699
Views
44
CrossRef citations to date
0
Altmetric
Original Article

Microscopic imaging of DNA repair foci in irradiated normal tissues

, & , MD, PhD, FRCPC
Pages 732-746 | Received 01 Oct 2008, Accepted 27 Jan 2009, Published online: 22 Sep 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Amit Kunwar & Christina K. Haston. (2015) DNA damage at respiratory distress, but not acute time-points, correlates with tissue fibrosis following thoracic radiation exposure in mice. International Journal of Radiation Biology 91:4, pages 360-367.
Read now
Salomeh Jelveh, Pavel Kaspler, Nirmal Bhogal, Javed Mahmood, Patricia E. Lindsay, Paul Okunieff, Susan R. Doctrow, Robert G. Bristow & Richard P. Hill. (2013) Investigations of antioxidant-mediated protection and mitigation of radiation-induced DNA damage and lipid peroxidation in murine skin. International Journal of Radiation Biology 89:8, pages 618-627.
Read now

Articles from other publishers (41)

Nikolaos I. Vlachogiannis, Panagiotis A. Ntouros, Maria Pappa, Evrydiki Kravvariti, Evangelia Georgia Kostaki, Georgios E. Fragoulis, Christina Papanikolaou, Dimitra Mavroeidi, Vasiliki-Kalliopi Bournia, Stylianos Panopoulos, Katerina Laskari, Aikaterini Arida, Vassilis G. Gorgoulis, Maria G. Tektonidou, Dimitrios Paraskevis, Petros P. Sfikakis & Vassilis L. Souliotis. (2023) Chronological Age and DNA Damage Accumulation in Blood Mononuclear Cells: A Linear Association in Healthy Humans after 50 Years of Age. International Journal of Molecular Sciences 24:8, pages 7148.
Crossref
Xia Shen, Xiaoyan Xu, Yujie Guo, Hongli Yang, Juan He & Peng Xie. (2022) Borna disease virus 1 impairs DNA double-strand break repair through the ATR/Chk1 signalling pathway, resulting in learning and memory impairment in rats. Journal of General Virology 103:12.
Crossref
Emma Mellhammar, Magnus Dahlbom, Oskar Vilhelmsson-Timmermand & Sven-Erik Strand. (2022) Small-scale dosimetry for alpha particle 241Am source cell irradiation and estimation of γ-H2AX foci distribution in prostate cancer cell line PC3. EJNMMI Physics 9:1.
Crossref
John M. Danforth, Luc Provencher & Aaron A. Goodarzi. (2022) Chromatin and the Cellular Response to Particle Radiation-Induced Oxidative and Clustered DNA Damage. Frontiers in Cell and Developmental Biology 10.
Crossref
Stefania Mamberti, Maruthi K. Pabba, Alexander Rapp, M. Cristina Cardoso & Michael Scholz. (2022) The Chromatin Architectural Protein CTCF Is Critical for Cell Survival upon Irradiation-Induced DNA Damage. International Journal of Molecular Sciences 23:7, pages 3896.
Crossref
Mahara Valverde & Aarón Sánchez-Brito. (2021) Sustained Activation of TNFα-Induced DNA Damage Response in Newly Differentiated Adipocytes. International Journal of Molecular Sciences 22:19, pages 10548.
Crossref
Xavier Tatin, Giovanna Muggiolu, Sylvie Sauvaigo & Jean Breton. (2021) Evaluation of DNA double-strand break repair capacity in human cells: Critical overview of current functional methods. Mutation Research/Reviews in Mutation Research 788, pages 108388.
Crossref
Yvonne Kohl, Elise Rundén-Pran, Espen Mariussen, Michelle Hesler, Naouale El Yamani, Eleonora Marta Longhin & Maria Dusinska. (2020) Genotoxicity of Nanomaterials: Advanced In Vitro Models and High Throughput Methods for Human Hazard Assessment—A Review. Nanomaterials 10:10, pages 1911.
