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Inhalation Toxicology
International Forum for Respiratory Research
Volume 11, 1999 - Issue 10
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Research Article

DOSIMETRIC ADJUSTMENT FACTORS FOR METHYL METHACRYLATE DERIVED FROM A STEADY-STATE ANALYSIS OF A PHYSIOLOGICALLY BASED CLEARANCE-EXTRACTION MODEL

Pages 899-926 | Published online: 01 Oct 2008

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Read on this site (9)

Jerry L. Campbell, Melvin E. Andersen & Harvey J. Clewell. (2014) A hybrid CFD-PBPK model for naphthalene in rat and human with IVIVE for nasal tissue metabolism and cross-species dosimetry. Inhalation Toxicology 26:6, pages 333-344.
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Guilherme J. M. Garcia & Julia S. Kimbell. (2009) Deposition of inhaled nanoparticles in the rat nasal passages: Dose to the olfactory region. Inhalation Toxicology 21:14, pages 1165-1175.
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R. A. Corley, K. R. Minard, S. Kabilan, D. R. Einstein, A. P. Kuprat, J. R. Harkema, J. S. Kimbell, M. L. Gargas & John H. Kinzell. (2009) Magnetic resonance imaging and computational fluid dynamics (CFD) simulations of rabbit nasal airflows for the development of hybrid CFD/PBPK models. Inhalation Toxicology 21:6, pages 512-518.
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Justin G. Teeguarden, Matthew S. Bogdanffy, Tammie R. Covington, Cecilia Tan & Annie M. Jarabek. (2008) A PBPK Model for Evaluating the Impact of Aldehyde Dehydrogenase Polymorphisms on Comparative Rat and Human Nasal Tissue Acetaldehyde Dosimetry. Inhalation Toxicology 20:4, pages 375-390.
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David C. Dorman, Melanie F. Struve, Brian A. Wong, Elizabeth A. Gross, Carl Parkinson, Gabrielle A. Willson, Yu-Mei Tan, Jerry L. Campbell, Justin G. Teeguarden, Harvey J. Clewell$suffix/text()$suffix/text() & Melvin E. Andersen. (2008) Derivation of an Inhalation Reference Concentration Based upon Olfactory Neuronal Loss in Male Rats following Subchronic Acetaldehyde Inhalation. Inhalation Toxicology 20:3, pages 245-256.
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GaryL. Ginsberg, Bahman Asgharian, JuliaS. Kimbell, JamesS. Ultman & AnnieM. Jarabek. (2007) Modeling Approaches for Estimating the Dosimetry of Inhaled Toxicants in Children. Journal of Toxicology and Environmental Health, Part A 71:3, pages 166-195.
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Rakesh Dixit, Jim Riviere, Kannan Krishnan & Melvin Andersen. (2003) Toxicokinetics and Physiologically Based Toxicokinetics in Toxicology and Risk Assessment. Journal of Toxicology and Environmental Health, Part B 6:1, pages 1-40.
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Melvin E. Andersen, Ramesh Sarangapani. (2001) PHYSIOLOGICALLY BASED CLEARANCE/EXTRACTION MODELS FOR COMPOUNDS METABOLIZED IN THE NOSE: An Example with Methyl Methacrylate. Inhalation Toxicology 13:5, pages 397-414.
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Articles from other publishers (22)

