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International Journal of Food Sciences and Nutrition Volume 56, 2005 - Issue 6
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Original

In vitro intestinal transport and antihypertensive activity of ACE inhibitory pea and whey digests

Vanessa Vermeirssen Laboratory for Microbial Ecology and Technology; Department of Food Technology and Nutrition, Ghent University, Faculty of Agriculture and Applied Biological Sciences, Ghent, Belgium
,
Patrick Augustijns Laboratory for Pharmacotechnology and Biopharmacy, Catholic University of Leuven (KUL), Faculty of Pharmaceutical Sciences, Leuven, Belgium
,
Nicole Morel Laboratory for Pharmacology, Catholic University of Louvain (UCL), Faculty of Medicine, Brussels, Belgium
,
John Van Camp Department of Food Technology and Nutrition, Ghent University, Faculty of Agriculture and Applied Biological Sciences, Ghent, Belgium
,
Anne Opsomer Department of Food Technology and Nutrition, Ghent University, Faculty of Agriculture and Applied Biological Sciences, Ghent, Belgium
&
Willy Verstraete Laboratory for Microbial Ecology and TechnologyCorrespondence[email protected]
Pages 415-430 | Published online: 06 Jul 2009

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Seyed Mohammad Taghi Gharibzahedi, Brennan Smith & Zeynep Altintas. (2022) Bioactive and health-promoting properties of enzymatic hydrolysates of legume proteins: a review. Critical Reviews in Food Science and Nutrition 0:0, pages 1-31.
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Alberta N. A. Aryee & Joyce I. Boye. (2016) Improving the Digestibility of Lentil Flours and Protein Isolate and Characterization of Their Enzymatically Prepared Hydrolysates. International Journal of Food Properties 19:12, pages 2649-2665.
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Damian Crowley, Yvonne O’Callaghan, Aoife McCarthy, Alan Connolly, Charles O. Piggott, Richard J. FitzGerald & Nora M. O’Brien. (2015) Immunomodulatory potential of a brewers’ spent grain protein hydrolysate incorporated into low-fat milk following in vitro gastrointestinal digestion. International Journal of Food Sciences and Nutrition 66:6, pages 672-676.
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Patrycja Puchalska, M. Luisa Marina Alegre & M. Concepción García López. (2015) Isolation and Characterization of Peptides with Antihypertensive Activity in Foodstuffs. Critical Reviews in Food Science and Nutrition 55:4, pages 521-551.
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Articles from other publishers (39)

Neha Gupta, Sameer Quazi, Saurabh Kumar Jha, Mohammad Khursheed Siddiqi, Kanika Verma, Swapnil Sharma, Rizwan Hassan Khan & Sameer Suresh Bhagyawant. (2022) Chickpea Peptide: A Nutraceutical Molecule Corroborating Neurodegenerative and ACE-I Inhibition. Nutrients 14:22, pages 4824.
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Jenny Bouchard, Maneka Malalgoda, Joanne Storsley, Lovemore Malunga, Thomas Netticadan & Sijo Thandapilly. (2022) Health Benefits of Cereal Grain- and Pulse-Derived Proteins. Molecules 27:12, pages 3746.
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Saima Rafiq, Nabila Gulzar, Aysha Sameen, Nuzhat Huma, Imran Hayat & Raina Ijaz. (2020) Functional role of bioactive peptides with special reference to cheeses. International Journal of Dairy Technology 74:1, pages 1-16.
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Fidel Toldrá, Marta Gallego, Milagro Reig, María-Concepción Aristoy & Leticia Mora. (2020) Recent Progress in Enzymatic Release of Peptides in Foods of Animal Origin and Assessment of Bioactivity. Journal of Agricultural and Food Chemistry 68:46, pages 12842-12855.
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Luísa Ozorio, Caroline Mellinger-Silva, Lourdes M. C. Cabral, Julien Jardin, Gaelle Boudry & Didier Dupont. (2020) The Influence of Peptidases in Intestinal Brush Border Membranes on the Absorption of Oligopeptides from Whey Protein Hydrolysate: An Ex Vivo Study Using an Ussing Chamber. Foods 9:10, pages 1415.
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Katya Anaya, Nadine Sus, Carlos Gadelha & Jan Frank. (2018) Development and validation of a rapid reversed-phase liquid chromatography method for CnAMP1 peptide quantification in human intestinal cell lines. Amino Acids 51:3, pages 407-418.
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Yuan‐Yuan He, Tao‐Tao Li, Jia‐Xin Chen, Xing‐Xing She, Di‐Feng Ren & Jun Lu. (2018) Transport of ACE Inhibitory Peptides Ile‐Gln‐Pro and Val‐Glu‐Pro Derived from Spirulina platensis Across Caco‐2 Monolayers . Journal of Food Science 83:10, pages 2586-2592.
