354
Views
87
CrossRef citations to date
0
Altmetric
Original Article

Platelets are covercytes, not phagocytes: Uptake of bacteria involves channels of the open canalicular system

Pages 121-131 | Published online: 07 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (5)

Luca Roncati, Giulia Ligabue, Vincenzo Nasillo, Beatrice Lusenti, William Gennari, Luca Fabbiani, Claudia Malagoli, Graziana Gallo, Silvia Giovanella, Massimo Lupi, Tiziana Salviato, Ambra Paolini, Matteo Costantini, Tommaso Trenti & Antonio Maiorana. (2020) A proof of evidence supporting abnormal immunothrombosis in severe COVID-19: naked megakaryocyte nuclei increase in the bone marrow and lungs of critically ill patients. Platelets 31:8, pages 1085-1089.
Read now
Peipei Xu, Ruju Wang, Xiaohui Wang & Jian Ouyang. (2016) Recent advancements in erythrocytes, platelets, and albumin as delivery systems. OncoTargets and Therapy 9, pages 2873-2884.
Read now
Elena Gupalo, Cynthia Kuk, Mohammad Qadura, Liudmila Buriachkovskaia & Maha Othman. (2013) Platelet–adenovirus vs. inert particles interaction: Effect on aggregation and the role of platelet membrane receptors. Platelets 24:5, pages 383-391.
Read now
James G. White. (2006) Why human platelets fail to kill bacteria. Platelets 17:3, pages 191-200.
Read now
Siham Boukour & Elisabeth M. Cramer. (2005) Platelet interaction with bacteria. Platelets 16:3-4, pages 215-217.
Read now

Articles from other publishers (82)

Fryad M. Rahman. (2023) Immunological Role of Megakaryocytes and Platelets during Influenza A Virus Infection. ARO-THE SCIENTIFIC JOURNAL OF KOYA UNIVERSITY 11:2, pages 1-16.
Crossref
Silvia M. G. Trivigno, Gianni Francesco Guidetti, Silvia Stella Barbieri & Marta Zarà. (2023) Blood Platelets in Infection: The Multiple Roles of the Platelet Signalling Machinery. International Journal of Molecular Sciences 24:8, pages 7462.
Crossref
Galit H. Frydman, Felix Ellett, Julianne Jorgensen, Anika L. Marand, Lawrence Zukerberg, Martin K. Selig, Shannon N. Tessier, Keith H. K. Wong, David Olaleye, Charles R. Vanderburg, James G. Fox, Ronald G. Tompkins & Daniel Irimia. (2023) Megakaryocytes respond during sepsis and display innate immune cell behaviors. Frontiers in Immunology 14.
Crossref
Lifeng Luo, Zhong Chen, Tong Gong, Qingsong Ye, Hao Li, Yunfei Guo, Jiqiu Wen, Yiqiao Hu & Jinhui Wu. (2023) Cytosolic perfluorocarbon delivery to platelets via albumin for antithrombotic therapy. Journal of Controlled Release 355, pages 109-121.
Crossref
Hajar El Filaly, Meryem Mabrouk, Farah Atifi, Fadila Guessous, Khadija Akarid, Yahye Merhi & Younes Zaid. (2023) Dissecting Platelet’s Role in Viral Infection: A Double-Edged Effector of the Immune System. International Journal of Molecular Sciences 24:3, pages 2009.
Crossref
Julia van der Linde, Stephan Diedrich, Thorben Klee, Claus-Dieter Heidecke, Stephan Kersting & Wolfram Keßler. (2022) Disseminated Intravascular Coagulation (DIC): Old player creates new perspectives on the polymicrobial sepsis model of CASP. PLOS ONE 17:12, pages e0277492.
Crossref
Roman Verkhovskii, Alexey Ermakov, Oleg Grishin, Mikhail A. Makarkin, Ilya Kozhevnikov, Mikhail Makhortov, Anastasiia Kozlova, Samia Salem, Valery Tuchin & Daniil Bratashov. (2022) The Influence of Magnetic Composite Capsule Structure and Size on Their Trapping Efficiency in the Flow. Molecules 27:18, pages 6073.
