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Food and Agricultural Immunology Volume 30, 2019 - Issue 1
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Punicalagin and ellagic acid from pomegranate peel induce apoptosis and inhibits proliferation in human HepG2 hepatoma cells through targeting mitochondria

Jia Lia College of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi’an, PR People’s Republic of China;b College of Bioscience and Food Engineering, Shaanxi Xue Qian Normal University, Xi’an, PR People’s Republic of ChinaView further author information
,
Guoliang Wanga College of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi’an, PR People’s Republic of ChinaView further author information
,
Chen Houa College of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi’an, PR People’s Republic of China;c University Key Laboratory of Food Processing Byproducts for Advanced Development and High Value Utilization, Xi’an, PR People’s Republic of ChinaView further author information
,
Jianke Lia College of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi’an, PR People’s Republic of China;c University Key Laboratory of Food Processing Byproducts for Advanced Development and High Value Utilization, Xi’an, PR People’s Republic of China;d National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest China, Xi’an, PR People’s Republic of ChinaCorrespondence[email protected]
View further author information
,
Ying Luoa College of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi’an, PR People’s Republic of China;c University Key Laboratory of Food Processing Byproducts for Advanced Development and High Value Utilization, Xi’an, PR People’s Republic of ChinaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-9733-7448View further author information
ORCID Icon &
Baicun Lib College of Bioscience and Food Engineering, Shaanxi Xue Qian Normal University, Xi’an, PR People’s Republic of ChinaView further author information
Pages 897-912 | Received 28 Apr 2019, Accepted 02 Jul 2019, Published online: 26 Jul 2019

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Maria Pierdomenico, Costanza Riccioni & Barbara Benassi. (2024) Anti-inflammatory effect of a pomegranate extract on LPS-stimulated HepG2 cells. Natural Product Research 38:5, pages 727-734.
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Mohamed Nasr, Suhaib Alsayed Naeem, Ibrahim El-Shenbaby, Fatma Mahmoud Abdelraheem Mohamed, Safinaz Moustafa Mahmoud, Tamer M M Abuamara, Wagih M Abd-Elhay, Fayez Mohammed Abd Elfattah Elbayoumy, Ahmad Elkot, Tarek Shikhon, Mostafa Abo-akrab, Mohamed A Doma & Abdulkarim Hasan. (2023) Pomegranate Seeds and Peel Ethanolic Extracts Anticancer Potentials and Related Genetic, Histological, Immunohistochemical, Apoptotic and Oxidative Stress Profiles: In vitro Study. Journal of Experimental Pharmacology 15, pages 191-205.
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Yongling Wu, Chang Liu, Wenjing Lu, Siting Li, Zhou Chen, Junxia Xia, Yiling Tian, Aijin Ma & Yingmin Jia. (2023) Transcriptomics reveals the potential mechanism of ellagic acid extract from raspberry on wound healing. Food and Agricultural Immunology 34:1.
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Articles from other publishers (24)

Gerardo Manuel González‐González, Sandra Cecilia Esparza‐González, Sendar Daniel Nery‐Flores, Jesús Antonio Morlett‐Chávez, Juan Alberto Ascacio‐Valdés, Adriana Carolina Flores‐Gallegos, Aidé Saenz‐Galindo & Raúl Rodríguez‐Herrera. (2023) Anticancer activity of polyphenolic Punica granatum peel extracts obtained by hybrid ultrasound‐microwave assisted extraction: Evaluation on HeLa and HepG2 cells . Environmental Quality Management 33:4, pages 295-304.
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Lubna F. Abu‐Niaaj, Hala I. Al‐Daghistani, Ibrahim Katampe, Bashaer Abu‐Irmaileh & Yasser K. Bustanji. (2024) Pomegranate peel: Bioactivities as antimicrobial and cytotoxic agents. Food Science & Nutrition 12:4, pages 2818-2832.