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Siriporn Khueychai, Nisachon Jangpromma, Kiattawee Choowongkomon, Anupong Joompang, Sakda Daduang, Mongkol Vesaratchavest, Wisarut Payoungkiattikun, Shinjiro Tachibana & Sompong Klaynongsruang. (2018) A novel ACE inhibitory peptide derived from alkaline hydrolysis of ostrich (Struthio camelus) egg white ovalbumin. Process Biochemistry 73, pages 235-245.
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Gilda Aiello, Simonetta Ferruzza, Giulia Ranaldi, Yula Sambuy, Anna Arnoldi, Giulio Vistoli & Carmen Lammi. (2018) Behavior of three hypocholesterolemic peptides from soy protein in an intestinal model based on differentiated Caco-2 cell. Journal of Functional Foods 45, pages 363-370.
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Tajendra Pal Singh & Dalbir Singh Sogi. (2018) Comparative study of structural and functional characterization of bran protein concentrates from superfine, fine and coarse rice cultivars. International Journal of Biological Macromolecules 111, pages 281-288.
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Nuzhat Huma, Saima Rafiq, Aysha Sameen, Imran Pasha & Muhammad Issa Khan. (2018) Antioxidant potential of buffalo and cow milk Cheddar cheeses to tackle human colon adenocarcinoma (Caco-2) cells. Asian-Australasian Journal of Animal Sciences 31:2, pages 287-292.
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Ceren Daskaya-Dikmen, Aysun Yucetepe, Funda Karbancioglu-Guler, Hayrettin Daskaya & Beraat Ozcelik. (2017) Angiotensin-I-Converting Enzyme (ACE)-Inhibitory Peptides from Plants. Nutrients 9:4, pages 316.
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Papungkorn Sangsawad, Sittiruk Roytrakul & Jirawat Yongsawatdigul. (2017) Angiotensin converting enzyme (ACE) inhibitory peptides derived from the simulated in vitro gastrointestinal digestion of cooked chicken breast. Journal of Functional Foods 29, pages 77-83.
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Yu Fu, Jette Feveile Young, Martin Krøyer Rasmussen, Trine Kastrup Dalsgaard, René Lametsch, Rotimi E. Aluko & Margrethe Therkildsen. (2016) Angiotensin I–converting enzyme–inhibitory peptides from bovine collagen: insights into inhibitory mechanism and transepithelial transport. Food Research International 89, pages 373-381.
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Sydney Moser, Jongbin Lim, Mohammad Chegeni, JoLynne Wightman, Bruce Hamaker & Mario Ferruzzi. (2016) Concord and Niagara Grape Juice and Their Phenolics Modify Intestinal Glucose Transport in a Coupled in Vitro Digestion/Caco-2 Human Intestinal Model. Nutrients 8:7, pages 414.
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Bjørn Petrat-Melin, Gitte H. Kristiansen, Thao T. Le, Nina A. Poulsen, Lotte B. Larsen & Jette F. Young. (2016) In vitro gastrointestinal digestion of purified bovine kappa-casein variants A, B, and E: Effects on antioxidant and angiotensin 1-converting enzyme inhibitory capacity. International Dairy Journal 57, pages 44-51.
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Marta Gallego, Charlotte Grootaert, Leticia Mora, M. Concepción Aristoy, John Van Camp & Fidel Toldrá. (2016) Transepithelial transport of dry-cured ham peptides with ACE inhibitory activity through a Caco-2 cell monolayer. Journal of Functional Foods 21, pages 388-395.
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G. Chevrier, P. Mitchell, M.-S. Beaudoin & A. Marette. 2016. The Molecular Nutrition of Amino Acids and Proteins. The Molecular Nutrition of Amino Acids and Proteins 241 264 .
Sami Saadi, Nazamid Saari, Farooq Anwar, Azizah Abdul Hamid & Hasanah Mohd Ghazali. (2015) Recent advances in food biopeptides: Production, biological functionalities and therapeutic applications. Biotechnology Advances 33:1, pages 80-116.
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Teresita de Jes?s Ariza-Ortega, Elia Yadet Zen?n-Briones, Jos? Luis Castrej?n-Flores, Jorge Y??ez-Fern?ndez, Yolanda de las Mercedes G?mez-G?mez & Mar?a del Carmen Oliver-Salvador. (2014) Angiotensin-I-converting enzyme inhibitory, antimicrobial, and antioxidant effect of bioactive peptides obtained from different varieties of common beans (Phaseolus vulgaris L.) with in vivo antihypertensive activity in spontaneously hypertensive rats. European Food Research and Technology 239:5, pages 785-794.
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Candida J. Rebello, Frank L. Greenway & John W. Finley. (2014) Whole Grains and Pulses: A Comparison of the Nutritional and Health Benefits. Journal of Agricultural and Food Chemistry 62:29, pages 7029-7049.
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M.C. García, P. Puchalska, C. Esteve & M.L. Marina. (2013) Vegetable foods: A cheap source of proteins and peptides with antihypertensive, antioxidant, and other less occurrence bioactivities. Talanta 106, pages 328-349.
