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A historical reflection on our understanding of radiation-induced DNA double strand break repair in somatic mammalian cells; interfacing the past with the present

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Pages 945-956 | Received 15 Oct 2018, Accepted 17 Dec 2018, Published online: 17 Jan 2019

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Sisi Qin, Ichiwa Kitty, Yalan Hao, Fei Zhao & Wootae Kim. (2023) Maintaining Genome Integrity: Protein Kinases and Phosphatases Orchestrate the Balancing Act of DNA Double-Strand Breaks Repair in Cancer. International Journal of Molecular Sciences 24:12, pages 10212.
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Ujjayinee Ray, Vindya K. Gopinatha, Shivangi Sharma, Laijau Goyary, Bibha Choudhary, Kempegowda Mantelingu, Kanchugarakoppal S. Rangappa & Sathees C. Raghavan. (2022) Identification and characterization of mercaptopyrimidine‐based small molecules as inhibitors of nonhomologous DNA end joining . The FEBS Journal 290:3, pages 796-820.
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Shaylee R. Kieffer & Noel F. Lowndes. (2022) Immediate-Early, Early, and Late Responses to DNA Double Stranded Breaks. Frontiers in Genetics 13.
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Pierre Philouze, Arnaud Gauthier, Alexandra Lauret, Céline Malesys, Giovanna Muggiolu, Sylvie Sauvaigo, Antoine Galmiche, Philippe Ceruse, Gersende Alphonse, Anne-Sophie Wozny & Claire Rodriguez-Lafrasse. (2022) CD44, γ-H2AX, and p-ATM Expressions in Short-Term Ex Vivo Culture of Tumour Slices Predict the Treatment Response in Patients with Oral Squamous Cell Carcinoma. International Journal of Molecular Sciences 23:2, pages 877.
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Atsushi Shibata. 2022. DNA Damage and Double Strand Breaks - Part A. DNA Damage and Double Strand Breaks - Part A 117 130 .
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Atsushi Shibata & Penny A. Jeggo. (2021) ATM’s Role in the Repair of DNA Double-Strand Breaks. Genes 12:9, pages 1370.
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Hideki Matsumoto, Yoshiya Shimada, Asako J Nakamura, Noriko Usami, Mitsuaki Ojima, Shizuko Kakinuma, Mikio Shimada, Masaaki Sunaoshi, Ryoichi Hirayama & Hiroshi Tauchi. (2021) Health effects triggered by tritium: how do we get public understanding based on scientifically supported evidence?. Journal of Radiation Research 62:4, pages 557-563.
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Yaping Qi, John William Warmenhoven, Nicholas Thomas Henthorn, Samuel Peter Ingram, Xie George Xu, Karen Joy Kirkby & Michael John Merchant. (2021) Mechanistic Modelling of Slow and Fast NHEJ DNA Repair Pathways Following Radiation for G0/G1 Normal Tissue Cells. Cancers 13:9, pages 2202.
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V. A. Vinnikov & T. V. Rubleva. (2021) Predictors of radiation-induced complications in radiation oncology based on cell survival tests after ex vivo exposure: literature review. Український радіологічний та онкологічний журнал 29:1, pages 89-118.
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Nelly Babayan, Natalia Vorobyeva, Bagrat Grigoryan, Anna Grekhova, Margarita Pustovalova, Sofya Rodneva, Yuriy Fedotov, Gohar Tsakanova, Rouben Aroutiounian & Andreyan Osipov. (2020) Low Repair Capacity of DNA Double-Strand Breaks Induced by Laser-Driven Ultrashort Electron Beams in Cancer Cells. International Journal of Molecular Sciences 21:24, pages 9488.
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Zhentian Li, David S. Yu, Paul W. Doetsch & Erica Werner. (2020) Replication stress and FOXM1 drive radiation induced genomic instability and cell transformation. PLOS ONE 15:11, pages e0235998.
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Atsushi Shibata & Penny A Jeggo. (2020) Canonical DNA non-homologous end-joining; capacity versus fidelity. The British Journal of Radiology 93:1115, pages 20190966.
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Anja Charlotte Lundgren Mortensen, Tabassom Mohajershojai, Mehran Hariri, Marika Pettersson & Diana Spiegelberg. (2020) Overcoming Limitations of Cisplatin Therapy by Additional Treatment With the HSP90 Inhibitor Onalespib. Frontiers in Oncology 10.
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Yoko Katsuki, Penny A. Jeggo, Yuki Uchihara, Minoru Takata & Atsushi Shibata. (2020) DNA double-strand break end resection: a critical relay point for determining the pathway of repair and signaling. Genome Instability & Disease 1:4, pages 155-171.
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Zhen-Yang Li, Hui-Fen Li, Ying-Ying Zhang, Xue-Lan Zhang, Bing Wang & Jiang-Ting Liu. (2020) Value of long non-coding RNA Rpph1 in esophageal cancer and its effect on cancer cell sensitivity to radiotherapy. World Journal of Gastroenterology 26:15, pages 1775-1791.
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Lei Cheng, Beata Brzozowska-Wardecka, Halina Lisowska, Andrzej Wojcik & Lovisa Lundholm. (2019) Impact of ATM and DNA-PK Inhibition on Gene Expression and Individual Response of Human Lymphocytes to Mixed Beams of Alpha Particles and X-Rays. Cancers 11:12, pages 2013.
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Anika Trenner & Alessandro A. Sartori. (2019) Harnessing DNA Double-Strand Break Repair for Cancer Treatment. Frontiers in Oncology 9.
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Hiro Sato, Penny A. Jeggo & Atsushi Shibata. (2019) Regulation of programmed death‐ligand 1 expression in response to DNA damage in cancer cells: Implications for precision medicine . Cancer Science 110:11, pages 3415-3423.
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Maxim Shevtsov, Hiro Sato, Gabriele Multhoff & Atsushi Shibata. (2019) Novel Approaches to Improve the Efficacy of Immuno-Radiotherapy. Frontiers in Oncology 9.
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