Crossref
Yuwei Wu, Yanfei Liu, Ting Wang, Qiao Jiang, Feng Xu & Zhenbao Liu. (2022) Living cell for drug delivery. Engineered Regeneration 3:2, pages 131-148.
Crossref
Mary K. Boudreaux & Pete W. Christopherson. 2022. Schalm's Veterinary Hematology. Schalm's Veterinary Hematology 658 666 .
Lea Miebach, Broder Poschkamp, Julia van der Linde & Sander Bekeschus. (2022) Medical Gas Plasma—A Potent ROS-Generating Technology for Managing Intraoperative Bleeding Complications. Applied Sciences 12:8, pages 3800.
Crossref
Dong Han, Jiafeng Zhang, Bartley P. Griffith & Zhongjun J. Wu. (2022) Models of Shear-Induced Platelet Activation and Numerical Implementation With Computational Fluid Dynamics Approaches. Journal of Biomechanical Engineering 144:4.
Crossref
Aqsa Shahid, Aimen Zulfiqar, Saima Muzammil, Sumreen Hayat, Maryam Zain, Muhammad Bilal & Mohsin Khurshid. 2022. Nanotechnology for Hematology, Blood Transfusion, and Artificial Blood. Nanotechnology for Hematology, Blood Transfusion, and Artificial Blood 167 193 .
Arkajyoti Mukherjee, Susmita Barik, Priyanka Sar & Arup Sarkar. (2021) Role of thrombopoiesis in leishmaniasis. Cytokine 147, pages 155310.
Crossref
Jun-ichiro Jo, Tsubasa Emi & Yasuhiko Tabata. (2021) Design of a Platelet-Mediated Delivery System for Drug-Incorporated Nanospheres to Enhance Anti-Tumor Therapeutic Effect. Pharmaceutics 13:10, pages 1724.
Crossref
Dermot Cox. (2021) Targeting SARS-CoV-2-Platelet Interactions in COVID-19 and Vaccine-Related Thrombosis. Frontiers in Pharmacology 12.
Crossref
Rana Bakhaidar, Sarah O’Neill & Zebunnissa Ramtoola. (2020) PLGA-PEG Nanoparticles Show Minimal Risks of Interference with Platelet Function of Human Platelet-Rich Plasma. International Journal of Molecular Sciences 21:24, pages 9716.
Crossref
Melania Dovizio, Patrizia Ballerini, Rosa Fullone, Stefania Tacconelli, Annalisa Contursi & Paola Patrignani. (2020) Multifaceted Functions of Platelets in Cancer: From Tumorigenesis to Liquid Biopsy Tool and Drug Delivery System. International Journal of Molecular Sciences 21:24, pages 9585.
Crossref
Conglei Li, June Li & Heyu Ni. (2020) Crosstalk Between Platelets and Microbial Pathogens. Frontiers in Immunology 11.
Crossref
Martin J. Page & Etheresia Pretorius. (2020) A Champion of Host Defense: A Generic Large-Scale Cause for Platelet Dysfunction and Depletion in Infection. Seminars in Thrombosis and Hemostasis 46:03, pages 302-319.
Crossref
Florian Gaertner & Steffen Massberg. (2019) Patrolling the vascular borders: platelets in immunity to infection and cancer. Nature Reviews Immunology 19:12, pages 747-760.
Crossref
Nadhim Kamil Hante, Carlos Medina & Maria Jose Santos-Martinez. (2019) Effect on Platelet Function of Metal-Based Nanoparticles Developed for Medical Applications. Frontiers in Cardiovascular Medicine 6.
Crossref
Steven W. Kerrigan, Tatyana Devine, Glenn Fitzpatrick, Jecko Thachil & Dermot Cox. (2019) Early Host Interactions That Drive the Dysregulated Response in Sepsis. Frontiers in Immunology 10.
Crossref
Yifei Lu, Quanyin Hu, Chen Jiang & Zhen Gu. (2019) Platelet for drug delivery. Current Opinion in Biotechnology 58, pages 81-91.
