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Platelets Volume 30, 2019 - Issue 2
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Plenary Paper

Very-low-dose twice-daily aspirin maintains platelet inhibition and improves haemostasis during dual-antiplatelet therapy for acute coronary syndrome

William A.E. ParkerDepartment of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, United Kingdom;Department of Cardiology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UKORCID Iconhttp://orcid.org/0000-0002-7822-8852View further author information
ORCID Icon,
Rachel C. OrmeDepartment of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, United Kingdom;Department of Cardiology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UKView further author information
,
Jessica HansonDepartment of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, United KingdomView further author information
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Hannah M. StokesDepartment of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, United KingdomView further author information
,
Claire M. BridgeDepartment of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, United KingdomView further author information
,
Patricia A. ShawDepartment of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, United KingdomView further author information
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Wael SumayaDepartment of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, United Kingdom;Department of Cardiology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UKView further author information
,
Kirstie ThorneycroftDepartment of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, United KingdomView further author information
,
Giovanna PetrucciInstitute of Pharmacology, Catholic University School of Medicine, Rome, ItalyView further author information
,
Benedetta PorroCentro Cardiologico Monzino, Istituto di Ricovero e Cura a Carattere Scientifico Cardiologico Monzino, Milan, ItalyView further author information
,
Heather M. JudgeDepartment of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, United KingdomView further author information
,
Ramzi A. AjjanLeeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UKView further author information
,
Bianca RoccaInstitute of Pharmacology, Catholic University School of Medicine, Rome, ItalyView further author information
&
Robert F. StoreyDepartment of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, United Kingdom;Department of Cardiology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UKCorrespondence[email protected]
View further author information
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Pages 148-157 | Received 09 Dec 2018, Accepted 11 Jan 2019, Published online: 13 Feb 2019

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Yue Wang, Beibei Liu, Leilei Chen, Yue Wang, Zhiqiang Wang, Xiaojiang Zhang, Min Suo, Gary S. Mintz & Xiaofan Wu. (2022) Safety and efficacy of low-dose ticagrelor in Chinese patients with acute coronary syndrome undergoing percutaneous coronary intervention. Platelets 33:2, pages 304-311.
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Barry W. Hennigan, Richard Good, Carly Adamson, William A.E. Parker, Lynn Martin, Lynne Anderson, Michael Campbell, Patrick W. Serruys, Robert F. Storey & Keith G. Oldroyd. (2022) Recovery of platelet reactivity following cessation of either aspirin or ticagrelor in patients treated with dual antiplatelet therapy following percutaneous coronary intervention: a GLOBAL LEADERS substudy. Platelets 33:1, pages 141-146.
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Steve P. Watson, Paul Harrison & Gayle M. Halford. (2021) Editorial Platelets 2021: toward a brighter year. Platelets 32:1, pages 1-2.
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William A. E. Parker & Robert F. Storey. (2021) Novel approaches to P2Y12 inhibition and aspirin dosing. Platelets 32:1, pages 7-14.
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William A. E. Parker. (2020) Aspirin after PCI: in the twilight of its years?. Platelets 31:7, pages 831-833.
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Articles from other publishers (19)

