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Original Article

A Versatile Plutonium-238 Irradiator for Radiobiological Studies with α-particles

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Pages 195-210 | Received 29 Mar 1990, Accepted 25 Jun 1990, Published online: 03 Jul 2009

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Adrianna Tartas, Mateusz Filipek, Marcin Pietrzak, Andrzej Wojcik & Beata Brzozowska. (2023) Modeling of dose and linear energy transfer homogeneity in cell nuclei exposed to alpha particles under various setup conditions. International Journal of Radiation Biology 99:8, pages 1248-1256.
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Magdalena Płódowska, Milagrosa Lopez-Riego, Pamela Akuwudike, Daniel Sobota, Mateusz Filipek, Mariusz Kłosowski, Urszula Kaźmierczak, Beata Brzozowska, Agnieszka Baliga, Halina Lisowska, Janusz Braziewicz, Paweł Olko, Lovisa Lundholm & Andrzej Wojcik. (2021) Small is beautiful: low activity alpha and gamma sources for small-scale radiation protection research experiments. International Journal of Radiation Biology 97:4, pages 541-552.
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Matthew Themis, Elisa Garimberti, Mark A. Hill & Rhona M. Anderson. (2013) Reduced chromosome aberration complexity in normal human bronchial epithelial cells exposed to low-LET γ-rays and high-LET α-particles. International Journal of Radiation Biology 89:11, pages 934-943.
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G. E. WATSON, S. A. LORIMORE, S. M. CLUTTON, M. A. KADHIM and E. G. WRIGHT. (1997) Genetic factors influencing alpha-particle-induced chromosomal instability. International Journal of Radiation Biology 71:5, pages 497-503.
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A. C. RICHES, Z. HERCEG, P. E. BRYANT, D. L. STEVENS and D. T. GOODHEAD. (1997) Radiation-induced transformation of SV40-immortalized human thyroid epithelial cells by single exposure to plutonium alpha-particles in vitro. International Journal of Radiation Biology 72:5, pages 515-521.
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G. E. Watson. (1996) Long-term in vivo transmission of alpha-particle-induced chromosomal instability in murine haemopoietic cells. International Journal of Radiation Biology 69:2, pages 175-182.
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C.S. Griffin, S.J. Marsden, D.L. Stevens, P. Simpson & J.R.K. Savage. (1995) Frequencies of Complex Chromosome Exchange Aberrations Induced by 238Pu α-particles and Detected by Fluorescence in Situ Hybridization Using Single Chromosome-specific Probes. International Journal of Radiation Biology 67:4, pages 431-439.
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S.D. Griffiths, S.J. Marsden, E.G. Wright, M.F. Greaves & D.T. Goodhead. (1994) Lethality and Mutagenesis of B Lymphocyte Progenitor Cells Following Exposure to α-particles and X-rays. International Journal of Radiation Biology 66:2, pages 197-205.
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C.S. Griffin, A.N. Harvey & J.R.K. Savage. (1994) Chromatid Damage Induced by 238Pu α-particles in G2 and S Phase Chinese Hamster V79 Cells. International Journal of Radiation Biology 66:1, pages 85-98.
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T.J. Jenner, C.M. deLara, P. O'Neill & D.L. Stevens. (1993) Induction and Rejoining of DNA Double-strand Breaks in V79-4 Mammalian Cells Following γ- and α-irradiation. International Journal of Radiation Biology 64:3, pages 265-273.
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S.A. Lorimore, D.T. Goodhead & E.G. Wright. (1993) Inactivation of Haemopoietic Stem Cells by Slow α-particles. International Journal of Radiation Biology 63:5, pages 655-660.
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D.T. Goodhead, M. Belli, A.J. Mill, D.A. Bance, L.A. Allens, S.C. Hall, F. Ianzani, G. Simone, D.L. Stevens, A. Stretch, M.A. Tabocchini & R.E. Wilkinson. (1992) Direct Comparison between Protons and Alpha-particles of the Same LET: I. Irradiation Methods and Inactivation of Asynchronous V79, HeLa and C3H 10T½ Cells. International Journal of Radiation Biology 61:5, pages 611-624.
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D.J. Brenner. (1992) Radon: Current Challenges in Cellular Radiobiology. International Journal of Radiation Biology 61:1, pages 3-13.
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E. Staaf, K. Brehwens, S. Haghdoost, K. Pachnerova-Brabcova, J. Czub, J. Braziewicz, S. Nievaart & A. Wojcik. (2012) Characterisation of a setup for mixed beam exposures of cells to 241Am alpha particles and X-rays. Radiation Protection Dosimetry 151:3, pages 570-579.
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Ben Phoenix, Stuart Green, Mark A. Hill, Bleddyn Jones, Andrew Mill & David L. Stevens. (2009) Do the various radiations present in BNCT act synergistically? Cell survival experiments in mixed alpha-particle and gamma-ray fields. Applied Radiation and Isotopes 67:7-8, pages S318-S320.
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V. Zareena Hamza & Mary N. Mohankumar. (2009) Cytogenetic damage in human blood lymphocytes exposed in vitro to radon. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 661:1-2, pages 1-9.
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Rhona M. Anderson, David L. Stevens, Natalia D. Sumption, K. M Stuart Townsend, Dudley T. Goodhead & Mark A. Hill. (2007) Effect of Linear Energy Transfer (LET) on the Complexity of α-Particle-Induced Chromosome Aberrations in Human CD34 + Cells . Radiation Research 167:5, pages 541-550.
