Advanced search
Publication Cover
International Journal of Radiation Biology Volume 65, 1994 - Issue 4
Submit an article Journal homepage
26
Views
59
CrossRef citations to date
0
Altmetric
Original Article

Hypersensitive Response of Normal Human Lung Epithelial Cells at Low Radiation Doses

B. Singh CRC Gray Laboratory, Mount Vernon Hospital, PO Box 100, Northwood, HA6 2JR, UK
,
J.E. Arrand CRC Gray Laboratory, Mount Vernon Hospital, PO Box 100, Northwood, HA6 2JR, UK
&
M.C. Joiner CRC Gray Laboratory, Mount Vernon Hospital, PO Box 100, Northwood, HA6 2JR, UK
Pages 457-464 | Received 12 Jul 1993, Accepted 20 Nov 1993, Published online: 03 Jul 2009

Citations (59)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (13)

Dorota Słonina, Beata Biesaga, Krzysztof Urbański & Zbigniew Kojs. (2008) Comparison of chromosomal radiosensitivity of normal cells with and without HRS-like response and normal tissue reactions in patients with cervix cancer. International Journal of Radiation Biology 84:5, pages 421-428.
Read now
Alexandru Daşu & Iuliana Toma-Daşu. (2008) Treatment modelling: The influence of micro-environmental conditions. Acta Oncologica 47:5, pages 896-905.
Read now
Dieter Frankenberg, Klaus-Dieter Greif & Ulrich Giesen. (2006) Radiation response of primary human skin fibroblasts and their bystander cells after exposure to counted particles at low and high LET. International Journal of Radiation Biology 82:1, pages 59-67.
Read now
Ferya Banaz-Yaşar, Rabea Tischka, George Iliakis, Elke Winterhager & Alexandra Gellhaus. (2005) Cell Line Specific Modulation of Connexin43 Expression after Exposure to Ionizing Radiation. Cell Communication & Adhesion 12:5-6, pages 249-259.
Read now
Alexandru Daşu & Iuliana Toma-Daşu. (2005) Dose-effect models for risk – relationship to cell survival parameters. Acta Oncologica 44:8, pages 829-835.
Read now
C. Caney, G. Singh, H. Lukka & A. J. Rainbow. (2004) Combined gamma‐irradiation and subsequent cisplatin treatment in human squamous carcinoma cell lines sensitive and resistant to cisplatin. International Journal of Radiation Biology 80:4, pages 291-299.
Read now
T. Robson, M. E. Price, M. L. Moore, M. C. Joiner, V. J. McKelvey-Martin, S. R. McKeown, D. G. Hirst. (2000) Increased repair and cell survival in cells treated with DIR1 antisense oligonucleotides: implications for induced radioresistance. International Journal of Radiation Biology 76:5, pages 617-623.
Read now
Juliana Denekamp. (1999) Inducible Repair and the Two Forms of Tumour Hypoxia - Time for a Paradigm Shift. Acta Oncologica 38:7, pages 903-918.
Read now
Nigel E. A. Crompton. (1998) Programmed Cellular Response in Radiation Oncology: Basic and Translational Studies. Acta Oncologica 37:11, pages 1-49.
Read now
V. VEGESNA W. H. McBRIDE J. M. G. TAYLOR and H. R. WITHERS. (1997) Effect of low-dose radiation on mouse dermal tissue using wound strength as an endpoint. International Journal of Radiation Biology 72:6, pages 645-652.
Read now
M. G. A. ALSBEIH. (1996) High split-dose recovery in hypersensitive human fibroblasts: a case of induced radioresistance?. International Journal of Radiation Biology 69:2, pages 225-239.
Read now
P. LAMBIN. (1996) Might intrinsic radioresistance of human tumour cells be induced by radiation?. International Journal of Radiation Biology 69:3, pages 279-290.
Read now
B. G. WOUTERS. (1996) Hypoxic cell sensitization: low-dose intrinsic radiosensitivity is predictive for etanidazole efficacy in a panel of human tumour cell lines. International Journal of Radiation Biology 70:6, pages 719-733.
