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Platelets Volume 34, 2023 - Issue 1
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Research Article

Recombinant human thrombopoietin (rhTPO) of different dosing regimens for refractory/relapsed primary immune thrombocytopenia: a multicenter, randomized controlled trial and pharmacokinetics study

Xiaofan Liu1 State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin Key Laboratory of Gene Therapy for Blood Diseases, CAMS Key Laboratory of Gene Therapy for Blood Diseases, Tianjin, ChinaORCID Iconhttps://orcid.org/0000-0002-9911-4491View further author information
ORCID Icon,
Yusheng Bai2 Department of Hematology, Traditional Chinese Medical Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang, ChinaView further author information
,
Tao Wang3 Department of Hematology, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, Henan, ChinaView further author information
,
Yanping Song4 Department of Hematology, Xi’an Central Hospital, Xi’an, Shaanxi, ChinaView further author information
,
Feng Sun5 Department of Hematology, First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, ChinaView further author information
,
Ruixiang Xia6 Department of Hematology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, ChinaView further author information
,
Feiyue Zhu7 Department of Hematology, Loudi Central Hospital, Loudi, Hunan, ChinaView further author information
,
Jun Ma8 Department of Hematology, Harbin Institute of Hematology and Oncology, Harbin, Heilongjiang, ChinaView further author information
,
Quanyi Lu9 Department of Hematology, Zhongshan Hospital, Xiamen University, Xiamen, Fujian, ChinaView further author information
,
Xu Ye10 Department of Hematology, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, ChinaView further author information
,
Xinrong Zhan11 Department of Hematology, Xinxiang Central Hospital, Xinxiang, Henan, ChinaView further author information
,
Linjie Li12 Department of Hematology, Lishui Central Hospital, Lishui, Zhejiang, ChinaView further author information
,
Xinhong Guo13 Department of Hematology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang Uygur Autonomous Region, ChinaView further author information
,
Shuqin Cheng14 Department of Hematology, Guangzhou Panyu Central Hospital, Guangzhou, Guangdong, ChinaView further author information
,
Yan Li15 Department of Hematology, The First Hospital of China Medical University, Shenyang, Liaoning, ChinaView further author information
,
Zhiqiang Guo16 Department of Hematology, Zhengzhou Central Hospital, Zhengzhou, Henan, ChinaView further author information
,
Youhua Chen17 Department of Hematology, Renmin Hospital of Wuhan University, Hubei General Hospital, Wuhan, Hubei, ChinaView further author information
,
Shenxian Qian18 Department of Hematology, Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, ChinaView further author information
,
Ling Qin19 Department of Hematology, The First Affiliated Hospital of Henan Technology University, Luoyang, Henan, ChinaView further author information
,
Qing Zhang20 Department of Hematology, Guangdong Second Provincial General Hospital, Guangzhou, Guangdong, ChinaView further author information
,
Sunqiong Cao21 Medical Department, Shenyang Sunshine Pharmaceuticals Co. Ltd, Shenyang, Liaoning, ChinaView further author information
&
Renchi Yang1 State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin Key Laboratory of Gene Therapy for Blood Diseases, CAMS Key Laboratory of Gene Therapy for Blood Diseases, Tianjin, ChinaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-3741-8518View further author information
ORCID Icon show all
Article: 2157806 | Received 02 Aug 2022, Accepted 07 Dec 2022, Published online: 03 Jan 2023

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Xiuli Wang, Hui Bi, Lin Liu, Yuebo Liu, Liefen Yin, Jin Yao, Jingxing Yu, Wei Tao, Yueping Wei, Yu Li, Lingmei Yin, Hongli Mu, Yadong Du & Zeping Zhou. (2023) Efficacy and safety of high dose recombinant human thrombopoietin in the treatment of immune thrombocytopenia. Platelets 34:1.
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Articles from other publishers (2)

Yilei Hong, Yingying Shen, Qi Liu, Jingjie Dong, Jingjing Xiang, Yiping Shen, Liqiang Wu, Yuhong Zhou, Baodong Ye & Dijiong Wu. (2023) Eltrombopag plus cyclosporine in refractory immune thrombocytopenia: a single-center study. Research and Practice in Thrombosis and Haemostasis 7:5, pages 100279.
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Jia Lai, Yueyue Li, Mei Ran, Qianqian Huang, Feihong Huang, Linjie Zhu, Yuesong Wu, Wenjun Zou, Xiang Xie, Yong Tang, Fei Yang, Anguo Wu, Guangbo Ge & Jianming Wu. (2023) Xanthotoxin, a novel inducer of platelet formation, promotes thrombocytopoiesis via IL-1R1 and MEK/ERK signaling. Biomedicine & Pharmacotherapy 163, pages 114811.
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