Advanced search
Publication Cover
International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine Volume 52, 1987 - Issue 6
Journal homepage
58
Views
76
CrossRef citations to date
0
Altmetric
Original Article

The Relationship between Radiation-induced DNA Double-strand Breaks and Cell Kill in Hamster V79 Fibroblasts Irradiated with 250 kVp X-rays, 2·3 MeV Neutrons or 238Pu α-particles

Kevin M. Prise Cancer Research Campaign, Gray Laboratory, Mount Vernon Hospital, Northwood, Middlesex, HA6 2RN, U.K.
,
Susan Davies Cancer Research Campaign, Gray Laboratory, Mount Vernon Hospital, Northwood, Middlesex, HA6 2RN, U.K.
&
Barry D. Michael Cancer Research Campaign, Gray Laboratory, Mount Vernon Hospital, Northwood, Middlesex, HA6 2RN, U.K.
Pages 893-902 | Received 19 Jun 1987, Accepted 09 Sep 1987, Published online: 23 Jul 2009

Citations (76)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (32)

Andrea Mairani, Till T. Böhlen, Ivana Dokic, Gonzalo Cabal, Stephan Brons & Thomas Haberer. (2013) Modelling of cell killing due to sparsely ionizing radiation in normoxic and hypoxic conditions and an extension to high LET radiation. International Journal of Radiation Biology 89:10, pages 782-793.
Read now
K. M. PRISE, G. AHNSTRÖM, M. BELLI, J. CARLSSON, D. FRANKENBERG, J. KIEFER, M. LOÖBRICH, B. D. MICHAEL, J. NYGREN, G. SIMONE & B. STENERLÖW. (1998) A review of dsb induction data for varying quality radiations. International Journal of Radiation Biology 74:2, pages 173-184.
Read now
F. POLLER, T. BAUCH, W. SAUERWEIN, W. BOCKER, A. WITTIG and C. STREFFER. (1996) Comet assay study of DNA damage and repair of tumour cells following boron neutron capture irradiation with fast d 14 Be neutrons. International Journal of Radiation Biology 70:5, pages 593-602.
Read now
K.H. Chadwick & H.P. Leenhouts. (1994) On the Linearity of the Dose—effect Relationship of DNA Double Strand Breaks. International Journal of Radiation Biology 66:5, pages 549-552.
Read now
K.M. Prise, M. Folkard, H.C. Newman & B.D. Michael. (1994) Effect of Radiation Quality on Lesion Complexity in Cellular DNA. International Journal of Radiation Biology 66:5, pages 537-542.
Read now
G.W. Barendsen. (1994) RBE—LET Relationships for Different Types of Lethal Radiation Damage in Mammalian Cells: Comparison with DNA Dsb and an Interpretation of Differences in Radiosensitivity. International Journal of Radiation Biology 66:5, pages 433-436.
Read now
B. Stenerlöw, J. Carlsson, E. Blomquist & K. Erixon. (1994) Clonogenic Cell Survival and Rejoining of DNA Double-strand Breaks: Comparisons between Three Cell Lines after Photon or He Ion Irradiation. International Journal of Radiation Biology 65:6, pages 631-639.
Read now
K.M. Prise. (1994) Use of Radiation Quality as a Probe for DNA Lesion Complexity. International Journal of Radiation Biology 65:1, pages 43-48.
Read now
D.T. Goodhead. (1994) Initial Events in the Cellular Effects of Ionizing Radiations: Clustered Damage in DNA. International Journal of Radiation Biology 65:1, pages 7-17.
Read now
M. Flentje, B. Asadpour, D. Latz & K.J. Weber. (1993) Sensitivity of Neutral Filter Elution but Not PFGE Can Be Modified by Non-dsb Chromatin Damage. International Journal of Radiation Biology 63:6, pages 715-724.
Read now
B.P. Kysela, J.E. Arrand & B.D. Michael. (1993) Relative Contributions of Levels of Initial Damage and Repair of Double-strand Breaks to the Ionizing Radiation-sensitive Phenotype of the Chinese Hamster Cell Mutant, XR-V15B. Part II. Neutrons. International Journal of Radiation Biology 64:5, pages 531-538.
