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Ocular Immunology and Inflammation Volume 28, 2020 - Issue 3
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Original Article

Evaluation of the Efficacy and Safety of A Novel 0.05% Cyclosporin A Topical Nanoemulsion in Primary Sjögren’s Syndrome Dry Eye

Min-Ji KangDepartment of Ophthalmology and Visual Science, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea;Catholic Institute for Visual Science, College of Medicine, The Catholic University of Korea, Seoul, Republic of KoreaView further author information
, MD,
Youn-Hee KimDepartment of Ophthalmology and Visual Science, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of KoreaView further author information
, BS,
Miyoung ChouDepartment of Ophthalmology and Visual Science, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of KoreaView further author information
, MD,
Jehyung HwangDepartment of Ophthalmology, Sanggye Paik Hospital, Seoul, KoreaORCID Iconhttps://orcid.org/0000-0001-8081-7771View further author information
, MDORCID Icon,
Eun-Jeong CheonDepartment of Ophthalmology and Visual Science, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of KoreaView further author information
, MS,
Hyun-Jung LeeDepartment of Biochemical Engineering, Seoil University, Seoul, Republic of KoreaView further author information
, PhD &
So-Hyang ChungDepartment of Ophthalmology and Visual Science, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea;Catholic Institute for Visual Science, College of Medicine, The Catholic University of Korea, Seoul, Republic of KoreaCorrespondence[email protected]
View further author information
, MD, PhD show all
Pages 370-378 | Received 28 Oct 2018, Accepted 22 Feb 2019, Published online: 15 Apr 2019

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Julie M Schallhorn, Selina McGee, Jeffrey Nau, Marian Macsai, Andrea Gibson, Gretchen Blemker, Laura H Hendrix & Mina Massaro-Giordano. (2023) OC-01 (Varenicline Solution) Nasal Spray for the Treatment of Dry Eye Disease Signs and Symptoms in Subjects with Autoimmune Disease: Integrated Data from ONSET-1 and ONSET-2. Clinical Ophthalmology 17, pages 725-734.
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Wenyan Peng, Xiuying Jiang, Lei Zhu, Xiaofeng Li, Qizhi Zhou, Ying Jie, Zhipeng You, Miaoqin Wu, Xiuming Jin, Xiaoyi Li & Shiyou Zhou. (2022) Cyclosporine A (0.05%) Ophthalmic Gel in the Treatment of Dry Eye Disease: A Multicenter, Randomized, Double-Masked, Phase III, COSMO Trial. Drug Design, Development and Therapy 16, pages 3183-3194.
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Mingjun Gao, Lin Zhao, Ran Liang, Qing Zhu, Qi Zhao & Xiaodan Kong. (2022) Evaluation of the Efficacy and Safety of Topical 0.05% Cyclosporine Eye Drops (II) in the Treatment of Dry Eye Associated with Primary Sjögren’s Syndrome. Ocular Immunology and Inflammation 0:0, pages 1-7.
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Articles from other publishers (17)

