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International Journal of Radiation Biology Volume 94, 2018 - Issue 5
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Original Articles

Prior irradiation results in elevated programmed cell death protein 1 (PD-1) in T cells

Deguan LiInstitute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China; View further author information
,
Renxiang ChenDepartment of Biochemistry and Molecular & Cellular Biology, Georgetown University, Washington, DC, USA; View further author information
,
Yi-Wen WangDepartment of Biochemistry and Molecular & Cellular Biology, Georgetown University, Washington, DC, USA; View further author information
,
Albert J. Fornace Jr.Department of Biochemistry and Molecular & Cellular Biology, Georgetown University, Washington, DC, USA; ;Department of Oncology, Georgetown University, Washington, DC, USAView further author information
&
Heng-Hong LiDepartment of Biochemistry and Molecular & Cellular Biology, Georgetown University, Washington, DC, USA; ;Department of Oncology, Georgetown University, Washington, DC, USACorrespondence[email protected]
View further author information
Pages 488-494 | Received 12 Jun 2017, Accepted 30 Oct 2017, Published online: 29 Nov 2017

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Deguan Li, Yong Guan, Yinping Dong, Jing Wu, Yuanyang Zhang, Renxiang Chen, Yun-Tien Lin, Albert J. Fornace, Heng-Hong Li & Zhiyong Yuan. (2021) Radiochemotherapy upregulates expression of checkpoint receptors on circulating T cells. International Journal of Radiation Biology 97:11, pages 1563-1568.
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Li-Fang Shen, Shui-Hong Zhou & Yu Guo. (2020) Role of GLUT-1 in the Upregulation of PD-L1 Expression After Radiotherapy and Association of PD-L1 with Favourable Overall Survival in Hypopharyngeal Cancer. OncoTargets and Therapy 13, pages 11221-11235.
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Mohsen Sisakht, Maryam Darabian, Amir Mahmoodzadeh, Ali Bazi, Sayed Mohammad Shafiee, Pooneh Mokarram & Zahra Khoshdel. (2020) The role of radiation induced oxidative stress as a regulator of radio-adaptive responses. International Journal of Radiation Biology 96:5, pages 561-576.
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Articles from other publishers (17)