Read now
T.J. Jenner, C.M. deLara, P. O'Neill & D.L. Stevens. (1993) Induction and Rejoining of DNA Double-strand Breaks in V79-4 Mammalian Cells Following γ- and α-irradiation. International Journal of Radiation Biology 64:3, pages 265-273.
Read now
C. Baumstark-Khan. (1993) X-ray-induced DNA Double-strand Breaks as Lethal Lesions in Diploid Human Fibroblasts Compared to Chinese Hamster Ovary Cells. International Journal of Radiation Biology 63:3, pages 305-311.
Read now
T.C. Akpa, K.J. Weber, E. Schneider, J. Kiefer, M. Frankenberg-Schwager, R. Harbich & D. Frankenberg. (1992) Heavy Ion-induced DNA Double-strand Breaks in Yeast. International Journal of Radiation Biology 62:3, pages 279-287.
Read now
D.J. Brenner & J.F. Ward. (1992) Constraints on Energy Deposition and Target Size of Multiply Damaged Sites Associated with DNA Double-strand Breaks. International Journal of Radiation Biology 61:6, pages 737-748.
Read now
K.M. Prise, S. Davies & B.D. Michael. (1992) A Comparison of the Chemical Repair Rates of Free Radical Precursors of DNA Damage and Cell Killing in Chinese Hamster V79 Cells. International Journal of Radiation Biology 61:6, pages 721-728.
Read now
R. Okayasu & G. Iliakis. (1992) The Shape of DNA Elution Dose-response Curves Under Non-denaturing Conditions: The Contribution of the Degree of Chromatin Condensation. International Journal of Radiation Biology 61:4, pages 455-463.
Read now
M.J. Peak, L. Wang, C.K. Hill & J.G. Peak. (1991) Comparison of Repair of DNA Double-strand Breaks Caused by Neutron or Gamma Radiation in Cultured Human Cells. International Journal of Radiation Biology 60:6, pages 891-898.
Read now
J.Y. Ostashevsky. (1990) Prediction of Cell Survival Curves from DNA Double-strand Break Repair Data for Low- and High-LET Radiation. International Journal of Radiation Biology 57:3, pages 523-536.
Read now
J.C. Fox & N.J. McNally. (1990) The Rejoining of DNA Double-strand Breaks Following Irradiation with 238Pu α-particles: Evidence for a Fast Component of Repair as Measured by Neutral Filter Elution. International Journal of Radiation Biology 57:3, pages 513-521.
Read now
N.J. McNally, M. Hinchliffe & J. Soranson. (1990) The Effect of Post-irradiation Anisotonic Treatment on Cell Survival and Repair of DNA Damage. International Journal of Radiation Biology 57:3, pages 503-512.
Read now
K. Suzuki, M. Suzuki, K. Nakano, I. Kaneko & M. Watanabe. (1990) Analysis of Chromatid Damage in G2 Phase Induced by Heavy Ions and X-rays. International Journal of Radiation Biology 58:5, pages 781-789.
Read now
T.J. McMillan, A.M. Cassoni, S. Edwards, A. Holmes & J.H. Peacock. (1990) The Relationship of DNA Double-strand Break Induction to Radiosensitivity in Human Tumour Cell Lines. International Journal of Radiation Biology 58:3, pages 427-438.
Read now
K.M. Prise, M. Folkard, S. Davies & B.D. Michael. (1990) The Irradiation of V79 Mammalian Cells by Protons with Energies below 2 MeV. Part II. Measurement of Oxygen Enhancement Ratios and DNA Damage. International Journal of Radiation Biology 58:2, pages 261-277.
Read now
M. Frankenberg-Schwager, D. Frankenberg, R. Harbich & C. Adamczyk. (1990) A Comparative Study of Rejoining of DNA Double-strand Breaks in Yeast Irradiated with 3·5 MeV α-particles or with 30 MeV Electrons. International Journal of Radiation Biology 57:6, pages 1151-1168.
Read now
G.W. Barendsen. (1990) Mechanisms of Cell Reproductive Death and Shapes of Radiation Dose-survival Curves of Mammalian Cells. International Journal of Radiation Biology 57:4, pages 885-896.
