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Ocular Immunology and Inflammation Volume 27, 2019 - Issue 5
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Original Articles

Methylene Blue Attenuates Diabetic Retinopathy by Inhibiting NLRP3 Inflammasome Activation in STZ-Induced Diabetic Rats

Jingfang HaoThe Affiliated Hospital of Medical College, Ningbo University, Ningbo, ChinaView further author information
,
Hongkui ZhangThe Affiliated Hospital of Medical College, Ningbo University, Ningbo, ChinaView further author information
,
Jibing YuThe Affiliated Hospital of Medical College, Ningbo University, Ningbo, ChinaView further author information
,
Xi ChenThe Affiliated Hospital of Medical College, Ningbo University, Ningbo, ChinaView further author information
&
Lu YangThe Affiliated Hospital of Medical College, Ningbo University, Ningbo, ChinaCorrespondence[email protected]
View further author information
Pages 836-843 | Received 15 Dec 2017, Accepted 06 Mar 2018, Published online: 02 Apr 2018

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Yu Gao, Zhounan Jiang, Bin Xu, Ran Mo, Shiyan Li, Yanan Jiang, Demei Zhao, Wangbin Cao, Bin Chen, Meng Tian & Qian Tan. (2023) Evaluation of topical methylene blue nanoemulsion for wound healing in diabetic mice. Pharmaceutical Biology 61:1, pages 1462-1473.
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Karanvir S. Raman & Joanne A. Matsubara. (2022) Dysregulation of the NLRP3 Inflammasome in Diabetic Retinopathy and Potential Therapeutic Targets. Ocular Immunology and Inflammation 30:2, pages 470-478.
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Zhiqiang Ye, Xiaoli Li, Dongliang Zheng, Shuaili Pei, Pei Cheng, Lishu Zhang & Lin Zhu. (2022) Intravitreally Injected Methylene Blue Protects Retina against Acute Ocular Hypertension in Rats. Current Eye Research 47:1, pages 91-101.
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Abdullah Al Mamun, Yanqing Wu, Fatema Nasrin, Afroza Akter, Masuma Afrin Taniya, Fahad Munir, Chang Jia & Jian Xiao. (2021) Role of Pyroptosis in Diabetes and Its Therapeutic Implications. Journal of Inflammation Research 14, pages 2187-2206.
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Articles from other publishers (21)