Crossref
Genevieve Couldwell & Kellie R. Machlus. (2019) Modulation of megakaryopoiesis and platelet production during inflammation. Thrombosis Research 179, pages 114-120.
Crossref
Steven G. Thomas. 2019. Platelets. Platelets 47 77 .
Jack Levin. 2019. Platelets. Platelets 1 23 .
Marion Mussbacher, Julia B. Kral-Pointner, Manuel Salzmann, Waltraud C. Schrottmaier & Alice Assinger. 2019. Fundamentals of Vascular Biology. Fundamentals of Vascular Biology 145 169 .
Pierre Lutgen. (2018) Platelets, eryptosis, amiodarone, aspirin, Artemisia. Pharmacy & Pharmacology International Journal 6:5.
Crossref
R. Palankar, T.P. Kohler, K. Krauel, J. Wesche, S. Hammerschmidt & A. Greinacher. (2018) Platelets kill bacteria by bridging innate and adaptive immunity via platelet factor 4 and FcγRIIA. Journal of Thrombosis and Haemostasis 16:6, pages 1187-1197.
Crossref
Caroline Sut, Sofiane Tariket, Cécile Aubron, Chaker Aloui, Hind Hamzeh-Cognasse, Philippe Berthelot, Sandrine Laradi, Andreas Greinacher, Olivier Garraud & Fabrice Cognasse. (2018) The Non-Hemostatic Aspects of Transfused Platelets. Frontiers in Medicine 5.
Crossref
María Francisca Matus, Cristian Vilos, Bruno A. Cisterna, Eduardo Fuentes & Iván Palomo. (2018) Nanotechnology and primary hemostasis: Differential effects of nanoparticles on platelet responses. Vascular Pharmacology 101, pages 1-8.
Crossref
Shuxia Fan, Michael Lorenz, Steffen Massberg & Florian Gaertner. (2018) Platelet Migration and Bacterial Trapping Assay under Flow. BIO-PROTOCOL 8:18.
Crossref
Jean-Marc Cavaillon & Mervyn SingerJack Levin. 2017. Inflammation - From Molecular and Cellular Mechanisms to the Clinic. Inflammation - From Molecular and Cellular Mechanisms to the Clinic 419 436 .
Sarah K. Bambach & Tim Lämmermann. (2017) Platelets, On Your Marks, Get Set, Migrate!. Cell 171:6, pages 1256-1258.
Crossref
Florian Gaertner, Zerkah Ahmad, Gerhild Rosenberger, Shuxia Fan, Leo Nicolai, Benjamin Busch, Gökce Yavuz, Manja Luckner, Hellen Ishikawa-Ankerhold, Roman Hennel, Alexandre Benechet, Michael Lorenz, Sue Chandraratne, Irene Schubert, Sebastian Helmer, Bianca Striednig, Konstantin Stark, Marek Janko, Ralph T. Böttcher, Admar Verschoor, Catherine Leon, Christian Gachet, Thomas Gudermann, Michael Mederos y Schnitzler, Zachary Pincus, Matteo Iannacone, Rainer Haas, Gerhard Wanner, Kirsten Lauber, Michael Sixt & Steffen Massberg. (2017) Migrating Platelets Are Mechano-scavengers that Collect and Bundle Bacteria. Cell 171:6, pages 1368-1382.e23.
Crossref
Konstanze Aurich, Jan Wesche, Raghavendra Palankar, Rabea Schlüter, Tamam Bakchoul & Andreas Greinacher. (2017) Magnetic Nanoparticle Labeling of Human Platelets from Platelet Concentrates for Recovery and Survival Studies. ACS Applied Materials & Interfaces 9:40, pages 34666-34673.
Crossref
Jan Simak & Silvia De Paoli. (2017) The effects of nanomaterials on blood coagulation in hemostasis and thrombosis. WIREs Nanomedicine and Nanobiotechnology 9:5.
Crossref
Jackson LiangYao Li, Alexander Zarbock & Andrés Hidalgo. (2017) Platelets as autonomous drones for hemostatic and immune surveillance. Journal of Experimental Medicine 214:8, pages 2193-2204.
