Advanced search
Publication Cover
International Journal of Radiation Biology Volume 81, 2005 - Issue 8
Submit an article Journal homepage
128
Views
31
CrossRef citations to date
0
Altmetric
Original

Apoptosis induced by high-LET radiations is not affected by cellular p53 gene status

A. Takahashi Department of Biology, Nara Medical University School of Medicine, Nara, Japan
,
H. Matsumoto Department of Experimental Radiology and Health Physics, Division of International Social and Health Science, Faculty of Medical Science, University of Fukui, Fukui, Japan
,
Y. Furusawa Heavy ion Radiobiology Research Group, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba, Japan
,
K. Ohnishi Department of Biology, Nara Medical University School of Medicine, Nara, Japan
,
N. Ishioka Department of Space Biology and Microgravity Sciences, Japan Aerospace Exploration Agency, Ibaraki, Japan
&
T. Ohnishi Department of Biology, Nara Medical University School of Medicine, Nara, JapanCorrespondence[email protected]
Pages 581-586 | Received 16 Dec 2004, Accepted 18 Jul 2005, Published online: 03 Jul 2009

Citations (31)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (2)

Koichi Ando & Yuki Kase. (2009) Biological characteristics of carbon-ion therapy. International Journal of Radiation Biology 85:9, pages 715-728.
Read now
M. S. Sasaki. (2009) Advances in the biophysical and molecular bases of radiation cytogenetics. International Journal of Radiation Biology 85:1, pages 26-47.
Read now

Articles from other publishers (29)