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Satyanarayana Bejjani & Jianping Wu. (2013) Transport of IRW, an Ovotransferrin-Derived Antihypertensive Peptide, in Human Intestinal Epithelial Caco-2 Cells. Journal of Agricultural and Food Chemistry 61:7, pages 1487-1492.
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Elena Sirtori, Ilena Isak, Donatella Resta, Giovanna Boschin & Anna Arnoldi. (2012) Mechanical and thermal processing effects on protein integrity and peptide fingerprint of pea protein isolate. Food Chemistry 134:1, pages 113-121.
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Daniel Martínez-Maqueda, Beatriz Miralles, Isidra Recio & Blanca Hernández-Ledesma. (2012) Antihypertensive peptides from food proteins: a review. Food & Function 3:4, pages 350.
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Anusha G.P. Samaranayaka & Eunice C.Y. Li-Chan. (2011) Food-derived peptidic antioxidants: A review of their production, assessment, and potential applications. Journal of Functional Foods 3:4, pages 229-254.
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Daniela Regazzo, Daniel Mollé, Gianfranco Gabai, Daniel Tomé, Didier Dupont, Joëlle Leonil & Rachel Boutrou. (2010) The (193–209) 17‐residues peptide of bovine β‐casein is transported through Caco‐2 monolayer. Molecular Nutrition & Food Research 54:10, pages 1428-1435.
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Chockry Barbana & Joyce Irene Boye. (2010) Angiotensin I-converting enzyme inhibitory activity of chickpea and pea protein hydrolysates. Food Research International 43:6, pages 1642-1649.
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Pedro Ruiz-Giménez, Aida Ibáñez, Juan B. Salom, Jose F. Marcos, Jose Javier López-Díez, Salvador Vallés, Germán Torregrosa, Enrique Alborch & Paloma Manzanares. (2010) Antihypertensive Properties of Lactoferricin B-Derived Peptides. Journal of Agricultural and Food Chemistry 58:11, pages 6721-6727.
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F. Roy, J.I. Boye & B.K. Simpson. (2010) Bioactive proteins and peptides in pulse crops: Pea, chickpea and lentil. Food Research International 43:2, pages 432-442.
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Anusha G. P. Samaranayaka, David D. Kitts & Eunice C. Y. Li-Chan. (2010) Antioxidative and Angiotensin-I-Converting Enzyme Inhibitory Potential of a Pacific Hake (Merluccius productus) Fish Protein Hydrolysate Subjected to Simulated Gastrointestinal Digestion and Caco-2 Cell Permeation. Journal of Agricultural and Food Chemistry 58:3, pages 1535-1542.
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Cristina Megías, Justo Pedroche, María del Mar Yust, Manuel Alaiz, Julio Girón-Calle, Francisco Millán & Javier Vioque. (2009) Stability of sunflower protein hydrolysates in simulated gastric and intestinal fluids and Caco-2 cell extracts. LWT - Food Science and Technology 42:9, pages 1496-1500.
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H. Gül Akıllıoğlu & Sibel Karakaya. (2009) Effects of heat treatment and in vitro digestion on the Angiotensin converting enzyme inhibitory activity of some legume species. European Food Research and Technology 229:6, pages 915-921.
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Lotte Usinger, Hans Ibsen & Lars T Jensen. (2009) Does fermented milk possess antihypertensive effect in humans?. Journal of Hypertension 27:6, pages 1115-1120.
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Marta Miguel, Alberto Dávalos, María A. Manso, Gema de la Peña, Miguel A. Lasunción & Rosina López‐Fandiño. (2008) Transepithelial transport across Caco‐2 cell monolayers of antihypertensive egg‐derived peptides. PepT1‐mediated flux of Tyr‐Pro‐Ile. Molecular Nutrition & Food Research 52:12, pages 1507-1513.
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Crystal D. Cinq-Mars, Chun Hu, David D. Kitts & Eunice C. Y. Li-Chan. (2007) Investigations into Inhibitor Type and Mode, Simulated Gastrointestinal Digestion, and Cell Transport of the Angiotensin I-Converting Enzyme–Inhibitory Peptides in Pacific Hake (Merluccius productus) Fillet Hydrolysate. Journal of Agricultural and Food Chemistry 56:2, pages 410-419.
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Martin Foltz, Evelyne E. Meynen, Veronique Bianco, Chris van Platerink, Thea M. M. G. Koning & Joris Kloek. (2007) Angiotensin Converting Enzyme Inhibitory Peptides from a Lactotripeptide-Enriched Milk Beverage Are Absorbed Intact into the Circulation. The Journal of Nutrition 137:4, pages 953-958.
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Soichi Tanabe, Nana Isobe, Eiji Miyauchi, Shoko Kobayashi, Masayuki Suzuki & Munehiro Oda. (2006) Identification of a Peptide in Enzymatic Hydrolyzate of Cheese That Inhibits Ovalbumin Permeation in Caco-2 Cells. Journal of Agricultural and Food Chemistry 54:18, pages 6904-6908.
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