Weiye Li & Jingfa Zhang. 2024. Therapeutic Targets for Diabetic Retinopathy. Therapeutic Targets for Diabetic Retinopathy 113 143 .
Tingting Bao, Xiangyuan Zhang, Weinan Xie, Ying Wang, Xiuyang Li, Cheng Tang, Yingying Yang, Jun Sun, Jiaqi Gao, Tongyue Yu, Linhua Zhao & Xiaolin Tong. (2023) Natural compounds efficacy in complicated diabetes: A new twist impacting ferroptosis. Biomedicine & Pharmacotherapy 168, pages 115544.
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Ke-Xin Sun, Yan-Yi Chen, Zhen Li, Shi-Jie Zheng, Wen-Juan Wan, Yan Ji & Ke Hu. (2023) Genipin relieves diabetic retinopathy by down-regulation of advanced glycation end products via the mitochondrial metabolism related signaling pathway. World Journal of Diabetes 14:9, pages 1349-1368.
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Yuyang Chen, Munire AiliFan ChenYu GongXiaoju ChenLan Zhang. (2023) Drugs Targeting NLRP3 Inflammasome in the Treatment of Diabetic Bone Disorders. Endocrine, Metabolic & Immune Disorders - Drug Targets 23:10, pages 1265-1277.
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Daniela Maria Tanase, Emilia Valasciuc, Evelina Maria Gosav, Anca Ouatu, Oana Nicoleta Buliga-Finis, Mariana Floria, Minela Aida Maranduca & Ionela Lacramioara Serban. (2023) Portrayal of NLRP3 Inflammasome in Atherosclerosis: Current Knowledge and Therapeutic Targets. International Journal of Molecular Sciences 24:9, pages 8162.
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Xiaoqin Zheng, Jia Wan & Gang Tan. (2023) The mechanisms of NLRP3 inflammasome/pyroptosis activation and their role in diabetic retinopathy. Frontiers in Immunology 14.
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Yan Huang, Jun Peng & Qiuhua Liang. (2023) Identification of key ferroptosis genes in diabetic retinopathy based on bioinformatics analysis. PLOS ONE 18:1, pages e0280548.
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Meini Chen, Rong Rong & Xiaobo Xia. (2022) Spotlight on pyroptosis: role in pathogenesis and therapeutic potential of ocular diseases. Journal of Neuroinflammation 19:1.
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Juliette Hepburn, Susan Williams-Lockhart, René Jean Bensadoun & Reem Hanna. (2022) A Novel Approach of Combining Methylene Blue Photodynamic Inactivation, Photobiomodulation and Oral Ingested Methylene Blue in COVID-19 Management: A Pilot Clinical Study with 12-Month Follow-Up. Antioxidants 11:11, pages 2211.
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Mengyuan Liu, Haibo Li, Rongliang Yang, Dan Ji & Xiaobo Xia. (2022) GSK872 and necrostatin-1 protect retinal ganglion cells against necroptosis through inhibition of RIP1/RIP3/MLKL pathway in glutamate-induced retinal excitotoxic model of glaucoma. Journal of Neuroinflammation 19:1.
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Junling Gu, Kang Geng, Man Guo, Wei Huang, Tingting Zhao, Xuling Li, You-Hua Xu & Yong Xu. (2022) Targeting Pyroptosis: New Insights into the Treatment of Diabetic Microvascular Complications. Evidence-Based Complementary and Alternative Medicine 2022, pages 1-11.
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Sheng Gao, Yun Zhang & Meixia Zhang. (2022) Targeting Novel Regulated Cell Death: Pyroptosis, Necroptosis, and Ferroptosis in Diabetic Retinopathy. Frontiers in Cell and Developmental Biology 10.
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Hallie M. Blevins, Yiming Xu, Savannah Biby & Shijun Zhang. (2022) The NLRP3 Inflammasome Pathway: A Review of Mechanisms and Inhibitors for the Treatment of Inflammatory Diseases. Frontiers in Aging Neuroscience 14.
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Tsunehiko Ikeda, Kimitoshi Nakamura, Teruyo Kida & Hidehiro Oku. (2021) Possible roles of anti-type II collagen antibody and innate immunity in the development and progression of diabetic retinopathy. Graefe's Archive for Clinical and Experimental Ophthalmology 260:2, pages 387-403.
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Chunren Meng, Chufeng Gu, Shuai He, Tong Su, Thashi Lhamo, Deji Draga & Qinghua Qiu. (2021) Pyroptosis in the Retinal Neurovascular Unit: New Insights Into Diabetic Retinopathy. Frontiers in Immunology 12.
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Abdullah Al Mamun, Anjuman Ara Mimi, Muhammad Zaeem, Yanqing Wu, Ilma Monalisa, Afroza Akter, Fahad Munir & Jian Xiao. (2021) Role of pyroptosis in diabetic retinopathy and its therapeutic implications. European Journal of Pharmacology 904, pages 174166.
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Patricia Fernandez-Robredo, Jorge González-Zamora, Sergio Recalde, Valentina Bilbao-Malavé, Jaione Bezunartea, Maria Hernandez & Alfredo Garcia-Layana. (2020) Vitamin D Protects against Oxidative Stress and Inflammation in Human Retinal Cells. Antioxidants 9:9, pages 838.
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Rayne R. Lim, Margaret E. Wieser, Rama R. Ganga, Veluchamy A. Barathi, Rajamani Lakshminarayanan, Rajiv R. Mohan, Dean P. Hainsworth & Shyam S. Chaurasia. (2020) NOD-like Receptors in the Eye: Uncovering Its Role in Diabetic Retinopathy. International Journal of Molecular Sciences 21:3, pages 899.
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Yvette Wooff, Si Ming Man, Riemke Aggio-Bruce, Riccardo Natoli & Nilisha Fernando. (2019) IL-1 Family Members Mediate Cell Death, Inflammation and Angiogenesis in Retinal Degenerative Diseases. Frontiers in Immunology 10.
Crossref
Chaobin Lin, Fujin Wu, Tongmei Zheng, Xiuchun Wang, Yiwei Chen & Xiaomin Wu. (2018) Kaempferol attenuates retinal ganglion cell death by suppressing NLRP1/NLRP3 inflammasomes and caspase-8 via JNK and NF-κB pathways in acute glaucoma. Eye 33:5, pages 777-784.
Crossref
Richard E. Kast. (2018) Inhibiting the NLRP3 Inflammasome With Methylene Blue as Treatment Adjunct in Myelodysplasia. Frontiers in Oncology 8.
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