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International Journal of Radiation Biology Volume 77, 2001 - Issue 2
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Research Article

Dose–response of initial G2-chromatid breaks induced in normal human fibroblasts by heavy ions

T. Kawata NASA Lyndon B. Johnson Space Center, Radiation Biophysics Laboratory, Mail Code SN, Houston, Texas, 77058, USA
,
M. Durante Department of Physics, University 'Frederico II', Naples, Italy
,
Y. Furusawa International Space Radiation Laboratory, National Institute of Radiological Sciences, Chiba, Japan
,
K. George NASA Lyndon B. Johnson Space Center, Radiation Biophysics Laboratory, Mail Code SN, Houston, Texas, 77058, USA and Wyle Laboratories, Hercules Drive, Houston, Texas, 77058, USA
,
N. Takai International Space Radiation Laboratory, National Institute of Radiological Sciences, Chiba, Japan
,
H. Wu NASA Lyndon B. Johnson Space Center, Radiation Biophysics Laboratory, Mail Code SN, Houston, Texas, 77058, USA and Kelsey-Seybold Clinic, Johnson Space Center, Houston, Texas, 77058, USA
&
F. A. Cucinotta NASA Lyndon B. Johnson Space Center, Radiation Biophysics Laboratory, Mail Code SN, Houston, Texas, 77058, USA
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Pages 165-174 | Published online: 03 Jul 2009

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Koichi Ando & Yuki Kase. (2009) Biological characteristics of carbon-ion therapy. International Journal of Radiation Biology 85:9, pages 715-728.
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M. Horstmann, M. Durante & G. Obe. (2004) Distribution of breakpoints and fragment sizes in human chromosome 5 after heavy‐ion bombardment. International Journal of Radiation Biology 80:6, pages 437-443.
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Articles from other publishers (26)

