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Original Article

The Induction of Chromosome Aberrations in Human Lymphocytes by Alpha-radiation

, , &
Pages 83-91 | Received 20 Jun 1979, Accepted 11 Oct 1979, Published online: 03 Jul 2009

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Adrianna Tartas, Mateusz Filipek, Marcin Pietrzak, Andrzej Wojcik & Beata Brzozowska. (2023) Modeling of dose and linear energy transfer homogeneity in cell nuclei exposed to alpha particles under various setup conditions. International Journal of Radiation Biology 99:8, pages 1248-1256.
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Robert Stainforth, Jan Schuemann, Aimee L. McNamara, Ruth C. Wilkins & Vinita Chauhan. (2021) Challenges in the quantification approach to a radiation relevant adverse outcome pathway for lung cancer. International Journal of Radiation Biology 97:1, pages 85-101.
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K. Karthik, Vasumathy Rajan, Badri N. Pandey, K. Sivasubramanian, Solomon F.D. Paul & P. Venkatachalam. (2019) Direct and bystander effects in human blood lymphocytes exposed to 241Am alpha particles and the relative biological effectiveness using chromosomal aberration and micronucleus assay. International Journal of Radiation Biology 95:6, pages 725-736.
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Xiao-Dan Liu, Da-Fei Xie, Yi-Long Wang, Hua Guan, Rui-Xue Huang & Ping-Kun Zhou. (2019) Integrated analysis of lncRNA–mRNA co-expression networks in the α-particle induced carcinogenesis of human branchial epithelial cells. International Journal of Radiation Biology 95:2, pages 144-155.
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Roser Puig, Mònica Pujol, Leonardo Barrios, María Rosa Caballín & Joan-Francesc Barquinero. (2016) Analysis of α-particle-induced chromosomal aberrations by chemically-induced PCC. Elaboration of dose-effect curves. International Journal of Radiation Biology 92:9, pages 493-501.
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Andrei Turtoi & Frank H. A. Schneeweiss. (2009) Effect of 211At α-particle irradiation on expression of selected radiation responsive genes in human lymphocytes. International Journal of Radiation Biology 85:5, pages 403-412.
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M. S. Sasaki. (2009) Advances in the biophysical and molecular bases of radiation cytogenetics. International Journal of Radiation Biology 85:1, pages 26-47.
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J. F. Barquinero, G. Stephan & E. Schmid. (2004) Effect of americium‐241 α‐particles on the dose–response of chromosome aberrations in human lymphocytes analysed by fluorescence in situ hybridization. International Journal of Radiation Biology 80:2, pages 155-164.
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Spiros Vamvakas, Esther H. Vock & Werner K. Lutz. (1997) On the Role of DNA Double-Strand Breaks in Toxicity and Carcinogenesis. Critical Reviews in Toxicology 27:2, pages 155-174.
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CharlesL. Sanders, GeraldE. Dagle & GeraldE. Dagle. (1996) A Threshold Model of Pulmonary Carcinogenesis: Carcinoma in the Rat After Deposition of Plutonium or Quartz. Applied Occupational and Environmental Hygiene 11:4, pages 391-397.
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C.S. Griffin, A.N. Harvey & J.R.K. Savage. (1994) Chromatid Damage Induced by 238Pu α-particles in G2 and S Phase Chinese Hamster V79 Cells. International Journal of Radiation Biology 66:1, pages 85-98.
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R.K. Sachs & D.J. Brenner. (1993) Effect of LET on Chromosomal Aberration Yields. I. Do Long-lived, Exchange-prone Double Strand Breaks Play a Role?. International Journal of Radiation Biology 64:6, pages 677-688.
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E. A. H. Lashin, H. F. Moustafa, E. M. Elaasar, Y. Y. Bakir & S. D. Al Zenki. (1990) Dose-response Relationship for Chromosome Aberations induced in Human Lymphocytes by 18 MeV Electron Beam Irradiation. Isotopenpraxis Isotopes in Environmental and Health Studies 26:1, pages 40-43.
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M. Frankenberg-Schwager, D. Frankenberg, R. Harbich & C. Adamczyk. (1990) A Comparative Study of Rejoining of DNA Double-strand Breaks in Yeast Irradiated with 3·5 MeV α-particles or with 30 MeV Electrons. International Journal of Radiation Biology 57:6, pages 1151-1168.
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H. Nagasawa, J. Robertson & J.B. Little. (1990) Induction of Chromosomal Aberrations and Sister Chromatid Exchanges by Alpha Particles in Density-inhibited Cultures of Mouse 10T½ and 3T3 Cells. International Journal of Radiation Biology 57:1, pages 35-44.
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A. Bilbao, J.S. Prosser, A.A. Edwards, J.C. Moody & D.C. Lloyd. (1989) The Induction of Micronuclei in Human Lymphocytes by in Vitro Irradiation with Alpha Particles from Plutonium-239. International Journal of Radiation Biology 56:3, pages 287-292.
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S.Z. Aghamohammadi, D.T. Goodhead & J.R.K. Savage. (1988) Induction of Sister Chromatid Exchanges (SCE) in G0 Lymphocytes by Plutonium-238 α-particles. International Journal of Radiation Biology 53:6, pages 909-915.
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C.J. Roberts, G.R. Morgan & P.D. Holt. (1987) The Production of Chromosome Aberration in Chinese Hamster Fibroblasts Exposed to 24 keV Neutrons. International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine 51:2, pages 341-351.
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A.A. Edwards, D.C. Lloyd, J.S. Prosser, P. Finnon & J.E. Moquet. (1986) Chromosome Aberrations Induced in Human Lymphocytes by 8·7 MeV Protons and 23·5 MeV Helium-3 Ions. International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine 50:1, pages 137-145.
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Jürgen Kiefer. (1985) Cellular and Subcellular Effects of Very Heavy Ions. International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine 48:6, pages 873-892.
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T. Takatsuji & M.S. Sasaki. (1984) Dose—effect Relationship of Chromosome Aberrations Induced by 23 MeV Alpha Particles in Human Lymphocytes. International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine 45:3, pages 237-243.
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T. Takatsuji, H. Takekoshi & M.S. Sasaki. (1983) Induction of Chromosome Aberrations by 4·9 MeV Protons in Human Lymphocytes. International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine 44:6, pages 553-562.
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Christine Lücke-Huhle, Ludwig Hieber & Rolf-Dieter Wegner. (1983) Caffeine-mediated Release of Alpha-radiation-induced G2 Arrest Increases the Yield of Chromosome Aberrations. International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine 43:2, pages 123-132.
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Darrell R. Fisher & Rebekah Harty. (1982) The Microdosimetry of Lymphocytes Irradiated by Alpha-particles. International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine 41:3, pages 315-324.
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R.J. Purrott, A.A. Edwards, D.C. Lloyd & J.W. Stather. (1980) The Induction of Chromosome Aberrations in Human Lymphocytes by in Vitro Irradiation with α-particles from Plutonium-239. International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine 38:3, pages 277-284.
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