Read now
K.M. Prise, S. Davies & B.D. Michael. (1989) Non-linear Dose—effect Curve for DNA Double-strand Breaks by Low LET Radiation: The Effect of Eluting Buffer Composition on the Measurement of Breaks by the Filter Elution Technique. International Journal of Radiation Biology 56:6, pages 943-950.
Read now
K.M. Prise, S. Davies & B.D. Michael. (1989) Cell Killing and DNA Damage in Chinese Hamster V79 Cells Treated with Hydrogen Peroxide. International Journal of Radiation Biology 55:4, pages 583-592.
Read now
Ryuichi Okayasu & George Iliakis. (1989) Linear DNA Elution Dose Response Curves Obtained in CHO Cells with Non-unwinding Filter Elution after Appropriate Selection of the Lysis Conditions. International Journal of Radiation Biology 55:4, pages 569-581.
Read now
Kevin M. Prise, Susan Davies & Barry D. Michael. (1989) An Improved Method for the Treatment of Data from DNA Strand Break Measurements Using Filter Elution Techniques with an Internal Standard. International Journal of Radiation Biology 55:3, pages 323-330.
Read now
J.C. Fox & N.J. McNally. (1988) Cell Survival and DNA Double-strand Break Repair Following X-ray or Neutron Irradiation of V79 Cells. International Journal of Radiation Biology 54:6, pages 1021-1030.
Read now
Ian R. Radford. (1988) The Dose—response for Low-LET Radiation-induced DNA Double-strand Breakage: Methods of Measurement and Implications for Radiation Action Models. International Journal of Radiation Biology 54:1, pages 1-11.
Read now

Articles from other publishers (44)

Daniel Suárez-García, Miguel Antonio Cortés-Giraldo & Alejandro Bertolet. (2023) A systematic analysis of the particle irradiation data ensemble in the key of the microdosimetric kinetic model: Should clonogenic data be used for clinical relative biological effectiveness?. Radiotherapy and Oncology 185, pages 109730.
Crossref
K H Chadwick. (2023) Radiosensitivity and early onset cancer. Journal of Radiological Protection 43:2, pages 024001.
Crossref
Francisco D. C. Guerra Liberal & Stephen J. McMahon. (2023) Characterization of Intrinsic Radiation Sensitivity in a Diverse Panel of Normal, Cancerous and CRISPR-Modified Cell Lines. International Journal of Molecular Sciences 24:9, pages 7861.
Crossref
Hugo MR. Moreira, Francisco DC. Guerra Liberal, Stephen J. McMahon & Kevin M. Prise. (2021) Characterization of a custom-made 241Am alpha-source for radiobiological studies. Applied Radiation and Isotopes 177, pages 109931.
Crossref
Alejandro Bertolet, José Ramos-Méndez, Harald Paganetti & Jan Schuemann. (2021) The relation between microdosimetry and induction of direct damage to DNA by alpha particles. Physics in Medicine & Biology 66:15, pages 155016.
Crossref
K H Chadwick. (2020) Low dose radiation risk: comment on the opinion article ‘Interpretation of risk for low dose radiation exposures: inconsistences, philosophical problems and fallacies’ by Walsh (2020). Journal of Radiological Protection 40:4, pages 1534-1538.
Crossref
Ganesh Chandra Jagetia & Preenu Sunil Jacob. (2020) (E)4-[4-N,N-dimethylaminophenyl]but-3-en-2-one mitigates radiation-induced chromosome damage in BALB/c mouse bone marrow. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 858-860, pages 503238.
Crossref
George Iliakis, Emil Mladenov & Veronika Mladenova. (2019) Necessities in the Processing of DNA Double Strand Breaks and Their Effects on Genomic Instability and Cancer. Cancers 11:11, pages 1671.
Crossref
K H Chadwick. (2017) Towards a new dose and dose-rate effectiveness factor (DDREF)? Some comments. Journal of Radiological Protection 37:2, pages 422-433.
Crossref
Lei Zhao, Dong Mi & Yeqing Sun. (2017) A novel multitarget model of radiation-induced cell killing based on the Gaussian distribution. Journal of Theoretical Biology 420, pages 135-143.
