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International Journal of Radiation Biology Volume 61, 1992 - Issue 3
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Original Article

Antimutagenic Effects of Radioprotector WR-2721 Against Fission-spectrum Neutrons and 60Co γ-rays in Mice

Y. Kataoka Biological and Medical Research Division, Argonne National Laboratory, 9700 South Cass Avenue, Argonne, IL, 60439-4833, USA
,
I. Basic Department of Animal Physiology, University of Zagreb, 41000, Zagreb, Croatia, Yugoslavia
,
J. Perrin Department of Radiation and Cellular Oncology, University of Chicago Medical Center, Chicago, IL, 60637, USA
&
D.J. Grdina Biological and Medical Research Division, Argonne National Laboratory, 9700 South Cass Avenue, Argonne, IL, 60439-4833, USA
Pages 387-392 | Received 26 Mar 1991, Accepted 04 Aug 1991, Published online: 03 Jul 2009

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Vijay K. Singh & Thomas M. Seed. (2017) A review of radiation countermeasures focusing on injury-specific medicinals and regulatory approval status: part I. Radiation sub-syndromes, animal models and FDA-approved countermeasures. International Journal of Radiation Biology 93:9, pages 851-869.
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David Paunesku, Tatjana Paunesku, Andrew Wahl, Yasushi Kataoka, Jeffrey Murley, David J. Grdina & Gayle E. Woloschak. (2008) Incidence of tissue toxicities in gamma ray and fission neutron-exposed mice treated with Amifostine. International Journal of Radiation Biology 84:8, pages 623-634.
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R. Lorenz, W. Deubel, K. Leuner, T. Göllner, E. Hochhäuser & K. Hempel. (1994) Dose and Dose-rate Dependence of the Frequency of HPRT Deficient T Lymphocytes in the Spleen of the 137Cs γ-irradiated Mouse. International Journal of Radiation Biology 66:3, pages 319-326.
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Articles from other publishers (31)