Crossref
Peipei Xu, Huaqin Zuo, Bing Chen, Ruju Wang, Arsalan Ahmed, Yong Hu & Jian Ouyang. (2017) Doxorubicin-loaded platelets as a smart drug delivery system: An improved therapy for lymphoma. Scientific Reports 7:1.
Crossref
Amy L. Oldenburg, Richard L. Blackmon & Justin M. Sierchio. (2016) Magnetic and Plasmonic Contrast Agents in Optical Coherence Tomography. IEEE Journal of Selected Topics in Quantum Electronics 22:4, pages 133-145.
Crossref
Caroline M. Larkin, Maria-Jose Santos-Martinez, Thomas Ryan & Marek W. Radomski. (2016) Sepsis-associated thrombocytopenia. Thrombosis Research 141, pages 11-16.
Crossref
Rabea Sandmann & Sarah Köster. (2016) Topographic Cues Reveal Two Distinct Spreading Mechanisms in Blood Platelets. Scientific Reports 6:1.
Crossref
Irene Lopez-Vilchez, Maribel Diaz-Ricart, Ana M. Galan, Merce Roque, Carolina Caballo, Patricia Molina, James G. White & Gines Escolar. (2016) Internalization of Tissue Factor-Rich Microvesicles by Platelets Occurs Independently of GPIIb-IIIa, and Involves CD36 Receptor, Serotonin Transporter and Cytoskeletal Assembly. Journal of Cellular Biochemistry 117:2, pages 448-457.
Crossref
Dermot Cox. 2016. Vascular Responses to Pathogens. Vascular Responses to Pathogens 23 30 .
Robert Flaumenhaft & Secil Koseoglu. 2016. Molecular and Cellular Biology of Platelet Formation. Molecular and Cellular Biology of Platelet Formation 133 152 .
María Esteban, Alberto Cuesta, Elena Chaves-Pozo & José Meseguer. (2015) Phagocytosis in Teleosts. Implications of the New Cells Involved. Biology 4:4, pages 907-922.
Crossref
Vivienne Chan, Stefanie K. Novakowski, Simon Law, Christa Klein‐Bosgoed & Christian J. Kastrup. (2015) Controlled Transcription of Exogenous mRNA in Platelets Using Protocells. Angewandte Chemie International Edition 54:46, pages 13590-13593.
Crossref
Vivienne Chan, Stefanie K. Novakowski, Simon Law, Christa Klein‐Bosgoed & Christian J. Kastrup. (2015) Controlled Transcription of Exogenous mRNA in Platelets Using Protocells. Angewandte Chemie 127:46, pages 13794-13797.
Crossref
Doris Cerecedo, Ivette Martínez‐Vieyra, Deneb Maldonado‐García, Enrique Hernández‐González & Steve J. Winder. (2015) Association of Membrane/Lipid Rafts With the Platelet Cytoskeleton and the Caveolin PY14: Participation in the Adhesion Process. Journal of Cellular Biochemistry 116:11, pages 2528-2540.
Crossref
Vuong Ba Lê, Jochen G. Schneider, Yvonne Boergeling, Fatma Berri, Mariette Ducatez, Jean-Luc Guerin, Iris Adrian, Elisabeth Errazuriz-Cerda, Sonia Frasquilho, Laurent Antunes, Bruno Lina, Jean-Claude Bordet, Martine Jandrot-Perrus, Stephan Ludwig & Béatrice Riteau. (2015) Platelet Activation and Aggregation Promote Lung Inflammation and Influenza Virus Pathogenesis. American Journal of Respiratory and Critical Care Medicine 191:7, pages 804-819.
Crossref
Amy L. Oldenburg, Brian E. Applegate, Jason M. Tucker-Schwartz, Melissa C. Skala, Jongsik Kim & Stephen A. Boppart. 2015. Optical Coherence Tomography. Optical Coherence Tomography 1429 1454 .
