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Ocular Immunology and Inflammation Volume 27, 2019 - Issue 6
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Original Articles

Topical Quercetin and Resveratrol Protect the Ocular Surface in Experimental Dry Eye Disease

Antonio Abengózar-VelaIOBA, University of Valladolid, Valladolid, SpainORCID Iconhttps://orcid.org/0000-0002-9604-9946View further author information
, PhDORCID Icon,
Chris S. SchaumburgBiological Sciences, Inflammation Research Program, Allergan, Inc., Irvine, CA, USAView further author information
, PhD,
Michael E. SternBiological Sciences, Inflammation Research Program, Allergan, Inc., Irvine, CA, USAView further author information
, PhD,
Margarita CalongeIOBA, University of Valladolid, Valladolid, Spain;Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Valladolid, SpainORCID Iconhttps://orcid.org/0000-0001-8178-4836View further author information
, MD, PhDORCID Icon,
Amalia Enríquez-de-SalamancaIOBA, University of Valladolid, Valladolid, Spain;Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Valladolid, SpainORCID Iconhttps://orcid.org/0000-0003-1274-7796View further author information
, PhDORCID Icon &
María Jesús González-GarcíaIOBA, University of Valladolid, Valladolid, Spain;Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Valladolid, SpainCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-3673-0585View further author information
, PhDORCID Icon
Pages 1023-1032 | Received 15 Jan 2018, Accepted 03 Jul 2018, Published online: 10 Aug 2018

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Miłosz Caban, Katarzyna Owczarek, Katarzyna Chojnacka & Urszula Lewandowska. (2022) Overview of Polyphenols and Polyphenol-rich Extracts as Modulators of Inflammatory Response in Dry Eye Syndrome. Food Reviews International 38:sup1, pages 501-528.
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Bruno Vincenzo Fiod Riccio, Bruno Fonseca-Santos, Priscileila Colerato Ferrari & Marlus Chorilli. (2020) Characteristics, Biological Properties and Analytical Methods of Trans-Resveratrol: A Review. Critical Reviews in Analytical Chemistry 50:4, pages 339-358.
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Articles from other publishers (31)

Jing Feng & Yangyang Zhang. (2023) The potential benefits of polyphenols for corneal diseases. Biomedicine & Pharmacotherapy 169, pages 115862.
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Vahideh Ghorani, Saeideh Saadat, Mohammad Reza Khazdair, Zahra Gholamnezhad, Hesham El-Seedi & Mohammad Hossein Boskabady. (2023) Phytochemical Characteristics and Anti-Inflammatory, Immunoregulatory, and Antioxidant Effects of Portulaca oleracea L.: A Comprehensive Review. Evidence-Based Complementary and Alternative Medicine 2023, pages 1-29.
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Chang Ho Yoon, Hyun-Jae Jang, Jin Suk Ryu, Jung Hwa Ko, Kyung-Seop Ahn, Sei-Ryang Oh, Jang-Hee Oh, Jin Ho Chung & Joo Youn Oh. (2023) 1,5-Dicaffeoylquinic acid from Pseudognaphalium affine ameliorates dry eye disease via suppression of inflammation and protection of the ocular surface. The Ocular Surface 29, pages 469-479.
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Umberto Rodella, Claudia Honisch, Claudio Gatto, Paolo Ruzza & Jana D’Amato Tóthová. (2023) Antioxidant Nutraceutical Strategies in the Prevention of Oxidative Stress Related Eye Diseases. Nutrients 15:10, pages 2283.
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Rohit Shetty, Parth D Joshi, Krithikaa Mahendran, Chaitra Jayadev & Debashish Das. (2023) Resveratrol for dry eye disease – Hope or Hype?. Indian Journal of Ophthalmology 71:4, pages 1270-1275.
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Archana Padmanabhan Nair, Sharon D’Souza, Pooja Khamar, Rudy M M A Nuijts, Swaminathan Sethu & Rohit Shetty. (2023) Ocular surface immune cell diversity in dry eye disease. Indian Journal of Ophthalmology 71:4, pages 1237-1247.