Crossref
Jiabian Lian, Lu Xia, Yixing Chen, Jiani Zheng, Ke Ma, Lingtao Luo & Feng Ye. (2019) Aldolase B impairs DNA mismatch repair and induces apoptosis in colon adenocarcinoma. Pathology - Research and Practice 215:11, pages 152597.
Crossref
Peng-Cheng Fan, Yao Zhang, Yu Wang, Wei Wei, Yan-Xia Zhou, Yi Xie, Xin Wang, Ying-Zi Qi, Lei Chang, Zheng-Ping Jia, Zhe Zhou, Hua Guan, Hong Zhang, Ping Xu & Ping-Kun Zhou. (2019) Quantitative proteomics reveals mitochondrial respiratory chain as a dominant target for carbon ion radiation: Delayed reactive oxygen species generation caused DNA damage. Free Radical Biology and Medicine 130, pages 436-445.
Crossref
Vinay Jain, Divyalakshmi Saini, P.R. Vivek Kumar, G. Jaikrishan & Birajalaxmi Das. (2017) Efficient repair of DNA double strand breaks in individuals from high level natural radiation areas of Kerala coast, south-west India. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 806, pages 39-50.
Crossref
Erica Werner, Ya Wang & Paul W. Doetsch. (2017) A Single Exposure to Low- or High-LET Radiation Induces Persistent Genomic Damage in Mouse Epithelial Cells In Vitro and in Lung Tissue . Radiation Research 188:4, pages 373-380.
Crossref
Kieran Murphy, Adam Thakore, Marie Constance Lacasse & Danyal Z Khan. (2016) Should future interventional neuroradiologists be screened for mutations that impair radiation-induced DNA repair?. Interventional Neuroradiology 23:1, pages 5-7.
Crossref
Andrew R. Collins, Balasubramanyam Annangi, Laura Rubio, Ricard Marcos, Marco Dorn, Carolin Merker, Irina Estrela‐Lopis, Mihaela Roxana Cimpan, Mohamed Ibrahim, Emil Cimpan, Melanie Ostermann, Alexander Sauter, Naouale El Yamani, Sergey Shaposhnikov, Sylvie Chevillard, Vincent Paget, Romain Grall, Jozo Delic, Felipe Goñi‐ de‐Cerio, Blanca Suarez‐Merino, Valérie Fessard, Kevin N. Hogeveen, Lise Maria Fjellsbø, Elise Runden Pran, Tana Brzicova, Jan Topinka, Maria João Silva, P. E. Leite, A. R. Ribeiro, J. M. Granjeiro, Roland Grafström, Adriele Prina‐Mello & Maria Dusinska. (2016) High throughput toxicity screening and intracellular detection of nanomaterials. WIREs Nanomedicine and Nanobiotechnology 9:1.
Crossref
Henning Willers, Liliana Gheorghiu, Qi Liu, Jason A. Efstathiou, Lori J. Wirth, Mechthild Krause & Cläre von Neubeck. (2015) DNA Damage Response Assessments in Human Tumor Samples Provide Functional Biomarkers of Radiosensitivity. Seminars in Radiation Oncology 25:4, pages 237-250.
Crossref
Mohammad Sabbir Siddiqui, Maxime François, Michael F. Fenech & Wayne R. Leifert. (2015) Persistent γH2AX: A promising molecular marker of DNA damage and aging. Mutation Research/Reviews in Mutation Research 766, pages 1-19.
Crossref
F. Antonelli, A. Campa, G. Esposito, P. Giardullo, M. Belli, V. Dini, S. Meschini, G. Simone, E. Sorrentino, S. Gerardi, G. A. P. Cirrone & M. A. Tabocchini. (2015) Induction and Repair of DNA DSB as Revealed by H2AX Phosphorylation Foci in Human Fibroblasts Exposed to Low- and High-LET Radiation: Relationship with Early and Delayed Reproductive Cell Death. Radiation Research 183:4, pages 417-431.
