3,043
Views
49
CrossRef citations to date
0
Altmetric
Microbiology & Fermentation Technology

Metabolic engineering of Saccharomyces cerevisiae to improve succinic acid production based on metabolic profiling

, &
Pages 151-159 | Received 12 Jun 2013, Accepted 19 Oct 2013, Published online: 14 Apr 2014

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (1)

Yoshihiro Toya, Takashi Hirasawa, Shu Ishikawa, Onuma Chumsakul, Takuya Morimoto, Shenghao Liu, Kenta Masuda, Yasushi Kageyama, Katsuya Ozaki, Naotake Ogasawara & Hiroshi Shimizu. (2015) Enhanced dipicolinic acid production during the stationary phase in Bacillus subtilis by blocking acetoin synthesis. Bioscience, Biotechnology, and Biochemistry 79:12, pages 2073-2080.
Read now

Articles from other publishers (48)

Evelyn Vásquez Castro, Golnaz Memari, Özge Ata & Diethard Mattanovich. (2023) Carbon efficient production of chemicals with yeasts. Yeast.
Crossref
Cristina Ubeda, David Cortejosa, M. Lourdes Morales, Raquel M. Callejón & Rocío Ríos-Reina. (2023) Determination of volatile compounds for the differentiation of PDO fortified wines with different ageing methods as a tool for controlling their authenticity. Food Research International 173, pages 113320.
Crossref
Ga Hyun Lee, Do-Wook Kim, Yun Hui Jin, Sang Min Kim, Eui Seok Lim, Min Ji Cha, Ja Kyong Ko, Gyeongtaek Gong, Sun-Mi Lee, Youngsoon Um, Sung Ok Han & Jung Ho Ahn. (2023) Biotechnological Plastic Degradation and Valorization Using Systems Metabolic Engineering. International Journal of Molecular Sciences 24:20, pages 15181.
Crossref
Taju Wu, Jingen Li & Chaoguang Tian. (2023) Fungal carboxylate transporters: recent manipulations and applications. Applied Microbiology and Biotechnology.
Crossref
Nooshin Arshadi, Hoda Nouri & Hamid Moghimi. (2023) Increasing the production of the bioactive compounds in medicinal mushrooms: an omics perspective. Microbial Cell Factories 22:1.
Crossref
Jina Son, Yu Jung Sohn, Kei-Anne Baritugo, Seo Young Jo, Hye Min Song & Si Jae Park. (2023) Recent advances in microbial production of diamines, aminocarboxylic acids, and diacids as potential platform chemicals and bio-based polyamides monomers. Biotechnology Advances 62, pages 108070.
Crossref
Daqiang Wu, Yongkang Chu, Wenfan Wei, Ling Liu & Chuanhai Fu. (2022) Fission yeast cells mix parental mitochondria in a progressive manner during meiosis. Journal of Molecular Cell Biology.
Crossref
William M. Shaw, Lucie Studená, Kyler Roy, Piotr Hapeta, Nicholas S. McCarty, Alicia E. Graham, Tom Ellis & Rodrigo Ledesma-Amaro. (2022) Inducible expression of large gRNA arrays for multiplexed CRISPRai applications. Nature Communications 13:1.
Crossref
Itziar A. Escanciano, Mateusz Wojtusik, Jesús Esteban, Miguel Ladero & Victoria E. Santos. (2022) Modeling the Succinic Acid Bioprocess: A Review. Fermentation 8:8, pages 368.
Crossref
Raffaella Desirè Di Lorenzo, Immacolata Serra, Danilo Porro & Paola Branduardi. (2022) State of the Art on the Microbial Production of Industrially Relevant Organic Acids. Catalysts 12:2, pages 234.
Crossref
Krishna Kalyani Sahoo, Swagata Datta, Anamika Nayak, Kumar Pranaw, Debjani Dutta & Gargi Goswami. 2022. Industrial Microbiology and Biotechnology. Industrial Microbiology and Biotechnology 427 461 .
April M. Miguez, Yan Zhang & Mark P. Styczynski. 2022. Cell-Free Gene Expression. Cell-Free Gene Expression 217 226 .
Olivier Perruchon, Isabelle Schmitz-Afonso, Carlos Afonso & Abdelhakim Elomri. (2021) State-of-the-art in analytical methods for metabolic profiling of Saccharomyces cerevisiae. Microchemical Journal 170, pages 106704.
Crossref
Verônica Sayury Nishida, Adenise Lorenci Woiciechowski, Kim Kley Valladares-Diestra, Luis Alberto Zevallos Torres, Luciana Porto de Souza Vandenberghe, Arion Zandona Filho & Carlos Ricardo Soccol. (2021) Bioethanol and succinic acid co-production from imidazole-pretreated soybean hulls. Industrial Crops and Products 172, pages 114060.
Crossref
Akhil Rautela & Sanjay Kumar. 2021. Biomolecular Engineering Solutions for Renewable Specialty Chemicals. Biomolecular Engineering Solutions for Renewable Specialty Chemicals 1 48 .
