Apoptosis induced by high-LET radiations is not affected by cellular p53 gene status

References

• Aoki M, Furusawa Y, Yamada T. LET dependency of heavy ion induced apoptosis in V79 cells. Journal of Radiation Research 2000; 41: 163–175
   PubMed Web of Science ®Google Scholar
• Biard D S, Martin M, Rhun Y L, Duthu A, Lefaix J L, May E, May P. Concomitant p53 gene mutation and increased radiosensitivity in rat lung embryo epithelial cells during neoplastic development. Cancer Research 1994; 54: 3361–3364
   PubMed Web of Science ®Google Scholar
• Blakely E A, Kronenberg A. Heavy ion radiobiology: new approaches to delineate mechanisms underlying enhanced biological effectiveness. Radiation Research 1998; 150: S126–S145
   PubMed Web of Science ®Google Scholar
• Brachman D G, Beckett M, Graves D, Haraf D, Vokes E, Weichselbaum R R. p53 mutation does not correlate with radiosensitivity in 24 head and neck cancer cell lines. Cancer Research 1993; 53: 3667–3669
   PubMed Web of Science ®Google Scholar
• Coelho D, Fischer B, Holl V, Dufour P, Denis J M, Gueulette J, Bergerat J P, Bischoff P. Induction of apoptosis by high linear energy transfer radiation: role of p53. Canadian Journal of Physiology and Pharmacology 2002; 80: 644–649
   PubMed Web of Science ®Google Scholar
• Cuddihy A R, Bristow R G. The p53 protein family and radiation sensitivity: yes or no. Cancer Metastasis Review 2004; 23: 237–257
   PubMed Web of Science ®Google Scholar
• Dertinger H, Lucke-Huhle C, Schlag H, Weibezahn K F. Negative pion irradiation of mammalian cells. 1. Survival characteristics of monolayers and spheroids of Chinese hamster lung cells. International Journal of Radiation Biology 1976; 29: 271–277
   Web of Science ®Google Scholar
• Goodhead D T. Mechanisms for the biological effectiveness of high-LET radiations. Journal of Radiation Research 1999; 40: S1–S13
   PubMed Web of Science ®Google Scholar
• Goodhead D T, Thacker J, Cox R. Weiss Lecture. Effects of radiations of different qualities on cells: molecular mechanisms of damage and repair. International Journal of Radiation Biology 1993; 63: 543–556
   PubMed Web of Science ®Google Scholar
• Heilmann J, Taucher-Scholz G, Haberer T, Scholz M, Kraft G. Measurement of intracellular DNA double-strand break induction and rejoining along the track of carbon and neon particle beams in water. International Journal of Radiation Oncology Biology Physics 1996; 34: 599–608
   PubMed Web of Science ®Google Scholar
• Hendry J H, Potten C S, Merritt A. Apoptosis induced by high- and low-LET radiations. Radiation and Environmental Biophysics 1995; 34: 59–62
   PubMed Web of Science ®Google Scholar
• Hollstein M, Sidransky D, Vogelstein B, Harris C C. p53 mutations in human cancers. Science 1993; 253: 49–53
   Web of Science ®Google Scholar
• Iwadate Y, Mizoe J, Osaka Y, Yamaura A, Tsujii H. High linear energy transfer carbon radiation effectively kills cultured glioma cells with either mutant or wild-type p53. International Journal of Radiation Oncology Biology Physics 2001; 50: 803–808
   PubMed Web of Science ®Google Scholar
• Kanai T, Furusawa Y, Fukutsu K, Itsukaichi H, Eguchi-Kasai K, Ohara H. Irradiation of mixed beam and design of spread-out Bragg peak for heavy ion radiotherapy. Radiation Research 1997; 147: 78–85
   PubMed Web of Science ®Google Scholar
• Lane D. p53, guardian of the genome. Nature 1992; 358: 15–16
   PubMed Web of Science ®Google Scholar
• Lee J, Bernstein A. p53 mutations increase resistance to ionizing radiation. Proceedings of the National Academy of Sciences, USA 1993; 90: 5742–5746
   PubMed Web of Science ®Google Scholar
• Lobrich M, Cooper P K, Rydberg B. Joining of correct and incorrect DNA ends at double-strand breaks produced by high-linear energy transfer radiation in human fibroblasts. Radiation Research 1998; 150: 619–626
   PubMed Web of Science ®Google Scholar