Takahiro Nagasawa, Chihaya Nakayasu, Aja M. Rieger, Daniel R. Barreda, Tomonori Somamoto & Miki Nakao. (2014) Phagocytosis by Thrombocytes is a Conserved Innate Immune Mechanism in Lower Vertebrates. Frontiers in Immunology 5.
Crossref
Michael R. Yeaman. (2014) Platelets: at the nexus of antimicrobial defence. Nature Reviews Microbiology 12:6, pages 426-437.
Crossref
Luciana Avigliano, I. Savini, M.V. Catani & D. Del Principe. 2014. Recent Advances in Medicinal Chemistry. Recent Advances in Medicinal Chemistry 404 432 .
Sounik Sarkar, Mohammed Aftab Alam, Jyoti Shaw & Anjan Kr. Dasgupta. (2013) Drug Delivery Using Platelet Cancer Cell Interaction. Pharmaceutical Research 30:11, pages 2785-2794.
Crossref
Neha B. Shah & John C. Bischof. (2013) Blood protein and blood cell interactions with gold nanoparticles: the need for in vivo studies. BioNanoMaterials 14:1-2.
Crossref
James G. White. 2013. Platelets. Platelets 117 144 .
Jack Levin. 2013. Platelets. Platelets 3 25 .
Irene Lopez-Vilchez, Ana Maria Galan, Maria Rosa Hernandez, Carolina Caballo, Merce Roque, Maribel Diaz-Ricart, James G. White & Gines Escolar. (2012) Platelet-associated tissue factor enhances platelet reactivity and thrombin generation in experimental studies in vitro. Thrombosis Research 130:6, pages e294-e300.
Crossref
Neha B. Shah, Gregory M. Vercellotti, James G. White, Adrian Fegan, Carston R. Wagner & John C. Bischof. (2012) Blood–Nanoparticle Interactions and in Vivo Biodistribution: Impact of Surface PEG and Ligand Properties . Molecular Pharmaceutics 9:8, pages 2146-2155.
Crossref
Konstanze Aurich, Mark-Christopher Spoerl, Birgitt Fürll, Rabea Sietmann, Andreas Greinacher, Norbert Hosten & Werner Weitschies. (2012) Development of a method for magnetic labeling of platelets. Nanomedicine: Nanotechnology, Biology and Medicine 8:5, pages 537-544.
Crossref
Nguyen ThanhNadine Sternberg, Hans Bäumler & Radostina Georgieva. 2012. Magnetic Nanoparticles. Magnetic Nanoparticles 387 418 .
Suryyani Deb, S.O. Raja, Anjan Kr. Dasgupta, Rajkumar Sarkar, Asoke P. Chattopadhyay, Utpal Chaudhuri, Pradipta Guha & Partha Sardar. (2012) Surface tunability of nanoparticles in modulating platelet functions. Blood Cells, Molecules, and Diseases 48:1, pages 36-44.
Crossref
Broes Naeye, Hendrik Deschout, Magnus Röding, Mats Rudemo, Joris Delanghe, Katrien Devreese, Jo Demeester, Kevin Braeckmans, Stefaan C. De Smedt & Koen Raemdonck. (2011) Hemocompatibility of siRNA loaded dextran nanogels. Biomaterials 32:34, pages 9120-9127.
Crossref
Suryyani Deb, Hirak K. Patra, Prabir Lahiri, Anjan Kr. Dasgupta, Kuntal Chakrabarti & Utpal Chaudhuri. (2011) Multistability in platelets and their response to gold nanoparticles. Nanomedicine: Nanotechnology, Biology and Medicine 7:4, pages 376-384.
Crossref
Irene Lopez-Vilchez, Ulla Hedner, Carmen Altisent, Maribel Diaz-Ricart, Gines Escolar & Ana M. Galan. (2011) Redistribution and Hemostatic Action of Recombinant Activated Factor VII Associated with Platelets. The American Journal of Pathology 178:6, pages 2938-2948.
Crossref
Adam J. Antczak, Joshua A. Vieth, Navinderjit Singh & Randall G. Worth. (2011) Internalization of IgG-Coated Targets Results in Activation and Secretion of Soluble CD40 Ligand and RANTES by Human Platelets. Clinical and Vaccine Immunology 18:2, pages 210-216.