Rui Pereira, Olena P. Ishchuk, Xiaowei Li, Quanli Liu, Yi Liu, Maximilian Otto, Yun Chen, Verena Siewers & Jens Nielsen. 2021. Metabolic Engineering. Metabolic Engineering 689 733 .
Sara L. Baptista, Carlos E. Costa, Joana T. Cunha, Pedro O. Soares & Lucília Domingues. (2021) Metabolic engineering of Saccharomyces cerevisiae for the production of top value chemicals from biorefinery carbohydrates. Biotechnology Advances 47, pages 107697.
Crossref
Chong Li, Khai Lun Ong, Zhiyong Cui, Zhenyu Sang, Xiaotong Li, Raffel Dharma Patria, Qingsheng Qi, Patrick Fickers, Jianbin Yan & Carol Sze Ki Lin. (2021) Promising advancement in fermentative succinic acid production by yeast hosts. Journal of Hazardous Materials 401, pages 123414.
Crossref
Wei Cao, Luwen Yan, Mengxin Li, Xinyuan Liu, Yongxue Xu, Zhoujie Xie & Hao Liu. (2020) Identification and engineering a C4-dicarboxylate transporter for improvement of malic acid production in Aspergillus niger. Applied Microbiology and Biotechnology 104:22, pages 9773-9783.
Crossref
Rajesh K. Srivastava, Nasim Akhtar, Malkhey Verma & Sarat Babu Imandi. (2020) Primary metabolites from overproducing microbial system using sustainable substrates. Biotechnology and Applied Biochemistry 67:6, pages 852-874.
Crossref
Ana Mendes Ferreira & Arlete Mendes-Faia. (2020) The Role of Yeasts and Lactic Acid Bacteria on the Metabolism of Organic Acids during Winemaking. Foods 9:9, pages 1231.
Crossref
Zhongxue Dai, Feng Guo, Shangjie Zhang, Wenming Zhang, Qiao Yang, Weiliang Dong, Min Jiang, Jiangfeng Ma & Fengxue Xin. (2019) Bio‐based succinic acid: an overview of strain development, substrate utilization, and downstream purification. Biofuels, Bioproducts and Biorefining 14:5, pages 965-985.
Crossref
Yao Lu, Jinxin Che, Xiaoguang Xu, Bing Pang, Xixi Zhao, Yanlin Liu & Junling Shi. (2019) Metabolomics Reveals the Response of the Phenylpropanoid Biosynthesis Pathway to Starvation Treatment in the Grape Endophyte Alternaria sp. MG1 . Journal of Agricultural and Food Chemistry 68:4, pages 1126-1135.
Crossref
Bernhard Schmelzer, Martin Altvater, Brigitte Gasser, Michael Sauer & Diethard Mattanovich. 2020. Genetics and Biotechnology. Genetics and Biotechnology 319 337 .
Ahmed Zahoor, Felix T. F. Küttner, Lars M. Blank & Birgitta E. Ebert. (2019) Evaluation of pyruvate decarboxylase‐negative Saccharomyces cerevisiae strains for the production of succinic acid . Engineering in Life Sciences 19:10, pages 711-720.
Crossref
Behrooz Darbani, Vratislav Stovicek, Steven Axel van der Hoek & Irina Borodina. (2019) Engineering energetically efficient transport of dicarboxylic acids in yeast Saccharomyces cerevisiae . Proceedings of the National Academy of Sciences 116:39, pages 19415-19420.
Crossref
Jens Nielsen. (2019) Yeast Systems Biology: Model Organism and Cell Factory. Biotechnology Journal 14:9, pages 1800421.
Crossref
Qinglin Yu, Zhiyong Cui, Yaqin Zheng, Hailiang Huo, Lingli Meng, Junjie Xu & Cuijuan Gao. (2018) Exploring succinic acid production by engineered Yarrowia lipolytica strains using glucose at low pH. Biochemical Engineering Journal 139, pages 51-56.
Crossref
Kaio C. S. Rodrigues, Jorge L. S. Sonego, André Bernardo, Marcelo P. A. Ribeiro, Antonio J. G. Cruz & Alberto C. Badino. (2018) Real-Time Monitoring of Bioethanol Fermentation with Industrial Musts Using Mid-Infrared Spectroscopy. Industrial & Engineering Chemistry Research 57:32, pages 10823-10831.
Crossref
April M. Miguez, Monica P. McNerney & Mark P. Styczynski. (2018) Metabolomics Analysis of the Toxic Effects of the Production of Lycopene and Its Precursors. Frontiers in Microbiology 9.
Crossref
Zhen Wang, Huanhuan Li, Jiao Feng, Alei Zhang, Hanxiao Ying, Xun He, Min Jiang, Kequan Chen & Pingkai Ouyang. (2017) Enhanced succinic acid production from polyacrylamide‐pretreated cane molasses in microbial electrolysis cells. Journal of Chemical Technology & Biotechnology 93:3, pages 855-860.
Crossref
