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Original Article

Measurement of the Kinetics of DNA Double Strand Break Repair in Ehrlich Ascites Tumour Cells Using the Unwinding Method

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Pages 335-347 | Received 27 Dec 1979, Accepted 20 Mar 1980, Published online: 03 Jul 2009

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P. Virsik-Peuckert, B. Volkmer & D. Mehmel. (1995) Influence of Ara A on the Formation of Dicentrics in Irradiated Quiescent CHO Cells. International Journal of Radiation Biology 68:3, pages 235-243.
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E. Dikomey & H. Jung. (1995) Correlation between Thermal Radiosensitization and Slowly Rejoined DNA Strand Breaks in CHO Cells. International Journal of Radiation Biology 68:3, pages 227-233.
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E. Dikomey, M. Flentje & J. Dahm-Daphi. (1995) Comparison between the Alkaline Unwinding Technique and Neutral Filter Elution Using CHO, V79 and EAT Cells. International Journal of Radiation Biology 67:3, pages 269-275.
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S.J. Whitaker, Y.C. Ung & T.J. McMillan. (1995) DNA Double-strand Break Induction and Rejoining as Determinants of Human Tumour Cell Radiosensitivity. A Pulsed-field Gel Electrophoresis Study. International Journal of Radiation Biology 67:1, pages 7-18.
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E. Dikomey & J. Lorenzen. (1993) Saturated and Unsaturated Repair of DNA Strand Breaks in CHO Cells after X-irradiation with Doses Ranging from 3 to 90 Gy. International Journal of Radiation Biology 64:6, pages 659-667.
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J. Dahm-Daphi, E. Dikomey, C. Pyttlik & P.A. Jeggo. (1993) Reparable and Non-reparable DNA Strand Breaks Induced by X-irradiation in CHO K1 Cells and the Radiosensitive Mutants xrs1 and xrs5. International Journal of Radiation Biology 64:1, pages 19-26.
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E. Dikomey & J. Franzke. (1992) Effect of Heat on Induction and Repair of DNA Strand Breaks in X-irradiated CHO Cells. International Journal of Radiation Biology 61:2, pages 221-233.
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S. Suzuki, K. Eguchi-Kasai, T. Kosaka, I. Watanabe, H. Ohara & I. Kaneko. (1990) Time-lapse Microscopy and DNA Double-strand Breakage of Chinese Hamster Cells Under Conditions Promoting or Preventing PLD Repair after Irradiation with 60Co γ Rays. International Journal of Radiation Biology 58:5, pages 769-779.
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E. Dikomey. (1990) Induction and Repair of DNA Strand Breaks in X-irradiated Proliferating and Quiescent CHO Cells. International Journal of Radiation Biology 57:6, pages 1169-1182.
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M. Frankenberg-Schwager, D. Frankenberg, R. Harbich & C. Adamczyk. (1990) A Comparative Study of Rejoining of DNA Double-strand Breaks in Yeast Irradiated with 3·5 MeV α-particles or with 30 MeV Electrons. International Journal of Radiation Biology 57:6, pages 1151-1168.
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H. Mozdarani & P.E. Bryant. (1989) Induction and Rejoining of Chromatid Breaks in X-irradiated A-T and Normal Human G2 Fibroblasts. International Journal of Radiation Biology 56:5, pages 645-650.
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Hossein Mozdarani & Peter E. Bryant. (1989) Kinetics of Chromatid Aberrations in G2 Ataxia-telangiectasia Cells Exposed to X-rays and Ara A. International Journal of Radiation Biology 55:1, pages 71-84.
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Detlef Blöcher. (1988) DNA Double-strand Break Repair Determines the RBE of α-particles. International Journal of Radiation Biology 54:5, pages 761-771.
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Kenneth T. Wheeler, Garret B. Nelson, Kathryn E. Terrell & C. Anne Wallen. (1988) Regulation of DNA Repair Kinetics in Proliferative and Quiescent Tumor Cells. International Journal of Radiation Biology 54:2, pages 245-255.
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Ryuichi Okayasu, Detlef Bloecher & George Iliakis. (1988) Variation through the Cell Cycle in the Dose-response of DNA Neutral Filter Elution in X-irradiated Synchronous CHO-cells. International Journal of Radiation Biology 53:5, pages 729-747.
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George Iliakis. (1988) Radiation-induced Potentially Lethal Damage: DNA Lesions Susceptible to Fixation. International Journal of Radiation Biology 53:4, pages 541-584.
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O. Östling, K. J. Johanson, E. Blomquist & E. Hagelqvist. (1987) Dna Damage in Clinical Radiation Therapy Studied by Microelectrophoresis in Single Tumour Cells a Preliminary Report. Acta Oncologica 26:1, pages 45-48.
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Kevin M. Prise, Susan Davies & Barry D. Michael. (1987) The Relationship between Radiation-induced DNA Double-strand Breaks and Cell Kill in Hamster V79 Fibroblasts Irradiated with 250 kVp X-rays, 2·3 MeV Neutrons or 238Pu α-particles. International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine 52:6, pages 893-902.
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George Iliakis, Gabriel E. Pantelias, Ryuichi Okayasu & Robert Seaner. (1987) 125IdUrd-induced Chromosome Fragments, Assayed by Premature Chromosome Condensation, and DNA Double-strand Breaks Have Similar Repair Kinetics in G1-phase CHO-cells. International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine 52:5, pages 705-722.
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O. Östling & K.J. Johanson. (1987) Bleomycin, in Contrast to Gamma Irradiation, Induces Extreme Variation of DNA Strand Breakage from Cell to Cell. International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine 52:5, pages 683-691.
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P.E. Bryant, D.A. Birch & P.A. Jeggo. (1987) High Chromosomal Sensitivity of Chinese Hamster Xrs 5 Cells to Restriction Endonuclease Induced DNA Double-strand Breaks. International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine 52:4, pages 537-554.
