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Inhalation Toxicology
International Forum for Respiratory Research
Volume 9, 1997 - Issue 3
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Research Article

INFLAMMATION AND CELL DAMAGE INDUCED BY REPEATED EXPOSURE OF HUMANS TO OZONE

Robert B. Devlin, Lawrence J. Folinsbee, Frank Biscardi, Gary Hatch, Susanne Becker, Michael C. Madden, Mark Robbins and Hillel S. Koren Human Studies Division, National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, USA; Center for Environmental Medicine and Lung Biology, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA; Environmental Toxicology Division, National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, USA; Human Studies Division, National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, USA; Center for Environmental Medicine and Lung Biology, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA; Human Studies Division, National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, USA
Pages 211-235 | Published online: 01 Oct 2008

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Konstantina Dimakopoulou, Ioannis Tomos, Effrosyni D. Manali, Spyros A. Papiris & Anna Karakatsani. (2023) Effects of short-term air pollution exposure on symptoms development in the course of idiopathic pulmonary fibrosis. Expert Review of Respiratory Medicine 0:0, pages 1-10.
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Gursharan Singh, Shailendra Kumar Arya, Mohit Bibra, Aditya Bhalla, Ashish Aggarwal & Jatinder Singh. (2022) Antimicrobial potential of ozone for the storage of grains: special focus on inhibition of bacterial contamination. Archives of Phytopathology and Plant Protection 55:14, pages 1625-1637.
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Annette C. Rohr. (2018) Ozone exposure and pulmonary effects in panel and human clinical studies: Considerations for design and interpretation. Journal of the Air & Waste Management Association 68:4, pages 288-307.
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Roger O. McClellan, Mark W. Frampton, Petros Koutrakis, William F. McDonnell, Suresh Moolgavkar, D. Warner North, Anne E. Smith, Richard L. Smith & Mark J. Utell. (2009) Critical considerations in evaluating scientific evidence of health effects of ambient ozone: a conference report. Inhalation Toxicology 21:sup2, pages 1-36.
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Christiaan B. Brink, Anita Pretorius, Barend P.J. van Niekerk, Douglas W. Oliver & Daniel P. Venter. (2008) Studies on cellular resilience and adaptation following acute and repetitive exposure to ozone in cultured human epithelial (HeLa) cells. Redox Report 13:2, pages 87-100.
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Ling Liu, Judith A. Leech, R. Bruce Urch, Raymond Poon, Barry Zimmerman, Joanne M. Kubay, Frances S. Silverman. (1999) A COMPARISON OF BIOMARKERS OF OZONE EXPOSURE IN HUMAN PLASMA, NASAL LAVAGE, AND SPUTUM. Inhalation Toxicology 11:8, pages 657-674.
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G. S. Gopikrishnan, J. Kuttippurath, S. Raj, A. Singh & K. Abbhishek. (2022) Air Quality during the COVID–19 Lockdown and Unlock Periods in India Analyzed Using Satellite and Ground-based Measurements. Environmental Processes 9:2.
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Emma C Bowers, Elizabeth M Martin, Annie M Jarabek, David S Morgan, Hannah J Smith, Lisa A Dailey, Emily R Aungst, David Diaz-Sanchez & Shaun D McCullough. (2022) Ozone Responsive Gene Expression as a Model for Describing Repeat Exposure Response Trajectories and Interindividual Toxicodynamic Variability In Vitro . Toxicological Sciences 185:1, pages 38-49.
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Alexandra Hicks, Galina Kourteva, Holly Hilton, Hongli Li, Tai-An Lin, Will Liao, Ying Li, Xin Wei, Thomas March, Janet Benson & Louis M. Renzetti. (2009) Cellular and Molecular Characterization of Ozone-Induced Pulmonary Inflammation in the Cynomolgus Monkey. Inflammation 33:3, pages 144-156.
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Mehrdad Arjomandi, Ira B. Tager, Maria Bastaki, Connie Chen, Nina Holland & John R. Balmes. (2008) Is There an Association Between Lifetime Cumulative Exposure and Acute Pulmonary Responses to Ozone?. Journal of Occupational & Environmental Medicine 50:3, pages 341-349.