Floriane Poignant, Ianik Plante, Zarana S. Patel, Janice L. Huff & Tony C. Slaba. (2022) Geometrical Properties of the Nucleus and Chromosome Intermingling Are Possible Major Parameters of Chromosome Aberration Formation. International Journal of Molecular Sciences 23:15, pages 8638.
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Ming Tsuey Chew, Andrew Nisbet, Bleddyn Jones, Masao Suzuki, Naruhiro Matsufuji, Takeshi Murakami & David A. Bradley. (2019) Ion beams for space radiation radiobiological effect studies. Radiation Physics and Chemistry 165, pages 108373.
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A.A. Almahwasi, J.C. Jeynes, M.J. Merchant, D.A. Bradley & P.H. Regan. (2017) Delayed persistence of giant-nucleated cells induced by X-ray and proton irradiation in the progeny of replicating normal human f ibroblast cells. Radiation Physics and Chemistry 137, pages 163-168.
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Eliedonna Cacao, Megumi Hada, Premkumar B. Saganti, Kerry A. George & Francis A. Cucinotta. (2016) Relative Biological Effectiveness of HZE Particles for Chromosomal Exchanges and Other Surrogate Cancer Risk Endpoints. PLOS ONE 11:4, pages e0153998.
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Shubhankar Suman, Kamal Datta, Daniela Trani, Evagelia C. Laiakis, Steven J. Strawn & Albert J. FornaceJr.Jr.. (2012) Relative biological effectiveness of 12C and 28Si radiation in C57BL/6J mice. Radiation and Environmental Biophysics 51:3, pages 303-309.
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Francesca Ballarini & Andrea Ottolenghi. 2012. Radiation Damage in Biomolecular Systems. Radiation Damage in Biomolecular Systems 371 384 .
Qiang Wang, Gang Zhou, Xigang Jing, Wenjian Li & Jianshe Yang. (2011) Avoid online radiation risk: Theoretical simulation of chromosome breaks in cells exposed to heavy ions. Advances in Space Research 47:11, pages 2039-2043.
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KOHEI INOUE, TETSUYA KAWATA, MASAYOSHI SAITO, CUIHUA LIU, TAKASHI UNO, KOUICHI ISOBE & HISAO ITO. (2010) Effect of an ATM Kinase Inhibitor on Thermo- and/or Radio-sensitization in Non-proliferating Normal Human Fibroblasts and Osteosarcoma Cells. Thermal Medicine 26:3, pages 97-107.
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Xigang Jing, Wenjian Li, Zhuanzi Wang, Wei Wei, Chuanling Guo, Dong Lu & Jianshe Yang. (2009) Radiosensitivity of hepatoma cell lines and human normal liver cell lines exposed in vitro to carbon ions and argon ions at the HIRFL. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms 267:10, pages 1837-1840.
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F Ballarini, D Alloni, A Facoetti & A Ottolenghi. (2008) Heavy-ion effects: from track structure to DNA and chromosome damage. New Journal of Physics 10:7, pages 075008.
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Chuanling Guo, Jufang Wang, Xiaodong Jin, Xigang Jing, Renmin Li, Wei Wei & Wenjian Li. (2007) Studies on advantages of heavy ions in radiotherapy compared with γ-rays. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms 259:2, pages 997-1003.
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K. George & F.A. Cucinotta. (2007) The influence of shielding on the biological effectiveness of accelerated particles for the induction of chromosome damage. Advances in Space Research 39:6, pages 1076-1081.
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Yang Jianshe, Jing Xigang, Li Wenjian, Wang Zhuanzi, Zhou Guangming, Wang Jufang, Dang Bingrong, Gao Qingxiang & Walsh Linda. (2006) Correlation between initial chromatid damage and survival of various cell lines exposed to heavy charged particles. Radiation and Environmental Biophysics 45:4, pages 261-266.
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Francis A. Cucinotta, Myung-Hee Y. Kim & Lei Ren. (2006) Evaluating shielding effectiveness for reducing space radiation cancer risks. Radiation Measurements 41:9-10, pages 1173-1185.
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Jianshe Yang, Xigang Jing, Zhuanzi Wang & Wenjian Li. (2006) A correlation between radiation sensitivity and initial chromatid breaks in cancer cell lines revealed by Calyculin A-induced premature condensation. Open Life Sciences 1:3, pages 451-462.
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Y Jianshe, L Wenjian, J Xiaodong, J Xigang, G Chuanling, W Wei & G Qingxiang. (2006) Survival and initial chromatid breakage in normal and tumour cells exposed in vitro to gamma rays and carbon ions at the HIRFL . The British Journal of Radiology 79:942, pages 518-521.
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Zhuan-Zi Wang. (2006) Comparison of clonogenic assay with premature chromosome condensation assay in prediction of human cell radiosensitivity. World Journal of Gastroenterology 12:16, pages 2601.
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Jianshe Yang, Wenjian Li, Xiaodong Jin, Xigang Jing, Chuanling Guo, Wei Wei & Qingxiang Gao. (2006) Radiobiological response of human hepatoma and normal liver cells exposed to carbon ions generated by Heavy Ion Research Facility in Lanzhou. Science in China Series G 49:1, pages 72-76.
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M. Horstmann, M. Durante, C. Johannes & G. Obe. (2005) Chromosomal intrachanges induced by swift iron ions. Advances in Space Research 35:2, pages 276-279.
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Ewa Gudowska-Nowak, Elena Nasonova, Sylvia Ritter & Michael Scholz. (2004) Chromosome fragmentation after irradiation with C ions. Radiotherapy and Oncology 73, pages S123-S126.
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Tetsuya Kawata, Hisao Ito, Kerry George, Honglu Wu & Francis A. Cucinotta. (2004) Chromosome Aberrations Induced by High-LET Radiations. Biological Sciences in Space 18:4, pages 216-223.
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Tetsuya Kawata, Hisao Ito, Kerry George, Honglu Wu, Takashi Uno, Kouichi Isobe & Francis A. Cucinotta. (2003) Radiation-Induced Chromosome Aberrations in Ataxia Telangiectasia Cells: High Frequency of Deletions and Misrejoining Detected by Fluorescence In Situ Hybridization . Radiation Research 159:5, pages 597-603.
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Kh.K. Muradian. (2002) The space radiation: nature, biological effects and shielding. Kosmìčna nauka ì tehnologìâ 8:1, pages 107-113.
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TETSUYA KAWATA, HISAO ITO, KEN MOTOORI, TAKUYA UEDA, NAOYUKI SHIGEMATSU, YOSHIYA FURUSAWA, MARCO DURANTE, KERRY GEORGE, HONGLU WU & FRANCIS A. CUCINOTTA. (2002) Induction of Chromatin Damage and Distribution of Isochromatid Breaks in Human Fibroblast Cells Exposed to Heavy Ions. Journal of Radiation Research 43:S, pages S169-S173.
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Francis A. Cucinotta, Walter Schimmerling, John W. Wilson, Leif E. Peterson, Gautam D. Badhwar, Premkumar B. Saganti & John F. Dicello. (2001) Space Radiation Cancer Risks and Uncertainties for Mars Missions. Radiation Research 156:5, pages 682-688.
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T. Kawata, M. Durante, Y. Furusawa, K. George, H. Ito, H. Wu & F. A. Cucinotta. (2001) Rejoining of Isochromatid Breaks Induced by Heavy Ions in G 2 -Phase Normal Human Fibroblasts . Radiation Research 156:5, pages 598-602.
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