Harpreet S. Bhatia, Richard C. Becker, Gregor Leibundgut, Mitul Patel, Paul Lacaze, Andrew Tonkin, Jagat Narula & Sotirios Tsimikas. (2023) Lipoprotein(a), platelet function and cardiovascular disease. Nature Reviews Cardiology.
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Sahar Zayed & Fathalla Belal. (2023) Determination of ticagrelol in rat plasma and tablets by micellar electrokinetic chromatography coupled with large volume sample stacking: Application to a pharmacokinetic study. Journal of Separation Science 46:22.
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Nawaz Z. Safdar, Noppadol Kietsiriroje & Ramzi A. Ajjan. (2023) The Cellular and Protein Arms of Coagulation in Diabetes: Established and Potential Targets for the Reduction of Thrombotic Risk. International Journal of Molecular Sciences 24:20, pages 15328.
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Li Wang, Zaoxiu Hu, Ceshi Chen, Ting Chen, Zhihong Yao, Wenhui Li & Zuozhang Yang. (2023) Low‐dose aspirin can inhibit exosomal release induced by radiotherapy in breast cancer and attenuate its inhibitory effect on NK cell proliferation . Cancer Medicine 12:15, pages 16386-16404.
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Patricia P. Wadowski, Benjamin Panzer, Alicja Józkowicz, Christoph W. Kopp, Thomas Gremmel, Simon Panzer & Renate Koppensteiner. (2023) Microvascular Thrombosis as a Critical Factor in Severe COVID-19. International Journal of Molecular Sciences 24:3, pages 2492.
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Mélina Del Bianco-Rondeau, Maxime Robert-Halabi, Samara Bloom, Remi Rabasa-Lhoret, Jean-Claude Tardif, Marie Lordkipanidzé & Guillaume Marquis-Gravel. (2022) Aspirin for Primary Cardiovascular Prevention in Patients with Diabetes: Uncertainties and Opportunities. Thrombosis and Haemostasis 122:09, pages 1443-1453.
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Alberto Giaretta, Giovanna Petrucci, Bianca Rocca & Gianna Maria Toffolo. (2022) Physiologically based modelling of the antiplatelet effect of aspirin: A tool to characterize drug responsiveness and inform precision dosing. PLOS ONE 17:8, pages e0268905.
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Ashis K. Mukherjee & Dhruba J. Chattopadhyay. (2022) Potential clinical applications of phytopharmaceuticals for the in‐patient management of coagulopathies in COVID ‐19 . Phytotherapy Research 36:5, pages 1884-1913.
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William A. E. Parker, Rebecca Sagar, Zeyad Kurdee, Fladia Hawkins, Khalid M. Naseem, Peter J. Grant, Robert F. Storey & Ramzi A. Ajjan. (2021) A randomised controlled trial to assess the antithrombotic effects of aspirin in type 1 diabetes: role of dosing and glycaemic control. Cardiovascular Diabetology 20:1.
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William A E Parker & Robert F Storey. (2021) Ticagrelor monotherapy in CKD: better safety at what price?. European Heart Journal 42:45, pages 4694-4696.
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Małgorzata Szczuko, Igor Kozioł, Dariusz Kotlęga, Jacek Brodowski & Arleta Drozd. (2021) The Role of Thromboxane in the Course and Treatment of Ischemic Stroke: Review. International Journal of Molecular Sciences 22:21, pages 11644.
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William A E Parker & Robert F Storey. (2021) Aspirin dosing for atherosclerotic cardiovascular disease: should we be more ADAPTABLE?. Cardiovascular Research 117:10, pages e123-e125.
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Peter R Sinnaeve & Tom Adriaenssens. (2021) Dual Antiplatelet Therapy De-escalation Strategies. The American Journal of Cardiology 144, pages S23-S31.
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Aleksandra Gąsecka, Josip A. Borovac, Rui Azevedo Guerreiro, Michela Giustozzi, William Parker, Daniel Caldeira & Gemma Chiva-Blanch. (2020) Thrombotic Complications in Patients with COVID-19: Pathophysiological Mechanisms, Diagnosis, and Treatment. Cardiovascular Drugs and Therapy 35:2, pages 215-229.
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Jessica Maiuolo, Rocco Mollace, Micaela Gliozzi, Vincenzo Musolino, Cristina Carresi, Sara Paone, Miriam Scicchitano, Roberta Macrì, Saverio Nucera, Francesca Bosco, Federica Scarano, Maria Caterina Zito, Stefano Ruga, Annamaria Tavernese & Vincenzo Mollace. (2020) The Contribution of Endothelial Dysfunction in Systemic Injury Subsequent to SARS-Cov-2 Infection. International Journal of Molecular Sciences 21:23, pages 9309.
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Krithika Loganath, Philip D Adamson & Alastair J Moss. (2020) Ticagrelor in the management of coronary artery disease. Future Cardiology.
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Mariusz Tomaniak, Ply Chichareon, Yoshinobu Onuma, Efthymios N. Deliargyris, Kuniaki Takahashi, Norihiro Kogame, Rodrigo Modolo, Chun Ching Chang, Tessa Rademaker-Havinga, Robert F. Storey, George D. Dangas, Deepak L. Bhatt, Dominick J. Angiolillo, Christian Hamm, Marco Valgimigli, Stephan Windecker, Philippe Gabriel Steg, Pascal Vranckx & Patrick W. Serruys. (2019) Benefit and Risks of Aspirin in Addition to Ticagrelor in Acute Coronary Syndromes. JAMA Cardiology 4:11, pages 1092.
Crossref
Carlo Patrono & Bianca Rocca. (2019) Measurement of Thromboxane Biosynthesis in Health and Disease. Frontiers in Pharmacology 10.
Crossref
Wael Sumaya & Robert F. Storey. (2019) Does Risk of Premature Discontinuation of Dual-Antiplatelet Therapy Following PCI Attenuate With Increasing Age?. JACC: Cardiovascular Interventions 12:10, pages 993-994.
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