Crossref
Dalong Pang, Sergey Chasovskikh, James E. Rodgers & Anatoly Dritschilo. (2016) Short DNA Fragments Are a Hallmark of Heavy Charged-Particle Irradiation and May Underlie Their Greater Therapeutic Efficacy. Frontiers in Oncology 6.
Crossref
Nicolaas AP Franken, Rosemarie ten Cate, Przemek M Krawczyk, Jan Stap, Jaap Haveman, Jacob Aten & Gerrit W Barendsen. (2011) Comparison of RBE values of high- LET α-particles for the induction of DNA-DSBs, chromosome aberrations and cell reproductive death. Radiation Oncology 6:1.
Crossref
Werner Friedland, Michael Dingfelder, Pavel Kundrát & Peter Jacob. (2011) Track structures, DNA targets and radiation effects in the biophysical Monte Carlo simulation code PARTRAC. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 711:1-2, pages 28-40.
Crossref
H P Leenhouts & K H Chadwick. (2011) Dose–effect relationships, epidemiological analysis and the derivation of low dose risk. Journal of Radiological Protection 31:1, pages 95-105.
Crossref
George Iliakis, Jochen Dahm-Daphi & Ekkehard Dikomey. 2009. The Impact of Tumor Biology on Cancer Treatment and Multidisciplinary Strategies. The Impact of Tumor Biology on Cancer Treatment and Multidisciplinary Strategies 251 271 .
Marlis Frankenberg-Schwager, Manuela Becker, Irmgard Garg, Elke Pralle, Hartmut Wolf & Dieter Frankenberg. (2008) The Role of Nonhomologous DNA End Joining, Conservative Homologous Recombination, and Single-Strand Annealing in the Cell Cycle-Dependent Repair of DNA Double-Strand Breaks Induced by H 2 O 2 in Mammalian Cells . Radiation Research 170:6, pages 784-793.
Crossref
Kenneth H. Chadwick & Hendrik P. Leenhouts. 2007. Radiation Dose from Adult and Pediatric Multidetector Computed Tomography. Radiation Dose from Adult and Pediatric Multidetector Computed Tomography 11 31 .
Douglas B. Chambers, Richard V. Osborne & Amy L. Garva. (2006) Choosing an alpha radiation weighting factor for doses to non-human biota. Journal of Environmental Radioactivity 87:1, pages 1-14.
Crossref
Dalong Pang, James E. Rodgers, Barry L. Berman, Sergey Chasovskikh & Anatoly Dritschilo. (2005) Spatial Distribution of Radiation-Induced Double-Strand Breaks in Plasmid DNA as Resolved by Atomic Force Microscopy. Radiation Research 164:6, pages 755-765.
Crossref
Qiang Li, Yoshiya Furusawa, Mitsutaka Kanazawa, Tatsuaki Kanai, Atsushi Kitagawa, Mizuho Aoki, Eriko Urakabe, Takehiro Tomitani, Shinji Sato, Mitsuo Yoshimoto & Zengquan Wei. (2005) Enhanced efficiency in cell killing at the penetration depths around the Bragg peak of a radioactive 9C-ion beam. International Journal of Radiation Oncology*Biology*Physics 63:4, pages 1237-1244.
Crossref
K H Chadwick & H P Leenhouts. (2005) Radiation risk is linear with dose at low doses. The British Journal of Radiology 78:925, pages 8-10.
Crossref
K H Chadwick, H P Leenhouts & M J P Brugmans. (2003) A contribution to the linear no-threshold discussion. Journal of Radiological Protection 23:1, pages 53-77.
Crossref
Natarajan Gajendiran, Kimio Tanaka & Nanao Kamada. (2000) Comet assay to sense neutron ‘fingerprint’. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 452:2, pages 179-187.
Crossref
D. Frankenberg, H.J. Brede, U.J. Schrewe, Ch. Steinmetz, M. Frankenberg-Schwager, G. Kasten & E. Pralle. (2000) Induction of DNA double-strand breaks in mammalian cells and yeast. Advances in Space Research 25:10, pages 2085-2094.
Crossref
Werner Burkart, Thomas Jung & Gerhard Frasch. (1999) Damage pattern as a function of radiation quality and other factors. Comptes Rendus de l'Académie des Sciences - Series III - Sciences de la Vie 322:2-3, pages 89-101.