Crossref
Preety M. Sharma, Brian Ponnaiya, Maria Taveras, Igor Shuryak, Helen Turner & David J. Brenner. (2015) High Throughput Measurement of γH2AX DSB Repair Kinetics in a Healthy Human Population. PLOS ONE 10:3, pages e0121083.
Crossref
Monica Mita, Michael Gordon, Lee Rosen, Nirmal Kapoor, Gavin Choy, Sanjeev Redkar, Pietro Taverna, Aram Oganesian, Amarpal Sahai, Mohammad Azab, Robert Bristow & Anthony W. Tolcher. (2014) Phase 1B study of amuvatinib in combination with five standard cancer therapies in adults with advanced solid tumors. Cancer Chemotherapy and Pharmacology 74:1, pages 195-204.
Crossref
Hiroyuki Date, Kosuke Wakui, Kohei Sasaki, Takahiro Kato & Takeshi Nishioka. (2013) A formulation of cell surviving fraction after radiation exposure. Radiological Physics and Technology 7:1, pages 148-157.
Crossref
Elsa Suberbielle, Pascal E Sanchez, Alexxai V Kravitz, Xin Wang, Kaitlyn Ho, Kirsten Eilertson, Nino Devidze, Anatol C Kreitzer & Lennart Mucke. (2013) Physiologic brain activity causes DNA double-strand breaks in neurons, with exacerbation by amyloid-β. Nature Neuroscience 16:5, pages 613-621.
Crossref
David Murray & Matthew Parliament. 2013. Advances in DNA Repair in Cancer Therapy. Advances in DNA Repair in Cancer Therapy 75 128 .
Alesia Ivashkevich, Christophe E. Redon, Asako J. Nakamura, Roger F. Martin & Olga A. Martin. (2012) Use of the γ-H2AX assay to monitor DNA damage and repair in translational cancer research. Cancer Letters 327:1-2, pages 123-133.
Crossref
Emad A. Ahmed, Diane Agay, Gerrit Schrock, Michel Drouet, Viktor Meineke & Harry Scherthan. (2012) Persistent DNA Damage after High Dose In Vivo Gamma Exposure of Minipig Skin. PLoS ONE 7:6, pages e39521.
Crossref
Yvonne Lorat, Stefanie Schanz, Nadine Schuler, Gunther Wennemuth, Christian Rübe & Claudia E. Rübe. (2012) Beyond Repair Foci: DNA Double-Strand Break Repair in Euchromatic and Heterochromatic Compartments Analyzed by Transmission Electron Microscopy. PLoS ONE 7:5, pages e38165.
Crossref
O. Zlobinskaya, G. Dollinger, D. Michalski, V. Hable, C. Greubel, G. Du, G. Multhoff, B. Röper, M. Molls & T. E. Schmid. (2012) Induction and repair of DNA double-strand breaks assessed by gamma-H2AX foci after irradiation with pulsed or continuous proton beams. Radiation and Environmental Biophysics 51:1, pages 23-32.
Crossref
Y. Yoshii, K.L. Sutherland & H. Date. (2011) Electron track analysis for damage formation in bio-cells. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms 269:17, pages 1887-1891.
Crossref
Manabu Koike, Yasutomo Yutoku & Aki Koike. (2011) Accumulation of p21 proteins at DNA damage sites independent of p53 and core NHEJ factors following irradiation. Biochemical and Biophysical Research Communications 412:1, pages 39-43.
Crossref
Juan Camilo Barreto-Andrade, Elena V. Efimova, Helena J. Mauceri, Michael A. Beckett, Harold G. Sutton, Thomas E. Darga, Everett E. Vokes, Mitchell C. Posner, Stephen J. Kron & Ralph R. Weichselbaum. (2011) Response of Human Prostate Cancer Cells and Tumors to Combining PARP Inhibition with Ionizing Radiation. Molecular Cancer Therapeutics 10:7, pages 1185-1193.