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Ramzi M. Kafoury, Jazmir M. Hernandez, Joseph A. Lasky, William A. ToscanoJr.Jr. & Mitchell Friedman. (2007) Activation of transcription factor IL‐6 (NF‐IL‐6) and nuclear factor‐κB (NF‐κB) by lipid ozonation products is crucial to interleukin‐8 gene expression in human airway epithelial cells. Environmental Toxicology 22:2, pages 159-168.
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Stefanie Ebelt Sarnat, Brent A. Coull, Joel Schwartz, Diane R. Gold & Helen H. Suh. (2006) Factors Affecting the Association between Ambient Concentrations and Personal Exposures to Particles and Gases. Environmental Health Perspectives 114:5, pages 649-654.
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Jeffrey RattoHofer Wong, Jane Liu, John Fahy, Homer Boushey, Colin Solomon & John Balmes. (2006) Effects of Multiday Exposure to Ozone on Airway Inflammation as Determined Using Sputum Induction. Environmental Health Perspectives 114:2, pages 209-212.
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Ramzi M. Kafoury & Ming-Ju Huang. (2005) Application of quantitative structure activity relationship (QSAR) models to predict ozone toxicity in the lung. Environmental Toxicology 20:4, pages 441-448.
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Bogdan Dolezych & Elzbieta Szulinska. (2003) Selenium modifies glutathione peroxidase activity and glutathione concentration in mice exposed to ozone-provoked oxidative stress. Journal of Trace Elements in Medicine and Biology 17:2, pages 133-137.
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O. Holz, M. Mücke, K. Paasch, S. Böhme, P. Timm, K. Richter, H. Magnussen & R. A. Jörres. (2002) Repeated ozone exposures enhance bronchial allergen responses in subjects with rhinitis or asthma. Clinical & Experimental Allergy 32:5, pages 681-689.
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J.I. Freijer, J.C.H. van Eijkeren & L. van Bree. (2002) A model for the effect on health of repeated exposure to ozone. Environmental Modelling & Software 17:6, pages 553-562.
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Scott C. Wesselkamper, Lung Chi Chen, Steven R. Kleeberger & Terry Gordon. (2001) Genetic variability in the development of pulmonary tolerance to inhaled pollutants in inbred mice. American Journal of Physiology-Lung Cellular and Molecular Physiology 281:5, pages L1200-L1209.
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ROBERT FRANK, MARK C. LIU, ERNST W. SPANNHAKE, STEVEN MLYNAREK, KRIS MACRI & GAIL G. WEINMANN. (2001) Repetitive Ozone Exposure of Young Adults. American Journal of Respiratory and Critical Care Medicine 164:7, pages 1253-1260.
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Jürgen Fuchs & Lester PackerCarroll Cross, Samuel Louie, Sunye Kwack, Pat Wong, Sharanya Reddy & Albert van der Vliet. 2001. Environmental Stressors in Health and Disease. Environmental Stressors in Health and Disease.
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W. Michael Foster, Robert H. Brown, Kristin Macri & Clifford S. Mitchell. (2000) Bronchial reactivity of healthy subjects: 18–20 h postexposure to ozone. Journal of Applied Physiology 89:5, pages 1804-1810.
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RUDOLF A. JÖRRES, OLAF HOLZ, WOLFGANG ZACHGO, PETRA TIMM, SILKE KOSCHYK, BERND MÜLLER, FRIEDRICH GRIMMINGER, WERNER SEEGER, FRANK J. KELLY, CHRISTINE DUNSTER, THOMAS FRISCHER, GERD LUBEC, MARC WASCHEWSKI, AXEL NIENDORF & HELGO MAGNUSSEN. (2000) The Effect of Repeated Ozone Exposures on Inflammatory Markers in Bronchoalveolar Lavage Fluid and Mucosal Biopsies. American Journal of Respiratory and Critical Care Medicine 161:6, pages 1855-1861.
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RAMZI M. KAFOURY, WILLIAM A. PRYOR, GIUSEPPE L. SQUADRITO, MARIA GIULIA SALGO, XIAOYAN ZOU & MITCHELL FRIEDMAN. (1999) Induction of Inflammatory Mediators in Human Airway Epithelial Cells by Lipid Ozonation Products. American Journal of Respiratory and Critical Care Medicine 160:6, pages 1934-1942.
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DOROTHY L. CHRISTIAN, LISA L. CHEN, CORNELIUS H. SCANNELL, RONALD E. FERRANDO, BARBARA S. WELCH & JOHN R. BALMES. (1998) Ozone-induced Inflammation Is Attenuated with Multiday Exposure. American Journal of Respiratory and Critical Care Medicine 158:2, pages 532-537.
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