Alexander Helm & Claudia Fournier. (2023) High-LET charged particles: radiobiology and application for new approaches in radiotherapy. Strahlentherapie und Onkologie 199:12, pages 1225-1241.
Crossref
Zihan Zhou, Bingjie Guan, Huang Xia, Rong Zheng & Benhua Xu. (2023) Particle radiotherapy in the era of radioimmunotherapy. Cancer Letters 567, pages 216268.
Crossref
A. Helm, C. Totis, M. Durante & C. Fournier. 2023. Ionizing Radiation and the Immune Response - Part A. Ionizing Radiation and the Immune Response - Part A 1 36 .
Dietrich Averbeck & Claire Rodriguez-Lafrasse. (2021) Role of Mitochondria in Radiation Responses: Epigenetic, Metabolic, and Signaling Impacts. International Journal of Molecular Sciences 22:20, pages 11047.
Crossref
Ping Li, Xiongxiong Liu, Ting Zhao, Feifei Li, Qiqi Wang, Pengcheng Zhang, Ryoichi Hirayama, Weiqiang Chen, Xiaodong Jin, Xiaogang Zheng, Zhen Wang & Qiang Li. (2021) Comparable radiation sensitivity in p53 wild-type and p53 deficient tumor cells associated with different cell death modalities. Cell Death Discovery 7:1.
Crossref
Akinori Morita, Bing Wang, Kaoru Tanaka, Takanori Katsube, Masahiro Murakami, Takashi Shimokawa, Yuichi Nishiyama, Shintaro Ochi, Hidetoshi Satoh, Mitsuru Nenoi & Shin Aoki. (2020) Protective Effects of p53 Regulatory Agents Against High-LET Radiation-Induced Injury in Mice. Frontiers in Public Health 8.
Crossref
Christine E. Hellweg, Arif Ali Chishti, Sebastian Diegeler, Luis F. Spitta, Bernd Henschenmacher & Christa Baumstark-Khan. (2018) Molecular Signaling in Response to Charged Particle Exposures and its Importance in Particle Therapy. International Journal of Particle Therapy 5:1, pages 60-73.
Crossref
Stephanie K. Schaub, Robert D. Stewart, George A. Sandison, Thomas Arbuckle, Jay J. Liao, George E. Laramore, Jing Zeng, Ramesh Rengan, Yolanda D. Tseng, Nina A. Mayr, Shailender Bhatia, Paul T. Nghiem & Upendra Parvathaneni. (2018) Does Neutron Radiation Therapy Potentiate an Immune Response to Merkel Cell Carcinoma?. International Journal of Particle Therapy 5:1, pages 183-195.
Crossref
Xiaodong Jin, Feifei Li, Bingtao Liu, Xiaogang Zheng, Hongbin Li, Fei Ye, Weiqiang Chen & Qiang Li. (2018) Different mitochondrial fragmentation after irradiation with X-rays and carbon ions in HeLa cells and its influence on cellular apoptosis. Biochemical and Biophysical Research Communications 500:4, pages 958-965.
Crossref
Annelies Suetens, Katrien Konings, Marjan Moreels, Roel Quintens, Mieke Verslegers, Els Soors, Kevin Tabury, Vincent Grégoire & Sarah Baatout. (2016) Higher Initial DNA Damage and Persistent Cell Cycle Arrest after Carbon Ion Irradiation Compared to X-irradiation in Prostate and Colon Cancer Cells. Frontiers in Oncology 6.
Crossref
Kathryn D. Held, Hidemasa Kawamura, Takuya Kaminuma, Athena Evalour S. Paz, Yukari Yoshida, Qi Liu, Henning Willers & Akihisa Takahashi. (2016) Effects of Charged Particles on Human Tumor Cells. Frontiers in Oncology 6.
Crossref
Shohei Kanno, Keita Utsunomiya, Yumiko Kono, Noboru Tanigawa & Satoshi Sawada. (2015) The effect of radiation exposure on multidrug resistance: in vitro and in vivo studies using non-small lung cancer cells. EJNMMI Research 5:1.
Crossref
Atanu Ghorai, Asitikantha Sarma, Nitai P. Bhattacharyya & Utpal Ghosh. (2015) Carbon ion beam triggers both caspase-dependent and caspase-independent pathway of apoptosis in HeLa and status of PARP-1 controls intensity of apoptosis. Apoptosis 20:4, pages 562-580.
Crossref
Akihisa Takahashi, Makoto Kubo, Hongyu Ma, Akiko Nakagawa, Yukari Yoshida, Mayu Isono, Tatsuaki Kanai, Tatsuya Ohno, Yoshiya Furusawa, Tomoo Funayama, Yasuhiko Kobayashi & Takashi Nakano. (2014) Nonhomologous End-Joining Repair Plays a More Important Role than Homologous Recombination Repair in Defining Radiosensitivity after Exposure to High-LET Radiation. Radiation Research 182:3, pages 338-344.
Crossref
Mingyuan He, Chen Dong, Teruaki Konishi, Wenzhi Tu, Weili Liu, Naoko Shiomi, Alisa Kobayashi, Yukio Uchihori, Yoshiya Furusawa, Tom K. Hei, Bingrong Dang & Chunlin Shao. (2014) Differential effects of p53 on bystander phenotypes induced by gamma ray and high LET heavy ion radiation. Life Sciences in Space Research 1, pages 53-59.