Read now

Articles from other publishers (46)

Anders Brahme. (2023) TP53 and the Ultimate Biological Optimization Steps of Curative Radiation Oncology. Cancers 15:17, pages 4286.
Crossref
Anders Brahme. (2022) Quantifying Cellular Repair, Misrepair and Apoptosis Induced by Boron Ions, Gamma Rays and PRIMA-1 Using the RHR Formulation. Radiation Research 198:3.
Crossref
C M Charlie Ma. (2022) Pulsed low dose-rate radiotherapy: radiobiology and dosimetry. Physics in Medicine & Biology 67:3, pages 03TR01.
Crossref
Anders Brahme. (2020) A DNA Repair-Based Model of Cell Survival with Important Clinical Consequences. Radiation Research 194:3, pages 202.
Crossref
Marta Kuchta‐Gładysz, Ewa Wójcik, Dorota Słonina, Anna Grzesiakowska, Agnieszka Otwinowska‐Mindur, Olga Szeleszczuk & Piotr Niedbała. (2020) Determination of cytogenetic markers for biological monitoring in coypu ( Myocastor coypu ) . Animal Science Journal 91:1.
Crossref
Rodrigo Andaur, Julio C. Tapia, José Moreno, Leopoldo Soto, Ricardo Armisen & Katherine Marcelain. (2018) Differential miRNA expression profiling reveals miR-205-3p to be a potential radiosensitizer for low- dose ionizing radiation in DLD-1 cells. Oncotarget 9:41, pages 26387-26405.
Crossref
Shigenori Tanaka. (2017) AN EFFECTIVE MICROSCOPIC INDEX ASSOCIATED WITH CELL SURVIVAL AND DNA LESIONS FOR ESTIMATING RADIATION RISK. Journal of Environment and Health Science 3:1, pages 1-5.
Crossref
J J Gordon, K Snyder, H Zhong, K Barton, Z Sun, I J Chetty, M Matuszak & R K Ten Haken. (2015) Extracting the normal lung dose–response curve from clinical DVH data: a possible role for low dose hyper-radiosensitivity, increased radioresistance. Physics in Medicine and Biology 60:17, pages 6719-6732.
Crossref
Lynn M. Martin, Brian Marples, Thomas H. Lynch, Donal Hollywood & Laure Marignol. (2014) Exposure to low dose ionising radiation: Molecular and clinical consequences. Cancer Letters 349:1, pages 98-106.
Crossref
A. Brahme. 2014. Comprehensive Biomedical Physics. Comprehensive Biomedical Physics 121 142 .
Patrick Beauchesne. (2013) Three-Times Daily Ultrafractionated Radiation Therapy, A Novel and Promising Regimen for Glioblastoma Patients. Cancers 5:4, pages 1199-1211.
Crossref
Lynn M. Martin, Brian Marples, Thomas H. Lynch, Donal Hollywood & Laure Marignol. (2013) Exposure to low dose ionising radiation: Molecular and clinical consequences. Cancer Letters 338:2, pages 209-218.
Crossref
D Guirado, M Aranda, M Ortiz, J A Mesa, L I Zamora, E Amaya, M Villalobos & A M Lallena. (2012) Low-dose radiation hyper-radiosensitivity in multicellular tumour spheroids. The British Journal of Radiology 85:1018, pages 1398-1406.
Crossref
M. Balducci, S. Chiesa, B. Diletto, G. R. D'Agostino, A. Mangiola, S. Manfrida, G. Mantini, A. Albanese, A. Fiorentino, V. Frascino, B. De Bari, F. Micciche'F. De Rose, A. G. Morganti, C. Anile & V. Valentini. (2011) Low-dose fractionated radiotherapy and concomitant chemotherapy in glioblastoma multiforme with poor prognosis: a feasibility study. Neuro-Oncology 14:1, pages 79-86.
Crossref
C.-M. Charlie Ma, Gary Luxton & Colin G. Orton. (2011) Pulsed reduced dose rate radiation therapy is likely to become the treatment modality of choice for recurrent cancers. Medical Physics 38:9, pages 4909-4911.