Crossref
Alesia N. Ivashkevich, Olga A. Martin, Andrea J. Smith, Christophe E. Redon, William M. Bonner, Roger F. Martin & Pavel N. Lobachevsky. (2011) γH2AX foci as a measure of DNA damage: A computational approach to automatic analysis. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 711:1-2, pages 49-60.
Crossref
Claudia E. Rübe, Yvonne Lorat, Nadine Schuler, Stefanie Schanz, Gunther Wennemuth & Christian Rübe. (2011) DNA repair in the context of chromatin: New molecular insights by the nanoscale detection of DNA repair complexes using transmission electron microscopy. DNA Repair 10:4, pages 427-437.
Crossref
Helen C. Turner, David J. Brenner, Youhua Chen, Antonella Bertucci, Jian Zhang, Hongliang Wang, Oleksandra V. Lyulko, Yanping Xu, Igor Shuryak, Julia Schaefer, Nabil Simaan, Gerhard Randers-Pehrson, Y. Lawrence Yao, Sally A. Amundson & Guy Garty. (2011) Adapting the γ-H2AX Assay for Automated Processing in Human Lymphocytes. 1. Technological Aspects. Radiation Research 175:3, pages 282-290.
Crossref
Claudia E. Rübe, Sheng Zhang, Nadine Miebach, Andreas Fricke & Christian Rübe. (2011) Protecting the heritable genome: DNA damage response mechanisms in spermatogonial stem cells. DNA Repair 10:2, pages 159-168.
Crossref
Keiji Suzuki, Masahiro Nakashima & Shunichi Yamashita. (2010) Dynamics of Ionizing Radiation-Induced DNA Damage Response in Reconstituted Three-Dimensional Human Skin Tissue. Radiation Research 174:4, pages 415-423.
Crossref
John Thoms & Robert G. Bristow. (2010) DNA Repair Targeting and Radiotherapy: A Focus on the Therapeutic Ratio. Seminars in Radiation Oncology 20:4, pages 217-222.
Crossref
Anthony J. Chalmers, Mina Lakshman, Norman Chan & Robert G. Bristow. (2010) Poly(ADP-Ribose) Polymerase Inhibition as a Model for Synthetic Lethality in Developing Radiation Oncology Targets. Seminars in Radiation Oncology 20:4, pages 274-281.
Crossref
L-J Mah, A El-Osta & T C Karagiannis. (2010) γH2AX: a sensitive molecular marker of DNA damage and repair. Leukemia 24:4, pages 679-686.
Crossref
I.Y. Belyaev. (2010) Radiation-induced DNA repair foci: Spatio-temporal aspects of formation, application for assessment of radiosensitivity and biological dosimetry. Mutation Research/Reviews in Mutation Research 704:1-3, pages 132-141.
Crossref
Devika B. Chithrani, Salomeh Jelveh, Farid Jalali, Monique van Prooijen, Christine Allen, Robert G. Bristow, Richard P. Hill & David A. Jaffray. (2010) Gold Nanoparticles as Radiation Sensitizers in Cancer Therapy. Radiation Research 173:6, pages 719.
Crossref
Nirmal Bhogal, Pavel Kaspler, Farid Jalali, Ollivier Hyrien, Rui Chen, Richard P. Hill & Robert G. Bristow. (2010) Late Residual γ-H2AX Foci In Murine Skin are Dose Responsive and Predict Radiosensitivity In Vivo . Radiation Research 173:1, pages 1-9.
Crossref
Jennifer S. Dickey, Christophe E. Redon, Asako J. Nakamura, Brandon J. Baird, Olga A. Sedelnikova & William M. Bonner. (2009) H2AX: functional roles and potential applications. Chromosoma 118:6, pages 683-692.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.