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Zhenju Tan, Xuemei Li, Xia Chen, Li Wang, Baijun Chen, Sichong Ren & Ming Zhao. (2024) Ellagic acid inhibits tumor growth and potentiates the therapeutic efficacy of sorafenib in hepatocellular carcinoma. Heliyon 10:1, pages e23931.
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Martina Čižmáriková, Radka Michalková, Ladislav Mirossay, Gabriela Mojžišová, Martina Zigová, Annamária Bardelčíková & Ján Mojžiš. (2023) Ellagic Acid and Cancer Hallmarks: Insights from Experimental Evidence. Biomolecules 13:11, pages 1653.
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Xiaoyan Wen, Mingshuai Zhou, Qingmei Lu, Bin Liu, Xiaoli Shi & Jiafu Zhao. (2023) Addition of ellagic acid improved the immune ability and delayed the apoptosis of ovarian granulosa cells of Guizhou black goat. Animal Production Science 64:1.
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Jyoti Singh, Hamita Preet Kaur, Anjali Verma, Arshminder Singh Chahal, Kaushal Jajoria, Prasad Rasane, Sawinder Kaur, Jaspreet Kaur, Mahendra Gunjal, Sezai Ercisli, Ravish Choudhary, Mehmet Ramazan Bozhuyuk, Ebru Sakar, Neva Karatas & Melekber Sulusoglu Durul. (2023) Pomegranate Peel Phytochemistry, Pharmacological Properties, Methods of Extraction, and Its Application: A Comprehensive Review. ACS Omega 8:39, pages 35452-35469.
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Jin Cheng, Jiahui Li, Ruo-Gu Xiong, Si-Xia Wu, Si-Yu Huang, Dan-Dan Zhou, Adila Saimaiti, Ao Shang, Yibin Feng, Ren-You Gan & Hua-Bin Li. (2023) Bioactive compounds and health benefits of pomegranate: An updated narrative review. Food Bioscience 53, pages 102629.
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Salvatore Velotto, Rosa Palmeri, Vincenzo Alfeo, Ignazio M. Gugino, Biagio Fallico, Giovanni Spagna & Aldo Todaro. (2023) The effect of different technologies in Pomegranate jam preparation on the phenolic compounds, vitamin C and antioxidant activity. Food Bioscience 53, pages 102525.
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Ahmed A. Abd-Rabou, Aziza B. Shalby & Soheir E. Kotob. (2023) An ellagitannin-loaded CS-PEG decorated PLGA nano-prototype promotes cell cycle arrest in colorectal cancer cells. Cell Biochemistry and Biophysics 81:2, pages 313-323.
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Haidan Shi, Xuezhi Li, Chen Hou, Li Chen, Yuhuan Zhang & Jianke Li. (2023) Effects of Pomegranate Peel Polyphenols Combined with Inulin on Gut Microbiota and Serum Metabolites of High-Fat-Induced Obesity Rats. Journal of Agricultural and Food Chemistry 71:14, pages 5733-5744.
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Kalyanee Jirasripongpun, Nuananong Jirakanjanakit, Rapeeporn Pomhong & Wilin Inheng. Pomegranate peel extract ameliorates UVA radiation induced skin damage in A375 cells. Pomegranate peel extract ameliorates UVA radiation induced skin damage in A375 cells.
Piteesha Ramlagan, Rola M. Labib, Mohamed A. Farag & Vidushi S. Neergheen. (2022) Advances towards the analysis, metabolism and health benefits of punicalagin, one of the largest ellagitannin from plants, with future perspectives. Phytomedicine Plus 2:3, pages 100313.
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Qiwen Xiang, Meifeng Li, Jiayu Wen, Fajian Ren, Zhou Yang, Xingyue Jiang & Yan Chen. (2022) The bioactivity and applications of pomegranate peel extract: A review. Journal of Food Biochemistry 46:7.
