Takase, Makoto Ohnishi, Susumu Tomono, Randa Hussein Abd el Hady, Katsumi Fukamachi, Jun Kanno, Akihiko Hirose, Jiegou Xu, Shugo Suzuki, Aya Naiki-Ito, Satoru Takahashi & Hiroyuki Tsuda. (2022) Assessment of the toxicity and carcinogenicity of double-walled carbon nanotubes in the rat lung after intratracheal instillation: a two-year study. Particle and Fibre Toxicology 19:1.
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Emanoela Lundgren Thá, Viviana Stephanie Costa Gagosian, Andrezza Di Pietro Micali Canavez, Desiree Cigaran Schuck, Carla Abdo Brohem, Daniela Fiori Gradia, Rilton Alves de Freitas, Karin Braun Prado, Marta Margarete Cestari, Márcio Lorencini & Daniela Morais Leme. (2022) In vitro evaluation of the inhalation toxicity of the cosmetic ingredient aluminum chlorohydrate. Journal of Applied Toxicology 42:12, pages 2016-2029.
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Shotaro Yamano, Tomoki Takeda, Yuko Goto, Shigeyuki Hirai, Yusuke Furukawa, Yoshinori Kikuchi, Tatsuya Kasai, Kyohei Misumi, Masaaki Suzuki, Kenji Takanobu, Hideki Senoh, Misae Saito, Hitomi Kondo & Yumi Umeda. (2022) No evidence for carcinogenicity of titanium dioxide nanoparticles in 26-week inhalation study in rasH2 mouse model. Scientific Reports 12:1.
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Kevin E. Driscoll. (2022) Review of Lung Particle Overload, Rat Lung Cancer, and the Conclusions of the Edinburgh Expert Panel—It's Time to Revisit Cancer Hazard Classifications for Titanium Dioxide and Carbon Black. Frontiers in Public Health 10.
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Kenneth A. Mundt, Annette B. Santamaria, William J. Thompson, Christopher A. Bates, Corey Boles, G. Scott Dotson & Mei Yong. (2022) Carcinogenicity of Poorly Soluble Low Toxicity Particles: Commentary on Epidemiology as a Risk Assessment “Reality Check”. Frontiers in Public Health 10.
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Emilio Di Ianni, Nicklas Raun Jacobsen, Ulla Birgitte Vogel & Peter Møller. (2022) Systematic review on primary and secondary genotoxicity of carbon black nanoparticles in mammalian cells and animals. Mutation Research/Reviews in Mutation Research 790, pages 108441.
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Stephanie Wright & Paul J. A. Borm. (2022) Applying Existing Particle Paradigms to Inhaled Microplastic Particles. Frontiers in Public Health 10.
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Paul J. A. Borm, Dominique Lison, Kevin Driscoll, Rodger Duffin, Jack Harkema, Klaus Weber & Alison Elder. (2022) Inflammation as a Key Outcome Pathway in Particle Induced Effects in the Lung. Frontiers in Public Health 10.
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Maaike Visser, Ilse Gosens, Delphine Bard, Pieter van Broekhuizen, Gemma Janer, Eileen Kuempel, Michael Riediker, Ulla Vogel & Susan Dekkers. (2022) Towards health-based nano reference values (HNRVs) for occupational exposure: Recommendations from an expert panel. NanoImpact 26, pages 100396.
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Nina Jeliazkova, Lan Ma-Hock, Gemma Janer, Heidi Stratmann & Wendel Wohlleben. (2022) Possibilities to group nanomaterials across different substances – A case study on organic pigments. NanoImpact 26, pages 100391.
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Arne Burzlaff, Otto Creutzenberg, Dirk Schaudien, Vanessa Viegas, Ruth Danzeisen & David Warheit. (2022) A tiered approach to investigate the inhalation toxicity of cobalt substances. Tier 4: Effects from a 28-day inhalation toxicity study with tricobalt tetraoxide in rats. Regulatory Toxicology and Pharmacology, pages 105129.
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Jin Kwon Kim, Hoi Pin Kim, Jung Duck Park, Kangho Ahn, Woo Young Kim, Mary Gulumian, Günter Oberdörster & Il Je Yu. (2021) Lung retention and particokinetics of silver and gold nanoparticles in rats following subacute inhalation co-exposure. Particle and Fibre Toxicology 18:1.
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Donald A. Hendrix, Joel A. Hurowitz, Timothy D. Glotch & Martin A. A. Schoonen. (2021) Olivine Dissolution in Simulated Lung and Gastric Fluid as an Analog to the Behavior of Lunar Particulate Matter Inside the Human Respiratory and Gastrointestinal Systems. GeoHealth 5:11.
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Heidi Stratmann, Wendel Wohlleben, Martin Wiemann, Antje Vennemann, Nicole End, Ulrich Veith, Lan Ma-Hock & Robert Landsiedel. (2021) Classes of organic pigments meet tentative PSLT criteria and lack toxicity in short-term inhalation studies. Regulatory Toxicology and Pharmacology 124, pages 104988.
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Peter Møller, Regitze Sølling Wils, Emilio Di Ianni, Claudia Andrea Torero Gutierrez, Martin Roursgaard & Nicklas Raun Jacobsen. (2021) Genotoxicity of multi-walled carbon nanotube reference materials in mammalian cells and animals. Mutation Research/Reviews in Mutation Research 788, pages 108393.
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Calvin C. Willhite, Nataliya A. Karyakina, Eirik Nordheim, Ian Arnold, Vic Armstrong, Franco Momoli, Natalia S. Shilnikova, Nagarajkumar Yenugadhati & Daniel Krewski. (2021) The REACH registration process: A case study of metallic aluminium, aluminium oxide and aluminium hydroxide. NeuroToxicology 83, pages 166-178.
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Paul J.A. Borm. (2022) The parallels between particle induced lung overload and particle induced periprosthetic osteolysis (PPOL). Open Research Europe 1, pages 16.
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Paul J.A. Borm. (2021) The parallels between particle induced lung overload and particle induced periprosthetic osteolysis (PPOL). Open Research Europe 1, pages 16.
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Kevin E. Driscoll, Paul A. Borm, Ishrat Chaudhuri, Len Levy, Mei Yong, David Warheit, Robert McCunney & Günter Oberdörster. (2020) Comment on Saber et al. (2019), “Commentary: the chronic inhalation study in rats for assessing lung cancer risk may be better than its reputation”. Particle and Fibre Toxicology 17:1.
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