Crossref
K Eguchi-Kasai, M Murakami, H Itsukaichi, K Fukutsu, F Yatagai, T Kanai, H Ohara & K Sato. (1998) Repair of DNA double-strand breaks and cell killing by charged particles. Advances in Space Research 22:4, pages 543-549.
Crossref
M.I. Núñez, T.J. McMillan, M.T. Valenzuela, J.M.Ruiz de Almodóvar & V. Pedraza. (1996) Relationship between DNA damage, rejoining and cell killing by radiation in mammalian cells. Radiotherapy and Oncology 39:2, pages 155-165.
Crossref
K. Eguchi-Kasai, M. Murakami, H. Itsukaichi, K. Fukutsu, T. Kanai, Y. Furusawa, K. Sato, H. Ohara & F. Yatagai. (1996) The role of DNA repair on cell killing by charged particles. Advances in Space Research 18:1-2, pages 109-118.
Crossref
M. Belli, F. Ianzini, O. Sapora, M.A. Tabocchini, F. Cera, R. Cherubini, A.M.I. Haque, G. Moschini, P. Tiveron & G. Simone. (1996) DNA double strand break production and rejoining in V79 cells irradiated with light ions. Advances in Space Research 18:1-2, pages 73-82.
Crossref
W.S. Meaking, J. Edgerton, C.W. Wharton & R.A. Meldrum. (1995) Electroporation-induced damage in mammalian cell DNA. Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 1264:3, pages 357-362.
Crossref
D. Frankenberg. (1994) Repair of DNA double-strand breaks and its effect on RBE. Advances in Space Research 14:10, pages 235-248.
Crossref
P. O'Neill. (1994) The role of hydration and radiation quality in the induction of DNA damage-chemical aspects. Advances in Space Research 14:10, pages 221-234.
Crossref
Kathryn D. Held & Karen L. Hopcia. (1993) Role of protein thiols in intrinsic radiation protection of DNA and cells. Mutation Research/Genetic Toxicology 299:3-4, pages 261-269.
Crossref
M. Frankenberg-Schwager. 1993. Biological Effects and Physics of Solar and Galactic Cosmic Radiation. Biological Effects and Physics of Solar and Galactic Cosmic Radiation 1 31 .
Michael C. Elia, John G. DeLuca & Matthews O. Bradley. (1991) Significance and measurement of DNA double strand breaks in mammalian cells. Pharmacology & Therapeutics 51:3, pages 291-327.
Crossref
D. Frankenberg. 1991. The Early Effects of Radiation on DNA. The Early Effects of Radiation on DNA 287 305 .
Biserka Nagy, David J. Grdina & Charles R. Ashman. 1991. Anticarcinogenesis and Radiation Protection 2. Anticarcinogenesis and Radiation Protection 2 85 92 .
H. P. Leenhouts & K. H. Chadwick. 1991. Photobiology. Photobiology 71 81 .
M. Frankenberg-Schwager. (1990) Induction, repair and biological relevance of radiation-induced DNA lesions in eukaryotic cells. Radiation and Environmental Biophysics 29:4, pages 273-292.
Crossref
S. Powell & T.J. McMillan. (1990) DNA damage and repair following treatment with ionizing radiation. Radiotherapy and Oncology 19:2, pages 95-108.
Crossref
Jennifer G. Peak & Meyrick J. Peak. (1990) ULTRAVIOLET LIGHT INDUCES DOUBLE-STRAND BREAKS IN DNA OF CULTURED HUMAN P3 CELLS AS MEASURED BY NEUTRAL FILTER ELUTION. Photochemistry and Photobiology 52:2, pages 387-393.
Crossref
H P Leenhouts & K H Chadwick. (1990) The influence of dose rate on the dose-effect relationship. Journal of Radiological Protection 10:2, pages 95-102.
Crossref
Jayne C. Fox. (1990) Evidence to support the existence of efficient DNA double-strand break rejoining in a radiosensitive mutant of V79-4 following irradiation with 250 kVp X-rays or neutrons. Mutation Research/DNA Repair 235:2, pages 41-47.
Crossref
T. Alper & W. A. Cramp. (1989) The role of repair in radiobiology. Experientia 45:1, pages 21-33.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.