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Cassandra Bonnie Huynh, Nijani Nagaarudkumaran, Subha Kalyaanamoorthy & William Ngo. (2023) In Silico and In Vitro Approach for Validating the Inhibition of Matrix Metalloproteinase-9 by Quercetin. Eye & Contact Lens: Science & Clinical Practice Publish Ahead of Print.
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Joicye Hernández‐Zulueta, José Navarro‐Partida, Oscar Eduardo Sánchez‐Aguilar, Héctor Daniel Santa Cruz‐Pavlovich, Carlos Rodrigo Castro‐Castañeda & Alejandro González‐De la Rosa. (2023) An insight on the eye bacterial microbiota and its role on dry eye disease. APMIS 131:3, pages 103-111.
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Kristína Krajčíková, Agnieszka Balicka, Mária Lapšanská, Alexandra Trbolová, Zuzana Guľašová, Daria Kondrakhova, Vladimír Komanický, Adriana Rašiová & Vladimíra Tomečková. (2023) The Effects of Fisetin on Cyclosporine-Treated Dry Eye Disease in Dogs. International Journal of Molecular Sciences 24:2, pages 1488.
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Deborah M. Hegarty, James R. Carroll, Dennis Nguyen, Victoria S. Halls, Dennis I. Robbins, Theodore J. Price, Gregory Dussor & Sue A. Aicher. (2022) Resveratrol increases tear production and ocular pain after corneal abrasion in male, but not female, rats using a photorefractive keratectomy model. Experimental Eye Research 225, pages 109281.
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Gamze Dereli Can, Gökçe Taner & Çiğdem İnci Aydemir. (2022) Evaluation of the cytotoxic and genotoxic/antigenotoxic effects of resveratrol in human limbal explant cultures. International Ophthalmology 43:6, pages 1977-1985.
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Takaaki Inaba, Mayumi Ohnishi-Kameyama, Ying Liu, Yasuhisa Tanaka, Masuko Kobori, Shusaku Tamaki, Tomotaka Ito, Kazunari Higa, Jun Shimazaki & Kazuo Tsubota. (2022) Quercetin improves lacrimal gland function through its anti-oxidant actions: Evidence from animal studies, and a pilot study in healthy human volunteers. Frontiers in Nutrition 9.
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Kara M. Cavuoto & Angela Y. Zhu. (2022) The Role of the Ocular Surface Microbiome (OSM) in Diseases of the Anterior Segment and Ocular Surface. Current Ophthalmology Reports 10:4, pages 179-187.
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Nikolaos Katsinas, Uta Gehlsen, Laura García-Posadas, Soraya Rodríguez-Rojo, Philipp Steven, María J. González-García & Amalia Enríquez-de-Salamanca. (2022) Olive Pomace Phenolic Compounds: From an Agro-Industrial By-Product to a Promising Ocular Surface Protection for Dry Eye Disease. Journal of Clinical Medicine 11:16, pages 4703.
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Luna Krstić, Pekka Jarho, Marika Ruponen, Arto Urtti, María J. González-García & Yolanda Diebold. (2022) Improved ocular delivery of quercetin and resveratrol: A comparative study between binary and ternary cyclodextrin complexes. International Journal of Pharmaceutics 624, pages 122028.
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Anna Bryl, Mariusz Falkowski, Katarzyna Zorena & Małgorzata Mrugacz. (2022) The Role of Resveratrol in Eye Diseases—A Review of the Literature. Nutrients 14:14, pages 2974.
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Jingyao Chen, Weijia Zhang, Yixin Zheng & Yanze Xu. (2022) Ameliorative Potential of Resveratrol in Dry Eye Disease by Restoring Mitochondrial Function. Evidence-Based Complementary and Alternative Medicine 2022, pages 1-10.
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Jie Deng, Deqing Lin, Xiangyu Ding, Yuan Wang, YuHan Hu, Hui Shi, Lin Chen, Bingyang Chu, Lei Lei, Chunmei Wen, Jiaqing Wang, Zhiyong Qian & Xingyi Li. (2022) Multifunctional Supramolecular Filament Hydrogel Boosts Anti‐Inflammatory Efficacy In Vitro and In Vivo. Advanced Functional Materials 32:16.