Omur O. Ucakhan, Tuna Celik-Buyuktepe, Lin Yang, Brian Wogu & Penny A. Asbell. (2023) Update on Dry Eye Disease Treatment: Evidence From Randomized Controlled Trials. Eye & Contact Lens: Science & Clinical Practice 49:12, pages 542-568.
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Jing Wei, Jinyu Mu, Yong Tang, Dalian Qin, Junguo Duan & Anguo Wu. (2023) Next-generation nanomaterials: advancing ocular anti-inflammatory drug therapy. Journal of Nanobiotechnology 21:1.
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Jae-Gon KimJae-Hong AnSoon Young ChoChong Eun LeeKyu Young ShimJong Hwa Jun. (2023) Efficacy of Topical 0.05% Cyclosporine A for Ocular Surface Disease Related to Topical Anti-Glaucoma Medications. Journal of Ocular Pharmacology and Therapeutics 39:6, pages 389-397.
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Vineet Pramod Joshi, Swati Singh, Minal Thacker, Falguni Pati, Geeta K Vemuganti, Sayan Basu & Vivek Singh. (2023) Newer approaches to dry eye therapy: Nanotechnology, regenerative medicine, and tissue engineering. Indian Journal of Ophthalmology 71:4, pages 1292-1303.
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Youngsub EomKyung Chul Yoon, Hong Kyun KimJong Suk SongJoon Young Hyon & Hyo Myung Kim. (2023) A Multicenter, Randomized, Double-Blind Evaluation of the Efficacy of TJO-087 Versus 0.05% Cyclosporine A in Moderate to Severe Dry Eye. Journal of Ocular Pharmacology and Therapeutics 39:1, pages 27-35.
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Minal Thacker, Vivek Singh, Sayan Basu & Swati Singh. (2023) Biomaterials for dry eye disease treatment: Current overview and future perspectives. Experimental Eye Research 226, pages 109339.
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Lianfei Fang, Jin Liu, Zeyang Liu & Huifang Zhou. (2022) Immune modulating nanoparticles for the treatment of ocular diseases. Journal of Nanobiotechnology 20:1.
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Dongyang Gao, Zhuoli Da, Kan Yang & Yuanyuan Shi. (2022) Comparison of seven cyclosporine A formulations for dry eye disease: A systematic review and network meta-analysis. Frontiers in Pharmacology 13.
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Semra Ozdemir, Sharon Wan Jie Yeo, Jia Jia Lee, Adithya Bhaskar, Eric Finkelstein & Louis Tong. (2022) Patient Medication Preferences for Managing Dry Eye Disease: The Importance of Medication Side Effects. The Patient - Patient-Centered Outcomes Research 15:6, pages 679-690.
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Fabiola Atzeni, Francesco Gozza, Giacomo Cafaro, Carlo Perricone & Elena Bartoloni. (2022) Cardiovascular Involvement in Sjögren’s Syndrome. Frontiers in Immunology 13.
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Jay Won Rhim, Youngsub Eom, Eun Gyu Yoon, Seo Yeon Park, Young Choi, Jong Suk Song & Hyo Myung Kim. (2022) Efficacy of a 0.05% cyclosporine a topical nanoemulsion in dry eyes with obstructive meibomian gland dysfunction. Japanese Journal of Ophthalmology 66:3, pages 254-263.
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Celine R. Garcia, Muhammad H. Malik, Sujit Biswas, Vincent H. Tam, Kendra P. Rumbaugh, Wei Li & Xinli Liu. (2022) Nanoemulsion delivery systems for enhanced efficacy of antimicrobials and essential oils. Biomaterials Science 10:3, pages 633-653.
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Sara Zandonella Callegher, Ivan Giovannini, Sabine Zenz, Valeria Manfrè, Martin H. Stradner, Alojzija Hocevar, Marwin Gutierrez, Luca Quartuccio, Salvatore De Vita & Alen Zabotti. (2022) Sjögren syndrome: looking forward to the future. Therapeutic Advances in Musculoskeletal Disease 14, pages 1759720X2211002.
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Mehmet Ozgur Cubuk, Ahmet Yucel Ucgul, Armagan Ozgur, Kemal Ozulken & Erdem Yuksel. (2021) Topical cyclosporine a (0.05%) treatment in dry eye patients: a comparison study of Sjogren’s syndrome versus non-Sjogren’s syndrome. International Ophthalmology 41:4, pages 1479-1485.
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Nurhan Sutcliffe, Alberto Recchioni, Shireen Hilmi, Saaeha Rauz & Anwar R Tappuni. (2021) What’s new in ocular and oral aspects of Sjögren’s syndrome and do new treatments work?. Rheumatology 60:3, pages 1034-1041.
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Amandine Gendron, Natalie Lan Linh Tran, Julie Laloy, Romain Brusini, Aurélie Rachet, Frédéric Gobeaux, Valérie Nicolas, Pierre Chaminade, Sonia Abreu, Didier Desmaële & Mariana Varna. (2021) New Nanoparticle Formulation for Cyclosporin A: In Vitro Assessment. Pharmaceutics 13:1, pages 91.
Crossref
Tamilvanan ShunmugaperumalSyed Nazrin Ruhina Rahman & Tamilvanan Shunmugaperumal. 2020. Oil‐in‐Water Nanosized Emulsions for Drug Delivery and Targeting. Oil‐in‐Water Nanosized Emulsions for Drug Delivery and Targeting 69 167 .

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