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Xialin Xie, Liuyi Hu, Lulu Liu, Jiuru Wang, Yongai Liu, Li Ma, Guangying Sun, Changfei Li, Haji Akber Aisa & Songdong Meng. (2022) Punicalagin promotes autophagic degradation of human papillomavirus E6 and E7 proteins in cervical cancer through the ROS-JNK-BCL2 pathway. Translational Oncology 19, pages 101388.
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Jing-Hui Ruan, Jun Li, Guliqire Adili, Guang-Ying Sun, Munire Abuduaini, Rahima Abdulla, Maitinuer Maiwulanjiang & Haji Akber Aisa. (2022) Phenolic Compounds and Bioactivities from Pomegranate ( Punica granatum L.) Peels . Journal of Agricultural and Food Chemistry 70:12, pages 3678-3686.
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Domenico Nuzzo, Pasquale Picone, Jesus Lozano Sanchez, Isabel Borras-Linares, Alessandro Guiducci, Emanuela Muscolino, Daniela Giacomazza, Tiziana Sanfilippo, Rossella Guggino, Donatella Bulone, Clelia Dispenza, Pier Luigi San Biagio & Romano Lapasin. (2022) Recovery from Food Waste—Biscuit Doughs Enriched with Pomegranate Peel Powder as a Model of Fortified Aliment. Biology 11:3, pages 416.
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Heba A. Fahmy & Mohamed A. Farag. (2021) Ongoing and potential novel trends of pomegranate fruit peel; a comprehensive review of its health benefits and future perspectives as nutraceutical. Journal of Food Biochemistry 46:1.
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Boran Yang, Kirk Kealey, Jinru Chen & Kevin Mis Solval. (2022) Developing microencapsulated powders containing polyphenols and pectin extracted from Georgia-grown pomegranate peels. LWT 154, pages 112644.
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Nawraj Rummun, Ahmed Serag, Philippe Rondeau, Srishti Ramsaha, Emmanuel Bourdon, Theeshan Bahorun, Mohamed A. Farag & Vidushi S. Neergheen. (2021) Antiproliferative activity of Syzygium coriaceum, an endemic plant of Mauritius, with its UPLC-MS metabolite fingerprint: A mechanistic study. PLOS ONE 16:6, pages e0252276.
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Le Fang, Hong Wang, Jie Zhang & Xiaolei Fang. (2021) Punicalagin induces ROS‐mediated apoptotic cell death through inhibiting STAT3 translocation in lung cancer A549 cells. Journal of Biochemical and Molecular Toxicology 35:6, pages 1-10.
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Hamza A. Alaswad, Amani A. Mahbub, Christine L. Le Maitre & Nicola Jordan-Mahy. (2021) Molecular Action of Polyphenols in Leukaemia and Their Therapeutic Potential. International Journal of Molecular Sciences 22:6, pages 3085.
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Guanghui Li, Yunfeng Xu, Liang Pan & Xiaodong Xia. (2020) Punicalagin Damages the Membrane of Salmonella Typhimurium. Journal of Food Protection 83:12, pages 2102-2106.
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Nawraj Rummun, Philippe Rondeau, Emmanuel Bourdon, Elisabete Pires, James McCullagh, Timothy D. W. Claridge, Theeshan Bahorun, Wen-Wu Li & Vidushi S. Neergheen. (2020) Terminalia bentzoë, a Mascarene Endemic Plant, Inhibits Human Hepatocellular Carcinoma Cells Growth In Vitro via G0/G1 Phase Cell Cycle Arrest. Pharmaceuticals 13:10, pages 303.
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Amria M. Mousa, Nermin M. El-Sammad, Abeer H. Abdel-Halim, Nayera Anwar, Wagdy K. B. Khalil, Mahmoud Nawwar, Amani N. Hashim, Elsayed A. Elsayed & Sherien K. Hassan. (2019) Lagerstroemia Speciosa (L.) Pers Leaf Extract Attenuates Lung Tumorigenesis via Alleviating Oxidative Stress, Inflammation and Apoptosis. Biomolecules 9:12, pages 871.
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