Li-Fang Shen, Zi-Ming Fu & Shui-Hong Zhou. (2023) The role of radiotherapy in tumor immunity and the potential of PET/CT in detecting the expression of PD-1/PD-L1. Japanese Journal of Radiology.
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Li Wang, Siyu Wang, Jiayu Zhang, Jianmin Peng, Bin Cheng, Huan Li & Qinchao Hu. (2023) Radiotherapy upregulated immune checkpoints contribute to the development of second primary OSCC . Oral Diseases.
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Jiao-jiao Ni, Zi-zhen Zhang, Ming-jie Ge, Jing-yu Chen & Wei Zhuo. (2022) Immune-based combination therapy to convert immunologically cold tumors into hot tumors: an update and new insights. Acta Pharmacologica Sinica 44:2, pages 288-307.
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J. M. Herter, M. Kiljan, S. Kunze, M. Reinscheid, O. Ibruli, J. Cai, L. Niu, I. Heßelmann, M. Trommer, G. S. Herter-Sprie, C. Köhler & S. Marnitz. (2022) Influence of chemoradiation on the immune microenvironment of cervical cancer patients. Strahlentherapie und Onkologie 199:2, pages 121-130.
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Mahdi Abdoli Shadbad, Zahra Asadzadeh, Negar Hosseinkhani, Afshin Derakhshani, Nazila Alizadeh, Oronzo Brunetti, Nicola Silvestris & Behzad Baradaran. (2021) A Systematic Review of the Tumor-Infiltrating CD8+ T-Cells/PD-L1 Axis in High-Grade Glial Tumors: Toward Personalized Immuno-Oncology. Frontiers in Immunology 12.
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Gregor Manukian, Charles Kivolowitz, Tiziana DeAngelis, Anuradha A. Shastri, Jason E. Savage, Kevin Camphausen, Ulrich Rodeck, Jelani C. Zarif & Nicole L. Simone. (2021) Caloric Restriction Impairs Regulatory T cells Within the Tumor Microenvironment After Radiation and Primes Effector T cells. International Journal of Radiation Oncology*Biology*Physics 110:5, pages 1341-1349.
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Adrian Witzleben, Adrian Fehn, Ayla Grages, Jasmin Ezić, Sandra S. Jeske, Lisa K. Puntigam, Cornelia Brunner, Johann M. Kraus, Hans A. Kestler, Johannes Doescher, Matthias Brand, Marie‐Nicole Theodoraki, Christian H. Ottensmeier, Thomas K. Hoffmann, Patrick J. Schuler & Simon Laban. (2020) Prospective longitudinal study of immune checkpoint molecule ( ICM ) expression in immune cell subsets during curative conventional therapy of head and neck squamous cell carcinoma ( HNSCC ) . International Journal of Cancer 148:8, pages 2023-2035.
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Hiroshi Fukushima, Soichiro Yoshida, Toshiki Kijima, Yuki Nakamura, Shohei Fukuda, Sho Uehara, Yosuke Yasuda, Hajime Tanaka, Minato Yokoyama, Yoh Matsuoka & Yasuhisa Fujii. (2021) Combination of Cisplatin and Irradiation Induces Immunogenic Cell Death and Potentiates Postirradiation Anti–PD-1 Treatment Efficacy in Urothelial Carcinoma. International Journal of Molecular Sciences 22:2, pages 535.
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Lijun Li, Renxiang Chen, Yun-Tien Lin, Arslon Humayun, Albert J. FornaceJr.Jr. & Heng-Hong Li. (2021) 3,3'-Diindolylmethane Enhances Tumor Regression After Radiation Through Protecting Normal Cells to Modulate Antitumor Immunity. Advances in Radiation Oncology 6:1, pages 100601.
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Lydia S. Lamb, Hao-Wen Sim & Ann I. McCormack. (2020) Case Report: A Case of Pituitary Carcinoma Treated With Sequential Dual Immunotherapy and Vascular Endothelial Growth Factor Inhibition Therapy. Frontiers in Endocrinology 11.
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Chaoxu Zhang, Yibo Fan, Xiaofang Che, Min Zhang, Zhi Li, Ce Li, Shuo Wang, Ti Wen, Kezuo Hou, Xinye Shao, Yunpeng Liu & Xiujuan Qu. (2020) Anti-PD-1 Therapy Response Predicted by the Combination of Exosomal PD-L1 and CD28. Frontiers in Oncology 10.
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Paola Ciciola, Priscilla Cascetta, Cataldo Bianco, Luigi Formisano & Roberto Bianco. (2020) Combining Immune Checkpoint Inhibitors with Anti-Angiogenic Agents. Journal of Clinical Medicine 9:3, pages 675.
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Jie Huang & Jian Jian Li. (2020) Cell repopulation, rewiring metabolism, and immune regulation in cancer radiotherapy. Radiation Medicine and Protection 1:1, pages 24-30.
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Jie Huang & Jian Jian Li. 2020. Tumor Microenvironment. Tumor Microenvironment 175 202 .
Lawrence Kleinberg, Lindsey Sloan, Stuart Grossman & Michael Lim. (2019) Radiotherapy, Lymphopenia, and Host Immune Capacity in Glioblastoma: A Potentially Actionable Toxicity Associated With Reduced Efficacy of Radiotherapy. Neurosurgery 85:4, pages 441-453.
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Gregor Manukian, Voichita Bar-Ad, Bo Lu, Athanassios Argiris & Jennifer M. Johnson. (2019) Combining Radiation and Immune Checkpoint Blockade in the Treatment of Head and Neck Squamous Cell Carcinoma. Frontiers in Oncology 9.
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Ming Yi, Dechao Jiao, Hanxiao Xu, Qian Liu, Weiheng Zhao, Xinwei Han & Kongming Wu. (2018) Biomarkers for predicting efficacy of PD-1/PD-L1 inhibitors. Molecular Cancer 17:1.
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