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Mohammad Hossein Boskabady, Mohammad Reza Khazdair, Arghavan Memarzia & Seyyedeh Zahra Ghasemi. 2022. Herbal Biomolecules in Healthcare Applications. Herbal Biomolecules in Healthcare Applications 551 572 .
Mohammad Reza Khazdair, Zahra Gholamnezhad, Ramin Rezaee & Mohammad Hossein Boskabady. (2021) Immuno-modulatory and anti-inflammatory effects of Thymus vulgaris, Zataria multiflora, and Portulaca oleracea and their constituents. Pharmacological Research - Modern Chinese Medicine 1, pages 100010.
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Lianghui Zhao, Hongwei Wang & Xianli Du. (2021) The therapeutic use of quercetin in ophthalmology: recent applications. Biomedicine & Pharmacotherapy 137, pages 111371.
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María Vivero-Lopez, Andrea Muras, Diana Silva, Ana Paula Serro, Ana Otero, Angel Concheiro & Carmen Alvarez-Lorenzo. (2021) Resveratrol-Loaded Hydrogel Contact Lenses with Antioxidant and Antibiofilm Performance. Pharmaceutics 13:4, pages 532.
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Gaia Favero, Enrico Moretti, Kristína Krajčíková, Vladimíra Tomečková & Rita Rezzani. (2021) Evidence of Polyphenols Efficacy against Dry Eye Disease. Antioxidants 10:2, pages 190.
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Luna Krstić, María J. González-García & Yolanda Diebold. (2021) Ocular Delivery of Polyphenols: Meeting the Unmet Needs. Molecules 26:2, pages 370.
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Rohit ShettyMurali SubramaniPonnalagu MurugeswariVenkata Ramana Anandula, Himanshu MataliaChaitra JayadevArkasubhra GhoshDebashish Das. (2020) Resveratrol Rescues Human Corneal Epithelial Cells Cultured in Hyperosmolar Conditions: Potential for Dry Eye Disease Treatment. Cornea 39:12, pages 1520-1532.
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Tin-Yun Ho, Hsin-Yi Lo, I-Chen Liu, Ken-An Lin, Yi-Fang Liao, Yuan-Chun Lo & Chien-Yun Hsiang. (2020) The protective effect of quercetin on retinal inflammation in mice: the involvement of tumor necrosis factor/nuclear factor-κB signaling pathways. Food & Function 11:9, pages 8150-8160.
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Francesco Petrillo, Danilo Pignataro, Maria Annunziata Lavano, Biagio Santella, Veronica Folliero, Carla Zannella, Carlo Astarita, Caterina Gagliano, Gianluigi Franci, Teresio Avitabile & Marilena Galdiero. (2020) Current Evidence on the Ocular Surface Microbiota and Related Diseases. Microorganisms 8:7, pages 1033.
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Minal Thacker, Ching-Li Tseng, Chih-Yen Chang, Subhaini Jakfar, Hsuan Yu Chen & Feng-Huei Lin. (2020) Mucoadhesive Bletilla striata Polysaccharide-Based Artificial Tears to Relieve Symptoms and Inflammation in Rabbit with Dry Eyes Syndrome. Polymers 12:7, pages 1465.
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Marco Pellegrini, Carlotta Senni, Federico Bernabei, Arrigo F. G. Cicero, Aldo Vagge, Antonio Maestri, Vincenzo Scorcia & Giuseppe Giannaccare. (2020) The Role of Nutrition and Nutritional Supplements in Ocular Surface Diseases. Nutrients 12:4, pages 952.
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Azadeh Tavakoli & Judith Louise Flanagan. (2019) The Case for a More Holistic Approach to Dry Eye Disease: Is It Time to Move beyond Antibiotics?. Antibiotics 8:3, pages 88.
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Simona Bungau, Mohamed M. Abdel-Daim, Delia Mirela Tit, Esraa Ghanem, Shimpei Sato, Maiko Maruyama-Inoue, Shin Yamane & Kazuaki Kadonosono. (2019) Health Benefits of Polyphenols and Carotenoids in Age-Related Eye Diseases. Oxidative Medicine and Cellular Longevity 2019, pages 1-22.
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