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Bioscience, Biotechnology, and Biochemistry Volume 80, 2016 - Issue 3
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Organic Chemistry

Reconstitution of biosynthetic machinery of fungal polyketides: unexpected oxidations of biosynthetic intermediates by expression host

Ryuya FujiiDivision of Chemistry, Graduate School of Science, Hokkaido University, Sapporo, Japan
,
Takahiro UgaiDivision of Chemistry, Graduate School of Science, Hokkaido University, Sapporo, Japan
,
Hirofumi IchinoseFaculty of Agriculture, Kyushu University, Fukuoka, Japan
,
Mayumi HatakeyamaFaculty of Agriculture, Kyushu University, Fukuoka, Japan
,
Takuto KosakiDivision of Chemistry, Graduate School of Science, Hokkaido University, Sapporo, Japan
,
Katsuya GomiGraduate School of Agricultural Science, Tohoku University, Sendai, Japan
,
Isao FujiiSchool of Pharmacy, Iwate Medical University, Yahaba, Japan
,
Atsushi MinamiDivision of Chemistry, Graduate School of Science, Hokkaido University, Sapporo, Japan
&
Hideaki OikawaDivision of Chemistry, Graduate School of Science, Hokkaido University, Sapporo, JapanCorrespondence[email protected]
 show all
Pages 426-431 | Received 10 Jul 2015, Accepted 16 Sep 2015, Published online: 05 Nov 2015