Hongyan Zhang, Naikun Shen, Yan Qin, Jing Zhu, Yi Li, Jiafa Wu & Ming-Guo Jiang. (2018) Complete Genome Sequence of Actinobacillus succinogenes GXAS137, a Highly Efficient Producer of Succinic Acid . Genome Announcements 6:8.
Crossref
Naikun Shen, Hongyan Zhang, Yan Qin, Qingyan Wang, Jing Zhu, Yi Li, Ming-Guo Jiang & Ribo Huang. (2018) Efficient production of succinic acid from duckweed (Landoltia punctata) hydrolysate by Actinobacillus succinogenes GXAS137. Bioresource Technology 250, pages 35-42.
Crossref
Burcu Turanlı-Yıldız, Burcu Hacısalihoğlu & Z. Petek Çakar. 2017. Old Yeasts - New Questions. Old Yeasts - New Questions.
Kiyotaka Y. Hara, Jyumpei Kobayashi, Ryosuke Yamada, Daisuke Sasaki, Yuki Kuriya, Yoko Hirono-Hara, Jun Ishii, Michihiro Araki & Akihiko Kondo. (2017) Transporter engineering in biomass utilization by yeast. FEMS Yeast Research 17:7.
Crossref
Xiaoju Chen, Xuefeng Wu, Shaotong Jiang & Xingjiang Li. (2017) Influence of pH and neutralizing agent on anaerobic succinic acid production by a Corynebacterium crenatum strain. Journal of Bioscience and Bioengineering 124:4, pages 439-444.
Crossref
Ricardo Franco-Duarte, Daniela Bessa, Filipa Gonçalves, Rosa Martins, António César Silva-Ferreira, Dorit Schuller, Paula Sampaio & Célia Pais. (2017) Genomic and transcriptomic analysis of Saccharomyces cerevisiae isolates with focus in succinic acid production. FEMS Yeast Research 17:6.
Crossref
K. N. Sorokina, Yu. V. Samoylova, A. V. Piligaev, Uthandi Sivakumar & V. N. Parmon. (2017) New methods for the one-pot processing of polysaccharide components (cellulose and hemicelluloses) of lignocellulose biomass into valuable products. Part 3: Products synthesized via the biotechnological conversion of poly- and monosaccharides of biomass. Catalysis in Industry 9:3, pages 270-276.
Crossref
Xiaofeng Yang, Huaimin Wang, Chong Li & Carol Sze Ki Lin. (2017) Restoring of Glucose Metabolism of Engineered Yarrowia lipolytica for Succinic Acid Production via a Simple and Efficient Adaptive Evolution Strategy . Journal of Agricultural and Food Chemistry 65:20, pages 4133-4139.
Crossref
Jung Ho Ahn, Yu-Sin Jang & Sang Yup Lee. 2017. Industrial Biotechnology. Industrial Biotechnology 505 544 .
Thomas C. Williams, Xin Xu, Martin Ostrowski, Isak S. Pretorius & Ian T. Paulsen. (2017) Positive-feedback, ratiometric biosensor expression improves high-throughput metabolite-producer screening efficiency in yeast. Synthetic Biology 2:1.
Crossref
Daniel Pleissner, Donna Dietz, Jozef Bernhard Johann Henri van Duuren, Christoph Wittmann, Xiaofeng Yang, Carol Sze Ki Lin & Joachim Venus. 2019. Biorefineries. Biorefineries 373 410 .
Jung Ho Ahn, Yu-Sin Jang & Sang Yup Lee. (2016) Production of succinic acid by metabolically engineered microorganisms. Current Opinion in Biotechnology 42, pages 54-66.
Crossref
Xian Luo, Shuang Zhao, Tao Huan, Difei Sun, R. Magnus N. Friis, Michael C. Schultz & Liang Li. (2016) High-Performance Chemical Isotope Labeling Liquid Chromatography–Mass Spectrometry for Profiling the Metabolomic Reprogramming Elicited by Ammonium Limitation in Yeast. Journal of Proteome Research 15:5, pages 1602-1612.
Crossref
C. Pais, R. Franco-Duarte, P. Sampaio, J. Wildner, A. Carolas, D. Figueira & B.S. Ferreira. 2016. Biotransformation of Agricultural Waste and By-Products. Biotransformation of Agricultural Waste and By-Products 237 269 .
Liang Wu. 2016. Quality Living Through Chemurgy and Green Chemistry. Quality Living Through Chemurgy and Green Chemistry 35 60 .
Judith Becker & Christoph Wittmann. (2015) Advanced Biotechnology: Metabolically Engineered Cells for the Bio-Based Production of Chemicals and Fuels, Materials, and Health-Care Products. Angewandte Chemie International Edition 54:11, pages 3328-3350.
Crossref
Judith Becker & Christoph Wittmann. (2015) Biotechnologie von Morgen: metabolisch optimierte Zellen für die bio-basierte Produktion von Chemikalien und Treibstoffen, Materialien und Gesundheitsprodukten. Angewandte Chemie 127:11, pages 3383-3407.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.