Crossref
Anders BRAHME. (2011) Accurate Description of the Cell Survival and Biological Effect at Low and High Doses and LET's. Journal of Radiation Research 52:4, pages 389-407.
Crossref
Peter Jacob. (2008) Promoting Action of Radiation in the Atomic Bomb Survivor Cancer Incidence Data. Radiation Research 169:5, pages 602-602.
Crossref
Dorota Słonina, Beata Biesaga, Krzysztof Urbański & Zbigniew Kojs. (2007) The Response of Primary Keratinocytes and Fibroblasts from Cancer Patients to Multiple Low-Dose Irradiations. Radiation Research 168:5, pages 631-636.
Crossref
Dorota Słonina, Beata Biesaga, Krzysztof Urbański & Zbigniew Kojs. (2007) Low-Dose Radiation Response of Primary Keratinocytes and Fibroblasts from Patients with Cervix Cancer. Radiation Research 167:3, pages 251-259.
Crossref
James Nol, Godfrey Isouard & Jerzy Mirecki. (2005) Uncovering the causes of unnecessary repeated medical imaging examinations, or part of, in two hospital departments. Radiographer 52:3, pages 26-31.
Crossref
Louise Enns, Kenneth T. Bogen, Juanita Wizniak, Albert D. Murtha & Michael Weinfeld. (2004) Low-Dose Radiation Hypersensitivity Is Associated With p53-Dependent Apoptosis. Molecular Cancer Research 2:10, pages 557-566.
Crossref
Anders Brahme. (2004) Recent advances in light ion radiation therapy. International Journal of Radiation Oncology*Biology*Physics 58:2, pages 603-616.
Crossref
Christian Streffer, H. Bolt, D. Føllesdal, P. Hall, J. G. Hengstler, P. Jakob, D. Oughton, K. Prieß, E. Rehbinder & E. SwatonChristian Streffer, H. Bolt, D. Føllesdal, P. Hall, J. G. Hengstler, P. Jakob, D. Oughton, K. Prieß, E. Rehbinder & E. Swaton. 2004. Low Dose Exposures in the Environment. Low Dose Exposures in the Environment 213 256 .
B. K. Lind, L. M. Persson, M. R. Edgren, I. Hedlöf & A. Brahme. (2003) Repairable–Conditionally Repairable Damage Model Based on Dual Poisson Processes. Radiation Research 160:3, pages 366-375.
Crossref
Catherine R. Mitchell, Melvyn Folkard & Michael C. Joiner. (2002) Effects of Exposure to Low-Dose-Rate 60 Co Gamma Rays on Human Tumor Cells In Vitro . Radiation Research 158:3, pages 311-318.
Crossref
Peter Jacob & Vesna Prokic. (2002) Increased radioresistance, modelling of carcinogenesis and low-dose risk estimation. Journal of Radiological Protection 22:3A, pages A51-A55.
Crossref
Sudhir Chandna, B. S. Dwarakanath, Divya Khaitan, T. Lazar Mathew & Viney Jain. (2002) Low-Dose Radiation Hypersensitivity in Human Tumor Cell Lines: Effects of Cell–Cell Contact and Nutritional Deprivation. Radiation Research 157:5, pages 516-525.
Crossref
G. Schettino, M. Folkard, K. M. Prise, B. Vojnovic, A. G. Bowey & B. D. Michael. (2001) Low-Dose Hypersensitivity in Chinese Hamster V79 Cells Targeted with Counted Protons Using a Charged-Particle Microbeam. Radiation Research 156:5, pages 526-534.
Crossref
E G Aird, M Folkard, C R Mayes, P J Bownes, J M Lawson & M C Joiner. (2001) A purpose-built iodine-125 irradiation plaque for low dose rate low energy irradiation of cell lines in vitro . The British Journal of Radiology 74:877, pages 56-61.
