Prior irradiation results in elevated programmed cell death protein 1 (PD-1) in T cells

References

• Ahmadzadeh M, Johnson LA, Heemskerk B, Wunderlich JR, Dudley ME, White DE, Rosenberg SA. 2009. Tumor antigen-specific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired. Blood. 114:1537–1544.
   PubMed Web of Science ®Google Scholar
• Andarawewa KL, Erickson AC, Chou WS, Costes SV, Gascard P, Mott JD, Bissell MJ, Barcellos-Hoff MH. 2007. Ionizing radiation predisposes nonmalignant human mammary epithelial cells to undergo transforming growth factor beta induced epithelial to mesenchymal transition. Cancer Res. 67:8662–8670.
   PubMed Web of Science ®Google Scholar
• Balkhi MY, Ma Q, Ahmad S, Junghans RP. 2015. T cell exhaustion and Interleukin 2 downregulation. Cytokine. 71:339–347.
   PubMed Web of Science ®Google Scholar
• Bennett F, Luxenberg D, Ling V, Wang IM, Marquette K, Lowe D, Khan N, Veldman G, Jacobs KA, Valge-Archer VE, et al. 2003. Program death-1 engagement upon TCR activation has distinct effects on costimulation and cytokine-driven proliferation: attenuation of ICOS, IL-4, and IL-21, but not CD28, IL-7, and IL-15 responses. J Immunol. 170:711–718.
   PubMed Web of Science ®Google Scholar
• Carter L, Fouser LA, Jussif J, Fitz L, Deng B, Wood CR, Collins M, Honjo T, Freeman GJ, Carreno BM. 2002. PD-1:PD-L inhibitory pathway affects both CD4(+) and CD8(+) T cells and is overcome by IL-2. Eur J Immunol. 32:634–643.
   PubMed Web of Science ®Google Scholar
• Dainiak N. 2002. Hematologic consequences of exposure to ionizing radiation. Exp Hematol. 30:513–528.
   PubMed Web of Science ®Google Scholar
• Deng L, Liang H, Burnette B, Beckett M, Darga T, Weichselbaum RR, Fu YX. 2014a. Irradiation and anti-PD-L1 treatment synergistically promote antitumor immunity in mice. J Clin Invest. 124:687–695.
   PubMed Web of Science ®Google Scholar
• Deng L, Liang H, Xu M, Yang X, Burnette B, Arina A, Li XD, Mauceri H, Beckett M, Darga T, et al. 2014b. STING-dependent cytosolic DNA sensing promotes radiation-induced type I interferon-dependent antitumor immunity in immunogenic tumors. Immunity. 41:843–852.
   PubMed Web of Science ®Google Scholar
• Dong H, Strome SE, Salomao DR, Tamura H, Hirano F, Flies DB, Roche PC, Lu J, Zhu G, Tamada K, et al. 2002. Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion. Nat Med. 8:793–800.
   PubMed Web of Science ®Google Scholar
• Dovedi SJ, Adlard AL, Lipowska-Bhalla G, McKenna C, Jones S, Cheadle EJ, Stratford IJ, Poon E, Morrow M, Stewart R, et al. 2014. Acquired resistance to fractionated radiotherapy can be overcome by concurrent PD-L1 blockade. Cancer Res. 74:5458–5468.
   PubMed Web of Science ®Google Scholar
• Haikerwal SJ, Hagekyriakou J, MacManus M, Martin OA, Haynes NM. 2015. Building immunity to cancer with radiation therapy. Cancer Lett. 368:198–208.
   PubMed Web of Science ®Google Scholar
• Hallahan D, Kuchibhotla J, Wyble C. 1996. Cell adhesion molecules mediate radiation-induced leukocyte adhesion to the vascular endothelium. Cancer Res. 56:5150–5155.
   PubMed Web of Science ®Google Scholar
• Hardee ME, Marciscano AE, Medina-Ramirez CM, Zagzag D, Narayana A, Lonning SM, Barcellos-Hoff MH. 2012. Resistance of glioblastoma-initiating cells to radiation mediated by the tumor microenvironment can be abolished by inhibiting transforming growth factor-β. Cancer Res. 72:4119–4129.
   PubMed Web of Science ®Google Scholar
• Hayashi T, Kusunoki Y, Hakoda M, Morishita Y, Kubo Y, Maki M, Kasagi F, Kodama K, Macphee DG, Kyoizumi S. 2003. Radiation dose-dependent increases in inflammatory response markers in A-bomb survivors. Int J Radiat Biol. 79:129–136.
   PubMed Web of Science ®Google Scholar
• Hernandez-Godoy J, Planelles D, Balsalobre B. 2013. Immediate and short-, mid- and long-term effects of in vivo ionizing radiation exposure in BALB/c mice: II. activation of phorbol myristate acetate and/or calcium ionophore on lymphocyte proliferation. In Vivo. 27:67–76.