Crossref
Roslyn Yomtovian & Michael R. Jacobs. (2010) A prospective bonus of platelet storage additive solutions: a reduction in biofilm formation and improved bacterial detection during platelet storage. Transfusion 50:11, pages 2295-2300.
Crossref
Amy L. Oldenburg, Caterina M. Gallippi, Frank Tsui, Timothy C. Nichols, Kellie N. Beicker, Raghav K. Chhetri, Dmitry Spivak, Aaron Richardson & Thomas H. Fischer. (2010) Magnetic and Contrast Properties of Labeled Platelets for Magnetomotive Optical Coherence Tomography. Biophysical Journal 99:7, pages 2374-2383.
Crossref
John W. Semple & John Freedman. (2009) Platelets and innate immunity. Cellular and Molecular Life Sciences 67:4, pages 499-511.
Crossref
Christoph Licht, Fred G. Pluthero, Ling Li, Hilary ChristensenSandra Habbig, Bernd Hoppe, Denis F. GearyPeter F. Zipfel & Walter H. A. Kahr. (2009) Platelet-associated complement factor H in healthy persons and patients with atypical HUS. Blood 114:20, pages 4538-4545.
Crossref
Michal Heger, Isabelle I. Salles, Wiebe van Vuure, Irene H.L. Hamelers, Anton I.P.M. de Kroon, Hans Deckmyn & Johan F. Beek. (2009) On the interaction of fluorophore-encapsulating PEGylated lecithin liposomes with hamster and human platelets. Microvascular Research 78:1, pages 57-66.
Crossref
Dorit M. W. Zander & Matthias Klinger. (2009) The blood platelets contribution to innate host defense - What they have learned from their big brothers. Biotechnology Journal 4:6, pages 914-926.
Crossref
Susanne Perkhofer, Beate E. Kehrel, Manfred P. Dierich, J. Peter Donnelly, Walter Nussbaumer, Johann Hofmann, Christof von Eiff & Cornelia Lass‐Flörl. (2008) Human Platelets Attenuate Aspergillus Species via Granule‐Dependent Mechanisms . The Journal of Infectious Diseases 198:8, pages 1243-1246.
Crossref
Jennifer L. Granick, Dexter V. Reneer, Jason A. Carlyon & Dori L. Borjesson. (2008) Anaplasma phagocytophilum infects cells of the megakaryocytic lineage through sialylated ligands but fails to alter platelet production. Journal of Medical Microbiology 57:4, pages 416-423.
Crossref
Xiangfeng Li, Takehisa Iwai, Hiroaki Nakamura, Yoshinori Inoue, Yiwen Chen, Makoto Umeda & Hidenori Suzuki. (2008) An ultrastructural study of Porphyromonas gingivalis-induced platelet aggregation. Thrombosis Research 122:6, pages 810-819.
Crossref
Gines Escolar, Irene Lopez-Vilchez, Maribel Diaz-Ricart, James G. White & Ana M. Galan. (2008) Internalization of tissue factor by platelets. Thrombosis Research 122, pages S37-S41.
Crossref
Carey Greco, Irene Martincic, Arjeta Gusinjac, Miloslav Kalab, Ann-Fook Yang & Sandra Ramírez-Arcos. (2007) Staphylococcus epidermidis forms biofilms under simulated platelet storage conditions. Transfusion 47:7, pages 1143-1153.
Crossref
R Cartier, L Kaufner, B R Paulke, R Wüstneck, S Pietschmann, R Michel, H Bruhn & U Pison. (2007) Latex nanoparticles for multimodal imaging and detection in vivo . Nanotechnology 18:19, pages 195102.
Crossref
Philipp von HundelshausenChristian Weber. (2007) Platelets as Immune Cells. Circulation Research 100:1, pages 27-40.
Crossref
James G. White. 2007. Platelets. Platelets 45 73 .
Jack Levin. 2007. Platelets. Platelets 3 22 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.