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F.H.A. Schneeweiss, G. Tisljar-Lentulis, K. Haustein & L.E. Feinendegen. (1987) ‘Periodical’ Pattern of Kinetics of DNA Strand Break Repair Following γ-irradiation of Human T1-cells. International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine 52:3, pages 491-493.
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Enno Aufderheide, H. Rink, L. Hieber & G. Kraft. (1987) Heavy Ion Effects on Cellular DNA: Strand Break Induction and Repair in Cultured Diploid Lens Epithelial Cells. International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine 51:5, pages 779-790.
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Therese M. Coquerelle, Karl F. Weibezahn & Christine Lücke-Huhle. (1987) Rejoining of Double Strand Breaks in Normal Human and Ataxia-telangiectasia Fibroblasts after Exposure to 60Co γ-rays, 241Am α-particles or Bleomycin. International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine 51:2, pages 209-218.
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Ekkehard Dikomey & Jochen Franzke. (1986) Three Classes of DNA Strand Breaks Induced by X-irradiation and Internal β-rays. International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine 50:5, pages 893-908.
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Hirotoshi Maki, Masahiro Saito, Tooru Kobayashi, Kenichi Kawai & Mitsuhiko Akaboshi. (1986) Cell Inactivation and DNA Single- and Double-strand Breaks in Cultured Mammalian Cells Irradiated by a Thermal Neutron Beam. International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine 50:5, pages 795-809.
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J. B. M. Jorritsma, H. H. Kampinga, A. H. J. Scaf & A. W. T. Konings. (1985) Strand break repair, DNA polymerase activity and heat radiosensitization in thermotolerant cells. International Journal of Hyperthermia 1:2, pages 131-145.
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R.P. Virsik-Peuckert & D. Harder. (1985) Temperature and the Formation of Radiation-induced Chromosome Aberrations. II. The Temperature Dependence of Lesion Repair and Lesion Interaction. International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine 49:4, pages 673-681.
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Ian R. Radford. (1985) The Level of Induced DNA Double-strand Breakage Correlates with Cell Killing after X-irradiation. International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine 48:1, pages 45-54.
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Paul G. Debenham & Michael B.T. Webb. (1984) The Effect of X-rays and Ultraviolet Light on DNA-mediated Gene Transfer in Mammalian Cells. International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine 46:5, pages 555-568.
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D. Frankenberg, M. Frankenberg-Schwager & R. Harbich. (1984) Split-dose Recovery Is Due to the Repair of DNA Double-strand Breaks. International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine 46:5, pages 541-553.
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B. Rydberg. (1984) Repair of DNA Double-strand Breaks in Colcemid-arrested Mitotic Chinese Hamster Cells. International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine 46:3, pages 299-304.
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P.E. Bryant. (1984) Enzymatic Restriction of Mammalian Cell DNA Using Pvu II and Bam H1: Evidence for the Double-strand Break Origin of Chromosomal Aberrations. International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine 46:1, pages 57-65.
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G.P. van der Schans, M.C. Paterson & W.G. Cross. (1983) DNA Strand Break and Rejoining in Cultured Human Fibroblasts Exposed to Fast Neutrons or Gamma Rays. International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine 44:1, pages 75-85.
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Detlef Blöcher, Michael Nüsse & Peter E. Bryant. (1983) Kinetics of Double Strand Break Repair in the DNA of X-irradiated Synchronized Mammalian Cells. International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine 43:5, pages 579-584.
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Ian R. Radford. (1983) Effects of Hyperthermia on the Repair of X-ray-induced DNA Double Strand Breaks in Mouse L Cells. International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine 43:5, pages 551-557.
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J.B.M. Jorritsma & A.W.T. Konings. (1983) Inhibition of Repair of Radiation-induced Strand Breaks by Hyperthermia, and Its Relationship to Cell Survival after Hyperthermia Alone. International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine 43:5, pages 505-516.
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George Iliakis, Michael Nüsse & Peter Bryant. (1982) Effects of Aphidicolin on Cell Proliferation, Repair of Potentially Lethal Damage and Repair of DNA Strand Breaks in Ehrlich Ascites Tumour Cells Exposed to X-rays. International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine 42:4, pages 417-434.
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Peter E. Bryant & Detlef Blöcher. (1982) The Effects of 9-β-D-arabinofuranosyladenine on the Repair of DNA Strand Breaks in X-irradiated Ehrlich Ascites Tumour Cells. International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine 42:4, pages 385-394.
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Detlef Blöcher & Wolfgang Pohlit. (1982) DNA Double Strand Breaks in Ehrlich Ascites Tumour Cells at Low Doses of X-rays. II. Can Cell Death be Attributed to Double Strand Breaks?. International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine 42:3, pages 329-338.
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Detlef Blöcher. (1982) DNA Double Strand Breaks in Ehrlich Ascites Tumour Cells at Low Doses of X-rays. I. Determination of Induced Breaks by Centrifugation at Reduced Speed. International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine 42:3, pages 317-328.
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Ekkehard Dikomey. (1982) Effect of Hyperthermia at 42 and 45°C on Repair of Radiation-induced DNA Strand Breaks in CHO Cells. International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine 41:6, pages 603-614.
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