   PubMed Web of Science ®Google Scholar
• Jin HT, Ahmed R, Okazaki T. 2011. Role of PD-1 in regulating T-cell immunity. Curr Top Microbiol Immunol. 350:17–37.
   PubMed Web of Science ®Google Scholar
• Kulpa DA, Lawani M, Cooper A, Peretz Y, Ahlers J, Sekaly RP. 2013. PD-1 coinhibitory signals: the link between pathogenesis and protection. Semin Immunol. 25:219–227.
   PubMed Web of Science ®Google Scholar
• Kusunoki Y, Hayashi T. 2008. Long-lasting alterations of the immune system by ionizing radiation exposure: implications for disease development among atomic bomb survivors. Int J Radiat Biol. 84:1–14.
   PubMed Web of Science ®Google Scholar
• Leitner J, Grabmeier-Pfistershammer K, Steinberger P. 2010. Receptors and ligands implicated in human T cell costimulatory processes. Immunol Lett. 128:89–97.
   PubMed Web of Science ®Google Scholar
• Li HH, Wang YW, Chen R, Zhou B, Ashwell JD, Fornace AJJ. 2015. Ionizing radiation impairs T cell activation by affecting metabolic reprogramming. Int J Biol Sci. 11:726–736.
   PubMed Web of Science ®Google Scholar
• Matsumura S, Wang B, Kawashima N, Braunstein S, Badura M, Cameron TO, Babb JS, Schneider RJ, Formenti SC, Dustin ML, et al. 2008. Radiation-induced CXCL16 release by breast cancer cells attracts effector T cells. J Immunol. 181:3099–3107.
   PubMed Web of Science ®Google Scholar
• Neriishi K, Nakashima E, Delongchamp RR. 2001. Persistent subclinical inflammation among A-bomb survivors. Int J Radiat Biol. 77:475–482.
   PubMed Web of Science ®Google Scholar
• Nguyen DH, Oketch-Rabah HA, Illa-Bochaca I, Geyer FC, Reis-Filho JS, Mao JH, Ravani SA, Zavadil J, Borowsky AD, Jerry DJ, et al. 2011. Radiation acts on the microenvironment to affect breast carcinogenesis by distinct mechanisms that decrease cancer latency and affect tumor type. Cancer Cell. 19:640–651.
   PubMed Web of Science ®Google Scholar
• Parikh F, Duluc D, Imai N, Clark A, Misiukiewicz K, Bonomi M, Gupta V, Patsias A, Parides M, Demicco EG, et al. 2014. Chemoradiotherapy-induced upregulation of PD-1 antagonizes immunity to HPV-related oropharyngeal cancer. Cancer Res. 74:7205–7216.
   PubMed Web of Science ®Google Scholar
• Partridge MA, Chai Y, Zhou H, Hei TK. 2010. High-throughput antibody-based assays to identify and quantify radiation-responsive protein biomarkers. Int J Radiat Biol. 86:321–328.
   PubMed Web of Science ®Google Scholar
• Schaue D, McBride WH. 2012. T lymphocytes and normal tissue responses to radiation. Front Oncol. 2:119.
   PubMedGoogle Scholar
• Sharabi AB, Nirschl CJ, Kochel CM, Nirschl TR, Francica BJ, Velarde E, Deweese TL, Drake CG. 2015. Stereotactic radiation therapy augments antigen-specific PD-1-mediated antitumor immune responses via cross-presentation of tumor antigen. Cancer Immunol Res. 3:345–355.
   PubMed Web of Science ®Google Scholar
• Siva S, MacManus M, Kron T, Best N, Smith J, Lobachevsky P, Ball D, Martin O. 2014. A pattern of early radiation-induced inflammatory cytokine expression is associated with lung toxicity in patients with non-small cell lung cancer. PLoS One. 9:e109560.
   PubMed Web of Science ®Google Scholar
• Wherry EJ, Kurachi M. 2015. Molecular and cellular insights into T cell exhaustion. Nat Rev Immunol. 15:486–499.
   PubMed Web of Science ®Google Scholar
• Yamaguchi M, Kashiwakura I. 2013. Role of reactive oxygen species in the radiation response of human hematopoietic stem/progenitor cells. PLoS One. 8:e70503.
   PubMed Web of Science ®Google Scholar
• Yamamori T, Yasui H, Yamazumi M, Wada Y, Nakamura Y, Nakamura H, Inanami O. 2012. Ionizing radiation induces mitochondrial reactive oxygen species production accompanied by upregulation of mitochondrial electron transport chain function and mitochondrial content under control of the cell cycle checkpoint. Free Radic Biol Med. 53:260–270.
   PubMed Web of Science ®Google Scholar