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Daniel I. Portess, Georg Bauer, Mark A. Hill & Peter O'Neill. (2007) Low-Dose Irradiation of Nontransformed Cells Stimulates the Selective Removal of Precancerous Cells via Intercellular Induction of Apoptosis. Cancer Research 67:3, pages 1246-1253.
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E. L. Pyke, D. L. Stevens & M. A. Hill. (2006) Keeping up with the neighbours—measuring the bystander response. Radiation Protection Dosimetry 122:1-4, pages 266-270.
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M. A. Hill, D. L. Stevens, M. Kadhim, M. Blake-James, A. J. Mill & D. T. Goodhead. (2006) Experimental techniques for studying bystander effects in vitro by high and low-LET ionising radiation. Radiation Protection Dosimetry 122:1-4, pages 260-265.
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Deborah A. Bowler, Stephen R. Moore, Denise A. Macdonald, Sharon H. Smyth, Peter Clapham & Munira A. Kadhim. (2006) Bystander-mediated genomic instability after high LET radiation in murine primary haemopoietic stem cells. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 597:1-2, pages 50-61.
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Natalia D. Sumption, Dudley T. Goodhead & Rhona M. Anderson. (2006) No increase in radiation-induced chromosome aberration complexity detected by m-FISH after culture in the presence of 5′-bromodeoxyuridine. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 594:1-2, pages 30-38.
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G Esposito, M Belli, G Simone, E Sorrentino & M A. Tabocchini. (2006) A 244CM IRRADIATOR FOR PROTRACTED EXPOSURE OF CULTURED MAMMALIAN CELLS WITH ALPHA PARTICLES. Health Physics 90:1, pages 66-73.
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Carol Griffin, Harm de Waard, Bryan Deans & John Thacker. (2005) The involvement of key DNA repair pathways in the formation of chromosome rearrangements in embryonic stem cells. DNA Repair 4:9, pages 1019-1027.
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Sylvain Gaillard, Vincent Armbruster, Mark A. Hill, Tijani Gharbi & Michel Fromm. (2005) Production and Validation of CR-39-Based Dishes for α-Particle Radiobiological Experiments. Radiation Research 163:3, pages 343-350.
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Mark A. Hill, M. Trent Herdman, David L. Stevens, Nigel J. Jones, John Thacker & Dudley T. Goodhead. (2004) Relative Sensitivities of Repair-Deficient Mammalian Cells for Clonogenic Survival after α-Particle Irradiation. Radiation Research 162:6, pages 667-676.
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Prasad V. S V. Neti, Sonia M. de Toledo, Venkatachalam Perumal, Edouard I. Azzam & Roger W. Howell. (2004) A Multi-port Low-Fluence Alpha-Particle Irradiator: Fabrication, Testing and Benchmark Radiobiological Studies. Radiation Research 161:6, pages 732-738.
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Akinari Yokoya, Siobhan M. T. Cunniffe, David L. Stevens & Peter O'Neill. (2002) Effects of Hydration on the Induction of Strand Breaks, Base Lesions, and Clustered Damage in DNA Films by α-Radiation. The Journal of Physical Chemistry B 107:3, pages 832-837.
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F. Petitot, J. P. Morlier, M. Debroche, J. F. Pineau & S. Chevillard. (2002) A New Method Specifically Designed to Expose Cells Isolated In Vitro to Radon and its Decay Products . Radiation Research 157:6, pages 693-699.
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I. Bailly, C. Champion, P. Massiot, P. Savarin, J.L. Poncy, S. Crespin, G. Alloy, V. Jacob & E. Petibon. (2002) Development of an experimental system for biological studies: Scintillation and solid-track detectors as dose monitors. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms 187:1, pages 137-148.
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Christina Søyland, Sindre P. Hassfjell & Harald B. Steen. (2000) A New Alpha-Particle Irradiator with Absolute Dosimetric Determination. Radiation Research 153:1, pages 9-15.
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Margaret M. Lehane, Peter E. Bryant, Andrew C. Riches, Louise A. Allen, Cecilie V. Briscoe, Jean Melville & Andrew J. Mill. (1999) 238Pu α-particle-induced C3H10T½ transformants are less tumorigenic than the X-ray-induced equivalent. Carcinogenesis 20:1, pages 35-40.
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S. A. Lorimore, M. A. Kadhim, D. A. Pocock, D. Papworth, D. L. Stevens, D. T. Goodhead & E. G. Wright. (1998) Chromosomal instability in the descendants of unirradiated surviving cells after α-particle irradiation. Proceedings of the National Academy of Sciences 95:10, pages 5730-5733.
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Jeffrey A. Coderre, Michael S. Makar, Peggy L. Micca, Marta M. Nawrocky, Hungyuan B. Liu, Darrel D. Joel, Daniel N. Slatkin & Howard I. Amols. (1993) Derivations of relative biological effectiveness for the high-let radiations produced during boron neutron capture irradiations of the 9l rat gliosarcoma in vitro and in vivo. International Journal of Radiation Oncology*Biology*Physics 27:5, pages 1121-1129.
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Shado Z. Aghamohammadi, Tracy Morris, David L. Stevens & John Thacker. (1992) Rapid screening for deletion mutations in the hprt gene using the polymerase chain reaction: X-ray and α-particle mutant spectra. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 269:1, pages 1-7.
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M. A. Kadhim, D. A. Macdonald, D. T. Goodhead, S. A. Lorimore, S. J. Marsden & E. G. Wright. (1992) Transmission of chromosomal instability after plutonium α-particle irradiation. Nature 355:6362, pages 738-740.
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