Wei-Chun Chou & Zhoumeng Lin. (2021) Development of a Gestational and Lactational Physiologically Based Pharmacokinetic (PBPK) Model for Perfluorooctane Sulfonate (PFOS) in Rats and Humans and Its Implications in the Derivation of Health-Based Toxicity Values. Environmental Health Perspectives 129:3.
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Wei-Chun Chou & Zhoumeng Lin. (2019) Bayesian evaluation of a physiologically based pharmacokinetic (PBPK) model for perfluorooctane sulfonate (PFOS) to characterize the interspecies uncertainty between mice, rats, monkeys, and humans: Development and performance verification. Environment International 129, pages 408-422.
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Heinz-Peter Gelbke, Robert Ellis-Hutchings, Harald Müllerschön, Sandra Murphy & Mark Pemberton. (2018) Toxicological assessment of lower alkyl methacrylate esters by a category approach. Regulatory Toxicology and Pharmacology 92, pages 104-127.
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Joseph A. Cichocki, Gregory J. Smith, Ryan Mendoza, Alan R. Buckpitt, Laura S. Van Winkle & John B. Morris. (2014) Sex Differences in the Acute Nasal Antioxidant/Antielectrophilic Response of the Rat to Inhaled Naphthalene. Toxicological Sciences 139:1, pages 234-244.
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Mark Pemberton, Lisa A. Bailey & Lorenz R. Rhomberg. (2013) Hypothesis-based weight-of-evidence evaluation of methyl methacrylate olfactory effects in humans and derivation of an occupational exposure level. Regulatory Toxicology and Pharmacology 66:2, pages 217-233.
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K. Sandy Pang & Matthew R. Durk. (2010) Physiologically-based pharmacokinetic modeling for absorption, transport, metabolism and excretion. Journal of Pharmacokinetics and Pharmacodynamics 37:6, pages 591-615.
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Bruce D. Naumann, Patricia A. Weideman, Ramesh Sarangapani, Shu-Cheih Hu, Rakesh Dixit & Edward V. Sargent. (2009) Investigations of the Use of Bioavailability Data to Adjust Occupational Exposure Limits for Active Pharmaceutical Ingredients. Toxicological Sciences 112:1, pages 196-210.
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Hon‐Wing Leung. 2009. General, Applied and Systems Toxicology. General, Applied and Systems Toxicology.
Jeffry D. Schroeter. (2009) The Use of Nasal Dosimetry Models in the Risk Assessment of Inhaled Gases. Toxicological Sciences 108:1, pages 1-3.
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Jan Gosepath, Juergen Brieger, Axel Muttray, Sandra Best, Mehrdad Pourianfar, Detlef Jung, Stephan Letzel & Wolf J. Mann. (2007) mRNA-induction and cytokine release during in vitro exposure of human nasal respiratory epithelia to methyl methacrylate. Toxicology Letters 171:1-2, pages 29-37.
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György A. Csanády & Johannes G. Filser. (2007) A Physiological Toxicokinetic Model for Inhaled Propylene Oxide in Rat and Human with Special Emphasis on the Nose. Toxicological Sciences 95:1, pages 37-62.
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Jeffry D. Schroeter, Julia S. Kimbell, Anna M. Bonner, Kay C. Roberts, Melvin E. Andersen & David C. Dorman. (2006) Incorporation of Tissue Reaction Kinetics in a Computational Fluid Dynamics Model for Nasal Extraction of Inhaled Hydrogen Sulfide in Rats. Toxicological Sciences 90:1, pages 198-207.
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Melvin E. Andersen, Roman W. Lutz, Kai H. Liao & Werner K. Lutz. (2006) Dose-Incidence Modeling: Consequences of Linking Quantal Measures of Response to Depletion of Critical Tissue Targets. Toxicological Sciences 89:1, pages 331-337.
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John Morris. 2005. Inhalation Toxicology, Second Edition. Inhalation Toxicology, Second Edition 349 371 .
P. M. Hinderliter, K. D. Thrall, R. A. Corley, L. J. Bloemen & M. S. Bogdanffy. (2005) Validation of Human Physiologically Based Pharmacokinetic Model for Vinyl Acetate Against Human Nasal Dosimetry Data. Toxicological Sciences 85:1, pages 460-467.
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Melvin E Andersen. (2003) Toxicokinetic modeling and its applications in chemical risk assessment. Toxicology Letters 138:1-2, pages 9-27.
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Matthew S Bogdanffy & Ramesh Sarangapani. (2003) Physiologically-based kinetic modeling of vapours toxic to the respiratory tract. Toxicology Letters 138:1-2, pages 103-117.
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Melvin E. Andersen, Trevor Green, Clay B. Frederick & Matthew S. Bogdanffy. (2002) Physiologically Based Pharmacokinetic (PBPK) Models for Nasal Tissue Dosimetry of Organic Esters: Assessing the State-of-Knowledge and Risk Assessment Applications with Methyl Methacrylate and Vinyl Acetate. Regulatory Toxicology and Pharmacology 36:3, pages 234-245.
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J. S. Kimbell, J. H. Overton, R. P. Subramaniam, P. M. Schlosser, K. T. Morgan, R. B. Conolly & F. J. Miller. (2001) Dosimetry Modeling of Inhaled Formaldehyde: Binning Nasal Flux Predictions for Quantitative Risk Assessment. Toxicological Sciences 64:1, pages 111-121.
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J. S. Kimbell, R. P. Subramaniam, E. A. Gross, P. M. Schlosser & K. T. Morgan. (2001) Dosimetry Modeling of Inhaled Formaldehyde: Comparisons of Local Flux Predictions in the Rat, Monkey, and Human Nasal Passages. Toxicological Sciences 64:1, pages 100-110.
Crossref
Melvin E Andersen & James E Dennison. (2001) Mode of action and tissue dosimetry in current and future risk assessments. Science of The Total Environment 274:1-3, pages 3-14.
Crossref
Michael L. Dourson, Melvin E. Andersen, Linda S. Erdreich & Judith A. MacGregor. (2001) Using Human Data to Protect the Public's Health. Regulatory Toxicology and Pharmacology 33:2, pages 234-256.
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