• McIlwrath A J, Vasey P A, Ross G M, Brown R. Cell cycle arrests and radiosensitivity of human tumor cell lines: dependence on wild-type p53 for radiosensitivity. Cancer Research 1994; 54: 3718–3722
   PubMed Web of Science ®Google Scholar
• O'Connor P M, Jackman J, Jondle D, Bhatia K, Magrath I, Kohn K W. Role of the p53 tumor suppressor gene in cell cycle arrest and radiosensitivity of Burkitt's lymphoma cell lines. Cancer Research 1993; 53: 4776–4780
   PubMed Web of Science ®Google Scholar
• Ohnishi T, Wang X, Ohnishi K, Matsumoto H, Takahashi A. p53-dependent induction of WAF1 by heat treatment in human glioblastoma cells. Journal of Biological Chemistry 1996; 271: 14510–14513
   PubMed Web of Science ®Google Scholar
• Ohnishi T, Wang X, Ohnishi K, Takahashi A. p53-dependent induction of WAF1 by cold shock in human glioblastoma cells. Oncogene 1998; 16: 1507–1511
   PubMed Web of Science ®Google Scholar
• Ohnishi T, Wang X, Takahashi A, Ohnishi K, Ejima Y. Low-dose-rate radiation attenuates the response of the tumor suppressor Tp53. Radiation Research 1999; 151: 368–372
   PubMed Web of Science ®Google Scholar
• Ohtsubo T, Wang X, Takahashi A, Ohnishi K, Saito H, Song C W, Ohnishi T. p53-dependent induction of WAF1 by low pH culture condition in human glioblastoma cells. Cancer Research 1997; 57: 3910–3913
   PubMed Web of Science ®Google Scholar
• Pardo F S, Su M, Borek C, Preffer F, Dombkowski D, Gerweck L, Schmidt E V. Transfection of rat embryo cells with mutant p53 increases the intrinsic radiation resistance. Radiation Research 1994; 140: 180–185
   PubMed Web of Science ®Google Scholar
• Slee E A, O'Connor D J, Lu X. To die or not to die: how does p53 decide. Oncogene 2004; 23: 2809–2818
   PubMed Web of Science ®Google Scholar
• Slichenmyer W J, Nelson W G, Slebos R J, Kastan M B. Loss of a p53-associated G1 checkpoint does not decrease cell survival following DNA damage. Cancer Research 1993; 53: 4164–4168
   PubMed Web of Science ®Google Scholar
• Takahashi A, Matsumoto H, Yuki K, Yasumoto J, Kajiwara A, Aoki M, Furusawa Y, Ohnishi K, Ohnishi T. High-LET radiation enhanced apoptosis but not necrosis regardless of p53 status. International Journal of Radiation Oncology Biology Physics 2004; 60: 591–597
   PubMed Web of Science ®Google Scholar
• Takahashi A, Ohnishi K, Ota I, Asakawa I, Tamamoto T, Furusawa Y, Matsumoto H, Ohnishi T. p53-dependent thermal enhancement of cellular sensitivity in human squamous cell carcinomas in relation to LET. International Journal of Radiation Biology 2001; 77: 1043–1051
   PubMed Web of Science ®Google Scholar
• Takahashi A, Ohnishi K, Wang X, Kobayashi M, Matsumoto H, Tamamoto T, Aoki H, Furusawa Y, Yukawa O, Ohnishi T. The dependence of p53 on the radiation enhancement of thermosensitivity at different LET. International Journal of Radiation Oncology Biology Physics 2000; 47: 489–494
   PubMed Web of Science ®Google Scholar
• The International Commission on Radiation Units and Measurements. Linear energy transfer. Oxford University Press, Oxford 1970, Report No. 16
   Google Scholar
• Tobias C A, Blakely E A, Alpen E L, Castro J R, Ainsworth E J, Curtis S B, Ngo F Q, Rodriguez A, Roots R J, Tenforde T, Yang T C. Molecular and cellular radiobiology of heavy ions. International Journal of Radiation Oncology Biology Physics 1982; 8: 2109–2120
   PubMed Web of Science ®Google Scholar
• Tsuboi K, Tsuchida Y, Nose T, Ando K. Cytotoxic effect of accelerated carbon beams on glioblastoma cell line with p53 mutation: clonogenic survival and cell-cycle analysis. International Journal of Radiation Biology 1998; 74: 71–79
   PubMed Web of Science ®Google Scholar
• Vousden K H, Lu X. Live or let die: the cell's response to p53. Nature Reviews: Cancer 2002; 2: 594–604
   PubMed Web of Science ®Google Scholar
• Wang X, Ohnishi T. p53-dependent signal transduction induced by stress. Journal of Radiation Research 1997; 38: 179–194
   PubMed Web of Science ®Google Scholar