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Hideaki Oikawa. (2020) Reconstitution of biosynthetic machinery of fungal natural products in heterologous hosts. Bioscience, Biotechnology, and Biochemistry 84:3, pages 433-444.
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Junya Takino, Takuto Kozaki, Taro Ozaki, Chengwei Liu, Atsushi Minami & Hideaki Oikawa. (2019) Elucidation of biosynthetic pathway of a plant hormone abscisic acid in phytopathogenic fungi. Bioscience, Biotechnology, and Biochemistry 83:9, pages 1642-1649.
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Zi Yun Fan, Jing Peng, Jun Qiao Lou, Yong Chen, Xue Ming Wu, Rui Tan & Ren Xiang Tan. (2023) Neuroprotective α-pyrones from Nigrospora oryzae, an endophytic fungus residing in Taxus chinensis var. mairei. Phytochemistry, pages 113873.
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Zhenger Wu, Heng Guo, Qilin Wu, Minghua Jiang, Junjie Chen, Bin Chen, Hanxiang Li, Lan Liu & Senhua Chen. (2023) Absolute configuration of cyclopropanes and the structural revision of pyrones from Marine-derived fungus Stagonospora sp. SYSU-MS7888. Bioorganic Chemistry 136, pages 106542.
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Lan Jiang, Kangjie Lv, Guoliang Zhu, Zhi Lin, Xue Zhang, Cuiping Xing, Huanting Yang, Weiyan Zhang, Zhixin Wang, Chengwei Liu, Xudong Qu, Tom Hsiang, Lixin Zhang & Xueting Liu. (2022) Norditerpenoids biosynthesized by variediene synthase-associated P450 machinery along with modifications by the host cell Aspergillus oryzae. Synthetic and Systems Biotechnology 7:4, pages 1142-1147.
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Akari Kotani, Taro Ozaki, Junya Takino, Susumu Mochizuki, Kazuya Akimitsu, Atsushi Minami & Hideaki Oikawa. (2022) Heterologous expression of a polyketide synthase ACRTS2 in Aspergillus oryzae produces host-selective ACR toxins: coproduction of minor metabolites . Bioscience, Biotechnology, and Biochemistry 86:3, pages 287-293.
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Mary L. Shenouda, Maria Ambilika & Russell J. Cox. (2021) Trichoderma reesei Contains a Biosynthetic Gene Cluster That Encodes the Antifungal Agent Ilicicolin H. Journal of Fungi 7:12, pages 1034.
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Lukas Kahlert, Darlon Bernardi, Maurice Hauser, Laura P. Ióca, Roberto G. S. Berlinck, Elizabeth J. Skellam & Russell J. Cox. (2021) Early Oxidative Transformations During the Biosynthesis of Terrein and Related Natural Products. Chemistry – A European Journal 27:46, pages 11895-11903.
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Lukas Kahlert, Carsten Schotte & Russell J. Cox. (2021) Total Mycosynthesis: Rational Bioconstruction and Bioengineering of Fungal Natural Products. Synthesis 53:14, pages 2381-2394.
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Haili Zhang, Verena Hantke, Pia Bruhnke, Elizabeth J. Skellam & Russell J. Cox. (2021) Chemical and Genetic Studies on the Formation of Pyrrolones During the Biosynthesis of Cytochalasans. Chemistry – A European Journal 27:9, pages 3106-3113.
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Hideaki OIKAWA. (2020) Heterologous production of fungal natural products: Reconstitution of biosynthetic gene clusters in model host <i>Aspergillus oryzae</i>. Proceedings of the Japan Academy, Series B 96:9, pages 420-430.
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Taishi Inoue, Hiroki Toji, Mizuki Tanaka, Mitsuru Takama, Sachiko Hasegawa-Shiro, Yuichi Yamaki, Takahiro Shintani & Katsuya Gomi. (2020) Alternative transcription start sites of the enolase-encoding gene enoA are stringently used in glycolytic/gluconeogenic conditions in Aspergillus oryzae. Current Genetics 66:4, pages 729-747.
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Francesco Trenti, Karen E. Lebe, Emilie Adelin, Jamal Ouazzani, Carsten Schotte & Russell J. Cox. (2020) Investigating the biosynthesis of Sch-642305 in the fungus Phomopsis sp. CMU-LMA . RSC Advances 10:46, pages 27369-27376.
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Mikkel Rank Nielsen, Rasmus Dam Wollenberg, Klaus Ringsborg Westphal, Teis Esben Sondergaard, Reinhard Wimmer, Donald Max Gardiner & Jens Laurids Sørensen. (2019) Heterologous expression of intact biosynthetic gene clusters in Fusarium graminearum. Fungal Genetics and Biology 132, pages 103248.
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Jens C. Frisvad, Lars L. H. Møller, Thomas O. Larsen, Ravi Kumar & José Arnau. (2018) Safety of the fungal workhorses of industrial biotechnology: update on the mycotoxin and secondary metabolite potential of Aspergillus niger, Aspergillus oryzae, and Trichoderma reesei. Applied Microbiology and Biotechnology 102:22, pages 9481-9515.
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Akihiro Tazawa, Ying Ye, Taro Ozaki, Chengwei Liu, Yasushi Ogasawara, Tohru Dairi, Yusuke Higuchi, Nobuo Kato, Katsuya Gomi, Atsushi Minami & Hideaki Oikawa. (2018) Total Biosynthesis of Brassicicenes: Identification of a Key Enzyme for Skeletal Diversification. Organic Letters 20:19, pages 6178-6182.
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Koji Narita, Atsushi Minami, Taro Ozaki, Chengwei Liu, Motoichiro Kodama & Hideaki Oikawa. (2018) Total Biosynthesis of Antiangiogenic Agent (−)-Terpestacin by Artificial Reconstitution of the Biosynthetic Machinery in Aspergillus oryzae . The Journal of Organic Chemistry 83:13, pages 7042-7048.
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Yi He, Bin Wang, Wanping Chen, Russell J. Cox, Jingren He & Fusheng Chen. (2018) Recent advances in reconstructing microbial secondary metabolites biosynthesis in Aspergillus spp.. Biotechnology Advances 36:3, pages 739-783.
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Elizabeth Skellam. (2017) The biosynthesis of cytochalasans. Natural Product Reports 34:11, pages 1252-1263.
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Takahiro Ugai, Atsushi Minami, Katsuya Gomi & Hideaki Oikawa. (2016) Genome mining approach for harnessing the cryptic gene cluster in Alternaria solani: production of PKS–NRPS hybrid metabolite, didymellamide B. Tetrahedron Letters 57:25, pages 2793-2796.
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Koji Narita, Ryota Chiba, Atsushi Minami, Motoichiro Kodama, Isao Fujii, Katsuya Gomi & Hideaki Oikawa. (2016) Multiple Oxidative Modifications in the Ophiobolin Biosynthesis: P450 Oxidations Found in Genome Mining. Organic Letters 18:9, pages 1980-1983.
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Hideaki Oikawa, Atsushi Minami & Chengwei Liu. (2016) Total Biosynthesis of Fungal Indole Diterpenes Using Cell Factories. HETEROCYCLES 92:3, pages 397.
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