Amrita K. Cheema, Yaoxiang Li, Michael Girgis, Meth Jayatilake, Madison Simas, Stephen Y. Wise, Ayodele O. Olabisi, Thomas M. Seed & Vijay K. Singh. (2019) Metabolomic studies in tissues of mice treated with amifostine and exposed to gamma-radiation. Scientific Reports 9:1.
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Norman J. Kleiman, Fiona A. Stewart & Eric J. Hall. (2017) Modifiers of radiation effects in the eye. Life Sciences in Space Research 15, pages 43-54.
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Richard J. Hatchett, David M. Weinstock & Ronald E. Goans. 2016. Koenig and Schultz's Disaster Medicine. Koenig and Schultz's Disaster Medicine 544 578 .
T. Paunesku & G.E. Woloschak. 2014. Encyclopedia of Environmental Health. Encyclopedia of Environmental Health 233 244 .
M I Koukourakis. (2012) Radiation damage and radioprotectants: new concepts in the era of molecular medicine. The British Journal of Radiology 85:1012, pages 313-330.
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Michael D. Story, Chaitanya Nirodi & Clinton Park. 2012. Stereotactic Body Radiation Therapy. Stereotactic Body Radiation Therapy 123 136 .
T. Paunesku & G.E. Woloschak. 2011. Encyclopedia of Environmental Health. Encyclopedia of Environmental Health 908 919 .
Richard J. Hatchett, Joseph M. Kaminski & Ronald E. Goans. 2011. Koenig and Schultz's Disaster Medicine. Koenig and Schultz's Disaster Medicine 477 510 .
Dale M. Walker, Adriana E. Kajon, Salina M. Torres, Meghan M. Carter, Consuelo L. McCash, James A. Swenberg, Patricia B. Upton, Andrew W. Hardy, Ofelia A. Olivero, Gene M. Shearer, Miriam C. Poirier & Vernon E. Walker. (2009) WR1065 mitigates AZT‐ddI‐induced mutagenesis and inhibits viral replication. Environmental and Molecular Mutagenesis 50:6, pages 460-472.
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Ricardo Camelo, Fernanda Kehdy, Carlos Salas & Miriam Lopes. (2008) Amifostine Protection Against Mitomycin-induced Chromosomal Breakage in Fanconi Anaemia Lymphocytes. Molecules 13:8, pages 1759-1772.
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Irene M. Jones, Karolyn Burkhart‐Schultz, Cheryl L. Strout & David O. Nelson. (2008) Studies of thioguanine‐resistant lymphocytes induced by in vivo irradiation of mice. Environmental and Molecular Mutagenesis 49:5, pages 343-350.
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Pavel Kuna. (2006) Chemical radioprotective substances: The past, the present and the future. Kontakt 8:1, pages 112-122.
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Joseph A. Spadaro, Mark T. Baesl, Amanda C. Conta, Bryan M. Margulies & Timothy A. Damron. (2003) Effects of Irradiation on the Appositional and Longitudinal Growth of the Tibia and Fibula of the Rat With and Without Radioprotectant. Journal of Pediatric Orthopaedics 23:1, pages 35-40.
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Joseph Spadaro, Mark Baesl, Amanda Conta, Bryan Margulies & Timothy Damron. (2003) Journal of Pediatric Orthopedics 23:1, pages 35-40.
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H. H. Evans, T. E. Evans & M. F. Horng. (2002) Antimutagenicity of WR-1065 in L5178Y Cells Exposed to Accelerated 56 Fe Ions . Radiation Research 158:1, pages 110-114.
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Timothy A. Damron, Joseph A. Spadaro, Robert M. Tamurian & Leatha A. Damron. (2000) Sparing of radiation-induced damage to the physis: fractionation alone compared to amifostine pretreatment. International Journal of Radiation Oncology*Biology*Physics 47:4, pages 1067-1071.
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Valerie K. Booth, Jeanette C. Roberts, Raymond L. Warters, Britta H. Wilmore & James R. Lepock. (2000) Radioprotective Thiolamines WR-1065 and WR-33278 Selectively Denature Nonhistone Nuclear Proteins. Radiation Research 153:6, pages 813-822.
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J Bourhis, R De Crevoisier, B Abdulkarim, E Deutsch, A Lusinchi, B Luboinski, P Wibault & F Eschwege. (2000) A randomized study of very accelerated radiotherapy with and without amifostine in head and neck squamous cell carcinoma. International Journal of Radiation Oncology*Biology*Physics 46:5, pages 1105-1108.
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G A P Hospers, E A Eisenhauer & E G E de Vries. (1999) The sulfhydryl containing compounds WR-2721 and glutathione as radio- and chemoprotective agents. A review, indications for use and prospects. British Journal of Cancer 80:5-6, pages 629-638.
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R. M. Tamurian, T. A. Damron & J. A. Spadaro. (2005) Sparing radiation‐induced damage to the physis by radioprotectant drugs: Laboratory analysis in a rat model. Journal of Orthopaedic Research 17:2, pages 286-292.
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D. J. Grdina, J. S. Murley & J. C. Roberts. (1998) Effects of thiols on topoisomerase‐IIα activity and cell cycle progression. Cell Proliferation 31:5-6, pages 217-229.
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I Donkor. (1998) Synthesis and radioprotective effects of adamantyl substituted 1,4-dihydropyridine derivatives. Bioorganic & Medicinal Chemistry 6:5, pages 563-568.
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Xiaoxin Zhou, Shashi Phadtare, Jefferey Schmidt, Krishna Agrawal & Vimal Kishore. (1997) Synthesis and radioprotective effects of new phosphorothioate esters of WR-2721, WR-3689 and WR-151327. Bioorganic & Medicinal Chemistry Letters 7:6, pages 693-698.
Crossref
Alan M. Diamond, Phylis Dale, Judith L. Murray & David J. Grdina. (1996) The inhibition of radiation-induced mutagenesis by the combined effects of selenium and the aminothiol WR-1065. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 356:2, pages 147-154.
Crossref
R.L. Capizzi. (1996) The preclinical basis for broad-spectrum selective cytoprotection of normal tissues from cytotoxic therapies by amifostine (Ethyol®). European Journal of Cancer 32, pages S5-S16.
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D.S. Alberts, L.A. Speicher, M. Krutzsch, J. Wymer, R.L. Capizzi, J. Conlon, A. Barrett & M. Aickin. (1996) WR-1065, the active metabolite of amifostine (ethyol®), does not inhibit the cytotoxic effects of a broad range of standard anticancer drugs against human ovarian and breast cancer cells. European Journal of Cancer 32, pages S17-S20.
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A.I. Gaziev, A.Ja. Podlutsky, B.M. Panfilov & R. Bradbury. (1995) Dietary· supplements of antioxidants reduce hprt mutant frequency in splenocytes of aging mice. Mutation Research/DNAging 338:1-6, pages 77-86.
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Lidia Mazur. (1995) Induction of micronucleated erythrocytes by MEA, AET, WR-2721 and X-rays. Mutation Research/Environmental Mutagenesis and Related Subjects 334:3, pages 317-322.
Crossref
G.J. Peters & W.J.F. van der Vijgh. (1995) Protection of Normal Tissues from the Cytotoxic Effects of Chemotherapy and Radiation by Amifostine (WR-2721): Preclinical Aspects. European Journal of Cancer 31, pages S1-S7.
Crossref
Jeffrey L. Schwartz. 1996. Chemical Induction of Cancer. Chemical Induction of Cancer 473 508 .
Carol S. Giometti, Sandra L. Tollaksen & Douglas Grahn. (1994) Altered protein expression detected in the F1 offspring of male mice exposed to fission neutrons. Mutation Research/Genetic Toxicology 320:1-2, pages 75-85.
Crossref

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