Crossref
Michael Kasper, Cora Roehlecke, Martin Witt, Heinz Fehrenbach, Andreas Hofer, Toshio Miyata, Cora Weigert, Richard H. W. Funk & Erwin D. Schleicher. (2000) Induction of Apoptosis by Glyoxal in Human Embryonic Lung Epithelial Cell Line L132. American Journal of Respiratory Cell and Molecular Biology 23:4, pages 485-491.
Crossref
Alexandru Daşu & Juliana Denekamp. (2000) Inducible Repair and Intrinsic Radiosensitivity: A Complex but Predictable Relationship?. Radiation Research 153:3, pages 279-288.
Crossref
Christina Søyland, Sindre P. Hassfjell & Harald B. Steen. (2000) A New Alpha-Particle Irradiator with Absolute Dosimetric Determination. Radiation Research 153:1, pages 9-15.
Crossref
Kirsten A Skov. (1999) Radioresponsiveness at low doses: hyper-radiosensitivity and increased radioresistance in mammalian cells. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 430:2, pages 241-253.
Crossref
Lewis G. Smith, Richard C. Miller, Marcia Richards, David J. Brenner & Eric J. Hall. (1999) Investigation of hypersensitivity to fractionated low-dose radiation exposure. International Journal of Radiation Oncology*Biology*Physics 45:1, pages 187-191.
Crossref
Alexandru Daşu & Juliana Denekamp. (1999) Superfractionation as a potential hypoxic cell radiosensitizer: prediction of an optimum dose per fraction. International Journal of Radiation Oncology*Biology*Physics 43:5, pages 1083-1094.
Crossref
Marco Zaider. (1998) Sequel to the discussion concerning the mechanistic basis of the linear quadratic formalism. Medical Physics 25:10, pages 2074-2075.
Crossref
S.C. Short & M.C. Joiner. (1998) Cellular response to low-dose irradiation. Clinical Oncology 10:2, pages 73-77.
Crossref
A. Dare, R. Hachisu, A. Yamaguchi, S. Yokose, S. Yoshiki & T. Okano. (2016) Effects of Ionizing Radiation on Proliferation and Differentiation of Osteoblast-like Cells. Journal of Dental Research 76:2, pages 658-664.
Crossref
M.C. Joiner, P. Lambin, E.P. Malaise, T. Robson, J.E. Arrand, K.A. Skov & B. Marples. (1996) Hypersensitivity to very-low single radiation doses: Its relationship to the adaptive response and induced radioresistance. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 358:2, pages 171-183.
Crossref
Lu Cai & M.George Cherian. (1996) Adaptive response to ionizing radiation-induced chromosome aberrations in rabbit lymphocytes: Effect of pre-exposure to zinc, and copper salts. Mutation Research/Genetic Toxicology 369:3-4, pages 233-241.
Crossref
Ingela Turesson & Michael C. Joiner. (1996) Clinical evidence of hypersensitivity to low doses in radiotherapy. Radiotherapy and Oncology 40:1, pages 1-3.
Crossref
Adel Courdi, Danielle Mari, Serge Marcié, Jeannine Gioanni & Pierre Chauvel. (1995) Micronucleus induction in 10 human tumour cells after high- and low-dose radiation. Radiotherapy and Oncology 37:2, pages 117-123.
Crossref
G. Némethová, I. Kalina & N. Račeková. (1995) The adaptive response of peripheral blood lymphocytes to low doses of mutagenic agents in patients with ataxia telangiectasia. Mutation Research Letters 348:3, pages 101-104.
Crossref
Bernard Dubray, Michel Henry-Amar, Jacobus H. Meerwaldt, Evert M. Noordijk, Dennis O. Dixon, Jean-Marc Cosset & Howard D. Thames. (1995) Radiation-induced lung damage after thoracic irradiation for Hodgkin's disease: the role of fractionation. Radiotherapy and Oncology 36:3, pages 211-217.
Crossref
. (1995) Radiation and other stress responses 18 November 1994. The British Journal of Radiology 68:809, pages 557-559.
Crossref
Kirsten Skov & Brian Marples. (2006) Increased radioresistance at clinical doses: Investigations from the survival perspective . Radiation Oncology Investigations 2:5, pages 201-211.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.