Crossref
Akihisa Takahashi, Hongyu Ma, Akiko Nakagawa, Yukari Yoshida, Tatsuaki Kanai, Tatsuya Ohno, Yoshikazu Kuwahara, Manabu Fukumoto & Takashi Nakano. (2014) Carbon-Ion Beams Efficiently Induce Cell Killing in X-Ray Resistant Human Squamous Tongue Cancer Cells. International Journal of Medical Physics, Clinical Engineering and Radiation Oncology 03:03, pages 133-142.
Crossref
Yosuke Nakagawa, Akihisa Takahashi, Atsuhisa Kajihara, Nobuhiro Yamakawa, Yuichiro Imai, Ichiro Ota, Noritomo Okamoto, Eiichiro Mori, Taichi Noda, Yoshiya Furusawa, Tadaaki Kirita & Takeo Ohnishi. (2012) Depression of p53-independent Akt survival signals in human oral cancer cells bearing mutated p53 gene after exposure to high-LET radiation. Biochemical and Biophysical Research Communications 423:4, pages 654-660.
Crossref
ICHIRO OTA, NORITOMO OKAMOTO, KATSUNARI YANE, AKIHISA TAKAHASHI, TAKASHI MASUI, HIROSHI HOSOI & TAKEO OHNISHI. (2012) Therapeutic strategies for head and neck cancer based on p53 status. Experimental and Therapeutic Medicine 3:4, pages 585-591.
Crossref
Jee Young Kwon, Jung Min Kim, Young Hoon Ji & Young Rok Seo. (2012) Genome-wide microarray investigation of molecular targets and signaling networks in response to high-LET neutron in in vivo-mimic spheroid of human carcinoma. Molecular & Cellular Toxicology 8:1, pages 9-18.
Crossref
C. Rodriguez-Lafrasse & J. Balosso. (2012) De la trace des ions carbone à l’efficacité thérapeutique de l’hadronthérapie. Cancer/Radiothérapie 16:1, pages 16-24.
Crossref
Susanne Oertel, Markus Thiemann, Karsten Richter, Klaus-J Weber, Peter E Huber, Ramon Lopez Perez, Stephan Brons, Marc Bischof, Andreas E Kulozik, Volker Ehemann, Jürgen Debus & Claudia Blattmann. (2011) Combination of suberoylanilide hydroxamic acid with heavy ion therapy shows promising effects in infantile sarcoma cell lines. Radiation Oncology 6:1.
Crossref
Xiaoming Su, Akihisa Takahashi, Guozhen Guo, Eiichiro Mori, Noritomo Okamoto, Ken Ohnishi, Toshiyasu Iwasaki & Takeo Ohnishi. (2010) Biphasic Effects of Nitric Oxide Radicals on Radiation-Induced Lethality and Chromosome Aberrations in Human Lung Cancer Cells Carrying Different p53 Gene Status. International Journal of Radiation Oncology*Biology*Physics 77:2, pages 559-565.
Crossref
Takuya KAMINUMA, Yoshiyuki SUZUKI, Katsuyuki SHIRAI, Toshiyuki MIZUI, Shin-ei NODA, Yukari YOSHIDA, Tomoo FUNAYAMA, Takeo TAKAHASHI, Yasuhiko KOBAYASHI, Tomoaki SHIRAO & Takashi NAKANO. (2010) Effectiveness of Carbon-ion Beams for Apoptosis Induction in Rat Primary Immature Hippocampal Neurons. Journal of Radiation Research 51:6, pages 627-631.
Crossref
Nobuyuki HAMADA, Tatsuhiko IMAOKA, Shin-ichiro MASUNAGA, Toshiyuki OGATA, Ryuichi OKAYASU, Akihisa TAKAHASHI, Takamitsu A. KATO, Yasuhiko KOBAYASHI, Takeo OHNISHI, Koji ONO, Yoshiya SHIMADA & Teruki TESHIMA. (2010) Recent Advances in the Biology of Heavy-Ion Cancer Therapy. Journal of Radiation Research 51:4, pages 365-383.
Crossref
A. Takahashi & T. Ohnishi. (2009) A low dose pre-irradiation induces radio- and heat-resistance via HDM2 and NO radicals, and is associated with p53 functioning. Advances in Space Research 43:8, pages 1185-1192.
Crossref
Nobuhiro Yamakawa, Akihisa Takahashi, Eiichiro Mori, Yuichiro Imai, Yoshiya Furusawa, Ken Ohnishi, Tadaaki Kirita & Takeo Ohnishi. (2008) High LET radiation enhances apoptosis in mutated p53 cancer cells through Caspase-9 activation. Cancer Science 99:7, pages 1455-1460.
Crossref
David Eriksson, Katrine Riklund, Lennart Johansson & Torgny Stigbrand. 2008. Targeted Radionuclide Tumor Therapy. Targeted Radionuclide Tumor Therapy 215 248 .
Takeo OHNISHI. (2007) Hyperthermic Cancer Therapy and Its Mechanism注目されるハイパーサーミアがん治療―そのしくみを科学する. Japanese Journal of Complementary and Alternative Medicine 4:1, pages 1-7.
Crossref
Takeo OHNISHI, Katsunari YANE & Ichiro OTA. (2006) MOLECULAR BIOLOGY OF HEAD AND NECK CANCER CELLS. Toukeibu Gan 32:3, pages 342-348.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.